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Patent # Description
2018/0369257 SELECTIVE PROGESTERONE RECEPTOR MODULATORS (SPRM) AND STABILIZED ESTROGEN LEVEL IN PATIENT
The present invention is related to Selective Progesterone Receptor Modulators (SPRM) as described and defined herein, and covers the use of said compounds for...
2018/0369256 GENETICALLY MODIFIED HOST ORGANISM FOR EXPRESSING AN ANTHRACYCLINONE ANALOGUE, METHOD ASSOCIATED THEREWITH, AND...
Disclosed is a genetically modified host organism for expressing an anthracyclinone analogue. The genetically modified host organism comprises (i) synthetic...
2018/0369255 PRECIPITATION RESISTANT SMALL MOLECULE DRUG FORMULATIONS
Embodiments of the invention are directed to formulations that provide a solution to the problem of small molecule (e.g., diazepam) precipitation at the...
2018/0369254 Polymer Conjugate Of Sulfoxide Derivative-Coordinated Platinum(II) Complex
A DDS preparation of a platinum complex, which exhibits a superior antitumor effect required as a medicine and reduced side effects, that is, a clinically...
2018/0369253 Treating Hearing Loss
This invention relates to methods for treating hearing loss associated with loss of cochlear hair cells, e.g., caused by noise exposure, using certain gamma...
2018/0369252 SALT OF 3-[(3-{[4-(4-MORPHOLINYLMETHYL)-1H-PYRROL-2-YL]METHYLENE}-2-OXO- ...
3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihyd- ro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione methanesulphonate of formula...
2018/0369251 INHIBITORS OF MACROPINOCYTOSIS IN PREVENTION AND TREATMENT OF DISEASE
Described herein are pharmaceutical compositions capable of inhibiting vesicle formation and methods of treatment or prophylactic administration of these...
2018/0369250 METHODS OF TREATMENT USING SELECTIVE BCL-2 INHIBITORS
This invention pertains to methods of treating systemic lupus erythematosus and Sjogren's Syndrome with compounds that selectively inhibit the activity of...
2018/0369249 PURINE COMPOUNDS POSSESSING ANTICANCER ACTIVITY
The present disclosure provides compounds of Formulas (I') and (I), and pharmaceutically acceptable salts thereof. The compounds described herein may be useful...
2018/0369248 LAYERED SUSTAINED-RELEASE MICROBEADS AND METHODS OF MAKING THE SAME
A layered microbead suitable for incorporating into a non-prescription consumable product is disclosed. The layered microbead may include a core and at least...
2018/0369247 USE OF BRAF INHIBITORS FOR TREATING CUTANEOUS REACTIONS
The invention discloses compositions comprising BRaf inhibitors and uses thereof for treating and/or preventing by topical or systemic administration cutaneous...
2018/0369246 METHODS FOR TREATING MITOCHONDRIAL DISEASES
The present invention provides pharmaceutical compounds and methods for preventing, ameliorating, or treating a mitochondrial disease by administering such...
2018/0369245 THIENOPYRIMIDINONE NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive...
2018/0369244 BTK Inhibitors to Treat Solid Tumors Through Modulation of the Tumor Microenvironment
In certain embodiments, the invention includes therapeutic methods of using a BTK inhibitor to treat solid tumor cancers by modulation of the tumor...
2018/0369243 FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND USES THEREOF
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers,...
2018/0369242 NOVEL EGFR AND ALK DUAL INHIBITOR
The present application provides a compound of formula I, which is a EGFR and ALK dual inhibitor and can be used alone or in combination with other therapeutic...
2018/0369241 TREATMENT OF CANCER WITH DNAPK INHIBITORS
Provided herein are methods for treating or preventing Wnt-associated cancers, comprising administering an effective amount of a DNAPK inhibitor to a patient...
2018/0369240 Preferential Vasoconstriction Compositions and Methods of Use
The invention generally relates to compositions and methods for preferential vasoconstriction of smaller blood vessels relative to larger blood vessels. The...
2018/0369239 ARIPIPRAZOLE FORMULATIONS HAVING INCREASED INJECTION SPEEDS
The present invention relates to pharmaceutical compositions comprising a compound of Formula (I) that are useful for the intramuscular delivery of ...
2018/0369238 DOPAMINE AGONISTS IN TREATING ALCOHOL USE DISORDERS ASSOCIATED WITH DOPAMINE RECEPTOR ACTIVITY
Disclosed are methods for treating disorders associated with dopamine receptor activity. In some embodiments, the disclosed methods include assaying the...
2018/0369237 Tamper-resistant dosage form with immediate release and resistance against solvent extraction
A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and...
2018/0369236 TAMPER-RESISTANT PHARMACEUTICAL COMPOSITIONS OF OPIOIDS AND OTHER DRUGS
Tamper-resistant pharmaceutical compositions have been developed to reduce the likelihood of improper administration of drugs, especially drugs such as...
2018/0369235 CRUSH RESISTANT DELAYED-RELEASE DOSAGE FORMS
The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or...
2018/0369234 MULTIDIRECTIONAL MUCOSAL DELIVERY DEVICES AND METHODS OF USE
The present invention relates to a pharmaceutical dosage form for transmucosal delivery of an active agent to two or more mucosal surfaces. The dosage form is...
