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Patent # Description
2019/0000843 SOLID DOSAGE FORMS OF (S)-ETHYL 2-AMINO-3-(4-(2-AMINO-6-((R)-1-(4-CHLORO-2-(3-METHYL-1H-PYRAZOL-1-YL)PHEN- ...
Solid pharmaceutical dosage forms comprising (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phen- ...
2019/0000842 Treating Sexual Desire Disorders with Flibanserin
The invention relates to the use of flibanserin, or a pharmaceutically acceptable acid addition salt thereof, for the treatment of disorders of sexual desire.
2019/0000841 METHOD OF TREATING A BRAIN TUMOR
Disclosed herein are methods of treating a brain tumor by administering Plinabulin. Some embodiments relate to treatment of glioblastoma multiforme by...
2019/0000840 COMBINATIONS FOR THE TREATMENT OF CANCER
Described herein are combinations comprising a therapeutically effective amount of a first agent and a therapeutically effective amount of a second agent,...
2019/0000839 CIPROFLOXACIN OTIC COMPOSITION AND KITS AND METHOD FOR USING SAME
Disclosed herein are otic product kits for administration of a sterilized formulation. In some embodiments, the otic product kit comprises: an aseptic...
2019/0000838 SYNTHETIC LETHALITY AND THE TREATMENT OF CANCER
Described herein are compounds, compositions and methods for treatment of cancer. Also described are methods and uses for identifying subject with cancer that...
2019/0000836 THERAPEUTIC USES OF 1-[2-(2,4-DIMETHYL-PHENYLSULFANYL)PHENYL]PIPERAZINE
The invention provides new therapeutic uses of 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]-piperazine and pharmaceutically acceptable salts thereof.
2019/0000835 BUPROPION AS A MODULATOR OF DRUG ACTIVITY
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically,...
2019/0000834 INJECTABLE COMPOSITION AND A METHOD OF TREATMENT OF THE PHYSICAL ADDICTION
An injectable liquid composition for the treatment of a physical addiction includes naltrexone in the amount of 5%-95% of the total weight of the composition;...
2019/0000833 ABUSE-RESISTANT MUCOADHESIVE DEVICES FOR DELIVERY OF BUPRENORPHINE
The present invention provides abuse deterrent mucoadhesive devices for delivery of buprenorphine. Each device comprises a mucoadhesive layer and a backing...
2019/0000832 TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF
To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a...
2019/0000831 COMPOSITIONS AND METHODS FOR TREATING DRUG-TOLERANT GLIOBLASTOMA
The present invention provides compositions and methods for the treatment of drug-tolerant glioblastoma, and in particular glioblastoma stem cells. ...
2019/0000830 INHIBITION AND TREATMENT OF BACTERIAL INFECTIONS BY SEX-SPECIFIC GPER TARGETING
The present invention is directed to the use of compounds which are modulators of the G protein-Coupled Estrogen Receptor (GPER) for the inhibition--and/or...
2019/0000829 THERAPEUTIC AGENT FOR BILIARY TRACT CANCER
A therapeutic agent for biliary tract cancer comprising 4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinoli- necarboxamide or a...
2019/0000828 COMPOSITIONS AND METHODS FOR TREATMENT RELATED TO FALL AND FALL FREQUENCY IN NEURODEGENERATIVE DISEASES
The present disclosure provides methods and compositions for treating fall-related symptoms in patients with neurodegenerative diseases such as Parkinson's...
2019/0000827 COMPOSITIONS AND METHODS FOR TREATMENT RELATED TO FALL AND FALL FREQUENCY IN NEURODEGENERATIVE DISEASES
The present disclosure provides methods and compositions for treating fall-related symptoms in patients with neurodegenerative diseases such as Parkinson's...
2019/0000826 ANTICHOLINERGIC NEUROPROTECTIVE COMPOSITION AND METHODS
The present invention relates to a pharmaceutical composition comprising propiverine, trospium or glycopyrrolate; and a non-anticholinergic antiemetic agent....
2019/0000825 Synergistic Compositions and Devices for Gynecological Procedures
Synergistic compositions and medical devices for use in treatment during gynecological procedures are provided. A gynecological device for treatment of...
2019/0000824 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present...
2019/0000823 2-AMINO-6-(DIFLUOROMETHYL)-5,5-DIFLUORO-6-PHENYL-3,4,5,6-TETRAHYDROPYRIDIN- ES AS BACE1 INHIBITORS
The present invention is directed to compounds of formula (I) which are inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to...
2019/0000822 CHLORINE OR BROMINE SALTS OF CETYLPYRIDINIUM FOR USE IN THE TREATMENT OF CUTANEOUS AND ACUTE PORPHYRIAS AND...
The present invention relates to chlorine or bromine salts of cetylpyridinium for use in the treatment of porphyrias and psoriasis, as well as methods of...
2019/0000821 METHOD OF PROVIDING PIRFENIDONE THERAPY TO A PATIENT
The invention relates to methods for decreasing adverse events associated with pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) therapy. The invention discloses...
2019/0000820 Durable Treatment with 4-Aminopyridine in Patients with Demyelination
Disclosed herein are methods and compositions related to the durable use of aminopyridines, such as 4-aminopyridine, to improve impairments of patients with a...
2019/0000819 Methods Of Treating Fabry Disease In Patients Having The G9331A Mutation In The GLA Gene
Provided are methods of treating a patient diagnosed with Fabry disease and methods of enhancing .alpha.-galactosidase A in a patient diagnosed with or...
