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Patent # Description
2018/0369207 RUFINAMIDE FOR USE IN THE TREATMENT OF MYOTONIA
The present invention relates to Rufinamide (or active derivatives thereof) for use in the treatment of myotonia, such as myotonia congenita, paramyotonia...
2018/0369206 Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme...
2018/0369205 Heterobifunctional Pan-Selectin Antagonists Having a Triazole Linker
Compounds, compositions, and methods for modulating in vitro and in vivo processes mediated by selectin binding. For example, heterobifunctional compounds that...
2018/0369204 PHARMACEUTICAL COMBINATIONS FOR TREATING CANCER
The present invention is directed to a combination comprising a proteasome inhibitor and a compound of formula I or a pharmaceutically acceptable salt...
2018/0369203 METHODS OF TREATING CANCER BY ADMINISTERING A MEK INHIBITOR IN COMBINATION WITH A PROTEASOME INHIBITOR
Presently disclosed are methods of treating cancer comprising administering a MEK inhibitor in combination with a proteasome inhibitor. In some embodiment, the...
2018/0369202 CHK1/2 Inhibitors for Use in the Treatment of Neuroblastomas and/or Soft Tissue Sarcomas
The present invention provides 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine.a- bout.2.about.carbonitrile and pharmaceutically...
2018/0369201 DBH INHIBITORS FOR TREATING OR PREVENTING MEMORY LOSS
The present invention relates to the use of DBH inhibitors (e.g., disulfiram and Nepicastat), and pharmaceutical compositions thereof, for treating subjects...
2018/0369200 COMPOUNDS FOR THE TREATMENT OF CANCERS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS
The present invention relates to the pyrrolidine substituted with flavone derivatives, represented by the compounds of Formula (I) or a pharmaceutically...
2018/0369198 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF OBESITY
The present invention relates to methods and pharmaceutical compositions for the treatment of obesity. In particular, the present invention relates to a method...
2018/0369197 METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR
Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor...
2018/0369196 PPARG Modulators for the Treatment of Osteoporosis
The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism,...
2018/0369195 COMBINATION THERAPY FOR TREATMENT OF MELANOMA
The present disclosure provides a pharmaceutical composition that inhibits the proliferation of a cancer cell, comprising a first compound selected from...
2018/0369194 TABLET COMPRISING 1-(3-(2-(1-BENZOTHIOPHEN-5-YL)ETHOXY)PROPYL)AZETIDIN-3-OL OR SALT THEREOF
A tablet which comprises (1) 1-(3-(2-(1-benzothiophen-5- yl)ethoxy)propyl)azetidin-3-ol or a salt thereof and (2) ethyl cellulose, said tablet having excellent...
2018/0369193 AVOCADO FLESH AND/OR SKIN EXTRACT RICH IN POLYPHENOLS AND COSMETIC, DERMATOLOGICAL AND NUTRACEUTICAL...
The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative...
2018/0369192 TERPENE-BASED COMPOSITIONS, METHODS OF PREPARATIONS AND USES THEREOF
The present disclosure generally relates to terpene-based compositions for applications in the pharmaceutical and recreational fields. In some embodiments, the...
2018/0369191 BLENDED CANNABIS COMPOUNDS AND METHODS OF MAKING THE SAME
Blended, processed marijuana and/or hemp cannabis compounds and methods of making the same are provided. In particular, the compound includes one or more...
2018/0369190 COMPOUNDS FOR TARGETING THYROID HORMONE RECEPTOR ALPHA ISOFORMS AND METHODS OF USE THEREOF
Two isoforms of thyroid receptor alpha (THR.alpha.1 and THR.alpha.2) have been found to be associated with the growth of cancer. Use of inhibitors of...
2018/0369189 CANCER SPECIFIC LIPID TARGETED PEPTIDOMEMETICS
A phosphatidylserine targeted peptoid has been identified with the ability to bind to cancer cells globally and specifically. A dimer of the peptoid decreases...
