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| Patent # | Description |
|---|---|
| 2019/0002869 |
METHOD FOR GENE EDITING The present disclosure relates to compositions and methods for modifying a gene sequence, and for systems for delivering such compositions. For example, the... |
| 2019/0002868 |
In Vitro Cleavage of DNA Using Argonaute Disclosed herein, among other things, are methods, kits and compositions that include a thermostable Argonaute protein and a thermostable single-stranded DNA... |
| 2019/0002867 |
ISOLATION OF STEM CELLS FROM ADIPOSE TISSUE BY ULTRASONIC CAVITATION, AND
METHODS OF USE In one embodiment, the present invention relates to a non-enzymatic method for isolating stem cells from adipose tissue, wherein the method comprises treating... |
| 2019/0002866 |
APPARATUS FOR IMMOBILIZING MICROBIAL CELL AND METHOD OF IMMOBILIZING
MICROBIAL CELL USING SAME An embodiment of the present disclosure provides an apparatus for immobilizing a microbial cell, the apparatus including: a mixing tank in which a... |
| 2019/0002865 |
RNase H-Based Assays Utilizing Modified RNA Monomers The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and... |
| 2019/0002864 |
Pectinases with Improved Thermostability The invention is in the field of protein chemistry, in particular in the field of enzymology. It provides pectinases, i.e. polypeptides with pectin-degrading... |
| 2019/0002863 |
POLYPEPTIDES HAVING PROTEASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME Disclosed are isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. Nucleic acid constructs, vectors, and host cells... |
| 2019/0002862 |
Polypeptides Having Protease Activity and Polynucleotides Encoding Same The present invention relates to isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. The invention also relates to... |
| 2019/0002861 |
PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents.... |
| 2019/0002860 |
BETA-GLUCOSIDASE AND USES THEREOF The application relates to a polypeptide having beta-glucosidase activity, its method of production and its uses. |
| 2019/0002859 |
BETA-GLUCOSIDASE AND USES THEREOF The application relates to a polypeptide having beta-glucosidase activity, its method of production and its uses. |
| 2019/0002858 |
Polypeptides Having Cellulolytic Enhancing Activity And Polynucleotides
Encoding Same The present invention relates to isolated polypeptides having cellulolytic enhancing activity, catalytic domains, cellulose binding domains and polynucleotides... |
| 2019/0002857 |
GENES ENCODING CELLULASE Polynucleotide sequences are provided encoding a thermostable cellulase and directing its increased expression are provided, and the use of the thermostable... |
| 2019/0002856 |
GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the... |
| 2019/0002855 |
POLYPEPTIDES HAVING GLUCOAMYLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING
SAME The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also... |
| 2019/0002854 |
IMPROVED GRANULAR STARCH CONVERSION ENZYMES AND METHODS Described are methods and compositions relating to granular starch-converting glucoamylases and .alpha.-amylases. The enzymes can be used to perform enzymatic... |
| 2019/0002853 |
GLUCOAMYLASE VARIANTS WITH ALTERED PROPERTIES The present invention relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In... |
| 2019/0002852 |
DEPHOSPHORYLATED LYSOSOMAL STORAGE DISEASE PROTEINS AND METHODS OF USE
THEREOF Provided are substantially dephosphorylated forms of lysosomal storage disease (LSD) proteins, including dephosphorylated forms of iduronate-2-sulfatase (IDS,... |
| 2019/0002851 |
T7 RNA POLYMERASE VARIANTS The present invention provides engineered T7 RNA polymerase variants and compositions thereof. These variants have been evolved for selective incorporation of... |
| 2019/0002850 |
T7 RNA POLYMERASE VARIANTS The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered... |
| 2019/0002849 |
HETERO-TRANSGLYCOSYLASE AND USES THEREOF The present invention relates to a hetero-transglycosylase protein having cellulose:xyloglucan endotransglucosylase (CXE) activity in addition to mixed-linkage... |
| 2019/0002848 |
BIOSYNTHESIS OF POLYKETIDES This disclosure generally relates to the use of microorganisms to make various functionalized polyketides through polyketoacyl-CoA thiolase-catalyzed... |
| 2019/0002847 |
NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a... |
| 2019/0002846 |
POLYPEPTIDES HAVING DEMETHYLATING ACTIVITY The present invention relates to fungal enzymes, more in particular of polyphenoloxidases (PPOs), and is based on a newly discovered enzymatic activity of a... |
| 2019/0002845 |
OMEGA-HYDROXYLASE-RELATED FUSION POLYPEPTIDE VARIANTS WITH IMPROVED
PROPERTIES The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when... |
| 2019/0002844 |
SCALABLE PURIFICATION METHOD FOR AAV8 A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the... |
