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Patent # Description
2019/0000893 COMPOSITIONS AND METHODS FOR INCREASING OR MAINTAINING FAECALIBACTERIUM PRAUSNITZII POPULATIONS
The present invention relates to the use of at least one lactic acid bacterium, or a composition comprising thereof or conditioned thereby, for increasing or...
2019/0000892 COMPOSITIONS COMPRISING BACTERIAL STRAINS
The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
2019/0000891 MATERIALS AND METHODS FOR CONTROLLING VASCULOGENESIS FROM ENDOTHELIAL COLONY FORMING CELLS
Materials and methods are disclosed for controlling vasculogenesis using building blocks of a collagen matrix and endothelial colony forming cells (ECFC). The...
2019/0000890 METHODS FOR TREATING CARDIAC CONDITIONS
Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of...
2019/0000889 METHODS FOR TREATING DIABETES
Disclosed herein are methods for treating type 1 diabetes by reversing autoimmunity and replenishing beta cells. More specifically, type 1 diabetes is treated...
2019/0000888 CARDIOSPHERE-DERIVED CELLS AND EXOSOMES SECRETED BY SUCH CELLS IN THE TREATMENT OF HEART FAILURE WITH PRESERVED...
Heart failure with preserved ejection fraction (HFpEF) is a disease condition characterized by heart failure (HF) signs and symptoms, but with normal or near...
2019/0000887 USE OF STEM CELLS EXPRESSING MESENCHYMAL AND NEURONAL MARKERS AND COMPOSITIONS THEREOF TO TREAT NEUROLOGICAL...
The invention provides pharmaceutical compositions comprising human immature dental pulp stem cells (hIDPSCs) wherein the hIDPSCs express CD44 and CD13. The...
2019/0000886 METHOD OF TREATMENT OF OSTEOCHONDRAL DEFECTS
Method and pharmaceutical compositions for enhancing osteochondral tissue, so that osteochondral defects may be repaired by the body and/or prevented or...
2019/0000885 TREATMENT WITH ANGIOGENIN TO ENHANCE HEMATOPOIETIC RECONSTITUTION
Aspects of the technology disclosed herein generally (and in part) relates to use of Angiogenin (ANG) for increasing hematopoietic reconstitution of in vivo...
2019/0000884 Therapeutic Methods Using Erythrocytes
The present disclosure relates to methods for modulating the level of proteins in a subject or in target cells by priming red blood cells with various agents...
2019/0000883 PROCESSES FOR PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF SAME IN IMMUNOTHERAPY
The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for...
2019/0000882 PROCESSES FOR PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF SAME IN IMMUNOTHERAPY
The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for...
2019/0000881 CONSTITUTIVE EXPRESSION OF COSTIMULATORY LIGANDS ON ADOPTIVELY TRANSFERRED T LYMPHOCYTES
The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at...
2019/0000880 IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY
Provided are the use of LSD1 inhibitors in connection with use and manufacture of immune effector cells (e.g., T cells, NK cells), e.g., engineered to express...
2019/0000879 CANINE AUTOLOGOUS IMMUNOTHERAPY USING DENDRITIC CELL INDUCED CANCER KILLING IMMUNOCYTES
Described are compositions of matter, protocols, and treatment means for induction of immune mediated killing in dogs suffering from cancer. The invention...
2019/0000878 Lymphocyte Cell Lines and Uses Thereof
Embodiments described herein relate to compositions including genetically modified CAR cells and uses thereof for treating cancer. Some embodiments of the...
2019/0000877 COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF HLA MISMATCHED GRAFTS
Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to an HLA mismatched recipient, where tolerance to...
2019/0000876 STABILIZED ANTISEPTIC PREPARATIONS
A stabilized antiseptic preparation comprises at least one vitamin, and/or at least one metal ion, and/or at least one surface-active compound, and/or at least...
2019/0000875 METHOD AND COMPOSITIONS FOR TREATING CANCEROUS TUMORS
The present invention relates to the use of chlorine dioxide compositions for treating cancerous tumors. The present invention relates to compositions and...
2019/0000874 Composition for the Treatment of Joint Conditions
The present invention relates to a composition comprising a cross-linked compound (A) selected from the group polysulphated and unsulphated polysaccharides,...
2019/0000873 PROPHYLACTIC USE OF INULIN AGAINST SINUSITIS
The present invention relates to an inulin composition comprising GF.sub.n- and F.sub.m-compounds, in particular for decreasing the risk of sinusitis,...
2019/0000872 METHOD FOR TREATING DIASTOLIC HEART FAILURE BY INHIBITING GALECTIN-3
A method for treating diastolic heart failure is provided including identifying a subject having diastolic heart failure and administering a therapeutically...
2019/0000871 TREATMENT AND DIAGNOSIS OF OCULAR SURFACE DISORDERS
The present invention provides an ophthalmic formulation consisting essentially of one or more pharmaceutically acceptable excipients; a pharmaceutically...
2019/0000870 COMPOSITIONS AND METHODS FOR INHIBITING HMGB1 EXPRESSION
This disclosure relates to oligonucleotides, compositions and methods useful for reducing HMGB1 expression, particularly in hepatocytes. Disclosed...
2019/0000869 COMPOSITION, FOR PREVENTING, REMEDYING OR TREATING FEMALE CLIMACTERIC SYNDROME, CONTAINING LOGANIN OR...
A pharmaceutical composition for preventing or treating female climacteric syndromes comprising Loganin which increases the concentration of estradiol...
