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Patent # Description
2019/0017050 ENGINEERED IMMUNOSTIMULATORY BACTERIAL STRAINS AND USES THEREOF
Provided are immunostimulatory bacteria and pharmaceutical compositions containing the bacteria. The immunostimulatory bacteria provided herein contain one or...
2019/0017049 METHODS AND COMPOSITIONS TO INHIBIT METASTASIS AND TO TREAT FIBROSIS AND TO ENHANCE WOUND HEALING
Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kifl9 and Cep192. Methods and compositions are...
2019/0017048 ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF USHER SYNDROME TYPE 2
The invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the...
2019/0017047 METHODS FOR MODULATING ATAXIN 2 EXPRESSION
Disclosed herein are methods for decreasing Ataxin 2 mRNA and protein expression. Such methods are useful to treat, prevent, or ameliorate Ataxin 2 associated...
2019/0017046 PREPARATION, MEMBER FOR PREPARATION, AND METHODS FOR MANUFACTURING THESE
Objects of the present invention are to provide a preparation, which satisfies both a sufficient drug carrying amount and a preferred decomposition rate, and a...
2019/0017045 METHODS AND COMPOSITION FOR THE PRODUCTION OF SEQUENCE SPECIFIC ANTIMICROBIALS
A method and composition for the production of sequence specific antimicrobials capable of overcoming inefficient delivery, narrow host range, and potential...
2019/0017044 METHOD FOR CONSTRUCTING NEXT-GENERATION SEQUENCING LIBRARY FOR DETECTION OF LOWFREQUENCY MUTATION AND KIT THEREOF
The present invention provides a method for constructing a next-generation sequencing library for detecting low-frequency mutations, and a kit thereof. The...
2019/0017043 INTRODUCING METHOD OF L-DIHYDROXYPHENYLALANINE IN TARGET PROTEIN
Provided is a method of genetically incorporating an L-dihydroxyphenylalanine in a target protein.
2019/0017042 USING NUCLEOSOME INTERACTING PROTEIN DOMAINS TO ENHANCE TARGETED GENOME MODIFICATION
Compositions and methods for using nucleosome interacting protein domains to increase accessibility of programmable DNA modification proteins to target...
2019/0017041 LEUCINE BETA ROLL DOMAINS AND USES THEREOF
In one aspect, the invention relates to a peptide that forms a calcium-dependent hydrogel using a rationally engineered beta roll peptide. In the absence of...
2019/0017040 Compounds and Methods for Stabilizing Thrombin Activity
The present invention is directed to compounds useful in stabilizing thrombin activity, thrombin compositions comprising the compounds, methods of using the...
2019/0017039 Factor IX Variants with Clotting Activity in Absence of Their Cofactor and Their Use for Treating Bleeding...
The present invention relates to variants of a vitamin K-dependent serine protease of the coagulation cascade, preferably variants of factor IX (F.IX), wherein...
2019/0017038 BEVERAGE WITH HIGH SOLID CONTENT COMPRISING BETA-MANNASE
The invention relates to compositions for preparing a beverage, the composition comprises a) a coffee liquor or dried coffee extract ranging between 1-40% w/w;...
2019/0017037 METHOD FOR USING HEAT-RESISTANT MISMATCH ENDONUCLEASE
Provided are a mismatch-specific cleavage reaction using a novel heat-resistant mismatch nuclease, a method for removing errors in a nucleic acid amplification...
2019/0017036 POLYPEPTIDE HAVING ENDONUCLEASE ACTIVITY AND METHOD FOR PRODUCING THE SAME
A polypeptide includes an amino acid sequence selected from the group consisting of: an amino acid sequence having at least 85% sequence identity to the amino...
2019/0017035 METHODS FOR MODULATING CYCLIC NUCLEOTIDE-MEDIATED SIGNALING IN CARDIAC MYOCYTES AND COMPOSITIONS
The invention provides a polypeptide possessing anti-hypertrophic activity in a cardiac myocyte, wherein the polypeptide is a mutant variant derived from...
2019/0017034 PROTEIN PROSTHESES FOR MITOCHONDRIAL DISEASES OR CONDITIONS
The invention encompasses water-forming NADH and NADPH oxidases and the use of these enzymes to treat mammalian diseases or conditions associated with an...
2019/0017033 RECOMBINANT AAV PRODUCTION IN MAMMALIAN CELLS
The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian...
2019/0017032 CELL REPROGRAMMING
The invention relates to methods and compositions for converting one cell type to another cell type. Specifically, the invention relates to ...
2019/0017031 SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
Disclosed herein are methods, compositions, kits, and agents useful for inducing .beta. cell maturation, and isolated populations of SC-.beta. cells for use in...
2019/0017030 Immortalized Stem Cells and Method for Producing Same
The purpose of the present invention is to provide immortalized stem cells for producing culture supernatant that can be used in the treatment of human...
2019/0017029 Generation of Expandable Cardiovascular Progenitor Cells
Methods and compositions for expanding cardiovascular progenitor cells are described herein that include use of compositions and culture media that have at...
2019/0017028 SYSTEMS AND METHODS FOR CARDIOMYOCYTE PACING
Provided herein are systems and methods for cardiomyocyte pacing of cultured cells, including cardiomyoctyes. In particular, provided herein are systems and...
2019/0017027 HEMANGIO-COLONY FORMING CELLS
Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods...
2019/0017026 METHOD AND DEVICE FOR CONSERVING VIABLE AND FUNCTIONAL HUMAN POLYMORPHONUCLEAR NEUTROPHILS
A method for keeping leukocytes alive ex vivo or in vitro, comprising maintaining the leukocytes in a medium comprising from 3 to 10 mM of glucose, in hypoxic...
