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Patent # Description
2018/0371079 ANTIBODIES TO IL-6 AND USE THEREOF
The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of...
2018/0371078 TREATMENT OF FIBROSIS
Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment,...
2018/0371077 TREATMENT OF FIBROSIS
Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment,...
2018/0371076 MATERNAL TH17 CELLS AND PSYCHIATRIC DISORDERS
The present invention provides a method for reducing the risk of developing a psychiatric disorder (e.g., ASD, of which autism is a particular example) in a...
2018/0371075 ANTI-HUMAN IL-3 ANTIBODIES, THEIR USE IN TREATMENT OF A DISEASE OR MALFUNCTION ASSOCIATED WITH ELEVATED...
Anti-human IL-3 antibodies or fragments thereof according to the present invention are useful as therapeutic agents. The antibodies can be used in ...
2018/0371074 STABLE AND SOLUBLE ANTIBODIES INHIBITING TNF ALPHA
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and...
2018/0371073 ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF
The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments,...
2018/0371072 COMBINATION THERAPY OF CANCER WITH ANTI-ENDOGLIN ANTIBODIES AND ANTI-VEGF AGENTS
The present application relates to compositions of chimeric anti-endoglin antibodies and anti-VEGF agents. Another aspect relates to the use of chimeric...
2018/0371071 Therapeutic DLL4 Binding Proteins
Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that...
2018/0371070 ANTIBODIES FOR DETECTING REDOX MODULATED PROTEINS
An isolated antibody, consisting of an anti-glutathionylated eNOS antibody, wherein the anti-glutathionylated eNOS antibody has been generated against an...
2018/0371069 MODULATING THE ALTERNATIVE COMPLEMENT PATHWAY
Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the...
2018/0371068 Compositions and Methods for Generating a Persisting Population of T Cells Useful for the Treatment of Cancer
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an...
2018/0371067 ANTI-LAMININ4 ANTIBODIES SPECIFIC FOR LG4-5
The invention provides antibodies that specifically bind to the LG4-5 modules of the G domain of laminin .alpha.4. The antibodies can preferentially stain...
2018/0371066 HUMANIZED ANTI-TAU ANTIBODIES
Provided herein is an isolated antibody or antigen-binding fragment that specifically binds tau, the antibody or fragment comprising a heavy chain variable...
2018/0371065 Human Anti-Alpha-Synuclein Antibodies
Provided are novel human .alpha.-synuclein-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto....
2018/0371064 LENTIVIRAL VECTOR EXPRESSING MEMBRANE-ANCHORED OR SECRETED ANTIBODY
The invention concerns a multicistronic nucleic acid, in particular an isolated multicistronic nucleic acid, comprising: A) a sequence comprising successively:...
2018/0371063 THERAPY AND PROPHYLAXIS OF INFECTIOUS DISEASE CAUSED BY ZIKA VIRUS
Provided are methods for prevention or treatment of an infection caused by a virus of Flavivirus genus, and in particular by Zika virus disease in a mammalian...
2018/0371062 HUMAN CYTOMEGALOVIRUS NEUTRALIZING ANTIBODIES AND USE THEREOF
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and...
2018/0371061 APPLICATION OF ZN7MT3 AND ITS DERIVATIVES IN THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE
The present disclosure provides a use based on Zn.sub.7MT3 or a derivative thereof. Zn.sub.7MT3 or a derivative thereof is used for prevention or treatment of...
2018/0371060 MODIFIED PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF) PEPTIDES AND USES THEREOF FOR TREATING NEOVASCULAR DISEASES,...
Disclosed are modified pigment epithelium-derived factor (PEDF) peptides, particulate carrier prodrugs thereof, and pharmaceutical compositions comprising the...
2018/0371059 ANTIMICROBIAL CONSTRUCTS AND USES THEREOF
Disclosed herein are antimicrobial constructs comprising a membrane interacting peptide and an antimicrobial agent. Also disclosed are methods for making and...
2018/0371058 IMPROVED MICROBE-BINDING MOLECULES AND USES THEREOF
Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting...
2018/0371057 COMPOSITIONS AND METHODS FOR IMPROVING IMMUNOTHERAPY
This disclosure provides compositions and methods for improving immunotherapy, specifically against diseases like HIV or lymphoma that manifest within B cell...
2018/0371056 Multi-Span Chimeric Antigen Receptor
The present invention relates to a multi-span chimeric antigen receptor (CAR) which comprises: i) at least one extra-cellular antigen binding domain; ii) a...
2018/0371055 Novel Epitope for Switching to TH2 Cell and Use Thereof
The present invention relates to a novel epitope to convert T cell to type 2 helper T (T.sub.H2) cell. Specifically, the present invention relates to an...
2018/0371054 CELL
The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an...
2018/0371053 METHODS AND COMPOSITIONS FOR CHIMERIC ANTIGEN RECEPTOR TARGETING CANCER CELLS
The present invention provides a chimeric antigen receptor (CAR) that recognizes B7-H3 (CD276), as well as methods of use in the treatment of diseases and...
