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Patent # Description
2018/0325925 COMPOSITION FOR PREVENTION OR TREATMENT OF NEUROINFLAMMATORY DISEASE, CONTAINING PROTEIN TYROSINE PHOSPHATASE...
The present invention relates to a pharmaceutical composition for prevention or treatment of a neuroinflammatory disease, in which the pharmaceutical...
2018/0325923 FATTY ACID ACETYLATED SALICYLATES AND THEIR USES
The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate...
2018/0325922 25-HYDROXY VITAMIN D3 COMPLEX AND METHODS OF MANUFACTURE AND ITS APPLICATIONS
This invention provides a 25-OH Vitamin D3 complex, this complex is made of .beta.-cycledextrin and/or its derivatives and 25-Hydroxy Vitamin D3. This...
2018/0325921 COMPOSITIONS FOR THE TREATMENT OF INFLAMMATION OF THE GASTROINTESTINAL TRACT
Provided herein are methods for treating the symptoms of and inflammation associated with gastroesophageal reflux disease (GERD) and other conditions. Also...
2018/0325920 System and Method for Diagnosis and Treatment
This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR...
2018/0325919 ANTIFUNGAL AGENTS USED IN COMBINATION
The present invention relates to the use of enfumafungin derivative triterpenoid antifungal compounds in combination with other antifungal agents such azoles,...
2018/0325918 IMMUNOREGULATORY AGENT
An immunoregulatory agent containing a regulatory agent that regulates Dedicator of cytokinesis 2 (DOCK2)-mediated Rac activation as an active ingredient is...
2018/0325917 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF
Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of...
2018/0325916 Dermal Delivery Compositions And Methods
A composition for transdermal delivery of a progestin for progestin hormone therapy is disclosed. Also disclosed is a transdermal delivery device comprising...
2018/0325915 CHLOROPHYLL COMPOSITION
This invention comprises a chlorophyllin composition and method of administering the same for using the same for treatment of kidney disease patients to...
2018/0325914 INCREASING STORAGE OF VITAMIN A, VITAMIN D AND/OR LIPIDS
The present disclosure provides compositions that include a nanoparticle and a compound that reduces the biological activity of one or more bromodomain and...
2018/0325913 REJECTION REACTION SUPPRESSANT
To provide a novel method for suppressing rejection after corneal transplantation. The method for suppressing rejection after corneal transplantation includes...
2018/0325912 METHOD OF TREATMENT OF AGGRESSION
The invention comprises a method of treatment of aggression and similar behavioral syndromes, such as impulsivity and irritability, by a pharmaceutical agent...
2018/0325911 NOVEL COMPOUNDS
The invention is directed to compounds of formula (I): ##STR00001## and salts thereof. The compounds of the invention are inhibitors of kinase activity, in...
2018/0325910 3-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINE AND THERAPEUTIC USES THEREOF
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
2018/0325909 COMBINATION TREATMENT OF SPECIFIC FORMS OF EPILEPSY
Formulations for and methods of treatment of Dravet syndrome that avoid side effects are disclosed. The formulations comprise a 5-HT receptor agonists which...
2018/0325908 METHODS AND COMPOSITIONS FOR TREATING PULMONARY HYPERTENSION
The present disclosure provides compositions and methods for treating pulmonary hypertension. The compositions and methods are based on administering a...
2018/0325907 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES
Provided herein is a pharmaceutical composition comprising two or more compounds, wherein each compound is independently a phosphodiesterase inhibitor, an...
2018/0325906 THEOBROMINE COMPOSITIONS USEFUL FOR INCREASING FETAL WEIGHT GAIN AND ENHANCING BONE PROPERTIES
Compositions and methods for culturing cells with theobromine are provided, as well as cells derived thereby. Theobromine compositions for enhancing bone...
2018/0325905 SUSTAINED RELEASE SMALL MOLECULE DRUG FORMULATION
An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small...
2018/0325904 ADMINISTRATION OF NEDD8-ACTIVATING ENZYME INHIBITOR AND CHEMOTHERAPEUTIC AGENTS
Disclosed are methods for the treatment of various solid tumors in patients in need of such treatment. The methods comprise administering to such a patient an...
2018/0325903 THERAPEUTIC METHODS AND COMPOSITIONS
The invention provides compositions and methods that are effective to improve NO production in vivo and/or to increase NO levels in blood. Such compositions...
2018/0325902 COMPOSITIONS AND METHODS RELATING TO CANCER
Compositions and methods continue to be required for treatment of cancer. Compositions and methods according to aspects of the present invention relate to...
