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Patent # Description
2019/0002565 BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In...
2019/0002564 BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In...
2019/0002563 Bispecific Monovalent Diabodies That are Capable of Binding B7-H3 and CD3, and Uses Thereof
The present invention is directed to B7-H3.times.CD3 bispecific monovalent diabodies, and particularly, to B7-H3.times.CD3 bispecific monovalent Fc diabodies,...
2019/0002562 Caninized Antibodies
The present invention discloses caninized antibodies with specific properties. The present invention also discloses caninized murine antibodies against canine...
2019/0002561 CD33 SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY
The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and...
2019/0002560 ANTI-CD33 ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments,...
2019/0002559 ANTIBODIES SPECIFIC FOR TROP-2 AND THEIR USES
The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody...
2019/0002558 COMPOSITIONS AND METHODS FOR THE IDENTIFICATION AND ISOLATION OF CELL-MEMBRANE PROTEIN SPECIFIC BINDING MOIETIES
Disclosed are methods of identifying binding moieties that recognize antigens displayed on cells, such as membrane proteins or recombinant proteins that...
2019/0002557 MITIGATING TISSUE DAMAGE AND FIBROSIS VIA LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN (LTBP4)
The disclosure relates to compositions and methods of mitigating tissue damage and fibrosis in a patient by modulating latent transforming growth factor beta...
2019/0002556 NOVEL T CELL RECEPTORS AND IMMUNE THERAPY USING THE SAME
The present invention pertains to antigen recognizing constructs against tumor associated antigens (TAA), in particular the TAA Serine protease inhibitor...
2019/0002555 ANTIGEN-BINDING PROTEINS TO MARINOBUFAGENIN
The present invention provides monoclonal antigen-binding proteins that bind to the cardiac glycoside marinobufagenin (MBG), and methods of use. In various...
2019/0002554 Methods of Treating Kawasaki Disease Using IL-1beta Antibodies
This invention relates to a novel use of IL-1.beta.-ligand/IL-1 receptor disrupting compounds (herein referred to as "IL-1beta Compounds"); such as small...
2019/0002553 TREATMENT OF FIBROSIS
Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment,...
2019/0002552 ANTIBODY FORMULATIONS
Formulations comprising an anti-IL-13 antibody are provided, including pharmaceutical formulations and methods of using such formulations.
2019/0002551 METHODS OF MODIFYING ANTIBODIES, AND MODIFIED ANTIBODIES WITH IMPROVED FUNCTIONAL PROPERTIES
The invention provides methods of using sequence based analysis and rational strategies to modify and improve the structural and biophysical properties of...
2019/0002550 METHODS AND COMPOSITIONS FOR TREATING MULTIPLE SCLEROSIS
The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome...
2019/0002549 ANTI-GM-CSF ANTIBODIES AND USES THEREOF
Provided are anti-GM-CSF antibodies or fragments thereof including humanized antibodies and fragments. Also provided are uses of the antibodies and fragments...
2019/0002548 ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE
The invention provides anti-myostatin antibodies and methods of using the same. In some embodiments, an isolated anti-myostatin antibody of the present...
2019/0002547 METHODS FOR TREATMENT OF MOTOR NEURON DISEASES
The invention relates to methods and agents useful for treating motor neuron diseases (MNDs), in particular, amyotrophic lateral sclerosis (ALS). Methods and...
2019/0002546 METHODS AND COMPOSITIONS FOR BINDING VEGF
The present invention relates to fusion polypeptide compositions comprising immunoglobulin-type-2 binding domains of Vascular Endothelial Growth Factor...
2019/0002545 Anti-Malarial Compositions
This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to...
2019/0002544 BLOOD-BRAIN BARRIER PERMEABLE PEPTIDE COMPOSITIONS
Blood-brain barrier permeable peptide compositions that contain variable antigen binding domains from camelid and/or shark heavy-chain only single-domain...
2019/0002543 Inflammatory Disease Treatment Composition Including Anti-Myosin Regulatory Light-Chain Polypeptide Antibody
Provided is a means for inhibiting a function of CD69, whereby allowing suppression of an inflammatory response. That is, provided are: a composition for...
2019/0002542 TRANSGLYCOSYLATION OF ENDO-S AND ENDO-S MUTANTS FOR ANTIBODY GLYCOSYLATION REMODELING
The present invention provides for a one-pot enzymatic approach which does not require removal of the enzyme and purification of the intermediate after...
2019/0002541 MODULATING THE ALTERNATIVE COMPLEMENT PATHWAY
Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the...
2019/0002540 METHODS OF TREATING S. AUREUS-ASSOCIATED DISEASES
The present invention provides for methods of preventing and/or treating S. aureus-associated bacteremia and sepsis, and methods for preventing and/or treating...
2019/0002539 BROADLY NEUTRALIZING ANTIBODIES AGAINST HIV-1 AND USE THEREOF
Broadly neutralizing antibodies against HIV-1 which specifically bind to gp120 of HIV-1, a method of preparing such antibodies and the use thereof are provided.