2019/0000868 COMPOSITIONS COMPRISING 4'-O-GLUCURONIDE EPICATECHIN AND METHODS OF MAKING AND USING SUCH COMPOSITIONS
Compositions can comprise the flavanol metabolite 4'-O-glucuronide epicatechin (4GEC). In some embodiments, the composition can be used in a method for blood...
2019/0000867 COMPOUNDS, COMPOSITIONS AND METHODS FOR PROTECTING BRAIN HEALTH IN NEURODEGENERATIVE DISORDERS
Aspects of the invention relate to compounds, extracts and compositions thereof, and methods of using of the same, to treat neurodegenerative disorders and/or...
2019/0000866 FOOD BASED DELIVERY OF THERAPEUTIC AGENT FOR TREATMENT OF HEPATIC ENCEPHALOPATHY
Described herein are compositions, methods, and kits for treating hepatic encephalopathy. A composition for treating or preventing hepatic encephalopathy...
2019/0000865 MATERIALS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS AND FOR INDUCTION OF ION SECRETION
The present invention provides materials and methods for inducing ion secretion and/or for treating cystic fibrosis. In one embodiment, the composition...
2019/0000864 COMPOSITIONS FOR ORAL ADMINISTRATION OF ZOLEDRONIC ACID OR RELATED COMPOUNDS FOR TREATING DISEASE
Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions.
2019/0000863 PHARMACEUTICAL COMPOSITION FOR PREVENTION, TREATMENT OR DELAY OF ALZHEIMER'S DISEASE OR DEMENTIA CONTAINING G...
The present invention relates to a pharmaceutical composition for preventing, treating or delaying an Alzheimer's disease (AD) or dementia including a G...
2019/0000862 METHODS AND SYSTEMS FOR THE DELIVERY OF A THERAPEUTIC AGENT
The present invention provides a liquid pharmaceutical composition comprising a therapeutic agent and an alkoxy-polyethylene glycol, for example,...
2019/0000861 DRUG COMBINATION AND ITS USE IN THERAPY
The invention relates to a combination of CXCR4 antagonist 6-{4-[1-(Propan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl}-N-(pyridin-4-yl)p- yridine-2-carboxamide and...
2019/0000860 USE OF COMPOSITIONS MODULATING CHROMATIN STRUCTURE FOR GRAFT VERSUS HOST DISEASE (GVHD)
In some aspects, the instant disclosure relates to methods of treating chronic graft versus host disease (cGVHD). In some embodiments, the method comprises...
2019/0000859 DRUG INCLUSION COMPOUND, PREPARATION THEREOF, AND PREPARATION METHOD THEREOF
A pharmaceutical composition comprises an active component KX2-361 represented by formula 1 or a medicinal salt thereof and ...
2019/0000858 Inhibitors of N-Linked Glycosylation and Methods Using Same
The present invention includes novel compounds and methods for preventing or treating diseases associated with N-linked glycosylation in a subject in need...
2019/0000857 FUSED TRICYCLIC COMPOUNDS AS RAF KINASE INHIBITORS
Provided are certain fused tricyclic compounds and salts thereof, compositions thereof and methods of use therefor.
2019/0000856 MTH1 INHIBITORS FOR TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS
A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions. ...
2019/0000855 TREATMENT OF GENOTYPED DIABETIC PATIENTS WITH DPP-IV INHIBITORS SUCH AS LINAGLIPTIN
The present invention relates to methods for preventing or treating of metabolic disorders and related conditions, such as in certain patient groups.
2019/0000854 TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE OR NON-ALCOHOLIC STEATOHEPATITIS WITH DELAYED-RELEASE...
Methods of treating patients suffering from non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), including those also suffering...
2019/0000853 ANTIVIRAL 4-(2-AMINO-6-HETEROCYLYL-9H-PURIN-9-YL)-2-CYCLOPENTENE-1 -METHANOL COMPOUNDS
The present invention relates to certain antiviral compounds of formula I as defined herein that function as nucleoside reverse transcriptase inhibitors. The...
2019/0000852 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
The present invention provides compounds of Formula A: ##STR00001## or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the...
2019/0000851 METHODS OF TREATING CANCER WITH SMALL MOLECULE NF-kB INHIBITORS
The present invention provides, inter alia, compounds capable of inhibiting NF-.kappa.B. Pharmaceutical compositions containing and methods of using the...
2019/0000850 COMBINATION CANCER THERAPY
Described herein, inter alia, are anti-cancer agents, anti-cancer pharmaceutical compositions, combinations of the agents and/or pharmaceutical compositions,...
2019/0000849 NOVEL COMPOUNDS
The invention provides compounds of formula (I): ##STR00001## Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of...
2019/0000848 MODULATORS OF KV3 CHANNELS TO TREAT PAIN
The present invention provides a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels for use in the prophylaxis or treatment of pain. Modulators for use in...
2019/0000847 THERAPEUTIC AGENT FOR A WOUND
The present invention provides a therapeutic agent for a wound comprising a compound represented by the formula (I) wherein R.sup.1 represents a hydroxy...
2019/0000846 Pharmaceutical Products and Drug Combinations for Treating Atherosclerosis by Stabilizing Atherosclerotic...
Foamy macrophages with senescence markers accumulate in the subendothelial space at the onset of atherosclerosis where they drive pathology by increasing...
2019/0000845 PHENYLOXADIAZOLE DERIVATIVES AS PGDS INHIBITORS
This invention is directed to a compound of formula (I): ##STR00001## wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the...
2019/0000844 METHODS FOR TREATING HUNTINGTON'S DISEASE
The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions...
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