2018/0325901 CHIRAL DIARYL MACROCYCLES AND USES THEREOF
This disclosure relates to the use of certain diaryl macrocycle compounds, specifically ...
2018/0325900 INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
2018/0325899 IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES
Compounds of formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFN.alpha., by acting...
2018/0325898 DNA-PK INHIBITORS
The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said...
2018/0325897 CO-CRYSTALS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: ##STR00001## wherein each of R.sup.1...
2018/0325896 SYK INHIBITORS
The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and...
2018/0325895 PHARMACEUTICAL COMPOSITION CONTAINING ...
A stabilized solid preparation containing 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsu- lfonyl)acetamide is provided, namely, a...
2018/0325894 COMBINATIONS COMPRISING BREXPIPRAZOLE OR A SALT THEREOF AND A SECOND DRUG FOR USE IN THE TREATMENT OF A CNS...
The present invention provides a medicament having a wider treatment spectrum, causing a fewer side effects and superior in tolerability and safety, as...
2018/0325893 SUBACUTE ADMINISTRATION OF NMDA MODULATORS ALONE OR IN COMBINATION
This disclosure features combinations of NMDA modulators and atypical antipsychotics. The disclosure provides for example, methods of treating schizophrenia,...
2018/0325892 PHARMACEUTICAL COMPOSITIONS
Methods and compositions are provided which comprise effective amounts of an analgesic to treat a subject, including reducing or eliminating an adverse effect...
2018/0325891 OCTAHYDRO AZADECALIN FORMULATIONS
Applicant provides formulations and pharmaceutical compositions containing glucocorticoid receptor modulators (GRMs) and suitable for treating diseases...
2018/0325890 METHODS AND PHARMACEUTICAL COMPOSTIONS FOR TREATING RHABDOMYOLYSIS
The present invention relates to methods and pharmaceutical compositions for treating rhabdomyolysis.
2018/0325889 IMMUNOREGULATORY AGENTS
Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such...
2018/0325888 Atropine Pharmaceutical Compositions
The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability....
2018/0325887 N-[2-(1-BENZYLPIPERIDIN-4-YL)ETHYL]-4-(PYRAZIN-2-YL)-PIPERAZINE-1-CARBOXAM- IDE DERIVATIVES AND RELATED...
Provided herein are small molecule compounds of the following formula (I): or a stereoisomer, tautomer, solvate, ester or pharmaceutically acceptable salt...
2018/0325886 STABLE NIMODIPINE PARENTERAL FORMULATION
A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a...
2018/0325885 FORMULATIONS OF 4-AMINO-2-(2,6-DIOXOPIPERIDINE-3-YL)ISOINDOLINE-1,3-DIONE
Pharmaceutical compositions and single unit dosage forms of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione, or a pharmaceutically acceptable...
2018/0325884 METHODS AND DEVICES FOR THE TREATMENT OF OCULAR DISEASES IN HUMAN SUBJECTS
Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject...
2018/0325883 Use of 2-carboxamide cycloamino urea derivatives in the treatment of EGFR dependent diseases or diseases that...
The use of compounds of formula (I) ##STR00001## in the treatment of Epidermal Growth Factor Receptor (EGFR) dependent diseases or diseases that have acquired...
2018/0325882 STABLE NIMODIPINE PARENTERAL FORMULATION
A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a...
2018/0325881 Methods for Treatment of Fabry Disease
Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological...
2018/0325880 PHARMACEUTICAL COMPOSITIONS OF THERAPEUTICALLY ACTIVE COMPOUNDS
Provided are compounds and pharmaceutical compositions useful for treating cancer and methods of treating cancer comprising administering to a subject in need...
2018/0325879 Antibacterial compositions
Pharmaceutical compositions comprising S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,- 5H-benzo[i,j]quinolizine-2-carboxylic acid...
2018/0325878 N-BIARYLAMIDES
The invention relates to N-biarylamides, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of...
2018/0325877 Use of Maleimide Derivatives for Preventing and Treating Cancer
The present invention is related to a compound of formula (I): ##STR00001## a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, a...
2018/0325876 Sibiriline Derivatives For Use For Preventing And/Or Treating Disorders Associated With Cellular Necroptosis
The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as...
2018/0325875 COMBINATION THERAPY FOR PULMONARY HYPERTENSION
The present invention provides compositions and methods for the treatment of pulmonary hypertension using combination therapy. The combination therapy...
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