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Patent # Description
2019/0015434 DOSAGE FORMS FOR ORAL ADMINISTRATION OF ZOLEDRONIC ACID OR RELATED COMPOUNDS FOR TREATING DISEASE
Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions,...
2019/0015433 LIPID COMPOSITIONS WITH HIGH DHA CONTENT
The invention provides lipid compositions comprising phospholipids having a high docosahexaenoic acid (DHA) content, which compositions are preferably...
2019/0015432 Lipid Disulfide Prodrugs and Uses Related Thereto
This disclosure relates to lipid disulfide prodrugs and in particular to lipid disulfide phosphodiester nucleosides and derivatives thereof, pharmaceutical...
2019/0015431 Compositions and Methods for the Treatment of Neurodegenerative and Other Diseases
In one embodiment, the present application discloses methods of treating diseases and disorders with sulfasalazine and pharmaceutical formulations of...
2019/0015430 PHARMACEUTICAL SPRAY COMPOSITION COMPRISING A VITAMIN D ANALOGUE AND A CORTICOSTEROID
The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its...
2019/0015429 COMBINATION OF 25-HYDROXYVITAMIN D AND ANTIOXIDANTS/ANTI-INFLAMMATORIES FOR HUMAN NUTRACEUTICALS
This invention relates to the use of the combination of 25-hydroxyvitamin D3 ("25-OH D3") and antioxidants/anti-inflammatories (ascorbic acid, vitamin E and at...
2019/0015428 CONTROLLED RELEASE AND TASTE MASKING ORAL PHARMACEUTICAL COMPOSITIONS
The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least...
2019/0015427 METHODS AND RELATED COMPOSITIONS FOR REDUCTION OF FAT AND SKIN TIGHTENING
Compositions and methods useful in the reduction of localized fat deposits and tightening of loose skin in subjects in need thereof using pharmacologically...
2019/0015426 BROAD ANTIVIRAL THERAPY WITH MEMBRANE MODIFYING OXYSTEROLS
This invention relates, e.g., to a method for inhibiting the growth and/or proliferation and/or infectivity of a virus in a cell, such as a mammalian cell...
2019/0015425 OCULAR IMPLANT MADE BY A DOUBLE EXTRUSION PROCES
The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants...
2019/0015424 METHODS AND FORMULATIONS FOR TREATMENT OF AND/OR PROTECTION AGAINST ACUTE LIVER FAILURE AND OTHER HEPATOTOXIC...
Methods, formulations and kits for treating and/or protecting against acute liver failure and other hepatotoxicities in an individual employ a combination of a...
2019/0015423 REGULATION OF GENE EXPRESSION BY MODULATING PRIMARY CILIA LENGTH
The presently disclosed subject matter relates to methods of regulating gene expression in a cell by modulating the length of primary cilia of a cell, wherein...
2019/0015422 METHODS FOR TREATING BRAIN METASTASES USING COMBINATIONS OF ANTI-P13K AND ANTI-mTOR AGENTS
The present invention relates to methods of treating brain metastases using synergistic combinations of anti-PI3K and anti-mTOR therapies. It has also been...
2019/0015421 Biomarkers for Treating Cancer with Apilimod
The present disclosure relates to compositions and methods for treating cancer in a subject having cancer cells over-expressing a microphthalmia (MiT)...
2019/0015419 DEUTERATED ANALOGS OF ETIFOXINE, THEIR DERIVATIVES AND USES THEREOF
This invention relates to deuterated analogs of etifoxine of Formula 1, solvates, prodrugs, and pharmaceutically acceptable salts thereof, as well as to...
2019/0015418 Tablet Formulation of 2-Fluoro-N-Methyl-4-[7-(Quinolin-6-Ylmethyl) Imidazo [1,2-B] [1,2,4] Triazin-2-YL] Benzamide
The present invention is related to tablets comprising of 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-- 2-yl]benzamide, processes...
2019/0015417 THERAPEUTIC AGENT FOR FGFR INHIBITOR-RESISTANT CANCER
The problem to be solved by the present invention is to provide an anticancer agent for treating tumors resistant to other antitumor agents that inhibit FGFR,...
2019/0015416 BTK INHIBITORS FOR TREATING NEUROBLASTOMA
The present invention provides a novel method, composition, and kit for treating neuroblastoma by way of the use of a BTK inhibitor. Also provided is a method...
2019/0015415 METHODS FOR TREATING SCHIZOPHRENIA
The disclosure provides methods for treating psychiatric diseases, such as schizophrenia, in patients with certain gene polymorphisms using antipsychotic...
2019/0015414 FORMULATIONS OF 5-FLUOROCYTOSINE AND USES THEREOF
The disclosure provides an extended release formulation of 5-fluorocytosine. In another aspect, a method of treating a fungal disease is provided. The method...
2019/0015413 ACRYLANILIDE DERIVATIVE, PREPARATION METHOD, AND APPLICATIONS THEREOF IN PHARMACY
Disclosed in the present invention are an acrylanilide compound represented by general formula (I) and a pharmaceutically acceptable salt thereof. The...
2019/0015412 PHARMACEUTICAL COMPOSITIONS COMPRISING PHENYLAMINOPYRIMIDINE DERIVATIVE
An oral pharmaceutical formulation containing an effective amount of NRC-AN-019 including its pharmaceutically acceptable salts and polymorphs thereof, by...
2019/0015411 COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS
The present disclosure provides combination therapy of a transcription inhibitor and a kinase inhibitor. The combination of the transcription inhibitor and the...
2019/0015410 HETEROCYCLIC PDK1 INHIBITORS FOR USE TO TREAT CANCER
Described are methods of use of compounds that inhibit PIF-mediated substrate binding by PDK1, which are useful as inhibitors of cancer growth or proliferation...
