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Patent # Description
2018/0326076 SUSTAINED-RELEASE PREPARATION OF POORLY SOLUBLE DRUG
The present invention relates to a pharmaceutical composition containing a poorly soluble drug, hyaluronic acid, and a fatty acid, and to a method for...
2018/0326075 DIALYSIS SOLUTION HAVING AT LEAST ONE OSMOTIC AGENT
The invention relates to a dialysis solution having at least one osmotic agent, with the osmotic agent being a polysaccharide modified by 2-sulfoethyl groups.
2018/0326074 METHODS FOR SYNTHESIZING PEPTIDE-TAGGED PEGYLATED CHITOSAN
Provided are synthetic schemes for the synthesis of a derivatized chitosan polymer, grafted with polyethylene glycol (PEG) and a peptide such as a...
2018/0326073 REDUCED AND OXIDIZED POLYSACCHARIDES AND METHODS OF USE THEREOF
The present invention is directed to reduced and highly oxidized polysaccharides, such as alginates, that are useful for encapsulating therapeutic or...
2018/0326072 ANTI-PROTOZOAL COMPOUNDS AND USES THEREOF
The present disclosure provides veterinary formulations comprising a therapeutically effective amount of an antiprotozoal compound and a polymer. The...
2018/0326071 COATED BALLOONS FOR BLOOD VESSEL STABILIZATION
A coated balloon device for stabilizing a section of a blood vessel in a living subject is disclosed. The coating layer of the coated balloon comprises a...
2018/0326070 CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES
The present invention provides iRNA agents comprising at least one subunit of the formula (I): ##STR00001## wherein: A and B are each independently for each ...
2018/0326069 THERAPEUTIC SOLUTION CONCENTRATE
A concentrated poly(ethylene glycol) solution that has good stability for extended storage is provided for use as a laxative. The concentrated solution...
2018/0326068 NON-AQUEOUS PATCH
Non-aqueous patches comprising lidocaine, which is not dissolved and is present in a crystalline state, have poor permeability to the skin. Therefore,...
2018/0326067 THERMOFORMED, TAMPER-RESISTANT PHARMACEUTICAL DOSAGE FORM CONTAINING ZINC
A thermoformed, tamper-resistant pharmaceutical dosage form comprises: a) a pharmacologically active ingredient; b) a polyalkylene oxide having a weight...
2018/0326066 SEMIFLUORINATED ALKANE COMPOSITIONS
The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be...
2018/0326065 METHODS AND COMPOSITIONS FOR SELF-REGULATED RELEASE OF ACTIVE PHARMACEUTICAL INGREDIENT
An abuse deterrent pharmaceutical composition including a pharmaceutically active ingredient; an acid soluble ingredient; and a buffering ingredient; wherein...
2018/0326064 COMPOSITION FOR ENHANCED ABSORPTION OF SUPPLEMENTS
A composition that includes at least one target supplement and at least one rehydration formulation is described. When the at least one target supplement is...
2018/0326063 COMPOSITE PARTICLES INCLUDING CELLULOSE, INORGANIC COMPOUND, AND HYDROXYPROPYL CELLULOSE
A composite particle comprising from 50 to 80 parts by mass of cellulose, from 10 to 40 parts by mass of an inorganic compound and from 4 to 11 parts by mass...
2018/0326062 PYRROLOBENZODIAZEPINE ANTIBODY DRUG CONJUGATES AND METHODS OF USE
The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, ...
2018/0326061 MODIFIED TRANSDERMAL DELIVERY DEVICE OR PATCH AND METHOD OF DELIVERING INSULIN FROM SAID MODIFIED TRANSDERMAL...
The invention is a means to provide enhanced delivery of a drug from a transdermal patch, employing a screen filter at the bottom of the patch which contacts...
2018/0326060 MESOTHELIN BINDING PROTEINS
Disclosed herein are MSLN binding proteins with improved binding affinities and improved ability to mediate T cell dependent killing of cancer cells expressing...
2018/0326059 COMBINATION THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER
The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including...
2018/0326058 COMBINATION THERAPY USING T CELL REDIRECTION ANTIGEN BINDING MOLECULE AGAINST CELL HAVING IMMUNOSUPPRESSING...
It was discovered that antigen-binding molecules comprising (1) a domain that binds to a molecule expressed on the surface of cells having immune ...
2018/0326057 SELECTIVELY ALTERING MICROBIOTA FOR IMMUNE MODULATION
The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of...
2018/0326056 METHOD, APPARATUS AND SYSTEMS FOR TRACKING FREIGHT
Methods, apparatus, and systems are provided for tracking freight. Embodiments include a tracking device for a trailer containing a load. The tracking device...
2018/0326055 NANOSTRUCTURE
In order to obtain a nanostructure that encapsulates an agent therein and that can be easily taken up by cells, a nanostructure of the present invention is a...
2018/0326054 BISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO PD1 AND LAG3
The invention relates to bispecific antibodies comprising a first antigen binding domain that specifically binds to PD1 and a second antigen binding domain...
2018/0326053 EPITOPE OF OPTIMIZED HUMANIZED MONOCLONAL ANTIBODIES AGAINST ACTIVATED PROTEIN C AND USES THEREOF
Provided are optimized humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. In...
2018/0326052 CANCER TREATMENT COMPOSITION COMBINING ANTI-CD26 ANTIBODY AND OTHER ANTICANCER AGENT
Mesothelioma growth inhibitory effect of standard cisplatin-pemetrexed concomitant therapy is potentiated by combination with an anti-CD26 antibody. A high...
2018/0326051 LIPIDATED IMMUNE RESPONSE MODIFIER COMPOUND COMPOSITIONS, FORMULATIONS, AND METHODS
The compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecan- amide is a useful drug compound for enhancing immune response and can...
