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Patent # Description
2019/0002869 METHOD FOR GENE EDITING
The present disclosure relates to compositions and methods for modifying a gene sequence, and for systems for delivering such compositions. For example, the...
2019/0002868 In Vitro Cleavage of DNA Using Argonaute
Disclosed herein, among other things, are methods, kits and compositions that include a thermostable Argonaute protein and a thermostable single-stranded DNA...
2019/0002867 ISOLATION OF STEM CELLS FROM ADIPOSE TISSUE BY ULTRASONIC CAVITATION, AND METHODS OF USE
In one embodiment, the present invention relates to a non-enzymatic method for isolating stem cells from adipose tissue, wherein the method comprises treating...
2019/0002866 APPARATUS FOR IMMOBILIZING MICROBIAL CELL AND METHOD OF IMMOBILIZING MICROBIAL CELL USING SAME
An embodiment of the present disclosure provides an apparatus for immobilizing a microbial cell, the apparatus including: a mixing tank in which a...
2019/0002865 RNase H-Based Assays Utilizing Modified RNA Monomers
The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and...
2019/0002864 Pectinases with Improved Thermostability
The invention is in the field of protein chemistry, in particular in the field of enzymology. It provides pectinases, i.e. polypeptides with pectin-degrading...
2019/0002863 POLYPEPTIDES HAVING PROTEASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME
Disclosed are isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. Nucleic acid constructs, vectors, and host cells...
2019/0002862 Polypeptides Having Protease Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. The invention also relates to...
2019/0002861 PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents....
2019/0002860 BETA-GLUCOSIDASE AND USES THEREOF
The application relates to a polypeptide having beta-glucosidase activity, its method of production and its uses.
2019/0002859 BETA-GLUCOSIDASE AND USES THEREOF
The application relates to a polypeptide having beta-glucosidase activity, its method of production and its uses.
2019/0002858 Polypeptides Having Cellulolytic Enhancing Activity And Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity, catalytic domains, cellulose binding domains and polynucleotides...
2019/0002857 GENES ENCODING CELLULASE
Polynucleotide sequences are provided encoding a thermostable cellulase and directing its increased expression are provided, and the use of the thermostable...
2019/0002856 GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the...
2019/0002855 POLYPEPTIDES HAVING GLUCOAMYLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also...
2019/0002854 IMPROVED GRANULAR STARCH CONVERSION ENZYMES AND METHODS
Described are methods and compositions relating to granular starch-converting glucoamylases and .alpha.-amylases. The enzymes can be used to perform enzymatic...
2019/0002853 GLUCOAMYLASE VARIANTS WITH ALTERED PROPERTIES
The present invention relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In...
2019/0002852 DEPHOSPHORYLATED LYSOSOMAL STORAGE DISEASE PROTEINS AND METHODS OF USE THEREOF
Provided are substantially dephosphorylated forms of lysosomal storage disease (LSD) proteins, including dephosphorylated forms of iduronate-2-sulfatase (IDS,...
2019/0002851 T7 RNA POLYMERASE VARIANTS
The present invention provides engineered T7 RNA polymerase variants and compositions thereof. These variants have been evolved for selective incorporation of...
2019/0002850 T7 RNA POLYMERASE VARIANTS
The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered...
2019/0002849 HETERO-TRANSGLYCOSYLASE AND USES THEREOF
The present invention relates to a hetero-transglycosylase protein having cellulose:xyloglucan endotransglucosylase (CXE) activity in addition to mixed-linkage...
2019/0002848 BIOSYNTHESIS OF POLYKETIDES
This disclosure generally relates to the use of microorganisms to make various functionalized polyketides through polyketoacyl-CoA thiolase-catalyzed...
2019/0002847 NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a...
2019/0002846 POLYPEPTIDES HAVING DEMETHYLATING ACTIVITY
The present invention relates to fungal enzymes, more in particular of polyphenoloxidases (PPOs), and is based on a newly discovered enzymatic activity of a...
2019/0002845 OMEGA-HYDROXYLASE-RELATED FUSION POLYPEPTIDE VARIANTS WITH IMPROVED PROPERTIES
The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when...
2019/0002844 SCALABLE PURIFICATION METHOD FOR AAV8
A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the...
2019/0002843 SCALABLE PURIFICATION METHOD FOR AAV1
A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the...
2019/0002842 SCALABLE PURIFICATION METHOD FOR AAV9
A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the...
2019/0002841 SCALABLE PURIFICATION METHOD FOR AAVRH10
A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the...
