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| Patent # | Description |
|---|---|
| 2019/0002565 |
BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In... |
| 2019/0002564 |
BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In... |
| 2019/0002563 |
Bispecific Monovalent Diabodies That are Capable of Binding B7-H3 and CD3,
and Uses Thereof The present invention is directed to B7-H3.times.CD3 bispecific monovalent diabodies, and particularly, to B7-H3.times.CD3 bispecific monovalent Fc diabodies,... |
| 2019/0002562 |
Caninized Antibodies The present invention discloses caninized antibodies with specific properties. The present invention also discloses caninized murine antibodies against canine... |
| 2019/0002561 |
CD33 SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and... |
| 2019/0002560 |
ANTI-CD33 ANTIBODIES AND METHODS OF USE THEREOF The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments,... |
| 2019/0002559 |
ANTIBODIES SPECIFIC FOR TROP-2 AND THEIR USES The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody... |
| 2019/0002558 |
COMPOSITIONS AND METHODS FOR THE IDENTIFICATION AND ISOLATION OF
CELL-MEMBRANE PROTEIN SPECIFIC BINDING MOIETIES Disclosed are methods of identifying binding moieties that recognize antigens displayed on cells, such as membrane proteins or recombinant proteins that... |
| 2019/0002557 |
MITIGATING TISSUE DAMAGE AND FIBROSIS VIA LATENT TRANSFORMING GROWTH
FACTOR BETA BINDING PROTEIN (LTBP4) The disclosure relates to compositions and methods of mitigating tissue damage and fibrosis in a patient by modulating latent transforming growth factor beta... |
| 2019/0002556 |
NOVEL T CELL RECEPTORS AND IMMUNE THERAPY USING THE SAME The present invention pertains to antigen recognizing constructs against tumor associated antigens (TAA), in particular the TAA Serine protease inhibitor... |
| 2019/0002555 |
ANTIGEN-BINDING PROTEINS TO MARINOBUFAGENIN The present invention provides monoclonal antigen-binding proteins that bind to the cardiac glycoside marinobufagenin (MBG), and methods of use. In various... |
| 2019/0002554 |
Methods of Treating Kawasaki Disease Using IL-1beta Antibodies This invention relates to a novel use of IL-1.beta.-ligand/IL-1 receptor disrupting compounds (herein referred to as "IL-1beta Compounds"); such as small... |
| 2019/0002553 |
TREATMENT OF FIBROSIS Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment,... |
| 2019/0002552 |
ANTIBODY FORMULATIONS Formulations comprising an anti-IL-13 antibody are provided, including pharmaceutical formulations and methods of using such formulations. |
| 2019/0002551 |
METHODS OF MODIFYING ANTIBODIES, AND MODIFIED ANTIBODIES WITH IMPROVED
FUNCTIONAL PROPERTIES The invention provides methods of using sequence based analysis and rational strategies to modify and improve the structural and biophysical properties of... |
| 2019/0002550 |
METHODS AND COMPOSITIONS FOR TREATING MULTIPLE SCLEROSIS The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome... |
| 2019/0002549 |
ANTI-GM-CSF ANTIBODIES AND USES THEREOF Provided are anti-GM-CSF antibodies or fragments thereof including humanized antibodies and fragments. Also provided are uses of the antibodies and fragments... |
| 2019/0002548 |
ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE The invention provides anti-myostatin antibodies and methods of using the same. In some embodiments, an isolated anti-myostatin antibody of the present... |
| 2019/0002547 |
METHODS FOR TREATMENT OF MOTOR NEURON DISEASES The invention relates to methods and agents useful for treating motor neuron diseases (MNDs), in particular, amyotrophic lateral sclerosis (ALS). Methods and... |
| 2019/0002546 |
METHODS AND COMPOSITIONS FOR BINDING VEGF The present invention relates to fusion polypeptide compositions comprising immunoglobulin-type-2 binding domains of Vascular Endothelial Growth Factor... |
| 2019/0002545 |
Anti-Malarial Compositions This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to... |
| 2019/0002544 |
BLOOD-BRAIN BARRIER PERMEABLE PEPTIDE COMPOSITIONS Blood-brain barrier permeable peptide compositions that contain variable antigen binding domains from camelid and/or shark heavy-chain only single-domain... |
| 2019/0002543 |
Inflammatory Disease Treatment Composition Including Anti-Myosin
Regulatory Light-Chain Polypeptide Antibody Provided is a means for inhibiting a function of CD69, whereby allowing suppression of an inflammatory response. That is, provided are: a composition for... |
| 2019/0002542 |
TRANSGLYCOSYLATION OF ENDO-S AND ENDO-S MUTANTS FOR ANTIBODY GLYCOSYLATION
REMODELING The present invention provides for a one-pot enzymatic approach which does not require removal of the enzyme and purification of the intermediate after... |
| 2019/0002541 |
MODULATING THE ALTERNATIVE COMPLEMENT PATHWAY Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the... |
| 2019/0002540 |
METHODS OF TREATING S. AUREUS-ASSOCIATED DISEASES The present invention provides for methods of preventing and/or treating S. aureus-associated bacteremia and sepsis, and methods for preventing and/or treating... |
| 2019/0002539 |