2019/0015409 COMPOSITIONS AND METHODS OF USING NINTEDANIB FOR IMPROVING GLAUCOMA SURGERY SUCCESS
Compositions and methods of using nintedanib for improving the success rate of glaucoma filtration surgery are disclosed herein. Nintedanib can be used alone...
2019/0015408 CRYSTALLIZATION PROCESS OF ARIPIPRAZOLE DERIVATIVES IN EXTENDED RELEASE FORMULATIONS FOR TREATMENT OF SCHIZOPHRENIA
Processes for providing depot injections of recrystallized aripiprazole lauroxil in which particles of the aripiprazole lauroxil have a surface area of about...
2019/0015407 COMPOSITIONS AND METHODS COMPRISING BUPROPION OR RELATED COMPOUNDS FOR SUSTAINED DELIVERY OF DEXTROMETHORPHAN
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically,...
2019/0015406 TREATMENTS AND PREVENTION OF OPIOID NEONATAL ABSTINENCE SYNDROME
Disclosed is a method for reducing or preventing fetal opioid dependence in a drug dependent or opioid tolerant pregnant subject. The method involves...
2019/0015405 DOSAGES OF IMMUNOCONJUGATES OF ANTIBODIES AND SN-38 FOR IMPROVED EFFICACY AND DECREASED TOXICITY
The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragment. The antibody may...
2019/0015404 KINASE INHIBITORS FOR TREATMENT OF DISEASE
Disclosed are therapeutic compositions including BA-1076 and/or BA-2057, methods of their use in the treatment of ophthalmological disorders. The therapeutic...
2019/0015403 NIACIN FORMULATION
The present invention provides a composition including an amphiphilic compound capable of self-assembling into a liquid crystalline phase; and a niacin...
2019/0015402 Anti-Viral Compounds
Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds,...
2019/0015401 DEUTERATED ANALOGS OF PRIDOPIDINE USEFUL AS DOPAMINERGIC STABILIZERS
The present invention provides novel deuterated analogs of Pridopidine, i.e. 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine. Pridopidine is a drug substance...
2019/0015400 Antifungal Compositions
Provided herein are antifungal compositions and methods of use thereof. The antifungal compositions include an antifungal agent and an antipsychotic agent or...
2019/0015399 Use of 4-Aminopyridine to Improve Neuro-Cognitive and/or Neuro-Psychiatric Impairment in Patients with...
Disclosed herein are methods and compositions related to use of aminopyridines, such as 4-aminopyridine, to improve the neuro-cognitive impairments and related...
2019/0015398 INHIBITION OF CRYSTAL GROWTH OF ROFLUMILAST
Roflumilast crystals have been shown to increase in size during storage. The size of the roflumilast crystals can affect the bioavailability and efficacy of a...
2019/0015397 SUBSTANCE THAT INHIBITS P2Y12 RECEPTOR, FOR USE IN THE PREVENTIVE TREATMENT OF SYSTEMIC SCLEROSIS IN PATIENTS...
Some embodiments are directed to a substance that inhibits P2Y12 receptor for use in the preventive treatment of systemic sclerosis in patients with Raynaud's...
2019/0015396 VMAT2 INHIBITORS FOR TREATING NEUROLOGICAL DISEASES OR DISORDERS
Methods are provided herein for treating agitation in a subject who has Alzheimer's disease comprising administering a VMAT2 inhibitor to a subject in need...
2019/0015395 TACROLIMUS FOR TREATING TDP-43 PROTEINOPATHY
The present invention provides tacrolimus for use in the treatment in a human subject of a TDP-43 proteinopathy, such as amyotrophic lateral sclerosis (ALS)...
2019/0015394 DETECTING AND TREATING GROWTH HORMONE DEFICIENCY
Described herein is a new oral method for using MK-0677 for detecting growth hormone (GH) deficiency (GHD). Also described is a method of treating growth...
2019/0015393 THE USE OF A TEMPORARY INHIBITOR OF P53 FOR PREVENTING OR REDUCING CANCER RELAPSE
The present invention relates to a temporary inhibitor of p53 for its use for preventing or reducing cancer relapse in cancer patients.
2019/0015392 Treatment of Gout and Hyperuricemia
Sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylt- hio)acetate is described. In addition, pharmaceutical compositions and uses of such...
2019/0015391 IL-8 INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY
The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of...
2019/0015390 NOVEL SOLID FORMS OF BENDAMUSTINE HYDROCHLORIDE
Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use.
2019/0015389 NOVEL CLONIDINE FORMULATION
An oral clonidine dosage unit providing a twenty-four hour extended release profile following a single dose administration is provided. The dosage unit...
2019/0015388 COMPOSITIONS COMPRISING CORNEOSCLERAL TISSUE CROSS-LINKING AGENTS
A composition for opththalmic administration comprising a formaldehyde releasing agent, sodium bicarbonate, and an ophthalmically suitable carrier or excipient...
2019/0015387 SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE THEREOF
This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including...
2019/0015386 Oxo-M and 4-PPBP induction of tenogenic differentiation of perivascular tendon stem cells
Provided herein are compositions including oxotremorine (e.g., oxotremorine methiodide or Oxo-M) and 4-PPBP (e.g., 4-PPBP maleate). Also provided are methods...
2019/0015385 VITAMIN E PHOSPHATE OR ACETATE FOR USE IN THE TREATMENT AND PREVENTION OF BIOFILM INFECTIONS
The present invention concerns vitamin E selected among vitamin E phosphate, optionally in combination with methylene blue, and/or vitamin E acetate in...
2019/0015384 Treatment and Prevention of Joint Disorders
The invention encompasses compositions and methods for effectively treating and/or preventing the development and/or progression of osteoarthritis and...
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