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Patent # Description
2018/0325874 [1,2,4]TRIAZOLO[1,5-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS
Disclosed are compounds of Formula (I) ##STR00001## or a salt thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, m, n, and p are defined herein. Also...
2018/0325873 PYRAZOLYLAMINOBENZIMIDAZOLE DERIVATIVES AS JAK INHIBITORS
The present invention provides compounds of the formula below (I'): where R, and R1-R3 are as described herein, methods of treating patients for certain types...
2018/0325872 COMPOUNDS FOR TREATMENT OF CANCER
The present invention relates to pharmaceutical compositions for treating cancer comprising BRAF inhibitors, (e.g. vemurafenib) and/or MEK inhibitor, (e.g....
2018/0325871 ANTIMITOTIC AMIDES FOR THE TREATMENT OF CANCER AND PROLIFERATIVE DISORDERS
Novel, antimitotic heteroaryl amides and pharmaceutically acceptable salts of Formula I where Ar, R.sup.5, R.sup.6, R.sup.8, R.sup.9, R.sup.11, X.sup.1, and...
2018/0325870 NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS
The present invention is directed to novel opioid receptor modulators of Formula (I). ##STR00001## The invention further relates to methods for preparing such...
2018/0325869 TARGETING OF THE FORMYL-PEPTIDE RECEPTOR 2/LIPOXIN A4 RECEPTOR (FPR2/ALX) FOR TREATMENT OF HEART DISEASE
The disclosure generally relates to a therapeutic approach based on the stimulation of resolution of inflammation by the Formyl-Peptide Receptor 2/Lipoxin...
2018/0325868 SELECTIVE OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE MODULATORS OF NR2B
Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods...
2018/0325867 USE OF NK-1 RECEPTOR ANTAGONIST SERLOPITANT IN PRURITUS
The invention relates to methods for treating pruritus with NK-1 receptor antagonists such as serlopitant. The invention further relates to pharmaceutical...
2018/0325866 USE OF NK-1 RECEPTOR ANTAGONISTS IN PRURITUS
The invention relates to methods for treating pruritus with NK-1 receptor antagonists such as serlopitant. The invention further relates to pharmaceutical...
2018/0325865 Composition, Method Of Manufacture, And Use Of Site-Specific Delivery Of Bruceolides For Treatment Of Cancer...
Disclosed are bruceolides for the treatment of cancer, and other diseases, selectively targeting unwanted cells. The disclosed bruceolides may include a site...
2018/0325864 COMPOUNDS AND METHODS FOR TREATING AUTISM SPECTRUM DISORDERS
The present invention relates to a compound of the following formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, for use in the prevention...
2018/0325863 ANTIMICROBIAL COMPOSITIONS FOR CLOSTRIDIUM DIFFICILE
Clostridium difficile infects and kills 30,000-40,000 people a year in the United States. Provided herein are methods to inhibit growth and reduce the spread...
2018/0325862 METHODS FOR TREATING ALZHEIMER?S DISEASE AND RELATED DISORDERS
The invention is directed to a method of treating Alzheimer's Disease by administering to a subject in need thereof a therapeutically effective amount of...
2018/0325861 NOVEL CANNABINOID FORMULATIONS
Provided are formulations and methods for improving oral bioavailability of cannabinoid compositions.
2018/0325860 Stable Analogs of CYP450 Lipid Metabolites and Inhibitors of Soluble Epoxide Hydrolase
This disclosure relates to methods of reducing inflammation, angiogenesis, vascular leakage and neovascularization by administering to a subject in need...
2018/0325859 COMPOSITIONS COMPRISING A COMPOUND FROM THE FAMILY OF AVERMECTINS AND AN AGONIST COMPOUND FOR AT LEAST ONE OF...
Compositions including a compound of the family of avermectins, preferably ivermectin, and an agonist compound for at least one of the retinoic acid receptors...
2018/0325858 METHODS OF TREATING UROLOGICAL DISORDERS USING SARMs
The present invention is directed to methods of treating, preventing, suppressing and/or inhibiting urological disorders such as urinary incontinence including...
