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Patent # Description
2019/0002919 In Vivo Methods for Enhancing Bioenergetic Status in Female Germ Cells
In vivo methods using bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g.,...
2019/0002918 DONOR PLASMID VECTORS
Certain donor plasmid vectors such as pFastBac.TM.1 and pFastBac.TM. Dual lack a cis DNA element upstream of the polh translation start codon (ATG) present in...
2019/0002917 GENE THERAPY FOR TREATING FAMILIAL HYPERCHOLESTEROLEMIA
Compositions and regimens useful in reducing one or more of: LDL-cholesterol, total cholesterol, and/or fasting triglycerides in a subject, and/or modifying...
2019/0002916 HYBRID DUAL RECOMBINANT AAV VECTOR SYSTEMS FOR GENE THERAPY
The invention relates to constructs, vectors, relative host cells and pharmaceutical compositions which allow an effective gene therapy, in particular of genes...
2019/0002915 COMPOSITIONS AND METHODS FOR REGULATABLE ANTIBODY EXPRESSION
Compositions containing multiple different AAV stock are provided which allow for regulated expression of an immunoglobulin in a variety of tissues. Also...
2019/0002914 METHODS AND COMPOSITIONS FOR TRANSPOSITION USING MINIMAL SEGMENTS OF THE EUKARYOTIC TRANSFORMATION VECTOR PIGGYBAC
Isolated nucleic acid molecules that include a minimally-sized, functional (minimally-functional) piggyBac transposon can incorporate (i) a 5' internal domain...
2019/0002913 PROMOTERS, EXPRESSION CASSETTES, VECTORS, KITS, AND METHODS FOR THE TREATMENT OF ACHROMATOPSIA AND OTHER DISEASES
The present invention provides isolated promoters, transgene expression cassettes, vectors, kits, and methods for treatment of genetic diseases that affect the...
2019/0002912 TUMOR IMMUNOTHERAPY
Aspects of the present disclosure provide a platform that triggers potent and effective immunotherapy against tumors from within tumors themselves, thus...
2019/0002911 Plants Having Increased Tolerance to Herbicides
The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing, at...
2019/0002910 PLANT PROMOTER FOR TRANSGENE EXPRESSION
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a...
2019/0002909 Drought-Tolerance in Plants
Drought-inducible plant promoters are described herein that are useful for expressing drought tolerance factors in plants.
2019/0002908 SOYBEAN PLANT AND SEED CORRESPONDING TO TRANSGENIC EVENT MON87712 AND METHODS FOR DETECTION THEREOF
The present invention provides a transgenic soybean comprising event MON87712 that exhibits increased yield. The invention also provides cells, plant parts,...
2019/0002907 SOYBEAN PLANT AND SEED CORRESPONDING TO TRANSGENIC EVENT MON87712 AND METHODS FOR DETECTION THEREOF
The present invention provides a transgenic soybean comprising event MON87712 that exhibits increased yield. The invention also provides cells, plant parts,...
2019/0002906 SYNTHESIS AND STRUCTURE OF HIGH POTENCY RNA THERAPEUTICS
This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or...
2019/0002905 SYNTHETIC BI-DIRECTIONAL PLANT PROMOTER
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a minimal core...
2019/0002904 USE OF MULTIPLE TRANSFORMATION ENHANCER SEQUENCES TO IMPROVE PLANT TRANSFORMATION EFFICIENCY
The present invention relates to methods and compositions for improving the efficiency of Agrobacterium- and Rhizobium-mediated plant cell transformation by...
2019/0002903 SOYBEAN VARIETY 01064344
The invention relates to the soybean variety designated 01064344. Provided by the invention are the seeds, plants and derivatives of the soybean variety...
2019/0002902 SOYBEAN VARIETY 01064327
The invention relates to the soybean variety designated 01064327. Provided by the invention are the seeds, plants and derivatives of the soybean variety...
2019/0002901 SOYBEAN VARIETY 01064265
The invention relates to the soybean variety designated 01064265. Provided by the invention are the seeds, plants and derivatives of the soybean variety...
2019/0002900 SOYBEAN VARIETY 01064519
The invention relates to the soybean variety designated 01064519. Provided by the invention are the seeds, plants and derivatives of the soybean variety...
2019/0002899 SOYBEAN VARIETY 01068093
The invention relates to the soybean variety designated 01068093. Provided by the invention are the seeds, plants and derivatives of the soybean variety...
2019/0002898 SOYBEAN VARIETY 01068088
The invention relates to the soybean variety designated 01068088. Provided by the invention are the seeds, plants and derivatives of the soybean variety...
2019/0002897 SOYBEAN VARIETY 01064280
The invention relates to the soybean variety designated 01064280. Provided by the invention are the seeds, plants and derivatives of the soybean variety...
2019/0002896 SOYBEAN VARIETY 01068084
The invention relates to the soybean variety designated 01068084. Provided by the invention are the seeds, plants and derivatives of the soybean variety...
2019/0002895 SOYBEAN VARIETY 01068083
The invention relates to the soybean variety designated 01068083. Provided by the invention are the seeds, plants and derivatives of the soybean variety...
2019/0002894 SOYBEAN VARIETY 01068085
The invention relates to the soybean variety designated 01068085. Provided by the invention are the seeds, plants and derivatives of the soybean variety...