2018/0371052 CHIMERIC ANTIGEN RECEPTORS AND ENHANCEMENT OF ANTI-TUMOR ACTIVITY
This disclosure relates to chimeric antigen receptors targeting T cell malignancies. The present disclosure also relates to the development of methods for...
2018/0371051 NKG2D DECOYS
Single chain, multimerized, and/or glycosylated NKG2D decoys are described. The NKG2D decoys have high affinity and avidity for surface bound and soluble NKG2D...
2018/0371050 MURINE ANTI-NY-ESO-1 T CELL RECEPTORS
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1. Also provided are related polypeptides,...
2018/0371049 HIGH AFFINITY NY-ESO T CELL RECEPTORS
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201. the SLLMWITQC SEQ ID NO:126 peptide being...
2018/0371048 FUSION PROTEIN FOR alpha-MELANOCYTE STIMULATING HORMONE AND PREPARATION METHOD AND USE THEREOF
Disclosed is a fusion protein for .alpha.-Melanocyte stimulating hormone, the fusion protein containing a protein transduction domain (PTD), a human serum...
2018/0371047 POLYNUCLEOTIDES ENCODING RELAXIN
The invention relates to mRNA therapy for the treatment of fibrosis and/or cardiovascular disease. mRNAs for use in the invention, when administered in vivo,...
2018/0371046 Therapy for Lower Urinary Tract Dysfunctions
The present invention relates to the use of relaxin for the treatment of lower urinary tract dysfunctions.
2018/0371045 NOVEL INSULIN DERIVATIVES
The novel insulin derivates delivers, after administration to humans, insulin as a function of the glucose concentration in the tissue.
2018/0371044 PEPTIDOMIMETIC MACROCYCLES
The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment...
2018/0371043 NOVEL GLYCOSAMINOGLYCAN-ANTAGONISING FUSION PROTEINS AND METHODS OF USING SAME
The present invention relates to novel monomeric fusion proteins derived from human GAG binding proteins such as chemokines with increased glycosaminoglycan...
2018/0371042 NOVEL CYTOKINE FUSION PROTEINS
The present invention relates to cytokine fusion proteins and to nucleic acid molecules encoding such cytokine fusion proteins. The present invention further...
2018/0371040 PEPTIDES OF PAGE5
The present invention relates to novel peptides derived from P antigen family member 5 (PAGE5), complexes comprising such peptides bound to recombinant MHC...
2018/0371039 PEPTIDES
The present invention relates to novel peptides derived from Melanoma-associated antigen C (MAGEC1), complexes comprising such peptides bound to recombinant...
2018/0371038 NOVEL PROTEINS SPECIFIC FOR PYOVERDINE AND PYOCHELIN
The present disclosure provides hNGAL muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical...
2018/0371037 NOVEL PROTEINS SPECIFIC FOR PYOVERDINE AND PYOCHELIN
The present disclosure provides hNGAL muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical...
2018/0371036 NUCLEAR REPROGRAMMING FACTOR AND INDUCED PLURIPOTENT STEM CELLS
The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced...
2018/0371035 SOLUBLE HIGH MOLECULAR WEIGHT (HMW) TAU SPECIES AND APPLICATIONS THEREOF
The disclosure provides novel forms of tau species and applications thereof, as well as methods of diagnosing and/or treating tau-associated neurodegeneration.
2018/0371034 METHODS FOR PREPARING AND USING MULTICHAPERONE-ANTIGEN COMPLEXES
The present invention relates to methods for preparing and using multichaperone-antigen complexes. The present invention uses HOP affinity molecules in...
2018/0371033 THERAPEUTIC PEPTIDES AND METHODS OF USE THEREOF
Peptides that home, distribute to, target, are directed to, or accumulate in tumors, cancers, or diseased cells are disclosed. Peptides that cross the blood...
2018/0371032 AXMI477, AXMI482, AXMI486 AND AXMI525 TOXIN GENES AND METHODS FOR THEIR USE
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding...
2018/0371031 HOST CELLS AND METHODS FOR PRODUCING FATTY ACID-DERIVATIVES WITH HIGH BRANCHED-CHAIN PERCENTAGE
The present disclosure is generally related to transformed host cells and their use for the production of branched-chain acyl-ACPs, branched-chain ...
2018/0371030 NEISSERIA MENINGITIDIS COMPOSITION AND METHODS THEREOF
In one aspect, the invention relates to a non-lipidated and non-pyruvylated Neisseria meningitidis serogroup B subfamily A A12 polypeptide. In another aspect,...
2018/0371029 MICROBIAL NANOWIRES WITH INCREASED CONDUCTIVITY AND REDUCED DIAMETERS
Improved electrically conductive pili were generated from a natural pilus protein from the microorganism Geobacter sulfurreducens. Substituting a tryptophan...
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