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Patent # Description
2018/0327391 COMPOUND, COMPOSITIONS, AND METHODS
Compounds having activity as LRRK2 inhibitors are disclosed. The compounds are of formula (I) including stereoisomers, tautomers, pharmaceutically acceptable...
2018/0327390 UREA DERIVATIVES AND USES THEREOF
The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g.,...
2018/0327389 UREA DERIVATIVES AND USES THEREOF
The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g.,...
2018/0327388 APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination...
2018/0327387 Cyanine Compounds
Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for...
2018/0327386 CRYSTALLINE FORMS OF (R)-N-((4-METHOXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-2-METHYL- ...
The present disclosure relates to a crystalline Forms A, B, and C of (R)--N-((4-methoxy-6-methyl-2-oxo-1,2-di-hydropyridin-3-yl)methyl)-2-meth- ...
2018/0327385 AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those...
2018/0327384 3-METHYL-PYRROLIDINE-2,5-DIONE DERIVATIVES USEFUL AS CGRP RECEPTOR ANTAGONISTS
The present invention provides a compound of Formula II: ##STR00001## or a pharmaceutically acceptable salt or hydrate thereof, useful as a CGRP receptor...
2018/0327383 PROCESS FOR THE PREPARATION OF CRYSTALLINE DEXLANSOPRAZOLE
The present invention relates to a process for the preparation of anhydrous crystalline ...
2018/0327382 PYRIDINYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation...
2018/0327381 ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS
Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in...
2018/0327380 4-((6-(2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1- ...
Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-1,2,4-triazol-- ...
2018/0327379 2',6'-DIOXO-3'-DEUTERO-PIPERDIN-3-YL-ISOINDOLINE COMPOUNDS
The present application describes 2-(2',6'-dioxo-3'-deutero-piperidin-3'-yl)isoindoles, deuterated derivatives thereof, stereoisomers thereof, pharmaceutically...
2018/0327378 COMPOUND USEFUL FOR MANUFACTURING SALACINOL, METHOD FOR MANUFACTURING THE COMPOUND, METHOD FOR MANUFACTURING...
An object of the present invention is to provide a novel compound useful for manufacturing salacinol, a method for manufacturing the compound, a method for...
2018/0327377 SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO- -D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE OF...
A compound represented by a formula [1D] as shown below (wherein R.sup.1A, R.sup.1B, R.sup.2A, R.sup.2B, R.sup.3A and R.sup.3B represent a hydrogen atom, an...
2018/0327376 METHODS OF FORMING AROMATIC CONTAINING COMPOUNDS
Methods that include acylating an aromatic containing compound by reacting the aromatic containing compound with an anhydride containing compound to form an...
2018/0327375 AROMATIC SURFACTANTS
Disclosed are compounds of the Formula 1 wherein A is an aromatic moiety; H is a hydrophobic group comprising a main alkyl chain having from about 3 to about...
2018/0327374 Cyanopyridine Derivatives as Liver X Receptor Beta Agonists, Compositions, and Their Use
In its many embodiments, the present invention provides substituted cyanopyridine containing compounds of the Formula (I): and acceptable salts thereof,...
2018/0327373 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME
Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores...
2018/0327372 METHODS OF CHEMICAL SYNTHESIS OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INCLUDING METHYLTHIONINIUM CHLORIDE (MTC)
Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compounds") including...
2018/0327371 PROTEASE INHIBITORS
Compounds of the formula II: ##STR00001## wherein R.sup.1 and R.sup.2 are independently H, F or CH.sub.3; or R.sup.1 forms an ethynyl bond and R.sup.2 is H or ...
2018/0327370 NOVEL SPIROQUINONE DERIVATIVE COMPOUND, PRODUCTION METHOD THEREOF, AND PHARAMACEUTICAL COMPOSITION FOR...
The present invention relates to a novel spiroquinone derivative compound, a production method thereof, and a pharmaceutical composition for preventing or...
2018/0327369 CFTR REGULATORS AND METHODS OF USE THEREOF
Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
2018/0327368 HETEROCYCLIC COMPOUNDS FOR CANCER IMAGING AND TREATMENT AND METHODS FOR THEIR USE
Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R.sup.1, R.sup.2, R.sup.3,...
2018/0327367 MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds...
2018/0327366 QUINOXALINE-FUSED DIBENZOSUBERANE BASED HELICENES AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME
A quinoxaline-fused dibenzosuberane based helicene is shown in formula (1), ##STR00001## wherein A is with a structure of formula (2), formula (3a) or...
2018/0327365 HYDROXYPYRIDINONE AND HYDROXYPYRIMIDINONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS
The present teachings relate to hydroxypyridinone and hydroxypyrimidinone derivatives, pharmaceutical compositions thereof, and methods of using such compounds...