2018/0326050 BACTERIAL RNAS AS VACCINE ADJUVANTS
The invention features vaccine adjuvants comprising prokaryotic mRNA, and methods of vaccination using the adjuvants.
2018/0326049 ENHANCED IMMUNE RESPONSE IN PORCINE SPECIES
The present invention generally relates to methods of eliciting an immune response in a porcine species subject. In particular, an immunomodulator composition...
2018/0326048 SMALLPOX VACCINE FOR CANCER TREATMENT
Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use...
2018/0326047 PORCINE EPIDEMIC DIARRHEA VIRUS VACCINES AND METHODS OF USE THEREOF
The present disclosure provides an isolated or purified Porcine Epidemic Diarrhea Virus (PEDV) or Porcine Epidemic Diarrhea Virus (PEDV) S1 protein, and...
2018/0326046 TUNABLE VACCINE PLATFORM AGAINST PATHOGENS OF THE PARAMYXOVIRUS FAMILY
Disclosed herein is a strategy for the engineering of recombinant vaccines against major human and animal pathogens of the paramyxovirus family. Also disclosed...
2018/0326045 COMBINATION PIV3/HMPV RNA VACCINES
The disclosure relates to respiratory virus ribonucleic acid (RNA) vaccines and combination vaccines, as well as methods of using the vaccines and compositions...
2018/0326044 NSP10 SELF-ASSEMBLING FUSION PROTEINS FOR VACCINES, THERAPEUTICS, DIAGNOSTICS AND OTHER NANOMATERIAL APPLICATIONS
A fusion protein is provided which is based on a self-assembling gene-regulatory NSP10 protein and a protein or peptide capable of being fused to NSP10 without...
2018/0326043 BROAD-SPECTRUM VACCINE AGAINST AVIAN REOVIRUS
A broad-spectrum vaccine against avian Reovirus is disclosed, which is effective in reducing the infection of avian Reovirus in an avian target. The vaccine...
2018/0326042 DRIED INFLUENZA VACCINE PREPARATION AND METHOD FOR PRODUCING DRIED INFLUENZA VACCINE PREPARATION
The present invention provides a dried influenza vaccine preparation in which the activity of an influenza vaccine can be stably maintained even if the...
2018/0326041 VACCINE PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION AND METHOD FOR MANUFACTURING VACCINE PHARMACEUTICAL...
The present invention provides a vaccine pharmaceutical composition for oral administration that enables stable storage of an influenza virus antigen and a...
2018/0326040 INFLUENZA VIRUS VACCINE AND VACCINE PLATFORM
Attenuated live or replication-deficient chimeric swine influenza virus vaccine, and a platform to develop a multitude of other vaccines in swine and other...
2018/0326039 VACCINE COMPOSITIONS
Provided herein are vaccine compositions for example in a dry powder form for intranasal delivery, and their preparation methods. Also provided are methods of...
2018/0326038 GENETICALLY ENGINEERED FOOT AND MOUTH DISEASE VIRUS AND RELATED PROTEINS, POLYNUCLEOTIDES, COMPOSITIONS,...
Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions,...
2018/0326037 Novel Vaccines Against Multiple Subtypes Of Dengue Virus
An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prME that elicits an...
2018/0326036 IMMUNOGENIC COMPOSITIONS AND USES THEREOF
Immunogenic compositions comprising viral vectors and surfactants are provided. Methods for administration and preparation of such compositions are also provided.
2018/0326035 POTENTIATED T-CELL MODULATOR ABLE TO MODULATE IMMUNE RESPONSE, SPECIFICALLY DESIGNED FOR THERAPEUTIC USE AS A...
Disclosed is a potentiated T-cell modulator (TCM) designed for treating the symptomology of the disease known as vitiligo. The TCM is obtained by means of a...
2018/0326034 VACCINES AND DIAGNOSTICS FOR NOVEL PORCINE ORTHOREOVIRUSES
Provided herein are diagnostics and vaccines to identify control and prevent novel porcine orthoreovirus type 3 (POV3) isolated from diarrheic feces of piglets...
2018/0326033 CODON-OPTIMIZED LENTIVIRAL VECTOR FOR STEM CELL REPROGRAMMING
The invention relates to methods and materials that can be used to product cytotoxic T cells that target cancer cells expressing the cancer-testis antigen NY...
2018/0326032 CHIMERIC ANTIGEN RECEPTORS TARGETING HER2
Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain targeted to HER2, a transmembrane region, a costimulatory domain and an...
2018/0326031 CYCLOPHOSPHAMIDE ANALOGS FOR USE AS IMMUNOGENS AND ASSAY CONJUGATES FOR AN IMMUNOASSAY OF CYCLOPHOSPHAMIDE AND...
The present application relates to antibodies that bind to small molecules such as cyclophosphamide, ifosfamide, and analogs thereof, and immunological assays...
2018/0326030 VACCINES AGAINST AN ONCOGENIC ISOFORM OF ESR1 AND METHODS OF USING THE SAME
Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods...
2018/0326029 Modified Natural Killer Cells and Natural Killer Cell Lines Having Increased Cytotoxicity
NK cells and NK cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production...
2018/0326028 CD200 INHIBITORS AND METHODS OF USE THEREOF
The present invention provides in certain embodiments compositions comprising at least one CD200 inhibitor, and methods of reversing or modulating immune...
2018/0326027 EPITOPES IN AMYLOID BETA AND CONFORMATIONALLY-SELECTIVE ANTIBODIES THERETO
The disclosure pertains to epitopes identified in A-beta including conformational epitopes, antibodies thereto and methods of making and using immunogens and...
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