2018/0369233 CRYSTAL FORM OF IMIDAZOLONE TYPE COMPOUNDS, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
The present invention relates to the crystal form of imidazolone type compounds, and a preparation method, pharmaceutical composition and use thereof, and...
2018/0369232 Composite Nanoparticles And Uses Thereof
Provided herein are composite nanoparticles, methods of making composite nanoparticles and methods of using composite nanoparticles to treat or ameliorate...
2018/0369231 PARTICLE AND PHARMACEUTICAL COMPOSITION COMPRISING AN INSOLUBLE CAMPTOTHECIN COMPOUND WITH DOUBLE CORE-SHELL...
The present invention relates to a drug delivery system having a double core-shell structure and, specifically, to a double nano-drug delivery system having an...
2018/0369230 TARGETED SELECTION OF PATIENTS FOR TREATMENT WITH SPECIFIC CORTISTATIN DERIVATIVES
The invention relates to methods to to treat patients with specific Cortistatin analogs.
2018/0369229 METHODS FOR TREATING CANCER
The present invention relates to methods of treating patients with advanced forms of cancer, such as clear cell renal cell carcinoma, in which X4P-001 is...
2018/0369228 COMBINATION OF LAQUINIMOD AND PRIDOPIDINE FOR TREATING NEURODEGENERATIVE DISORDERS, IN PARTICULAR HUNTINGTON'S...
This invention provides a method of treating a patient afflicted with a neurodegenerative disorder, e.g., Huntington's disease (HD), comprising administering...
2018/0369227 ALKYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS
The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels,...
2018/0369226 ALKYNYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS
The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in...
2018/0369225 FLAVORED NICOTINE POWDER
A nicotine powder inhaler (10) comprises a body extending between a mouthpiece portion (12) and a distal end portion (14), an airflow channel (15) extending...
2018/0369224 NOVEL PIPERIDINE COMPOUND OR SALT THEREOF
A piperidine compound represented by a general formula (I) or a salt thereof: wherein, R.sub.1 represents a carboxyl group, --C(.dbd.O)NR.sub.5R.sub.6, or an...
2018/0369223 COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS
The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises piperlongumine (PL) or...
2018/0369222 PHENYLETHYNYL-SUBSTITUTED BENZENES AND HETEROCYCLES FOR THE TREATMENT OF CANCER
Halogenated phenylethynyl-substituted heterocycles that possess either an N-alkylamino or N,N-dialkylarnino group attached to the heterocycle or halogenated...
2018/0369221 PHARMACEUTICAL COMPOSITIONS FOR DIRECT SYSTEMIC INTRODUCTION
The invention relates to pharmaceutical compositions for direct systemic introduction, are also known as DSI pharmaceutical compositions, for used as human...
2018/0369220 DRUG FOR TREATING OR PREVENTING DISORDER CAUSED BY TGF-B SIGNALS, AND APPLICATION THEREOF
Provided is a drug or method for treating or preventing a condition, disorder, or disease of the corneal endothelium caused by transforming growth...
2018/0369219 USING DABIGATRAN TO TREAT PANCREATITIS
This document provides materials and methods for treating pancreatitis (e.g., acute pancreatitis). For example, methods and materials for administering...
2018/0369218 LIQUID COMPOSITION FOR WASH OF SCALP AND AND HAIR, OR FOR WASH OF SKIN
A liquid composition for use in the treatment of psoriasis or ichtyosis in the scalp, or for treatment of psoriasis or ichtyosis on other skin than the one on...
2018/0369217 THERAPEUTIC METHODS AND COMBINATIONS
Combinations comprising substituted 1-hydroxypyridine-2(1H)-thiones or a pharmaceutically acceptable salt thereof and an antibacterial agent are disclosed....
2018/0369216 SUSTAINED RELEASE AMINOPYRIDINE COMPOSITION
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for examples, a...
2018/0369215 S1P MODULATING AGENTS
Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
2018/0369214 Methods of Diagnosing and Treating Small Cell Lung Cancer Using Polo-Like Kinase 1 (PLK1) Inhibitors
This disclosure relates to methods of diagnosing and treating small cell lung cancer. In certain embodiments, this disclosure relates to methods of treating...
2018/0369213 ANTAGONISTS OF CHEMOKINE RECEPTORS
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl...
2018/0369212 SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and...
2018/0369211 METHODS AND COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISORDERS
The invention relates to the treatment of neurodegenerative disorders with ceramidase inhibitor.
2018/0369210 METHODS AND COMPOSITIONS FOR TREATING LYSOSOMAL STORAGE DISORDERS
The invention relates to a method of treating lysosomal storage disorders caused by a deficiency in lysosomal hydrolase activity. The method comprises...
2018/0369209 METHODS OF TREATING PULMONARY DISEASES AND DISORDERS
The present disclosure features disclosed method of treating disorders such as COPD, bronchitis and/or asthma using disclosed compounds, optionally together...
2018/0369208 POLYMORPHIC FORMS AND PROCESS
The present invention relates to a polymorph of a compound of formula (I) ##STR00001## This polymorph is particularly suitable in treating IPF by pulmonary ...
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