2019/0002840 PHAGE THERAPY OF PSEUDOMONAS INFECTIONS
The present invention relates to bacteriophage therapy. More particularly, the present invention relates to novel bacteriophages having a high specificity...
2019/0002838 SINDBIS CONTROL VIRUS
Disclosed are compositions and methods related to replication deficient Sindbis viruses that are able to function as controls for nucleic acid diagnostic...
2019/0002837 RECODED ARBOVIRUS AND VACCINES
This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon...
2019/0002836 Method for Manufacturing Body Substitutes by Additive Deposition
The invention relates to a method for manufacturing a bio-ink by additive deposition, which comprises supplying: a first solution including between 5 and 40...
2019/0002835 METHODS FOR GENERATING NEURAL TISSUE AND USES THEREOF
Disclosed herein are 3-D neural tissue structures or "brain organoids" created from human pluripotent cells (e.g., stem cells) differentiated into neuronal...
2019/0002834 METHOD FOR PREPARING POPULATION OF STEM CELL SPHEROIDS
The present invention relates to a method for forming cell aggregates. In the method, two or more clusters of cells are distributed into each of two or more...
2019/0002833 MEDICAMENT FOR TREATING CEREBRAL INFARCTION
Provided is new means for reducing risk of cerebral hemorrhage associated with a reperfusion therapy for vessel occlusion (for example, administration of a...
2019/0002832 HUMANIZED MOUSE MODEL OF MYASTHENIA GRAVIS AND MSC THERAPY
The present invention relates to an animal model of myasthenia gravis, and to uses thereof.
2019/0002831 CELL MEDIUM FORMULATION FOR CELL STABILIZATION
A cell preservation medium, a cell recovery medium and a cell culture medium, and methods which employ the media, are provided.
2019/0002830 METHOD FOR PROMOTING DIFFERENTIATION OF CULTURED CELLS AND CULTURED CELL DIFFERENTIATION-PROMOTING AGENT
The invention is a method for promoting differentiation of cultured cells, including bringing a norbornene-based addition polymer formed article into contact...
2019/0002829 LARGE SCALE GENERATION OF FUNCTIONAL MEGAKARYOCYTES AND PLATELETS FROM HUMAN EMBRYONIC STEM CELLS UNDER...
The present invention provides a method of generating megakaryocytes and platelets. In various embodiments, method involves the use of human embryonic stem...
2019/0002828 METHODS FOR PRODUCING ENUCLEATED ERYTHROID CELLS DERIVED FROM PLURIPOTENT STEM CELLS
Methods for generating enucleated erythroid cells using pluripotent stem cells are provided. The methods permit the production of large numbers of cells. The...
2019/0002827 COMPOSITIONS AND METHODS FOR THE GENERATION OF MELANOCYTES THROUGH DIRECT REPROGRAMMING
Compositions and methods for generating melanocytes through direct reprogramming are disclosed. Also disclosed are methods of use of such compositions for the...
2019/0002826 METHOD AND COMPOSITION FOR GENERATING BASAL FOREBRAIN CHOLINERGIC NEURONS (BFCNS)
The invention relates to methods and compositions for developing basal forebrain cholinergic neurons (BFCNs) from stem cells, and in particular, BFCNs having...
2019/0002825 Method for Inducing Targeted Differentiation of Human Stem Cells Toward Hepatic Cells
The present invention relates to a novel method for multi-target-directed inducing direct differentiation of human stem cells, such as human embryonic stem...
2019/0002824 NUCLEOTIDE-SPECIFIC RECOGNITION SEQUENCES FOR DESIGNER TAL EFFECTORS
The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell,...
2019/0002823 INDUCTION MEDIUM AND METHODS FOR STEM CELL CULTURE AND THERAPY
Novel MSC stem-cell culture and therapy methods and culture medium compositions for the purpose of inducing, activating, or priming discrete uniform cell...
2019/0002822 CELL CULTURE COMPOSITIONS WITH ANTIOXIDANTS AND METHODS FOR POLYPEPTIDE PRODUCTION
Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells....
2019/0002821 METHODS AND COMPOSITIONS FOR DETACHING ADHERENT CELLS
This disclosure is directed to methods and systems for harvesting cells.
2019/0002820 TARGETED MUTAGENESIS IN SPIRULINA
This disclosure describes techniques for creating stable, targeted mutations in Spirulina (Athrospiria) and Spirulina having stable, targeted mutations.
2019/0002819 HEAT PRIMING OF BACTERIAL SPORES
The present invention relates to methods for heat treating spores, which improves subsequent germination properties.
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