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Patent # Description
2019/0017101 FUNCTIONAL LIGANDS TO THC
The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for...
2019/0017100 METHOD FOR ANALYSIS OF AN RNA MOLECULE
The present invention relates to the field of RNA analysis. In particular, the invention concerns the use of a catalytic nucleic acid molecule for the analysis...
2019/0017099 METHODS AND MATERIALS FOR DETECTING VIRAL OR MICROBIAL INFECTIONS
This document provides methods and materials for detecting target nucleic acid. For example, methods and materials for detecting the presence or absence of...
2019/0017098 Sorbents for the Extraction and Stabilization of Nucleic Acids
Mesoporous sorbents are effective for storing and transporting nucleic acids. In particular, two ethane-bridged silica sorbents with amine functionalities are...
2019/0017097 HIGH THROUGHPUT OPTICAL ASSAY OF HUMAN MIXED CELL POPULATION SPHEROIDS
The present disclosure provides a method of performing a functional assay on human spheroids, e.g., three-dimensional human cell spheroids using, in one...
2019/0017096 PRENYLATION ASSAY
A method for determining the activity of Rab escort protein 1 (REP1) comprising the steps: (a) providing a sample comprising REP1; (b) contacting the sample of...
2019/0017095 COMPOSITIONS, METHODS AND TREATMENTS FOR INHIBITING CELL ADHESION AND VIRUS BINDING AND PENETRATION
Disclosed herein are glyco-decoy acceptor compositions that sidetrack or inhibit the activity of biosynthetic enzymes participating in synthesis of ligands...
2019/0017094 METHOD FOR IMMOBILIZATION OF GLUCURONIDASE ENZYMES FOR THE DETECTION OF PRODUCTS DERIVED FROM GLUCURONIDE COMPOUNDS
The present invention provides an insoluble enzymatic reagent for detecting products derived from glucuronide metabolites in a sample, containing an enzyme...
2019/0017093 PROCESS FOR DETERMINING VIABILITY OF TEST MICROORGANISMS OF BIOLOGICAL INDICATOR AND STERILIZATION DETECTION...
A process for determining the viability of a biological indicator includes exposing the biological indicator to a viability detection medium, the biological...
2019/0017092 PROCESS FOR DETERMINING VIABILITY OF TEST MICROORGANISMS OF BIOLOGICAL INDICATOR AND STERILIZATION DETECTION...
A process for determining the viability of a biological indicator includes exposing the biological indicator to a viability detection medium, the biological...
2019/0017091 PROCESS FOR DETERMINING VIABILITY OF TEST MICROORGANISMS OF BIOLOGICAL INDICATOR AND STERILIZATION DETECTION...
A process for determining the viability of a biological indicator includes exposing the biological indicator to a viability detection medium, the biological...
2019/0017090 Rapid Antibiotic Susceptibility Test Using Membrane Fluorescence Staining and Spectral Intensity Ratio Improved...
Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of...
2019/0017089 MYO1A FOR PREDICTING CONVERSION OF ACUTE PAIN INTO CHRONIC PAIN AND USE OF MYO1A FOR THERAPY OF PAIN
The present invention relates to the identification of Myo1a as a biomarker of conversion of acute pain into chronic pain, and as a therapeutic target. The...
2019/0017088 RADIATION SENSOR
A radiation sensor, comprising a housing, a first chamber disposed in the housing and configured to contain a microorganism. A second chamber is disposed in...
2019/0017087 COENZYME-LINKED GLUCOSE DEHYDROGENASE AND POLYNUCLEOTIDE ENCODING THE SAME
The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability...
2019/0017086 COENZYME-LINKED GLUCOSE DEHYDROGENASE AND POLYNUCLEOTIDE ENCODING THE SAME
The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability...
2019/0017085 COENZYME-LINKED GLUCOSE DEHYDROGENASE AND POLYNUCLEOTIDE ENCODING THE SAME
The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability...
2019/0017084 MULTIPLE STAGE ISOTHERMAL ENZYMATIC AMPLIFICATION
Disclosed herein are methods for multiple stage isothermal amplification of nucleic acid comprising a first substantially isothermal amplification reaction on...
2019/0017083 ENZYMATIC PRODUCTION OF D-TAGATOSE
The current disclosure provides a process for enzymatically converting a saccharide into tagatose. The invention also relates to a process for preparing...
2019/0017082 INCREASED TRIACYLGLYCEROL PRODUCTION IN MICROALGAE
The application generally relates to bioproduction of molecules of interest in micro- organisms, more particularly in microalgae. In particular, the...
2019/0017081 METHODS AND COMPOSITIONS FOR PRODUCING FATTY ALCOHOLS
Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
2019/0017080 PROCESSES FOR RECOVERING PRODUCTS FROM A CORN FERMENTATION MASH
Processes and systems for recovering products from a fermentation mash. In some examples, a process for recovering products from a fermentation mash can...
2019/0017079 METHOD FOR FERMENTING SUGARS
In a first aspect of the present invention, there is provided a fermentation process for fermenting a carbon source comprising glucose and one or more...
2019/0017078 MICROORGANISMS AND METHODS FOR PRODUCING BUTADIENE AND RELATED COMPOUNDS BY FORMATE ASSIMILATION
Provided herein are non-naturally occurring microbial organisms having a formaldehyde fixation pathway and a formate assimilation pathway, which can further...