2019/0002893 YEAST STRAINS AND METHODS FOR PRODUCING COLLAGEN
Strains of yeast genetically engineered to produce increased amounts of non-hydroxylated collagen or hydroxylated collagen are described. An all-in-one vector...
2019/0002892 METHODS AND COMPOSITIONS FOR PRODUCTION OF AROMATIC AND OTHER COMPOUNDS IN YEAST
The present disclosure includes methods and components for production of valuable industrial compounds in yeast. In an embodiment, the present invention...
2019/0002891 Listeria-Based Compositions Comprising A Peptide Minigene Expression System And Methods Of Use Thereof
This disclosure provides compositions, including Listeria delivery vectors comprising minigene expression constructs, and methods of using the same for...
2019/0002890 POLYNUCLEOTIDES ENCODING ALPHA-GALACTOSIDASE A FOR THE TREATMENT OF FABRY DISEASE
The invention relates to mRNA therapy for the treatment of Fabry disease. mRNAs for use in the invention, when administered in vivo, encode human the...
2019/0002889 NOVEL CRISPR RNA TARGETING ENZYMES AND SYSTEMS AND USES THEREOF
The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes...
2019/0002888 FLT3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OR THE PREVENTION OF PAIN DISORDERS
The present invention relates to FLT3 receptor antagonists or inhibitors of FLT3 receptor gene expression for the treatment or the prevention of pain disorders.
2019/0002887 METHODS FOR REDUCING ATAXIN-2 EXPRESSION
Provided herein are methods for decreasing Ataxin-2 mRNA expression. Such methods are useful to ameliorate symptoms of Ataxin-2 associated diseases. Such...
2019/0002886 SIGNALING CENTERS OF ERYTHROID DIFFERENTIATION
Described herein are methods, compounds, pharmaceutical compositions, and kits for modulating erythropoiesis by altering occupancy at genomic signaling-centers.
2019/0002885 ANTI-ADAM33 OLIGONUCLEOTIDES AND RELATED METHODS
The present disclosure provides antisense compounds, methods, and compositions for silencing ADAM33 mRNA. The present disclosure provides antisense compounds,...
2019/0002884 METHODS OF TREATING CANCER BY INHIBITION OF DNA REPAIR PROTEINS USING ANTISENSE BASED THERAPIES
Methods of treating cancer using antisense based therapies including antisense oligonucleotides of si RNAs directed against DNA double-strand break repair...
2019/0002883 METHOD FOR EXPRESSION OF SMALL ANTIVIRAL RNA MOLECULES WITH REDUCED CYTOTOXICITY WITHIN A CELL
In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A)....
2019/0002882 MOLECULAR ROBOT
Provided herein is a molecular robot comprising (v) a molecular motor composed of a first nucleic acid scaffold and a functional core with a catalytic center...
2019/0002881 RNA-INTERFERENCE-INDUCING NUCLEIC ACID MOLECULE ABLE TO PENETRATE INTO CELLS, AND USE THEREFOR
The present invention relates to a novel, RNAi-inducing nucleic acid molecule having cell penetrating ability and the use thereof, and more particularly, to a...
2019/0002880 DOUBLE-STRANDED OLIGONUCLEOTIDES
Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention...
2019/0002879 METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF BETA-CATENIN BY DOUBLE-STRANDED RNA
This invention relates to compounds, compositions, and methods useful for reducing .beta.-catenin target RNA and protein levels via use of dsRNAs, e.g., Dicer...
2019/0002878 Isolated dsRNA Molecules And Methods Of Using Same For Silencing Target Molecules Of Interest
An isolated dsRNA molecule comprising an antisense RNA sequence for regulating a target gene of interest in a plant or a phytopathogen of the plant, wherein...
2019/0002877 SELECTIVE REDUCTION OF ALLELIC VARIANTS
Disclosed herein are antisense compounds and methods for selectively reducing expression of an allelic variant of a gene containing a single nucleotide...
2019/0002876 COMPOSITIONS AND METHODS FOR TREATMENT OF FRIEDREICH'S ATAXIA
Described are compounds and methods useful for the treatment and investigation of Friedreich's Ataxia.
2019/0002875 NOVEL CRISPR RNA TARGETING ENZYMES AND SYSTEMS AND USES THEREOF
The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes...
2019/0002874 CELL LIBRARIES CREATED USING RATIONALLY DESIGNED NUCLEIC ACIDS
In an illustrative embodiment, cell libraries created by rationally designed nucleic acids comprising sequences to facilitate nuclease-directed genome editing...
2019/0002873 METHODS AND COMPOSITIONS FOR CREATING ALTERED AND IMPROVED CELLS AND ORGANISMS
The present invention relates to compositions involving randomized in-frame fusion polynucleotides and their introduction into a host organism to identify...
2019/0002872 LIBRARY PREPARATION METHODS AND COMPOSITIONS AND USES THEREFOR
Provided are methods for preparing a library of target nucleic acid sequences, as well as compositions and uses therefor. Methods comprise contacting a nucleic...
2019/0002871 MAGNETIC NANOPARTICLES FOR NUCLEIC ACID PURIFICATION
The present invention relates to monodisperse silanized ferrimagnetic iron oxide particles, a method for producing the same and a method for independent...
2019/0002870 METHOD AND COMPOSITION
A method of extracting DNA and/or RNA from a cell or capsid, the method comprising steps of: (a) contacting a composition comprising the cell or capsid with a...
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