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Patent # Description
2018/0371028 EXPRESSION OF KLEBSIELLA OXYTOCA POLYPEPTIDES INVOLVED IN LYSINE DECARBOXYLATION, AND METHODS AND APPLICATIONS...
Provided are lysine decarboxylase polypeptides comprising mutants of SEQ ID NO: 2 and/or fragments thereof. The mutants or fragments have at least 95% sequence...
2018/0371027 ZIKA VIRUS VACCINE
Described herein are Zika virus vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.
2018/0371026 FELINE CALICIVIRUS VACCINE
The present invention relates to a new feline capsid protein, to live attenuated feline calicivirus comprising that capsid protein, to live recombinant carrier...
2018/0371025 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA
Described herein is the generation of optimized HIN1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus...
2018/0371024 METHODS AND COMPOSITIONS FOR DUAL GLYCAN BINDING AAV VECTORS
The present invention provides methods and compositions comprising an adeno-associated virus (AAV) capsid protein, comprising one or more amino acids...
2018/0371023 NOVEL MURAMYL PEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF
The invention relates to novel Muramyl Dipeptide (MDP) derivative compound of structural Formula-VIII, a process for synthesis, intermediates used in the...
2018/0371022 LINACLOTIDE SYNTHESIS METHOD
Disclosed is a method of synthesizing linaclotide through completely selective formation of three disulfide bonds, comprising the steps of: 1) synthesizing...
2018/0371021 PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present...
2018/0371020 BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE MOIETIES AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
2018/0371019 MODULATION OF COMPLEMENT ACTIVITY
The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
2018/0371018 POLYPEPTIDE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
The present invention discloses a polypeptide compound, a method for preparing the polypeptide compound, and an application of the polypeptide compound. The...
2018/0371017 NOVEL ANALGESIC PHARMACEUTICAL FORMULATIONS AND USES THEREOF
The subject invention provides compositions and methods for alleviating pain. Specifically, the subject invention provides pharmaceutical formulations of...
2018/0371016 TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES AS HTRA1 INHIBITORS
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.3, ...
2018/0371015 NEW DIFLUOROKETAMIDE DERIVATIVES AS HTRA1 INHIBITORS
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, ...
2018/0371014 CHIRAL COMPOUNDS OF VARYING CONFORMATIONAL RIGIDITY AND METHODS OF SYNTHESIS
Synthesis of compounds having varying degrees of conformational rigidity is obtained via a low cost, high yield and efficient synthetic reactions. The library...
2018/0371013 METHOD FOR PRODUCING LACOSAMIDE AND INTERMEDIATE THEREOF
The present invention provides a method of industrially and safely producing lacosamide high in diastereomeric excess at a high yield and a low cost. Adopting...
2018/0371012 QUINSTATIN COMPOUNDS
The present disclosure relates to Quinstatin compounds, pharmaceutical compositions comprising such compounds, kits, and methods for using such compounds or...
2018/0371011 Protein purification using intein-hydrophobin tag and alcohol precipitation
A method of downstream purification of a recombinant protein in fusion with a hydrophobin-intein tag using alcohol precipitation. The method comprises (1)...
2018/0371010 BACTERIAL COLICIN-IMMUNITY PROTEIN PROTEIN PURIFICATION SYSTEM
Provided herein are compositions and methods for protein purification.
2018/0371009 METHODS AND INTERMEDIATES FOR THE PREPARATION OF BILE ACID DERIVATIVES
The present disclosure relates to methods and novel intermediates useful in the preparation of a compound of formula I ##STR00001## or pharmaceutically...
2018/0371008 METHODS OF SYNTHESIZING AND LABELING NUCLEIC ACID MOLECULES
The present invention is generally related to composition, kits and methods for synthesizing nucleic acid molecules and particularly for synthesizing labeled...
2018/0371007 METHODS FOR TREATING DISEASES RELATED TO MITOCHONDRIAL STRESS
Means and methods for therapeutic intervention of mitochondrial disorders or diseases, and in particular to a method for the treatment, prevention and/or...
2018/0371006 METHODS OF LIBRARY CONSTRUCTION FOR POLYNUCLEOTIDE SEQUENCING
Disclosed herein are methods and compositions for the detection of small RNAs in a sample. The methods and compositions disclosed herein may be used for...
2018/0371005 MODIFIED NUCLEOSIDES, ANALOGS THEREOF AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
The present invention provides modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom. More particularly, the present invention...
2018/0371004 URIDINE PHOSPHORAMIDE PRODRUG, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF
The present invention relates to a uridine phosphoramide prodrug, the preparation method therefor, and the medicinal uses thereof. The prodrug of the present...
2018/0371003 STEVIOL GLYCOSIDE COMPOSITION
The present invention relates to a composition comprising one or more steviol glycosides which composition comprises kaurenoic acid in an amount of no more...