| 2019/0002843 |
SCALABLE PURIFICATION METHOD FOR AAV1 A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the... |
| 2019/0002842 |
SCALABLE PURIFICATION METHOD FOR AAV9 A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the... |
| 2019/0002841 |
SCALABLE PURIFICATION METHOD FOR AAVRH10 A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the... |
| 2019/0002840 |
PHAGE THERAPY OF PSEUDOMONAS INFECTIONS The present invention relates to bacteriophage therapy. More particularly, the present invention relates to novel bacteriophages having a high specificity... |
| 2019/0002838 |
SINDBIS CONTROL VIRUS Disclosed are compositions and methods related to replication deficient Sindbis viruses that are able to function as controls for nucleic acid diagnostic... |
| 2019/0002837 |
RECODED ARBOVIRUS AND VACCINES This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon... |
| 2019/0002836 |
Method for Manufacturing Body Substitutes by Additive Deposition The invention relates to a method for manufacturing a bio-ink by additive deposition, which comprises supplying: a first solution including between 5 and 40... |
| 2019/0002835 |
METHODS FOR GENERATING NEURAL TISSUE AND USES THEREOF Disclosed herein are 3-D neural tissue structures or "brain organoids" created from human pluripotent cells (e.g., stem cells) differentiated into neuronal... |
| 2019/0002834 |
METHOD FOR PREPARING POPULATION OF STEM CELL SPHEROIDS The present invention relates to a method for forming cell aggregates. In the method, two or more clusters of cells are distributed into each of two or more... |
| 2019/0002833 |
MEDICAMENT FOR TREATING CEREBRAL INFARCTION Provided is new means for reducing risk of cerebral hemorrhage associated with a reperfusion therapy for vessel occlusion (for example, administration of a... |
| 2019/0002832 |
HUMANIZED MOUSE MODEL OF MYASTHENIA GRAVIS AND MSC THERAPY The present invention relates to an animal model of myasthenia gravis, and to uses thereof. |
| 2019/0002831 |
CELL MEDIUM FORMULATION FOR CELL STABILIZATION A cell preservation medium, a cell recovery medium and a cell culture medium, and methods which employ the media, are provided. |
| 2019/0002830 |
METHOD FOR PROMOTING DIFFERENTIATION OF CULTURED CELLS AND CULTURED CELL
DIFFERENTIATION-PROMOTING AGENT The invention is a method for promoting differentiation of cultured cells, including bringing a norbornene-based addition polymer formed article into contact... |
| 2019/0002829 |
LARGE SCALE GENERATION OF FUNCTIONAL MEGAKARYOCYTES AND PLATELETS FROM
HUMAN EMBRYONIC STEM CELLS UNDER... The present invention provides a method of generating megakaryocytes and platelets. In various embodiments, method involves the use of human embryonic stem... |
| 2019/0002828 |
METHODS FOR PRODUCING ENUCLEATED ERYTHROID CELLS DERIVED FROM PLURIPOTENT
STEM CELLS Methods for generating enucleated erythroid cells using pluripotent stem cells are provided. The methods permit the production of large numbers of cells. The... |
| 2019/0002827 |
COMPOSITIONS AND METHODS FOR THE GENERATION OF MELANOCYTES THROUGH DIRECT
REPROGRAMMING Compositions and methods for generating melanocytes through direct reprogramming are disclosed. Also disclosed are methods of use of such compositions for the... |
| 2019/0002826 |
METHOD AND COMPOSITION FOR GENERATING BASAL FOREBRAIN CHOLINERGIC NEURONS
(BFCNS) The invention relates to methods and compositions for developing basal forebrain cholinergic neurons (BFCNs) from stem cells, and in particular, BFCNs having... |
| 2019/0002825 |
Method for Inducing Targeted Differentiation of Human Stem Cells Toward
Hepatic Cells The present invention relates to a novel method for multi-target-directed inducing direct differentiation of human stem cells, such as human embryonic stem... |
| 2019/0002824 |
NUCLEOTIDE-SPECIFIC RECOGNITION SEQUENCES FOR DESIGNER TAL EFFECTORS The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell,... |
| 2019/0002823 |
INDUCTION MEDIUM AND METHODS FOR STEM CELL CULTURE AND THERAPY Novel MSC stem-cell culture and therapy methods and culture medium compositions for the purpose of inducing, activating, or priming discrete uniform cell... |
| 2019/0002822 |
CELL CULTURE COMPOSITIONS WITH ANTIOXIDANTS AND METHODS FOR POLYPEPTIDE
PRODUCTION Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells.... |
| 2019/0002821 |
METHODS AND COMPOSITIONS FOR DETACHING ADHERENT CELLS This disclosure is directed to methods and systems for harvesting cells. |
| 2019/0002820 |
TARGETED MUTAGENESIS IN SPIRULINA This disclosure describes techniques for creating stable, targeted mutations in Spirulina (Athrospiria) and Spirulina having stable, targeted mutations. |
| 2019/0002819 |
HEAT PRIMING OF BACTERIAL SPORES The present invention relates to methods for heat treating spores, which improves subsequent germination properties. |
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