2018/0369188 APPLICATION OF PHOSPHODIESTERASE 4 INHIBITOR ZL-N-91 IN PREPARATION OF MEDICATIONS FOR LUNG CANCER...
The present invention discloses uses of a novel phosphodiesterase 4 (PDE4) inhibitor ZL-n-91 in preparing drugs against lung cancer proliferation and...
2018/0369187 TREATMENT OF ALLERGIC RHINITIS USING A COMBINATION OF MOMETASONE AND OLOPATADINE
The present invention relates to a method of treating allergic rhinitis in a subject (e.g., a human) in need thereof comprising nasally administering to the...
2018/0369186 METHOD FOR MODULATING AUTOPHAGY AND APPLICATIONS THEREOF
The present disclosure relates to method of modulating autophagy by modulators of autophagy, wherein the autophagy includes but is not limited to...
2018/0369185 SELF-EMULSIFYING COMPOSITION OF w3 FATTY ACID
This invention provides a self-emulsifying composition comprising 50 to 95% by weight in total of at least one compound selected from the group consisting of...
2018/0369184 Compositions and Uses and Methods Relating Thereto
A method for delivering a benefit agent to the surface of the eye, the method comprising applying an ocular benefit composition to a lid margin of the eye...
2018/0369183 PHARMACEUTICAL COMPOSITIONS OF DIMETHYL FUMARATE
The present invention relates to pharmaceutical compositions comprising dimethyl fumarate and a pharmaceutically acceptable agent which inhibits the enzyme...
2018/0369182 TOPICAL PHARMACEUTICAL COMPOSITION OF ACITRETIN
The present invention relates to a topical pharmaceutical composition comprising acitretin and a process for its preparation. It also relates to a method of...
2018/0369181 TREATMENT OF NERVOUS SYSTEM DISORDERS USING COMBINATIONS OF RXR AGONISTS AND THYROID HORMONES
Disclosed herein are methods of treating disease with a combination of a RXR agonist and a thyroid hormone.
2018/0369180 DOSAGE FORMS AND THERAPEUTIC USES OF L-4-CHLOROKYNURENINE
Compositions of L-4-chlorokynurenine are provided, as are methods for the treatment of neurological dysfunction
2018/0369179 METHODS OF TREATING OR PREVENTING FIBROTIC LUNG DISEASES
The invention includes a method of preventing or treating a fibrotic lung disease in a subject, comprising administering to the subject a thyroid hormone by...
2018/0369178 Methods of Treating Hair Related Conditions
Disclosed herein are methods for treating hair related disorders, including compounds that may be specific or modulate PPAR receptors.
2018/0369177 COMPOSITIONS AND METHODS FOR INDUCING SATIETY AND TREATING NON-INSULIN DEPENDENT DIABETES MELLITUS,...
The invention provides methods of treatment that induce satiety in a subject for a period of at least around twenty-four hours by once-daily administration to...
2018/0369176 WOUND CLEANSING METHOD
An aqueous composition with a higher-than-neutral pH includes a significant amount of one or more surfactants and large amounts of osmotically active solutes....
2018/0369175 NUTRITIONAL SUPPLEMENT AND USE TO PREVENT NUTRITIONAL DEFICIENCIES IN PATIENTS UNDERGOING TREATMENT IN WHICH...
A formulation and method for treating or preventing a deficiency of certain nutrients in patients undergoing a therapy in which one or more proton pump...
2018/0369174 METHODS AND COMPOSITIONS FOR TREATING PERIPHERAL NEUROPATHY
The present disclosure provides methods and compositions which treat, alleviate, prevent, diminish or otherwise ameliorate the symptoms associated with...
2018/0369173 Increasing Cancer Patient Survival Time by Administration of Dithio-Containing Compounds
The present invention discloses and claims compositions, methods of treatment, and kits which cause an increase in the time of survival in cancer patients,...
