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Patent # Description
2019/0000994 Method For Inducing Antitumor Immunity Using Sindbis Viral Vectors And Tumor Associated Antigens
The subject application is directed to a method for treating a mammal harboring a tumor comprising identifying a tumor associated antigen (TAA) expressed by...
2019/0000993 TREATMENT OF DEVELOPMENTAL SYNDROMES
A method of treating a developmental syndrome in a patient in need thereof includes applying ultrasound to a target location in the patient's brain to enhance...
2019/0000992 Piggyback Delivery of CRISPR/CAS9 RNA into Zebrafish Blood Cells
The present invention includes nucleic acid hybrid molecules capable of entering cells comprising at least one vivo-morpholino oligonucleotide (vivo-MO)...
2019/0000991 GENE THERAPY FOR AADC DEFICIENCY
The present invention is directed to compositions and methods for treating aromatic L-amino acid decarboxylase (AADC) deficiency. This invention includes a...
2019/0000990 Carrier Nanoparticles And Related Compositions, Methods And Systems
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid and a linkage cleavable under reducing...
2019/0000989 BISPECIFIC TARGETING AGENTS AND METHODS FOR THEIR PREPARATION
The present invention is directed to a platform for new bispecific targeting agents using liposomes or nanoparticles as linkers. The bispecific targeting agent...
2019/0000988 COMPOSITIONS AND METHODS TO EXPEDITE ANTIBODY-BASED EXCHANGE IMAGING
A method for exchange imaging of at least two targets in a sample includes (a) incubating a sample with at least two or more target-recognizing antibodies,...
2019/0000987 NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also...
2019/0000986 NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND METHODS OF INDUCING EXON SKIPPING
Disclosed herein are molecules and pharmaceutical compositions that induce an insertion, deletion, duplication, or alteration in an incorrectly spliced mRNA...
2019/0000985 Polyoxazoline Anitbody Drug Conjugates
In the present disclosure, polymer conjugates, including polymer-antibody-drug conjugates (polymer ADCs) are described, as well as the use of such conjugates...
2019/0000984 MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF
The present disclosure provides multispecific antigen-binding molecules and uses thereof. The multispecific antigen-binding molecules comprise a first...
2019/0000983 AN EYE DROP SOLUTION FOR ENHANCED HYALURONIC ACID RETENTION AND DELIVERY
The present invention provides biomaterial compositions that can immobilize HA to the ocular surfaces through an HABpep and transmembrane mucins and collagen...
2019/0000982 METHODS, SYSTEMS AND COMPOSITIONS RELATING TO CELL CONVERSION VIA PROTEIN-INDUCED IN-VIVO CELL REPROGRAMMING
Methods for treating a subject in need thereof are provided which include administering a pharmaceutical composition comprising a protein transduction...
2019/0000981 TRIPARTITE MODULATORS OF ENDOSOMAL G PROTEIN-COUPLED RECEPTORS
The present invention relates to tripartite compounds comprising a modulator moiety for endosomal G protein-coupled receptors like neurokinin-1 receptor, a...
2019/0000980 SURFACTANT-FREE, WATER-FREE FORMABLE COMPOSITION AND BREAKABLE FOAMS AND THEIR USES
A substantially surface active agent-free and foam adjuvant-free composition which includes a hydrophobic solvent, a wax and a propellant. A substantially...
2019/0000979 POLYTETRAFLUOROETHYLENE CO-POLYMER EMULSIONS
The present disclosure is directed to a class of fluorinated copolymers, such as PTFE copolymers, that can be dissolved in low toxicity solvents, such as Class...
2019/0000978 REDUCED FOAMING VACCINE COMPOSITIONS
The present invention relates to novel stable compressed vaccine composition comprising least one anhydrous antigenic component comprising a stabilizer...
2019/0000977 CORTICOSTEROID COMPOSITIONS
The present disclosure generally relates to pharmaceutical corticosteroid compositions, and methods of making the same.
2019/0000976 Purgative Composition
The present invention relates to a purgative composition containing polyethylene glycol and sodium picosulfate, wherein the stability of sodium picosulfate is...
2019/0000975 PHARMACEUTICAL COMPOSITIONS COMPRISING MELOXICAM
Disclosed herein are compositions comprising an NSAID such as meloxicam in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These...
2019/0000974 METHOD FOR TREATING CANCER BY PHOTODYNAMIC THERAPY
The present invention discloses a method for treating cancer disease by photodynamic therapy. The photodynamic therapy in the present invention uses a...
2019/0000973 RADIO-WAVE RESPONSIVE DOPED NANOPARTICLES FOR IMAGE-GUIDED THERAPEUTICS
The invention discloses nanoparticles comprising compounds of calcium with anions such as phosphate, pyrophosphate, sulphate, silicate, carbonate, molybdate,...
2019/0000972 METHOD FOR BINDING ACTIVE AGENTS TO ACTIVATED AUTOLOGOUS BLOOD NOSODES AND DEVICE FOR PERFORMING SAID METHOD
A method for binding an active substance or an active agent to an activated autologous blood nosode comprises a) dissolving blood of a patient in an aqueous or...
2019/0000971 PEPTIDES AND ANTIBODIES FOR THE REMOVAL OF BIOFILMS
This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a...
2019/0000970 Methods and Monitoring of Treatment with a WNT Pathway Inhibitor
Methods for treating diseases such as cancer comprising administering a Wnt pathway inhibitor, either alone or in combination with other anti-cancer agents,...