2018/0325857 METHOD FOR TREATING HEMOLYTIC UREMIC SYNDROME
The present invention provides methods for treating, controlling or mitigating hemolytic uremic syndrome (HUS), comprising administering a ...
2018/0325856 HALOGENATED ESTERS OF CYCLOPROPANATED UNSATURATED FATTY ACIDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE...
The present disclosure describes novel PKC-.epsilon. activators chosen from halogenated esters of unsaturated fatty acids and derivatives thereof, including...
2018/0325855 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER
The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are...
2018/0325854 USE OF PROTEASOME INHIBITORS TO TREAT OCULAR DISORDERS
Hydrocinnamate compounds that exhibit proteasome modulation activity, and in particular, proteasome inhibitory activity, can be used to topically or...
2018/0325853 BENZOQUINONE DERIVATIVE E3330 IN COMBINATION WITH CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF COLON CANCER
Disclosed are novel methods for the therapeutic treatment of cancer and angiogenesis. The enzyme Ape1/Ref-1, via its redox function, enhances the DNA binding...
2018/0325852 ALDITOL-FREE, STORAGE-STABLE THYROID HORMONE ACTIVE DRUG FORMULATIONS AND METHODS FOR THEIR PRODUCTION
Embodiments of the present invention provide pharmaceutical compositions in unit dosage form that comprise a therapeutically effective amount of levothyroxine...
2018/0325851 Transdermally-Delivered Combination Drug Therapy for Pain
The invention provides a topical formulation for treating pain comprising a nonsteroidal anti-inflammatory agent or a Cox-2 inhibitor and a gabapentin family...
2018/0325850 VALPROIC ACID FOR TREATMENT OF MYOCARDIAL ISCHEMIA
Provided herein are pharmaceutical compositions comprising valproic acid and methods of use thereof for the treatment and/or prevention of myocardial ischemia...
2018/0325849 GLYCOLIC ACID PROTECTS AGAINST ISCHEMIC INSULTS
The present invention relates to glycolic acid or a pharmaceutically acceptable salt or ester thereof for use in the treatment or prevention of ischemic...
2018/0325848 ORAL COMPOSITION
The present invention relates to an oral composition showing increased adsorption performance of an oil-soluble medicinal ingredient such as glycyrrhetinic...
2018/0325847 METHODS OF TREATING LIVER FIBROSIS BY ADMINISTERING 3-BROMOPYRUVATE
Methods for treating or preventing liver fibrosis in a subject by administering to the subject a therapeutically effective amount of 3-bromopyruvate (3-BrPA)...
2018/0325846 PHARMACEUTICAL FORMULATION FOR REDUCING FREQUENCY OF URINATION AND METHOD OF USE THEREOF
Methods and compositions for reducing frequency of urination are disclosed. The methods comprise administering to a subject having a condition that resulting...
2018/0325845 AMINONAPHTHOQUINONE COMPOUNDS FOR TREATMENT AND/OR PREVENTION OF FIBROSIS DISEASES
The invention relates to the use of a compound of Formula (I) as described herein and its effective dose in the prevention and/or treatment of fibrosis...
2018/0325844 PHARMACOLOGICAL PROPHYLACTICS AGAINST STRESS-INDUCED AFFECTIVE DISORDERS AND THEIR ASSOCIATED SYMPTOMS
Methods for prophylactically treating a stress-induced affective disorder or stress-induced psychopathology in a subject are provided. Also provided are...
2018/0325843 PHYTONADIONE COMPOSITIONS AND RELATED METHODS
Stable Phytonadione compositions for parenteral administration are provided which comprise (E) isomer of phytonadione at or greater than 97% w/w as the active...
2018/0325842 Mixture of stabilised biologically available curcumin for orodispersible formulations, formulations of...
Orodispersible tablet with biologically available curcumin containing particles of extract of rhizome of plant Curciuma longa containing, at least, 95% by...
