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Patent # Description
2018/0369358 CONSTRUCTION OF WEST NILE VIRUS AND DENGUE VIRUS CHIMERAS FOR USE IN A LIVE VIRUS VACCINE TO PREVENT DISEASE...
The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live,...
2018/0369357 Bordetella Pertussis Immunogenic Vaccine Compositions
This invention is directed to composition, vaccines, tools and methods in the treatment and prevention of Bordetella pertussis. In particular, the invention is...
2018/0369356 GNA1870-Based Vesicle Vaccines for Broad Spectrum Protection Against Diseases Caused by Neisseria Meningitidis
The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly...
2018/0369355 Targeting of Ligand Binding Sites in CLFA
The present invention provides methods and compositions to reduce binding of fibrinogen to the ClfA in a gram positive bacterial infections using monoclonal...
2018/0369354 AIPA, OMPA, AND ASP14 IN VACCINE COMPOSITIONS AND DIAGNOSTIC TARGETS FOR ANAPLASMA PHAGOCYTOPHILUM INFECTION
Anaplasma phagocytophilum surface protein AipA and/or fragments thereof which comprise an invasin domain are used in compositions suitable to elicit an immune...
2018/0369353 VACCINATION AGAINST DIABETES, OBESITY AND COMPLICATIONS THEREOF
The present invention concerns a composition comprising at least one prophylactically or therapeutically active agent selected from the group consisting of...
2018/0369352 VECTORS FOR EXPRESSION OF PROSTATE-ASSOCIATED ANTIGENS
The present disclosure provides (a) vectors comprising a multi-antigen construct encoding two, three, or more immunogenic PAA polypeptides; (b) compositions...
2018/0369351 THERAPEUTIC IMMUNE MODULATION BY STEM CELL SECRETED EXOSOMES
Disclosed are methods, compositions of matter, and protocols useful for the induction of a therapeutic immune modulatory response through administration of...
2018/0369350 ANTIGEN-SPECIFIC T CELLS FOR INDUCING IMMUNE TOLERANCE
Described herein are agents and methods for targeting antigen-specific B cells using engineered T cells, such as regulatory T cells or cytotoxic T cells, or...
2018/0369349 COOPERIA VACCINE
The present invention relates to nucleotide sequences encoding Cooperia antigens, as well as to recombinant DNA molecules containing such nucleotide sequences...
2018/0369348 BOTULINUM TOXIN TREATMENTS OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS
Methods for preventing or treating neuropsychiatric disorder and/or a neurological disorder including a neurological disorder mediated by the thalamus....
2018/0369347 Stabilised Compositions of Factor VII Polypeptides
The invention relates to chemically as well as physically stable kits and compositions comprising polypeptides, in particular Factor VII or Factor VII-related...
2018/0369346 METHODS, COMPOSITIONS AND KITS FOR REDUCING TISSUE ADHESIONS
The present invention provides a composition, comprising: proaccelerin (factor V) and at least one factor selected from the group consisting of: prothrombin...
2018/0369345 METHOD FOR PREVENTING OR TREATING DIABETES MELLITUS NERVE INJURY AND RELATED DISEASES
The present invention relates to the use of plasminogen in the prevention and/or treatment of diabetic neuropathic pain and neurohypersensitivity, and in the...
2018/0369344 Compositions and Methods for Treating Metabolic Disorders
The present invention relates to the unexpected discovery of an exceptionally non-conservative mutation in a very large kindred with a high prevalence of early...
2018/0369343 SYSTEMIC GENE REPLACEMENT THERAPY FOR TREATMENT OF X-LINKED MYOTUBULAR MYOPATHY (XLMTM)
The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for...
2018/0369342 CARDIAC METABOLIC EFFECT OF LANTUS
The present invention relates to a insulin or insulin analogue for use in increasing cardiac efficiency or cardiac stroke volume in a patient at risk of...
2018/0369341 Pharmaceutical Compositions
The present invention provides liquid compositions comprising albiglutide or a variant thereof, a buffering agent, at least one saccharide and/or at least one...
2018/0369340 LONG-ACTING GLP-1R AGONIST AS A THERAPY OF NEUROLOGICAL AND NEURODEGENERATIVE CONDITIONS
The present invention relates to compositions and methods for treating neurodegenerative conditions using GLP-1r agonists. In certain embodiments, long-acting...
2018/0369339 Methods and Compositions for Oral Administration of Proteins
This invention provides compositions that include a protein and at least two protease inhibitors, method for treating diabetes mellitus, and methods for...
2018/0369338 TREATING CARDIOVASCULAR OR RENAL DISEASES
This document provides methods and materials for treating cardiovascular and/or renal diseases. For example, AAV9 vectors designed to express natriuretic...
2018/0369337 Methods of Using Interleukin-10 for Treating Diseases and Disorders
Methods of treating subjects having a cancer-related disease, disorder, or condition, or preventing the occurrence of such a disease, disorder or condition,...
2018/0369336 B CELL-BASED CANCER IMMUNOTHERAPY
The technology described herein is directed to cellular cancer immunotherapies involving natural IgM producing phagocytic B (NIMPAB) cells and chemokines that...
2018/0369335 IMMUNE FUNCTION DEVELOPMENT PROMOTER AND GROWTH PROMOTER
The present invention discloses immune function development promoters and growth promoters comprising CCL25. The development of immune functions in a subject...