2019/0002538 ANTIBODIES THAT POTENTLY NEUTRALIZE RSV AND USES THEREOF
The invention relates to antibodies, and antigen binding fragments thereof, that neutralize infection of both group A and group B RSV. The invention also...
2019/0002537 METHOD FOR ENRICHING A PREPARATION OF IMMUNOGLOBULINS WITH ANTI RSV IMMUNOGLOBULINS AND PREPARATION ENRICHED IN...
Disclosed is a method for preparing an immunoglobulin (Ig) concentrate useful for treating RSV infection, including a step consisting in subjecting an Ig...
2019/0002536 NOVEL HA BINDING AGENTS
This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses,...
2019/0002535 ANTIBODY CAPABLE OF BINDING TO NOROVIRUS, COMPOSITE, DETECTION DEVICE AND METHOD USING THE SAME
The present invention provides a novel antibody capable of binding to a norovirus. The present invention is an antibody that consists of an amino acid...
2019/0002534 HUMAN ANTIBODIES AGAINST RABIES AND USES THEREOF
The invention provides human antibodies against rabies and methods of using the same.
2019/0002533 POLYOMAVIRUS NEUTRALIZING ANTIBODIES
The present disclosure is directed to anti-VP1 antibodies, antibody fragments, and their uses for the reducing the likelihood or treatment of polyoma virus...
2019/0002532 METHODS AND REAGENTS FOR CREATING MONOCLONAL ANTIBODIES
In some embodiments, the invention relates to methods for creating a monoclonal antibody that specifically binds to antigen. The method may start from a...
2019/0002531 MIMETIC PEPTIDES DERIVED FROM COLLAGEN TYPE IV AND THEIR USE FOR TREATING ANGIOGENESIS- AND LYMPHANGIOGENESIS-...
Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related...
2019/0002530 GELATIN PARTICLES, METHOD FOR PRODUCING GELATIN PARTICLES, GELATIN PARTICLE-CONTAINING CELL, AND METHOD FOR...
Disclosed herein are gelatin particles including gelatin, wherein when a major-axis length of dried gelatin particles is defined as a and a major-axis length...
2019/0002529 Assembly of Intermediate Filament Proteins in to Filamentous Materials
Intermediate filament (IF) recombinant protein, such as from hagfish, can be purified under denaturing conditions either as a single protein (alpha or gamma...
2019/0002528 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DRY EYES
The present invention relates to a pharmaceutical composition for preventing or treating dry eye, the pharmaceutical composition including, as an active...
2019/0002527 METHODS AND COMPOSITIONS FOR THE INHIBITION OF TRPV4
TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. This activation of TRPV4 can contribute to a number...
2019/0002526 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST ESOPHAGEAL CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0002525 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST ESOPHAGEAL CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0002524 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0002523 T CELL RECEPTORS SPECIFIC FOR THE NY-ESO-1 TUMOR ANTIGEN-HLA-A*02 COMPLEX
The present invention relates to T cell receptors (TCRs) which bind the HLA-A*02 restricted peptide SLLMWITQC derived from the cancer antigen NY-ESO-1. Said...
2019/0002522 COMPOSITIONS AND METHODS FOR USE OF RECOMBINANT T CELL RECEPTORS FOR DIRECT RECOGNITION OF TUMOR ANTIGEN
Provided are compositions and methods for prophylaxis and/or therapy of a variety of cancers which express a NY-ESO-1 antigen. Included are recombinant T cell...
2019/0002521 THERAPEUTIC AGENTS
An immunoresponsive cell, such as a T-cell expressing (i) a second generation chimeric antigen receptor comprising: (a) a signalling region; (b) a...
2019/0002520 TRIPLE GLUCAGON/GLP-1/GIP RECEPTOR AGONIST
The present invention relates to a triple agonist having activities to all of glucagon, GLP-1, and GIP receptors and uses thereof.
2019/0002519 PRO-DRUG PEPTIDE WITH IMPROVED PHARMACEUTICAL PROPERTIES
The present disclosure relates to a pro-drug peptide, or a salt thereof, having improvement for at least one biological property relative to a parent peptide...
2019/0002518 METHODS OF PURIFICATION AND/OR VIRAL INACTIVATION
Methods of purification and/or viral deactivation of a protein (e.g. glycoprotein) comprising a step of treating the protein (e.g. glycoprotein) with a...
2019/0002517 NEUROPEPTIDE Y-DERIVED PEPTIDES
The present invention discloses peptide fragments derived from neuropeptide Y (NPY), which are capable of selective binding to the neural cell adhesion...
2019/0002516 Drug Design Method, Obtained Drug and Application Thereof
Provided is a drug system design method, comprising selecting a target moiety specifically binding to a target of interest, and connecting the target moiety to...
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