2019/0017025 Methods for Inducing the Differentiation of Blood Monocytes into Functional Dendritic Cells
Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is...
2019/0017024 Methods for Inducing Migration by Dendritic Cells and An Immune Response
Compositions and methods of activating dendritic cells with LMP1 and LMP1-activated dendritic cell based compositions and methods are effective for dendritic...
2019/0017023 Augmentation of Cell Therapy Efficacy Including Treatment with Alpha 1,3 Fucosyltransferase
Disclosed are methods, compositions of matter, and kits useful for augmentation of cells through modification of cellular membrane properties following ex vivo...
2019/0017022 B-CELL CULTIVATION METHOD
Herein is reported a method for co-cultivating one or more B-cells comprising the step of incubating the one or more B-cells with EL4-B5 cells, whereby the...
2019/0017021 ENHANCED EXPRESSION OF HUMAN OR HUMANIZED IMMUNOGLOBULIN IN NON-HUMAN TRANSGENIC ANIMALS
The present invention describes transgenic animals with human(ized) immunoglobulin loci and transgenes encoding human(ized) Ig.alpha. and/or Ig.beta....
2019/0017020 DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS TO MULTIPOTENT NEURAL CREST CELLS
The present invention relates to the differentiation of human pluripotent cells, including human pluripotent stems cells to produce a self-renewing multipotent...
2019/0017019 INDUCTION OF NEURAL PROGENITOR CELLS, OLIGODENDROCYTE PROGENITOR CELLS, AND OLIGODENDROCYTES BY STEM CELL...
A novel method of inducing neural progenitor cells, oligodendrocyte progenitor cells, oligodendrocytes from human iPSCs at an unprecedented efficiency and...
2019/0017018 A NEURAL ORGANOID COMPOSITION AND METHODS OF USE
The present invention features a neural organoid that recapitulates in vitro most characteristics of the brain (e.g., human), and methods of using this neural...
2019/0017017 USE OF VASCULAR CELLS TO CREATE THE CONVENTIONAL OUTFLOW TRACT
Provided is a system for modeling the conventional outflow tract, including: a porous scaffold with trabecular meshwork cells attached to one surface and...
2019/0017016 SUPPORTED IN VITRO DEVELOPED TISSUE CULTURE AND CULTURING METHODS
An elongated or fiber-supported multicellular aggregation of multipotent cells, wherein multipotent cells are arranged in an oblong or longish arrangement with...
2019/0017015 Compositions And Methods For Epithelial Stem Cell Expansion And Culture
Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in...
2019/0017014 SUSPENSION CULTURE OF HUMAN EMBRYONIC STEM CELLS
This disclosure provides an improved system for culturing human embryonic stem cells. The cells are cultured in suspension so as to maximize the production...
2019/0017013 MECHANICAL LYSIS APPARATUS AND METHOD
A mechanical lysis method includes (a) spinning a mixing head at a spin rate in a liquid sample, containing cells and beads, such that the mixing head...
2019/0017012 FILTER FOR FILTRATION OF NUCLEATED CELLS AND FILTRATION METHOD USING THE SAME
A filtration method for filtration of nucleated cells that includes providing a filter containing at least one of a metal and a metal oxide as a major...
2019/0017011 Improvements in and Relating to Biomanufacturing Apparatus
Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door...
2019/0017010 System and Method for Transferring Tissue
A transfer device designed to extract an amorphous or semi-solid structure, tissue, or construct from supporting media while maintaining the spatial...
2019/0017009 FULLY AUTOMATED CONTINUOUS CELL CULTURE SYSTEM
The invention provides a full-automatic cell culture system, at least comprising: a control module, a control platform, a dark field microscope for on-line...
2019/0017008 Personal Laboratory for Genetic Engineering, Culturing and Analysis of Microorganisms and Biochemicals
A personal laboratory apparatus includes a plurality of life sciences laboratory modules disposed on or in a common housing. The laboratory modules include a...
2019/0017007 Model-animal functional-improvement evaluation apparatus and nerve-cell culturing apparatus
Proposed are a functional improvement evaluation apparatus and a nerve cell culture apparatus of model animals capable of performing feedback control, even to...
2019/0017006 METHOD AND DEVICE FOR KEEPING SHAPE OF FRAGILE MATERIAL IN LIQUID
A method, a device, and an annular member are disclosed for keeping a shape of a fragile material in a liquid in a container. The method includes covering a...
2019/0017005 IMPROVEMENTS IN AND RELATING TO CELL HARVESTING APPARATUS
Disclosed herein is a cell harvesting instrument suitable for concentrating cells from a source suspension of cells and/or washing said cells, the instrument...
2019/0017004 METHODOLOGY FOR PREPARING ETHANOL-REDUCED FERMENTED BEVERAGES
The present invention is directed to a generic methodology for preparing wines and other beverages having reduced ethanol content, where said wines or...
2019/0017003 Single Stage Winemaking Apparatus and Method
A novel fermentation method uses a novel single stage horizontal cylindrical or partial cylindrical fermentor, larger in volume than the target volume of wine,...
2019/0017002 Apparatus and Method for Drying Hops
An apparatus is provided for drying hops having a gas distribution supply duct, a source of heated gas, and a blower. The gas distribution supply duct has an...
2019/0017001 MULTI-COMPARTMENT DETERGENT COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF
The present invention is in the fields of household and industrial cleaning, particularly in applications for cleaning of dishware or laundry. The present...
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