2018/0369172 METHODS AND COMPOSITIONS FOR PROMOTING WOUND HEALING WITH DECREASED SCAR FORMATION AFTER GLAUCOMA FILTRATION...
Disclosed is a method of promoting wound healing with reduced scarring after glaucoma filtration surgery in a mammalian subject in need thereof, which involve...
2018/0369171 PPAR-ALPHA AGONIST TREATMENT OF NEUROPSYCHIATRIC DISORDERS
Described herein are PPAR.alpha. agonists, including, but not limited to, endocannabinoids that can be used for treatment of a neuropsychiatric disorder and/or...
2018/0369170 METHOD OF TREATMENT WITH ANTI-INFLAMMATORY AND ANALGESIC COMPOUNDS WHICH ARE GI-, RENAL-, AND PLATELET-SPARING
Disclosed herein are compounds, pharmaceutical compositions, and methods for the treatment of diseases such as inflammation and/or pain, comprising the...
2018/0369169 SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and...
2018/0369168 METHOD FOR TREATING HYPERHIDROSIS
The present invention relates to dexmecamylamine and the use of dexmecamylamine, substantially free of exo-R-mecamylamine, in the treatment of hyperhidrosis.
2018/0369167 METHODS FOR TREATING CANCER
The present invention relates to methods of treating patients with advanced forms of cancer, such as clear cell renal cell carcinoma, in which X4P-001 is...
2018/0369166 GARCINOL COMPOSITIONS FOR THERAPEUTIC MANAGEMENT OF ENDOPLASMIC RETICULUM STRESS
Disclosed is the use of garcinol for the therapeutic management of ER stress. More specifically, the invention discloses the ability of garcinol in decreasing...
2018/0369165 Deacetylnemorone Abietane Diterpenoids for Use in Cancer Treatment
A deacetylnemorone abietane diterpenoid is utilized in the prevention of growth and development of pathogenic cells, e.g., cancer cells. The deacetylnemorone...
2018/0369164 USE OF COENZYME Q10 FORMULATIONS IN THE TREATMENT AND PREVENTION OF EPIDERMOLYSIS BULLOSA
The present invention is directed, in part, to methods of treating Epidermolysis Bullosa (EB) in a subject in need thereof, comprising topical administration...
2018/0369163 ANTIBACTERIAL S-HETEROSUBSTITUTED DISULFIDES
Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including...
2018/0369162 NOVEL USE OF PINOCARVEOL
The present invention relates to a pharmaceutical composition comprising pinocarveol for preventing or treating metabolic diseases, and functional food...
2018/0369161 NALFURAFINE-CONTAINING PERCUTANEOUS ABSORPTION PATCH
The present invention relates to a nalfurafine-containing percutaneous absorption patch having a support, a drug layer and a control layer which are laminated...
2018/0369160 DEVICES AND METHODS FOR LOCAL DELIVERY OF TACROLIMUS OR DERIVATIVES THEREOF
Devices for local delivery of tacrolimus or a derivative thereof are provided, wherein the devices comprise a polymeric matrix containing tacrolimus or a...
2018/0369159 PROTEIN NANOCAPSULES WITH DETACHABLE ZWITTERIONIC COATING FOR PROTEIN DELIVERY
The invention relates to protein nanocapsules that exhibit material properties that change in different in vivo environments. A zwitterion moiety on the...
2018/0369158 NUCLEIC ACID NANOCAPSULES FOR DRUG DELIVERY AND TARGETED GENE KNOCKDOWN
The present disclosure provides multifunctional nanoparticles. More particularly, the present disclosure relates to multifunctional nanoparticles having one or...
2018/0369157 Multiparticulate L-Carnitine Compositions and Related Methods
An oral controlled-release multiparticulate dosage form comprises a plurality of individually enteric coated particulates containing an L-carnitine that...
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