2019/0000969 NOVEL ANTI-UPK1B ANTIBODIES AND METHODS OF USE
Provided are novel anti-UPK1B antibodies and antibody drug conjugates, and methods of using such anti-UPK1B antibodies and antibody drug conjugates to treat...
2019/0000968 ADJUVANT COMPOSITION CONTAINING AT LEAST ONE INFLUENZA VIRUS NEUTRALIZING AND BINDING MOLECULE AND VACCINE...
This invention relates to an adjuvant composition containing at least one binding molecule for neutralizing influenza virus and a vaccine composition...
2019/0000967 VECTOR CO-EXPRESSING VACCINE AND COSTIMULATORY MOLECULES
Compositions and methods for co-expressing a secretable vaccine protein (such as gp96-Ig) and T-cell co-stimulatory molecules from a single vector, among...
2019/0000966 SKIN MICROENVIRONMENT TARGETED DELIVERY FOR PROMOTING IMMUNE AND OTHER RESPONSES
Methods are provided for promoting, reducing, or desensitizing various immune responses by delivery of sub-immunogenic doses of an allergen, alone or with...
2019/0000965 Canine Parvovirus (CPV) Virus-like Particle (VLP) Vaccines and uses thereof
The present disclosure encompasses canine parvovirus (CPV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing CPV...
2019/0000964 THERAPEUTIC PEPTIDES AND VACCINES
Compositions are disclosed that induce broadly HIV theraputic and vaccine inducing antibodies against diverse HIV clades and relate to the ability to identify...
2019/0000963 VACCINE AGAINST BOVINE LEUKEMIA VIRUS
The invention relates to recombinant bovine leukemia viruses that have an attenuated phenotype and comprise a combination of at least two specific mutations....
2019/0000962 RESPIRATORY SYNCYTIAL VIRUS VACCINE
A respiratory syncytial virus (RSV) vaccine comprising a recombinant fusion protein antigen. In one embodiment, the recombinant fusion protein antigen...
2019/0000961 VACCINE COMPOSITIONS
The present invention relates to the use of an excipient which is a compound of formula (I) or a physiologically acceptable salt or ester thereof: wherein:...
2019/0000960 VACCINE CONTAINING IMMOBILIZED VIRUS PARTICLES
The present invention relates to a vaccine containing fixed virus particles, wherein a summed fever response of three rabbits to the fixed virus particles in a...
2019/0000959 NUCLEIC ACID VACCINES
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising...
2019/0000958 METHODS AND COMPOSITIONS RELATED TO INCREASING THE FIDELITY OF INFLUENZA A VIRUS FOR VACCINE DEVELOPMENT
Disclosed are compositions and methods for related to mutant influenza viruses with increased fidelity.
2019/0000957 THERMALLY STABLE ROTAVIRUS VACCINE FORMULATIONS AND METHODS OF USE THEREOF
The present invention relates to thermally stable oral rotavirus vaccine formulations comprising one or more rotavirus reassortant or attenuated rotavirus...
2019/0000956 ANTI-HUMAN PAPILLOMAVIRUS (HPV) ANTIGEN-BINDING PROTEINS AND METHODS OF USE THEREOF
The present invention provides antigen-binding proteins that specifically bind to an HLA-displayed human papillomavirus (HPV) peptide, and therapeutic and...
2019/0000955 NOVEL TARGETS OF ACINETOBACTER BAUMANNII
The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising...
2019/0000954 ATTENUATED MANNHEIMIA HAEMOLYTICA STRAINS
The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said...
2019/0000953 STREPTOCOCCUS PNEUMONIAE CAPSULAR POLYSACCHARIDES AND CONJUGATES THEREOF
The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation. The invention also...
2019/0000952 IMMUNOGENIC COMPOSITIONS FOR USE IN PNEUMOCOCCAL VACCINES
An object of the present invention is to provide immunogenic compositions for protection against S. pneumoniae, in particular against S. pneumoniae serogroup...
2019/0000951 STAPHYLOCOCCUS AUREUS MATERIALS AND METHODS
The disclosure generally relates to the field of prevention and treatment of Staphylococcus aureus infections. In particular, the disclosure relates to...
2019/0000950 COCCIDIOSIS VACCINE
The present invention relates to an improved vaccine against Coccidiosis in poultry. The vaccine comprises live Eimeria oocysts in a composition with...
2019/0000949 DENDRITIC CELL COMPOSITION
The present invention contemplates dendritic cell compositions. The dentritic cell compositions employ MHC class-II targeting signals fused to an antigen or...
2019/0000948 METHODS AND VACCINES FOR INDUCING IMMUNE RESPONSES TO MULTIPLE DIFFERENT MHC MOLECULES
This document provides methods and materials relating to isolated polypeptides, polypeptide preparations, vaccine preparations (e.g., anti-cancer vaccine...
2019/0000947 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST HEPATOCELLULAR CARCINOMA (HCC) AND...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0000946 TELOMERASE ENCODING DNA VACCINE
The invention provides a nucleic acid construct comprising a sequence that encodes a human telomerase reverse transcriptase (hTERT) protein which is devoid of...
2019/0000945 THERAPEUTIC CANCER VACCINES DERIVED FROM A NOVEL DENDRITIC CELL LINE
The invention is in the field of medical sciences. It provides means and methods for the treatment of cancer. More in particular, it provides cells and cell...
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