BROADLY NEUTRALIZING ANTIBODIES AGAINST HIV-1 AND USE THEREOF Broadly neutralizing antibodies against HIV-1 which specifically bind to gp120 of HIV-1, a method of preparing such antibodies and the use thereof are provided. |
| 2019/0002538 |
ANTIBODIES THAT POTENTLY NEUTRALIZE RSV AND USES THEREOF The invention relates to antibodies, and antigen binding fragments thereof, that neutralize infection of both group A and group B RSV. The invention also... |
| 2019/0002537 |
METHOD FOR ENRICHING A PREPARATION OF IMMUNOGLOBULINS WITH ANTI RSV
IMMUNOGLOBULINS AND PREPARATION ENRICHED IN... Disclosed is a method for preparing an immunoglobulin (Ig) concentrate useful for treating RSV infection, including a step consisting in subjecting an Ig... |
| 2019/0002536 |
NOVEL HA BINDING AGENTS This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses,... |
| 2019/0002535 |
ANTIBODY CAPABLE OF BINDING TO NOROVIRUS, COMPOSITE, DETECTION DEVICE AND
METHOD USING THE SAME The present invention provides a novel antibody capable of binding to a norovirus. The present invention is an antibody that consists of an amino acid... |
| 2019/0002534 |
HUMAN ANTIBODIES AGAINST RABIES AND USES THEREOF The invention provides human antibodies against rabies and methods of using the same. |
| 2019/0002533 |
POLYOMAVIRUS NEUTRALIZING ANTIBODIES The present disclosure is directed to anti-VP1 antibodies, antibody fragments, and their uses for the reducing the likelihood or treatment of polyoma virus... |
| 2019/0002532 |
METHODS AND REAGENTS FOR CREATING MONOCLONAL ANTIBODIES In some embodiments, the invention relates to methods for creating a monoclonal antibody that specifically binds to antigen. The method may start from a... |
| 2019/0002531 |
MIMETIC PEPTIDES DERIVED FROM COLLAGEN TYPE IV AND THEIR USE FOR TREATING
ANGIOGENESIS- AND LYMPHANGIOGENESIS-... Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related... |
| 2019/0002530 |
GELATIN PARTICLES, METHOD FOR PRODUCING GELATIN PARTICLES, GELATIN
PARTICLE-CONTAINING CELL, AND METHOD FOR... Disclosed herein are gelatin particles including gelatin, wherein when a major-axis length of dried gelatin particles is defined as a and a major-axis length... |
| 2019/0002529 |
Assembly of Intermediate Filament Proteins in to Filamentous Materials Intermediate filament (IF) recombinant protein, such as from hagfish, can be purified under denaturing conditions either as a single protein (alpha or gamma... |
| 2019/0002528 |
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DRY EYES The present invention relates to a pharmaceutical composition for preventing or treating dry eye, the pharmaceutical composition including, as an active... |
| 2019/0002527 |
METHODS AND COMPOSITIONS FOR THE INHIBITION OF TRPV4 TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. This activation of TRPV4 can contribute to a number... |
| 2019/0002526 |
NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY
AGAINST ESOPHAGEAL CANCER AND OTHER CANCERS The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates... |
| 2019/0002525 |
NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY
AGAINST ESOPHAGEAL CANCER AND OTHER CANCERS The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates... |
| 2019/0002524 |
NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY
AGAINST VARIOUS TUMORS The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates... |
| 2019/0002523 |
T CELL RECEPTORS SPECIFIC FOR THE NY-ESO-1 TUMOR ANTIGEN-HLA-A*02 COMPLEX The present invention relates to T cell receptors (TCRs) which bind the HLA-A*02 restricted peptide SLLMWITQC derived from the cancer antigen NY-ESO-1. Said... |
| 2019/0002522 |
COMPOSITIONS AND METHODS FOR USE OF RECOMBINANT T CELL RECEPTORS FOR
DIRECT RECOGNITION OF TUMOR ANTIGEN Provided are compositions and methods for prophylaxis and/or therapy of a variety of cancers which express a NY-ESO-1 antigen. Included are recombinant T cell... |
| 2019/0002521 |
THERAPEUTIC AGENTS An immunoresponsive cell, such as a T-cell expressing (i) a second generation chimeric antigen receptor comprising: (a) a signalling region; (b) a... |
| 2019/0002520 |
TRIPLE GLUCAGON/GLP-1/GIP RECEPTOR AGONIST The present invention relates to a triple agonist having activities to all of glucagon, GLP-1, and GIP receptors and uses thereof. |
| 2019/0002519 |
PRO-DRUG PEPTIDE WITH IMPROVED PHARMACEUTICAL PROPERTIES The present disclosure relates to a pro-drug peptide, or a salt thereof, having improvement for at least one biological property relative to a parent peptide... |
| 2019/0002518 |
METHODS OF PURIFICATION AND/OR VIRAL INACTIVATION Methods of purification and/or viral deactivation of a protein (e.g. glycoprotein) comprising a step of treating the protein (e.g. glycoprotein) with a... |
| 2019/0002517 |
NEUROPEPTIDE Y-DERIVED PEPTIDES The present invention discloses peptide fragments derived from neuropeptide Y (NPY), which are capable of selective binding to the neural cell adhesion... |
| 2019/0002516 |
Drug Design Method, Obtained Drug and Application Thereof Provided is a drug system design method, comprising selecting a target moiety specifically binding to a target of interest, and connecting the target moiety to... |
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