2019/0000818 Method To Predict Response To Pharmacological Chaperone Treatment Of Diseases
The present invention provides methods to determine whether a patient with a lysosomal storage disorder will benefit from treatment with a specific...
2019/0000817 METHODS AND COMPOSITIONS FOR TREATING OBESITY AND/OR DIABETES AND FOR IDENTIFYING CANDIDATE TREATMENT AGENTS
Provided are methods and compositions for identifying candidate agents for treatment of obesity, liver disease, and/or diabetes. Such methods include, e.g.,...
2019/0000816 CYCLOPAMINE ANALOGS
The invention provides derivatives of cyclopamine having the following formula: ##STR00001##
2019/0000815 COMPOSITION COMPRISING COMBINATION OF RAPAMYCIN AND AN ACTIVATOR OF AMP KINASE AND USE THEREOF FOR TREATING...
A formulation, especially one that is topically administered, comprising a combination of rapamcycin and metformin in a molar ratio of about 20:1, 10:1, 5:1,...
2019/0000814 Antifungal Compounds
The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as...
2019/0000813 METHODS OF TREATMENT FOR CHOLESTATIC AND FIBROTIC DISEASES
The present invention relates to the compound [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate (Nitazoxanide) ...
2019/0000812 ALPHA-AMINO ESTERS OF HYDROXYPROPYLTHIAZOLIDINE CARBOXAMIDE DERIVATIVE AND SALT FORM, CRYSTAL POLYMORPH THEREOF
The invention provides pharmaceutical compositions comprising a compound of formula (I) or (II) and an additional therapeutic agent Also provided is the HCI...
2019/0000811 BENZOTHIAZOLE AMPHIPHILES
Disclosed herein, inter alia, are compounds and methods for increasing spine density in a neuron, and for treatment of neuronal diseases and cancer.
2019/0000810 OINTMENT
An ointment is provided. The ointment stably comprises an oxazole compound that has specific inhibitory activity against PDE4 and that is represented by the...
2019/0000809 ANGIOTENSIN IN TREATING BRAIN CONDITIONS
The present invention provides, among other things, methods and compositions for treating brain conditions. In some embodiments, the methods include...
2019/0000808 COMPOSITION AND METHODS FOR THE TREATMENT OF BLEPHOPHAROPTOSIS
The present invention relates to compositions and methods for the treatment and prevention of ptosis and more specifically to compositions and methods for the...
2019/0000807 ORGANIC COMPOUNDS
The present invention relates to certain PDE2 inhibitory compounds, in free or salt form, pharmaceutical compositions containing such compounds and methods for...
2019/0000806 COMPOUNDS USEFUL AS KINASE INHIBITORS
This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are...
2019/0000805 Compounds and Compositions That Bind and Stabilize Transthyretin and Their Use for Inhibiting Transthyretin...
Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form...
2019/0000804 METHODS OF USING (+)-2-[1-(3-ETHOXY-4-METHOXYPHENYL)-2-METHYLSULFONYLETHYL]-4-ACETYLAMINOI- ...
Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoi- soindoline-1,3-dione, substantially free of its (-) isomer, and...
2019/0000803 CHONDROITIN COMPLEXES FOR TRANSCUTANEOUS ABSORPTION
The present invention relates to the use of chondroitin as a transdermal carrier and slow-release system for active ingredients in pharmaceutical and...
2019/0000802 DRUG COMBINATION PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USING THEM
The invention provides preparations, formulations, kits and other products of manufacture (e.g., blister packs) comprising combinations of beneficial...
2019/0000801 METHODS OF TREATING AUTOIMMUNE AND/OR GLOMERULONEPHRITIS-ASSOCIATED DISEASES USING SHP2 INHIBITORS
Methods are disclosed herein for administering a oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitor for treating...
2019/0000800 COMPOSITION COMPRISING A DIINDOLYLMETHANE AND A RETINOID TO TREAT A SKIN CONDITION
Provided is a composition for use in treating a skin condition, the composition comprising: (a) a first component comprising a substituted or unsubstituted...
2019/0000799 COMPOSITIONS AND METHODS FOR TREATING ALLERGIC INFLAMMATORY CONDITIONS
The invention provides methods of treating an allergic inflammatory condition characterized by inflammation of the squamous epithelium of a target tissue by...
2019/0000798 APPLICATION OF DIMETHYLAMINO MICHELIOLIDE
The present invention provides an application of a dimethylamino micheliolide for preparing a pharmaceutical product for treating pulmonary fibrosis.
2019/0000797 TUMOR THERAPEUTIC AGENT
A novel tumor therapeutic agent for a combination therapy is disclosed. More specifically, a tumor therapeutic agent used for a combination therapy of...
2019/0000796 ANTI-NOROVIRUS COMPOSITION AND UTILIZATION THEREOF
Provided are: a composition having an excellent anti-norovirus effect; use of a theaflavin compound for the preparation of the composition; and a method for...
2019/0000795 Methods of using cannabinoids and/or molecular similars for modulating, waking-up and/or disabling cellular...
Methods using cannabinoids and/or molecular similars for modulating, waking-up and/or disabling cellular functions involved in causing disease are provided for...
2019/0000794 TRANSMUCOSAL CANNABINOID FORMULATION INCLUDING A CHITOSAN EXCIPEINT
A cannabinoid formulation for transmucosal delivery includes a first excipient comprising shea butter containing at least 40% oleic acid, at least 20% steraic...
2019/0000793 METHODS OF INDUCING ANESTHESIA
The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water...
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