2018/0327364 MTOR INHIBITORS AND METHODS OF USE THEREOF
Disclosed are small molecule inhibitors of mammalian target of rapamycin (mTOR), and methods of using them.
2018/0327363 DERIVATIVES OF 5-(HETERO)ARYLPYRAZOL-3-CARBOXYLIC AMIDE OR 1-(HETERO)ARYLTRIAZOL-4-CARBOXYLIC AMIDE USEFUL FOR...
The present disclosure is based, in part, on the discovery that disclosed compounds such as those having Formula (IVa), (Va), (IV), or (V) can increase cystic...
2018/0327362 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS
The present application provides compounds useful in methods of treating neurological disorders such as Alzheimer's disease, and cancer such as prostate...
2018/0327361 PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation...
2018/0327360 NOVEL PYRIDINE DERIVATIVES
The invention relates to a compound of formula (I) ##STR00001## wherein R.sup.1 to R.sup.4 are defined as in the description and in the claims. The compound of...
2018/0327359 4-((6-(2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-OXOETHYL)PYRIDIN-3-YL)OXY)BEN- ZONITRILE AND PROCESSES OF PREPARATION
Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-oxoethyl)pyridin-3-yl)oxy)be- nzonitrile.
2018/0327358 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS
The disclosure relates to compounds of formula I, which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The...
2018/0327357 NOVEL ORGANIC COMPOUND, NEAR-INFRARED FLUORESCENT CONSTANT MEDIUM CONTAINING SAME, AND METHOD FOR...
The present invention relates to a novel organic compound, a near-infrared fluorescent constant medium containing the same, and a method for nano-granulating...
2018/0327356 IMPROVED PROCESS AND NOVEL POLYMORPHIC FORM OF APREMILAST
The present invention provides an improved process for the preparation of Apremilast using novel intermediates. The present invention also relates to the novel...
2018/0327355 ISOINDOLINE DERIVATIVES
Compounds of Formula I are disclosed and methods of treating viral infections with compositions comprising such compounds. ##STR00001##
2018/0327354 Unnatural Analogues of Calcitriol and Uses Thereof
Disclosed is a compound of Formula (I) ##STR00001## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X, and a are defined herein, or a...
2018/0327353 SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF
Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods...
2018/0327352 METHOD OF REPROCESSING ALKANESULFONIC ACID
The invention relates to a method of reprocessing alkanesulfonic acid employed in a chemical process as an agent, catalyst or solvent and comprising the steps...
2018/0327351 PRODRUGS OF CHLOROKYNURENINES
The present disclosure relates to prodrugs of 7-chlorokynurenic acid. In certain embodiments, the prodrugs include those having the structure of any one of...
2018/0327350 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula XII: ##STR00001## where R.sup.a, R.sup.b, R.sup.2, R.sup.7, and X are as defined in the ...
2018/0327349 PROCESSES FOR THE PREPARATION OF DIASTEREOMERICALLY AND ENANTIOMERICALLY ENRICHED OXAZOLINES
The invention relates to an industrially viable and advantageous process for the preparation of (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic...
2018/0327348 LONG-TERM MEMORY INDUCING AGENT
[Problem] To provide a method for inducing a long-term memory in a subject need thereof. [Solution to problem] A method for inducing a long-term memory, ...
2018/0327347 ISOMERIZATION OF MDACH
A method for isomerizing a starting mixture comprising 2,4-diamino-1-methylcyclohexane, 2,4-MDACH for short, 2,6-diamino-1-methylcyclohexane, 2,6-MDACH for...
2018/0327345 PRODUCTION OF ESTERS OF 3-HYDROXYPROPIONIC ACID AND ACRYLIC ACID
3-Hydroxypropionic acid esters are obtained by reacting ethylene oxide with carbon monoxide in the presence of a cobalt catalyst, wherein ...
2018/0327344 CRYSTAL OF MONOVALENT CATION SALT OF 3-HYDROXYISOVALERIC ACID AND PROCESS FOR PRODUCING THE CRYSTAL
The present invention provides a crystal of a monovalent cation salt of 3-hydroxyisovaleric acid (hereinafter, referred to as HMB), which is excellent in...
2018/0327343 COMPOSITIONS AND METHODS FOR PREPARING BETA,GAMMA-UNSATURATED ACIDS
The present disclosure provides methods for enantioselective synthesis of acyclic .alpha.-quaternary carboxylic acid derivatives via iridium-catalyzed allylic...
2018/0327342 METHOD FOR PRODUCING DIOL
The present invention provides a method for producing a diol having a specific structure in high yields while keeping high selectivity. Provided is a method...
2018/0327341 PROCESS FOR THE PREPARATION OF 2,3,3,3-TETRAFLUOROPROPENE
The present invention provides a process for preparing 2,3,3,3-tetrafluoropropene from 1,1,1,2,3-pentachloropropane and/or 1,1,2,2,3-pentachloropropane,...
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