2018/0325841 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE
The present disclosure relates to a use of a phloroglucinol-based compound and its salt for preventing and treating Alzheimer's disease. The pharmaceutical...
2018/0325840 COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING FATTY PANCREAS OR AMELIORATING PANCREAS DISEASES CAUSED BY...
The present invention relates to a composition and method for preventing or treating fatty pancreas, or ameliorating a pancreas disease caused by fatty...
2018/0325839 TRANSDERMAL PATCHES
The present invention relates to a transdermal patch comprising a pharmaceutical formulation, the formulation comprising ropivacaine or an opioid, a...
2018/0325838 TRANSDERMAL ADHESIVE COMPOSITIONS, DEVICES, AND METHODS
A stable transdermal adhesive composition comprising: an adhesive comprising a washed polymerization reaction product of at least two ethylenically unsaturated...
2018/0325837 Base Composition for Tape Agent
The present invention provides a composition for a non-aqueous patch preparation having an excellent adhesibility which can sustainedly release a drug. The...
2018/0325836 ULTRASONIC TRANSDUCERS SUITABLE FOR ULTRASONIC DRUG DELIVERY VIA A SYSTEM, WHICH IS PORTABLE AND WEARABLE BY...
The invention is a device for transmitting acoustical energy between an ultrasonic generator, through a medicine-containing patch, and into the exterior...
2018/0325835 MODIFIED TRANSDERMAL DELIVERY PATCH WITH MULTIPLE ABSORBENT PADS
The invention is modified transdermal patch, which contains two or more absorbent pads placed atop one another within the drag reservoir of the patch, enabling...
2018/0325834 COMPOSITIONS COMPRISING ELECTROHYDRODYNAMICALLY OBTAINED FIBRES FOR ADMINISTRATION OF SPECIFIC DOSAGES OF AN...
The present invention relates to electrospun fibers comprising i) a hydrophilic polymer that is soluble in a first solvent, ii) a bioadhesive substance that is...
2018/0325833 NANOPARTICLES BASED ON OPTIONALLY ALKOXYLATED POLY(ALKYL CYANOACRYLATES) HAVING A DEFINED DEGREE OF POLYMERIZATION
The present invention relates to nanoparticles based on optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity, a...
2018/0325831 NANO COMPLEX MATERIAL, DRUG CARRIER COMPRISING SAME, CONTRAST AGENT COMPRISING SAME, AND METHOD FOR PREPARING...
The present disclosure relates to a nano complex material, a drug carrier including the same, a contract agent including the same, and a method for preparing...
2018/0325830 COATED BIOLOGICAL COMPOSITION
A coated biological composition has a mixture of biologic material and a volume of a liquid protectant. The mixture of biologic material has non-whole cellular...
2018/0325829 MILLICAPSULE FORMULATIONS COMPRISING POLYUNSATURATED FREE FATTY ACIDS
Capsular dosage forms containing polyunsaturated fatty acid (PUFA) compositions are provided herein. In certain embodiments, unit dosage forms comprising a...
2018/0325828 Device and Method for Granulating, Agglomerating, Pelletising, Drying and/or Coating
Provided is a device for granulating, agglomerating, pelletising, drying and/or coating, the device including a swirl chamber, a distribution chamber, wherein...
2018/0325827 DELIVERY SYSTEM
A delivery vehicle with a core surrounded by a digestible polymer shell having a melting and/or softening point above the body temperature of an animal or...
2018/0325826 CONTROLLED-RELEASE FORMULATION
The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject...
2018/0325825 GEMCABENE COMBINATIONS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE
The present invention provides pharmaceutical compositions formulated to include a statin and gemcabene, wherein the composition is useful for treating,...
2018/0325824 METHOD FOR ACCELERATING THE SUGAR-COATING FORMATION OF SUGAR ALCOHOL COATING WITH CALCIUM LACTATE
[Problem] To provide a method for forming a smooth sugar-coating layer having sufficient practical strength that enables to significantly shorten the time...
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