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Patent # Description
2019/0002414 NK1 RECEPTOR ANTAGONIST
A problem of the present invention is to provide a new compound which has NK.sub.1 receptor antagonist activity, and thus is useful for the prevention or...
2019/0002413 ZWITTERIONIC PROPARGYL-LINKED ANTIFOLATES USEFUL FOR TREATING BACTERIAL INFECTIONS
The disclosure provides compounds of the formula I and the pharmaceutically acceptable salts thereof. The variables, e.g. R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
2019/0002412 PYRIMIDINES AS SODIUM CHANNEL BLOCKERS
The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof,...
2019/0002411 13-Cis-RAMBA RETINAMIDES THAT DEGRADE MNKs FOR TREATING CANCER
The synthesis and in vitro and in vivo anti-breast and anti-prostate cancers activities of novel C-4 heteroaryl 13-cis retinamides that modulate Mnk-eIF4E and...
2019/0002410 METHODS AND SYSTEMS FOR MASK ALIGNMENT IN MANUFACTURING PROCESS OF ARRAYS
Provided herein are molecules and salts thereof, arrays containing molecules and salts thereof, solid supports containing molecules and salts thereof, kits...
2019/0002409 SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS
The present application relates to novel substituted N,2-diarylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof...
2019/0002408 OLIGO-GUANIDINES BASED CELLULAR TRANSPORTER COMPRISING HETEROCYCLIC RINGS WITH HYDROPHOBIC AND/OR LIPOPHILIC...
An oligo-guanidine as cell penetrating agents/carriers includes a heterocyclic ring including 4-aminopiperidine, piperazine, morpholine having at least one...
2019/0002407 PROCESS FOR THE PREPARATION OF CHIRAL 3-AMINO-PIPERIDINS, USEFUL INTERMEDIATES FOR THE PREPARATION OF TOFACITINIB
Object of the present invention is an improved process for the preparation of (3R,4R)-1-benzyl-4-methylpiperidin-3-amine by means of chiral Rhodium catalysts.
2019/0002406 CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
Inhibitors of HBV replication of formula (I) ##STR00001## including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R.sup.1 to...
2019/0002405 PREPARATION OF LATANOPROSTENE BUNOD OF DESIRED, PRE-DEFINED QUALITY BY GRAVITY CHROMATOGRAPHY
The subject of the invention is a process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% where chromatography is used...
2019/0002404 PGAM1 Inhibitors and Methods Related Thereto
In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising...
2019/0002403 ACID-RESISTANT BASE AND/OR RADICAL GENERATOR, AND CURABLE RESIN COMPOSITION CONTAINING SAID BASE AND/OR RADICAL...
The present invention relates to a compound represented by the general formula (A), a base- and/or radical-generating agent comprising the compound, and so...
2019/0002402 IDO INHIBITORS
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said...
2019/0002401 COMBINED APPARATUS FOR THE SYNTHESIS OF UREA
Combined apparatus (1) for the synthesis of urea from ammonia and carbon dioxide, comprising an internal wall (3) which delimits two coaxial zones (4) inside...
2019/0002400 Acrylonitrile Derivatives from Epoxide and Carbon Monoxide Reagents
The present invention is directed to reactor systems and processes for producing acrylonitrile and acrylonitrile derivatives. In preferred embodiments of the...
2019/0002399 OLIGOMER CONJUGATES OF LIDOCAINE AND ITS DERIVATIVES
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer.
2019/0002398 C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
The present invention is directed to a compound represented by Structural Formula (A): ##STR00001## or a pharmaceutically acceptable salt thereof. The variables...
2019/0002397 PROCESS FOR THE SEPARATION OF LONG CHAIN AMINO ACIDS AND DIBASIC ACIDS
There is disclosed a process for the separation of long chain dibasic acid and fatty acid, comprising: (1) reacting a mixture of long chain dibasic acid and...
2019/0002396 PROCESS FOR THE SEPARATION OF LONG CHAIN AMINO ACIDS AND DIBASIC ACIDS
There is disclosed a process for the separation of long chain amino acid and long chain dibasic acid, comprising: (1) recovering alkylamine from an aqueous...
2019/0002395 PROCESS FOR THE PREPARATION OF A QUELATING AGENT
It is provided a compound of formula (I'); wherein R.sup.5 is selected from the group consisting of --H, --OM, --COOM, --NH.sub.2, --SO.sub.3M, ...
2019/0002394 SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE OR DEXTROMETHADONE HYDROCHLORIDE AND METHODS FOR USE THEREOF
Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine,...
2019/0002393 Lipids and Lipid Compositions for the Delivery of Active Agents
This invention provides for a compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.A, R.sup.B, R.sub.2 and R.sub.4...
2019/0002392 IMPROVED METHOD FOR SYNTHESISING PARTIALLY N-HYDROXYETHYLATED TERTIARY 1,6-HEXANEDIAMINES
The invention relates to a synthesis method for at least one nitrogen compound belonging to the family of partly N-hydroxyethylated tertiary 1,6-hexanediamines...
2019/0002391 METABOLISM RESISTANT FENFLURAMINE ANALOGS AND METHODS OF USING THE SAME
Metabolism-resistant fenfluramine analogs are provided. The subject fenfluramine analogs find use in the treatment of a variety of diseases. For example,...
2019/0002390 COMPOSITIONS AND METHODS OF USE OF PHORBOL ESTERS IN THE TREATMENT OF NEOPLASMS
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such...