2018/0371002 CRYSTALLINE FORM A OF REBAUDIOSIDE D, AND PREPARATION METHOD AND APPLICATION THEREFOR
Provided are crystalline form A of rebaudioside D, and a preparation method and application therefor. In X-ray powder diffraction analysis measured using...
2018/0371001 FERMENTATIVE PRODUCTION OF OLIGOSACCHARIDES
The invention relates to a microbial production of recombinant oligosaccharides, particularly of human milk oligosaccharides (HMOs), using a genetically...
2018/0371000 PROCESS FOR OBTAINING AN AQUEOUS EXTRACT ENRICHED WITH SMALL RNAS FROM A PLANT MATERIAL AND EXTRACTS RESULTING...
The invention relates to a method for obtaining an aqueous extract enriched with small RNA having a maximum length of 150 nucleotides, from plant material. The...
2018/0370999 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
The present invention includes a series of novel osmium bis(tridenatate) complexes with emission profiles in the near-infrared region.
2018/0370998 Novel AminoBisPhosphonate Antiwear Additives
The present invention relates to novel aminobisphosphonate compounds useful as antiwear and/or friction modifier additive components, lubricant additive...
2018/0370997 WATER-SOLUBLE DERIVATIVES OF 3,5-DIPHENYL-DIAZOLE COMPOUNDS
The present invention is concerned with derivatives of 3,5-diphenyl-diazole compounds, which are effective therapeutic agents for use in treating diseases...
2018/0370996 FLUORIDE FLUORESCENCE PROBE
Methylene blue (MB) derivatives selectively detect F.sup.- by desilylation reaction to act as a fluorescent probe.
2018/0370995 FLUOROSILICON NITRILE COMPOUNDS
Novel fluorosilicon nitrile compounds, and methods of preparing them, are described. The fluorosilicon nitrile compounds are characterized by having a total of...
2018/0370994 SILOXANE OLIGOMERS FOR THE TREATMENT OF SOLID SURFACES
A siloxane oligomer of the following formula is provided. This siloxane can increase the hydrophobicity and/or the lipophobicity of a surface of a solid...
2018/0370993 COMPOSITION OF MATTER FOR USE IN ORGANIC LIGHT-EMITTING DIODES
The present disclosure relates to compounds of Formula (I) ##STR00001## as compounds capable of emitting delayed fluorescence, and uses of the compounds in...
2018/0370992 Catalysts for reversing formaldehyde adducts and crosslinks
Catalysts act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting catalysts to formaldehyde fixed samples is a useful way...
2018/0370991 HETEROCYCLES USEFUL AS ANTI-CANCER AGENTS
The present invention provides compounds of Formula (I), and the pharmaceutically acceptable salts, hydrates, and solvates thereof. It also provides...
2018/0370990 TETRAHYDROPYRIDO[4,3-d]PYRIMIDINE INHIBITORS OF ATR KINASE
The present invention relates to tetrahydropyrido[4,3-d]pyrimidine based compounds and methods which may be useful as inhibitors of ATR kinase for the...
2018/0370989 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF
4-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2018/0370988 BICYCLIC HETEROCYCLYL DERIVATIVES AS IRAK4 INHIBITORS
The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors,...
2018/0370987 HISTONE DEACETYLASE INHIBITORS
This invention relates to generally inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).
2018/0370986 ASYMMETRIC BENZOTRICHALCOGENOPHENE COMPOUND AND POLYMER
An asymmetric benzotrichalcogenophene compound and a polymer are provided. The asymmetric benzotrichalcogenophene compound is a heterocyclic compound having...
2018/0370985 A Novel Method To Isolate Inoscavin A From Fulviformes Fastuosus And Medicinal Preparation Thereof To Treat...
The invention relates to a novel method to isolate a natural product, a flavonoid namely inoscavin A from a Sri Lankan mushroom, medicinal preparation thereof...
2018/0370984 PRODUCTION OF XYLENE DERIVATIVES
The present invention relates to the production of xylene derivatives from furfural and its derivatives. The invention describes new routes for converting...
2018/0370983 OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES, THEIR PREPARATION AND USE
This invention provides compounds having the structure ##STR00001## which may be used for the treatment of tumors.
2018/0370982 PROCESS FOR THE PREPARATION OF [(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL] ...
The present invention relates to an improved process for the preparation of [(1 S,2R)-3-[[(4-aminophenyl)sulfonyl] ...
2018/0370981 HETERO-CONDENSED PHENYLQUINAZOLINES AND THEIR USE IN ELECTRONIC DEVICES
The present invention relates to compounds of the general formula (I) and to a process for their preparation, to an electronic device comprising at least one...
2018/0370980 CRYSTAL FORM OF SUBSTITUTED AMINOPYRAN DERIVATIVE
The present invention relates to a crystal form of a substituted aminopyran compound, and a pharmaceutical composition, a preparation method and a use thereof...
2018/0370979 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
The present invention includes novel organic materials comprising indolo[2,3-c]carbazole linked to an aromatic heterocycle via a carbazole linker. These...
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