2018/0369334 VEGF VARIANT POLYPEPTIDE COMPOSITIONS
Provided herein are VEGF variant polypeptides and Fc-VEGF variant polypeptide fusions, comprising a first VEGF monomer joined to a second VEGF monomer by a...
2018/0369333 Nanoparticle-mediated delivery of cytokines for maintenance of the regulatory T cell phenotype
Compositions for delivery of growth factors needed for stable Tregs and methods of use thereof are provided. In preferred embodiments, the compositions can...
2018/0369332 FGF21-Fc FUSION PROTEINS FOR TREATING METABOLIC DISORDERS
The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved...
2018/0369331 NOVEL THERAPEUTIC USE OF FGF19
The present invention relates to a FGF19 polypeptide for its use as an agent increasing muscle fibers size, in the prevention and/or treatment of muscle...
2018/0369330 METHODS AND COMPOSITIONS USING INTEGRIN-BASED THERAPEUTICS
The present invention is directed to modified integrin proteins and methods and compositions using integrin-based therapeutics. In one embodiment, the modified...
2018/0369329 COMBINATION TUMOR TREATMENT WITH AN INTEGRIN-BINDING-FC FUSION PROTEIN AND IMMUNE MODULATOR
The present invention provides a method of treating cancer with an integrin-binding-Fc fusion protein alone or in combination with IL-2 and/or an immune...
2018/0369328 Modulators of Complement Function
The invention relates generally to a modified human C3 protein containing a number of single amino acid changes in the .alpha. and .beta.-chain of human C3...
2018/0369327 METHOD FOR TREATING OR PREVENTING OSTEOARTHRITIS
A method for treating or preventing osteoarthritis includes promoting the expression of STAMP2 in chondrocyte. Osteoarthritis is diagnosed by measuring an...
2018/0369326 PEPTIDES AND METHODS RELATED TO ICOS SIGNALING
The present disclosure relates to methods and compositions useful for initiating and propagating ICOS-mediated signaling. In particular, the present disclosure...
2018/0369325 COMPOUNDS AND METHODS FOR TREATING METABOLIC DISORDERS
The present disclosure relates to methods and reagents for treating or preventing metabolic disorders, including, but not limited to, type 2 diabetes, obesity,...
2018/0369324 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CARDIAC FIBROSIS
The present invention relates to a pharmaceutical composition for the treatment of cardiac fibrosis or heart diseases accompanied by cardiac fibrosis....
2018/0369323 MODULATION OF HEPATITIS B VIRUS CCCDNA TRANSCRIPTION
The present invention provides small molecule inhibitors of hepatitis B virus (HBV) covalently closed circular (ccc) DNA, which are useful as therapeutics in...
2018/0369322 MODULATORS OF COMPLEMENT ACTIVITY
The present invention relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such...
2018/0369321 COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO ADRENOCORTICAL ACTIVITY AND/OR EXCESSIVE STEROID...
Provided herein are methods for treating subjects having conditions related to adrenocortical activity and/or excessive steroid production. In particular,...
2018/0369320 SAFE DESMOPRESSIN ADMINISTRATION
Disclosed is a family of intranasal spray dispensers for administering uniform low doses of desmopressin so as to achieve safe antidiuresis in human patients....
2018/0369319 Method of Reducing Injury to Mammalian Cells
A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron is disclosed. The method comprises administering to...
2018/0369318 Methods for regulating transcription of multiple genes and expression of multiple targets
Methods for regulating multiple organs, multiple genes and multiple targets by using a polypeptide, wherein the polypeptide comprising the amino acid sequence...
2018/0369317 WEEKLY DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES
Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about...
2018/0369316 PROTEASOME MODULATION FOR TREATMENT OF CORNEAL DISORDERS
Disclosed herein are methods and compositions useful for preventing or reducing corneal haze of opacification resulting from Limbal Stem Cell Deficiency...
2018/0369315 MULTIFUNCTIONAL FORMULATION COMPRISED OF NATURAL INGREDIENTS AND METHOD OF PREPARATION/MANUFACTURING THEREOF
This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a...
2018/0369314 PROCESS OF MAKING WINE FROM A WHOLE GRAPE BUNCH, PROCESS OF MAKING POMACE JUICE AND POWDER, AND METHOD OF...
A food composition for human consumption comprising a plurality of grape ingredients, wherein the plurality of grape ingredients comprise ground flesh, seed,...
2018/0369313 Absorption Enhancer for Polyphenol
An absorption enhancer for polyphenol containing at least one kind of extract selected from the group consisting of an extract from Kochia scoparia (L.)...
2018/0369312 USES OF TOONA SINENSIS EXTRACT
A Toona sinensis extract for antibacterial. The Toona sinensis extract has the ability to inhibit growth or reproduction of bacteria and also to prevent...
2018/0369311 EFFICIENT LIPID DELIVERY TO HUMAN TEAR FILM USING A SALT-SENSITIVE EMULSION SYSTEM
Provided herein are low salt ophthalmic pharmaceutical composition and methods of use thereof, for example, in the treatment of dry eye syndrome.
2018/0369310 MACA COMPOSITIONS AND METHODS OF USE
The present application is directed to composition comprising various maca extracts and the use of such compositions for treating certain diseases, disorders,...
2018/0369309 COMPOSITION CONTAINING SAPONINS OF PANAX GINSENG AS ACTIVE INGREDIENT
Disclosed are uses of ginseng saponin, which contains at least 90% of a compound K, Rd, F2, and Rg3 as a main ingredient and has effects in extending the...
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