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Patent # Description
2018/0370978 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
The present invention includes novel compounds containing an alkylated or alkylsilyl fused benzimidazole and deuterated or partially deuterated variants...
2018/0370977 IMIDAZO[1,2-B][1,2,4]TRIAZINES AS C-MET INHIBITORS
The present invention relates to imidazo[1,2-b][1,2,4]triazines that are inhibitors of c-Met and are useful in the treatment of c-Met associated diseases...
2018/0370976 7-(THIAZOL-5-YL) PYRROLOPYRIMIDINE COMPOUND AS TLR7 AGONIST
The present invention relates to a 7-(thiazol-5-yl)pyrrolopyrimidine compound as a TLR7 agonist, and particularly relates to a compound shown in formula (I),...
2018/0370975 2-AMINOQUINAZOLINE DERIVATIVES AS P70S6 KINASE INHIBITORS
The invention provides compound that inhibit or modulate the activity of p70S6 kinase, the compounds being of the formula (1): ##STR00001## or a salt, tautomer...
2018/0370974 Compounds And Their Use As Inhibitors Of N-Myristoyl Transferase
This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also...
2018/0370973 FUSED HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to fused heteroaryl derivative compounds which are antagonists of orexin receptors. The present invention is also directed to...
2018/0370972 CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
2018/0370971 Substituted-Quinoxaline-Type Bridged-Piperidine Compounds and the Uses Thereof
The invention relates to Substituted-Quinoxaline-Type Bridged-Piperidine Compounds, compositions comprising an effective amount of a ...
2018/0370970 FORMS OF METHYL {4,6-DIAMINO-2-[1 (2-FLUOROBENZYL)-1H-PYRAZOLO[3-4-B]PYRIDINO-3-YL]PYRIMIDINO-5-YL}METHYL ...
This present invention relates to forms of methyl {4.6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3.4-b]pyridino-3-yl]pyrimi- dino-5-yl}methylcarbamate...
2018/0370969 Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
The invention provides novel compounds having the general formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X, Y, W and n are...
2018/0370968 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA
Provided are novel compounds of Formula (I): ##STR00001## pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in...
2018/0370967 6-5 FUSED RINGS AS C5a INHIBITORS
The present disclosure provides, inter alia, Compounds of Formula (I) ##STR00001## or pharmaceutically acceptable salts thereof that are modulators of the C5a...
2018/0370966 METHODS OF TREATMENT USING PYRIDINONYL PDK1 INHIBITORS
The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.
2018/0370965 SUBSTITUTED PERHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND THE USE OF SAME
The present application relates to novel (2-phenylimidazo[1,2-a]pyridin-3-yl)methyl-substituted perhydropyrrolo[3,4-c]pyrrole derivatives, to methods for the...
2018/0370964 PHARMACEUTICAL COMPOSITION CONTAINING, AS ACTIVE INGREDIENT, 7-AZAINDOLIN-2-ONE DERIVATIVE OR PHARMACEUTICALLY...
The present invention relates to a 7-azaindolin-2-one derivative or a pharmaceutically acceptable salt thereof, and the 7-azaindolin-2-one derivative or the...
2018/0370963 4,5,6,7-TETRAHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE AND 1,4,5,6,7,8-HEXAHYDROIMIDAZO[4,5-D]AZEPINE DERIVATIVES AS...
There are provided compounds of formula I, wherein X, Ak, s, A, R.sup.1 and R.sup.2 have meanings given in the description, which compounds have ...
2018/0370962 NOVEL 1,2,3 TRIAZOLE-THIAZOLE COMPOUNDS, PROCESS FOR PREPARATION AND USE THEREOF
A 1,2,3 triazole-thiazole compound of formula (I) or pharmaceutically acceptable salt thereof, process for its preparation, its pharmaceutical composition and...
2018/0370961 OREXIN RECEPTOR ANTAGONISTS
The disclosures herein relate to novel compounds of formula wherein W, X and Y.sub.1, Y.sub.2, Y.sub.3 and Y.sub.4 are defined herein, and their use in...
2018/0370959 Liver X. Receptor (LXR) Modulators for the Treatment of Dermal Diseases, Disorders and Conditions
Described herein are liver X receptor (LXR) modulators and methods of utilizing LXR modulators in the treatment of dermal diseases, disorders or conditions....
2018/0370958 Route Of Synthesis For Opicapone
The present invention relates to a new route of synthesis for obtaining Opicapone ((4Z)-4-[3-(2,5-dichloro-4,6-dimethyl-1-oxidopyridin-1-ium-3-yl- ...
2018/0370957 COMPOUND AND ORGANIC LIGHT EMITTING DISPLAY DEVICE
The disclosure relates to the technical field of organic electroluminescent materials, and particularly to a compound and an organic light emitting display...
2018/0370956 HETEROARYL SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE MODULATORS
Compounds having the following formula: ##STR00001## or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R.sup.2 is a monocyclic heteroaryl...
2018/0370955 TANK-BINDING KINASE INHIBITOR COMPOUNDS
Compounds having the following formula (I) and methods of their use and preparation are disclosed: ##STR00001##
2018/0370954 AN IMPROVED PROCESS FOR THE PREPARATION OF MACITENTAN
The present invention relates to an improved process for the preparation of macitentan and pharmaceutical acceptable salts thereof. Further present invention...