2019/0002388 PROCESS FOR PREPARING BIS(2-HYDROXYETHYL) TEREPHTHALATE
A process for preparing bis(2-hydroxyethyl) terephthalate, comprising a step of: subjecting ethylene oxide and terephthalic acid in a molar ratio of from 2:1...
2019/0002387 CYCLOBUTANE-1, 3-DIACID BUILDING BLOCKS
A method of making polymers utilizes cyclobutane-1,3-diacid (CBDA) molecules as polymer building blocks includes and linker molecules with a non-reactive R...
2019/0002386 REACTION CONTROL IN ACETIC ACID PROCESSES
The present disclosure provides for a method for measuring the concentration of one or more components in a feed stream or reactor mixture of a process for...
2019/0002385 COMPOSITIONS FOR IMPROVED PRODUCTION OF ACRYLIC ACID
The present invention is directed to compositions which may undergo thermolysis to produce a higher purity acrylic acid product. In preferred embodiments of...
2019/0002384 Process For Production of Ketones From Secondary Alcohols
The present invention relates to the process for production of ketones from secondary alcohols by the use of a hybrid material, formed by the ...
2019/0002383 PROCESS AND APPARATUS FOR REMOVING ALDEHYDES FROM ACETONE
The present invention relates to process and apparatus for removing aldehydes from acetone. More specifically, the present invention relates to a process and...
2019/0002382 METHOD FOR KETONISATION OF BIOLOGICAL MATERIAL
A method for producing ketones includes a) providing a feedstock of biological origin having fatty acids and/or fatty acid derivatives having an average chain...
2019/0002381 HYDROGENATION OF OXYGENATED MOLECULES FROM BIOMASS REFINING
The present disclosure relates to methods, processes, and systems for utilizing the dehydrogenation of 2-butanol for hydrogen consuming reactions of biomass or...
2019/0002380 NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME
Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective...
2019/0002379 Method for Preparing Phenolics Using a Catalyst
The invention is directed to a method for preparing a phenolic compound comprising reacting a furanic compound with a dienophile in the presence of a catalyst...
2019/0002378 BIAROMATIC VITAMIN D ANALOGS
Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations...
2019/0002377 Novel Fire Retardant Compounds
Compounds with fire extinguishing properties having the formula: ##STR00001## wherein R.sup.1 is --CR.sup.5R.sup.6R.sup.7 or ...
2019/0002376 METHOD FOR PRODUCING AND PURIFYING 2,3,3,3-TETRAFLUORO-1-PROPENE
The present invention concerns a method for purifying 2,3,3,3-tetrafluoro-1-propene (1234yf) from a first composition comprising 2,3,3,3-tetrafluoro-1-propene...
2019/0002375 MANUFACTURING METHOD OF PURIFIED 1-CHLORO-2,3,3,3-TETRAFLUOROPROPENE AND PURIFIED...
There is provided a method of efficiently manufacturing purified 1224yd containing 1224yd at a high concentration from a mixture containing 1224yd and a...
2019/0002374 PROCESS FOR PRODUCING CHLOROTRIFLUOROETHYLENE
The present invention relates, at least in part, to a process for making chlorotrifluoroethylene (CFO-1113) from 1,2-dichloro-1,1,2-trifluoroethane...
2019/0002373 METHOD OF SEPARATING HEXENE
A method of producing hexene, comprising: passing a feed stream comprising C.sub.1 to C.sub.24 hydrocarbons and water through a distillation column; wherein...
2019/0002372 CATALYST AND HYDROCARBON CONVERSION PROCESS UTILIZING THE CATALYST
The present invention relates to a hydrocarbon conversion catalyst comprising i) a catalyst, in oxidic form, metals M1, M2, M3 and M4, wherein: M1 is selected...
2019/0002371 DUAL RAFFINATE PARAXYLENE EXTRACTION PROCESS
The present invention relates to heavy desorbent and light desorbent aromatics complex flow scheme. More particularly, this invention relates to the...
2019/0002370 INTEGRATION OF A DEHYDROGENATION UNIT AND AN ALKYLATION UNIT
The present invention relates to the integration of an alkylation unit for use in a hydrocarbon conversion process. More specifically, the present invention...
2019/0002369 PROCESS TO PREPARE PROPYLENE
The invention is directed to a process to prepare propylene from a mixture of hydrocarbons by performing the following steps. (a) extracting aromatics from the...
2019/0002368 NATURAL GAS LIQUID UPGRADING BY IONIC LIQUID CATALYZED ALKYLATION
We provide a process, comprising: a. dehydrogenating natural gas liquid to produce a mixture comprising olefins and unconverted paraffins; b. without further...
2019/0002367 Systems and Methods for Producing Naphthalenes and Methylnaphthalenes
A process for producing naphthalene or methylnaphthalenes from an alkane-containing stream. In an embodiment, the produce includes providing an...
2019/0002366 Production of Olefin Dimers
A process for producing alpha-olefin dimers comprises contacting, at a temperature of 80.degree. C. or more, a feedstock comprising at least one C.sub.8+...
2019/0002365 METHODS FOR TOLUENE RECOVERY FROM LINEAR ALPHA OLEFIN PRODUCTION
The present disclosure provides a method of flushing a reactor used in the production of linear alpha olefins, including flushing reactor equipment with...
2019/0002364 Photocatalytic Conversion of Carbon Dioxide and Water Into Substituted or Unsubstituted Hydrocarbon(s)
A method for the production of hydrocarbon(s), such as methane, substituted hydrocarbons, such as methanol, or the production of hydrogen, the method...
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