2019/0017077 MICROBIAL ENGINEERING FOR THE PRODUCTION OF CHEMICAL AND PHARMACEUTICAL PRODUCTS FROM THE ISOPRENOID PATHWAY
The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
2019/0017076 METHODS, CELLS AND REAGENTS FOR PRODUCTION OF ISOPRENE, DERIVATIVES AND INTERMEDIATES THEREOF
This application describes methods, including non-naturally occurring methods, for biosynthesizing 3-hydroxy-3-methylglutaryl-coA and intermediates thereof, as...
2019/0017075 ENGINEERED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN THE HUMAN BETA-2 MICROGLOBULIN GENE
Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human beta-2 microglobulin gene. The...
2019/0017074 METHODS FOR GENOMIC INTEGRATION
Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain...
2019/0017073 COMPOSITIONS AND METHODS FOR DELIVERING NUCLEIC ACID TO A CELL
Provided are novel compositions useful for delivering nucleic acids to cells. Also provided are methods for making and using such compositions.
2019/0017072 INTRACELLULAR DELIVERY OF COMPLEXES
The present invention provides methods for delivering a transient and/or reversible complex into a cell including passing a cell suspension through a...
2019/0017071 METHOD FOR THE OPTOINJECTION OF EXOGENOUS MATERIAL INTO A BIOLOGICAL CELL
A method for the optoinjection of exogenous material in a recipient biological cell is disclosed and comprises: placing a biological cell on a planar surface...
2019/0017070 STRAIN PTODUCING ALLOSE FROM FRUCTOSE AND METHOD FOR PRODUCING ALLOSE USING SAME
The present invention relates to a recombinant strain for producing an allose from a fructose, a composition for producing an allose which produces an allose...
2019/0017069 ADENO-ASSOCIATED VIRUS VECTORS FOR TREATMENT OF GLYCOGEN STORAGE DISEASE
The present disclosure describes improved adeno-associated virus (AAV) vectors for gene therapy applications in the treatment of glycogen storage disease,...
2019/0017068 ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such...
2019/0017067 GLYPHOSATE TOLERANT PLANTS HAVING MODIFIED 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE GENE REGULATION
This document provides methods and materials related to plants (e.g., nontransgenic plants) that are tolerant to glyphosate-based herbicides. For example,...
2019/0017066 HERBICIDE TOLERANCE GENES AND METHODS OF USE THEREOF
Polypeptides and recombinant DNA molecules useful for conferring tolerance to AOPP herbicides, phenoxy acid herbicides, and pyridinyloxy acid herbicides are...
2019/0017065 METHOD FOR MODIFYING LATERAL BUDDING IN PLANTS AND PLANTS RESULTING FROM SAID METHOD
The present invention relates to a method for modifying lateral budding in a plant comprising modifying the expression or function of a protein comprising the...
2019/0017063 PLANTS WITH MODIFIED TRAITS
The present invention relates to transgenic plants, or parts thereof, with modified traits, as well as methods of selecting and using these plants or parts. In...
2019/0017062 NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN...
Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment,...
2019/0017061 AP2 DOMAIN TRANSCRIPTION FACTOR ODP2 (OVULE DEVELOPMENT PROTEIN 2) AND METHODS OF USE
Methods and compositions for modulating plant development are provided. Nucleotide sequences and amino acid sequences encoding Ovule Development Protein 2...
2019/0017060 MANIPULATION OF PROANTHOCYANIDIN (PA) COMPOSITION BY AFFECTING ANTHOCYANIDIN SYNTHASE (ANS) AND...
Using methods described in preferred embodiments, the composition of proanthocyanidins (PAs) in plants can be modified to produce plants that produce PAs with...
2019/0017059 METHOD FOR MODIFYING LATERAL BUDDING
The present invention relates to a method for modifying lateral budding in a plant comprising modifying the expression or function of a protein comprising the...
2019/0017058 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and...
2019/0017057 LIVE BACTERIAL VECTORS FOR PROPHYLAXIS OR TREATMENT
A live bacterium, having a DNA construct stabilized against transduction of other bacteria, having a promoter sequence and encoding a fusion peptide,...
2019/0017056 NOVEL TRANSPOSON THAT PROMOTES FUNCTIONAL DNA EXPRESSION IN EPISOMAL DNAS AND METHOD TO ENHANCE DNA...
A transposon (TnC_T7) was developed to partially supply the transcriptional machinery during functional analysis of genomic/metagenomic libraries. This...
2019/0017055 REAL-TIME REPORTER SYSTEMS FOR MONITORING BASE EDITING
Real-time systems for monitoring base editing in living cells, including base editing by APOBEC-Cas9 fusions, is provided herein.
2019/0017054 METHOD OF MODULATING SURVIVAL AND STEMNESS OF CANCER STEM CELLS BY MDA-9/SYNTENIN (SDCBP)
This invention discloses a method of modulating the survival and stemness of cancer stem cells (CSCs) by modulating the expression of MDA-9/Syntenin (SDCBP),...
2019/0017053 TREATMENT USING TRUNCATED TRK B AND TRK C ANTAGONISTS
Disclosed herein are methods, compositions, vectors, and kits comprising an antagonist of a truncated TrkC or a truncated TrkB. Also described herein are...
2019/0017052 Splice Switching Oligomers for TNF Superfamily Receptors and Their Use in Treatment of Disease
Methods and compositions are disclosed for controlling expression of TNF receptors (TNFR1 and TNFR2) and of other receptors in the TNFR superfamily using...
2019/0017051 OLIGONUCLEOTIDE COMPOSITIONS WITH ENHANCED EFFICIENCY
The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an...
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