2018/0370953 Bis-Triazole Compounds with Anti-Biofilm and Anti-Corrosion Properties
The present invention deals with novel bis-triazole compounds (I), compositions comprising said compounds, and their uses as a medicament, an antibacterial...
2018/0370952 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES
The invention relates to an organic molecule, in particular for use in organic optoelectronic devices. According to the invention, the organic molecule...
2018/0370951 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound...
2018/0370950 THERAPEUTIC COMPOUNDS
The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): ##STR00001## ##STR00002## which are useful in the treatment of a...
2018/0370949 Imaging of Glycogen Synthase Kinase 3
Provided herein are radiolabelled compounds useful for imaging GSK-3 kinase. An exemplary radiolabelled compound provided herein is useful as a radiotracer for...
2018/0370948 P-TOLUENESULFONATE FOR MEK KINASE INHIBITOR, METHOD OF PREPARATION THEREOF, AND METHOD OF USE THEREOF
Disclosed are a p-toluenesulfonate of a MEK kinase inhibitor, and a crystal form thereof and a preparation method thereof. Specifically disclosed are a ...
2018/0370947 FACTOR XIa INHIBITORS
The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said...
2018/0370946 4-((6-(2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1- ...
Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-1,2,4-triazol-- ...
2018/0370945 TETRAZOLONE-SUBSTITUTED DIHYDROPYRIDINONE MGAT2 INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, a solvate...
2018/0370944 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
The present invention includes novel compounds containing deuterated or partially deuterated xanthene and thioxanthene structures. These compounds may be...
2018/0370943 Chiral Cyclodecynes and Methods
Provided herein are cyclodecynes, including chiral cyclodecynes, and methods of making cyclodecynes. The methods may include providing a 1,1'-biaryl compound...
2018/0370942 NEW 5-AZIDO-5-DEOXY-2 :3-ISOPROPYLIDENE-D-ARABINOSE COMPOUNDS; THEIR METHOD OF MANUFACTURE AND THEIR USE FOR...
Disclosed are new compounds of formulae: ##STR00001## Wherein: R.sup.1 and R.sup.2 can be independently H; a C.sub.1 to C.sub.6 alkyl including methyl, ethyl,...
2018/0370941 STEREOISOMER OF FLOCOUMAFEN, COMPOSITION AND RODENTICIDE BAIT COMPRISING SAME, AND METHOD FOR CONTROLLING...
Disclosed is a configurational stereoisomer, named enantiomer E.sub.1, of flocoumafen, the enantiomer E.sub.1 having, by chromatographic analysis of...
2018/0370940 SALICYLIC ACID DERIVATIVE, METHOD FOR PREPARING SAME, AND COSMETIC COMPOSITION FOR WHITENING COMPRISING SAME
The present invention relates to a novel salicylic acid derivative, a method for preparing the same, and a cosmetic composition for whitening having the same....
2018/0370939 NOVEL HYDROXYL PYRANONE COMPOUND, METHOD FOR PRODUCING SAME, AND COSMETICS COMPOSITION COMPRISING COMPOUND
The present invention relates to a novel hydroxyl pyranone compound, a method for producing same, and a cosmetic composition having the compound. The hydroxyl...
2018/0370938 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES
The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent...
2018/0370937 PROCESS FOR THE PRODUCTION OF 5-HYDROXYMETHYLFURFURAL IN THE PRESENCE OF ORGANIC CATALYSTS FROM THE THIOUREA FAMILY
A process for the transformation of a feed of at least one sugar into 5-hydroxymethylfurfural, contacting the feed with one or more organic catalysts in the...
2018/0370936 PROCESSES AND SYSTEMS FOR REMOVING AN ALKYL IODIDE IMPURITY FROM A RECYCLE GAS STREAM IN THE PRODUCTION OF...
Processes for reducing the amount of a gaseous iodide-containing impurity present in a recycle gas stream used in the production of ethylene oxide, in...
2018/0370935 PROCESSES AND SYSTEMS FOR REMOVING IODIDE IMPURITIES FROM A RECYCLE GAS STREAM IN THE PRODUCTION OF ETHYLENE OXIDE
Processes for reducing the amount of a gaseous iodide-containing impurity present in a recycle gas stream used in the production of ethylene oxide, in...
2018/0370934 PROCESS AND REACTOR FOR THE EPOXIDATION OF PROPENE
Propene is continuously reacted with hydrogen peroxide in a tube bundle reactor comprising a multitude of parallel reaction tubes in the presence of a titanium...
2018/0370933 NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN
The present invention relates to compounds and compositions for inhibition of FASN, their synthesis, applications, and antidotes.
2018/0370932 PROCESSES FOR PREPARING OXATHIAZIN-LIKE COMPOUNDS
Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are...
2018/0370931 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS
The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): ##STR00001## wherein X is alkyl,...
2018/0370930 GLUTAMINASE INHIBITORS AND METHOD OF USE
Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that...
2018/0370929 WATER-BASED CELL STAINING COMPOSITION, METHOD FOR PREPARING SAME AND USE THEREOF, CELL SAMPLE PREPARATION AND...
This invention patent relates, in a first aspect, to cell staining compositions comprising a mixture of dyes or salts and complexes thereof in an aqueous...
2018/0370928 4-Oxo-4,5-Dihydrothiazole Derivative, Preparation Method and Use Thereof
The present invention relates to a compound represented by Formula I, a racemate or optical isomer thereof, or a pharmaceutically acceptable salt, a solvate or...
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