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Patent # Description
2019/0016797 IMMUNE-STIMULATING HUMANIZED MONOCLONAL ANTIBODIES AGAINST HUMAN INTERLEUKIN-2, AND FUSION PROTEINS THEREOF
The present invention relates to antibodies binding to human interleukin-2 (hIL-2). The invention more specifically relates to humanized antibodies...
2019/0016796 COMBINATION THERAPY COMPRISING A SUPERAGONISTIC ANTIBODY AGAINST INTERLEUKIN-2 AND A CHECKPOINT BLOCKADE AGENT
The invention relates to a combination medicament comprising a human interleukin-2 (hIL-2)-specific monoclonal antibody (mAb), or antigen binding fragment...
2019/0016795 INHIBITION OF ALLERGIC REACTION USING AN IL-33 INHIBITOR
A method of inhibiting or preventing an allergic reaction, particularly to a food antigen, in a mammal comprising administering to the mammal an IL-33 inhibitor.
2019/0016794 COMPOUND TARGETING IL-23A AND TNF-ALPHA AND USES THEREOF
The disclosure relates to compounds specific for IL23A and TNF-alpha, compositions comprising the compounds, and methods of use thereof. Nucleic acids, cells,...
2019/0016793 Albumin binding domain fusion proteins
Compositions that include an albumin binding domain and a fusion partner (e.g., a cytokine or a binding moiety) are provided. Such therapeutics have increased...
2019/0016792 FC-REGION VARIANTS WITH MODIFIED FCRN-BINDING PROPERTIES
Herein is reported a polypeptide comprising a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a...
2019/0016791 HIGH DOSE TREATMENTS FOR ALZHEIMER'S DISEASE
Methods of treating Alzheimer's Disease (AD) in patients suffering from early AD, including amyloid positive patients, ApoE4 positive patients, and patients...
2019/0016790 RECOMBINANT PICP PROTEIN, AND METHOD FOR PREPARING ANTIBODY SPECIFICALLY BINDING THERETO
The present invention relates to an antibody specifically binding to PICP or a fragment thereof; an enzyme-linked immunosorbent assay (ELISA) kit and a...
2019/0016789 Antigen Binding Regions Against Fibronectin Type III Domains and Methods of Using The Same
Fibronectin type III (FN3) domain antibodies, polynucleotides capable of encoding the FN3 domain antibodies or antigen-binding fragments, cells expressing FN3...
2019/0016788 ANTIBODY AND ANTIBODY-CONTAINING COMPOSITION
For many diseases due to microbes or the like, proliferation of microbes themselves is a cause of a symptom. However, there were cases where a substance...
2019/0016787 ANTIBODIES TO S. AUREUS SURFACE DETERMINANTS
Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are...
2019/0016786 BROADLY NEUTRALIZING HIV-1 ANTIBODIES THAT BIND TO THE CD4-BINDING SITE OF THE ENVELOPE PROTEIN
Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids...
2019/0016785 ANTIBODIES THAT POTENTLY NEUTRALIZE HEPATITIS B VIRUS AND USES THEREOF
The present invention relates to antibodies, and antigen binding fragments thereof that bind to the antigenic loop region of hepatitis B surface antigen...
2019/0016784 MUTATED VON WILLEBRAND FACTOR
The present invention provides a modified polypeptide which binds Factor VIII. The modified polypeptide comprises a sequence as shown in SEQ ID NO:3 in which...
2019/0016783 METHODS OF USE OF SOLUBLE CD24 FOR THERAPY OF RHEUMATOID ARTHRITIS
Provided herein is a CD24 protein. The CD24 protein may include mature human or mouse CD24, as well as a N- or C-terminally fused portion of a mammalian...
2019/0016782 STABLE FORM OF SIGNAL CONVERTING PROTEIN FUSION PROTEINS, AND METHODS OF USE AND PREPARATION THEREOF
A stable fusion protein, wherein in solution, a majority of the fusion proteins are in the homo-hexamer form, which may be prepared for example as a CTLA4-FasL...
2019/0016781 POLYNUCLEOTIDES ENCODING IMMUNE MODULATING POLYPEPTIDES
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one...
2019/0016780 CD27L COLLECTIN FUSION PROTEINS
The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin...
2019/0016779 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST ESOPHAGEAL CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0016778 TARGETED HETERODIMERIC Fc FUSION PROTEINS CONTAINING IL-15 IL-15alpha AND ANTIGEN BINDING DOMAINS
The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15R.alpha. Fc fusion protein and an antigen...
2019/0016777 T CELL RECEPTORS RECOGNIZING HLA-A1- OR HLA-CW7-RESTRICTED MAGE
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of...
2019/0016776 TUMOR-SPECIFIC IFNA SECRETION BY CAR T-CELLS TO REPROGRAM THE SOLID TUMOR MICROENVIRONMENT
The present application relates to fusion proteins, chimeric antigen bearing cells expressing fusion proteins and compositions comprising chimeric antigen...
2019/0016775 Immunogenic Compositions
The present disclosure provides: (a) isolated immunogenic CEA polypeptides; (b) isolated nucleic acid molecules encoding (i) an immunogenic CEA polypeptide,...
2019/0016774 METHODS AND COMPOSITIONS RELATED TO GPCR AGONIST POLYPEPTIDES
The invention provides combinatorial peptide or polypeptide libraries that can become membrane tethered once expressed in cells. The invention additionally...
2019/0016773 ENDOTHELIN-1 RECEPTOR BASED ENDOTHELIN-1 SPONGE
Fusion polypeptides capable of binding endothelin-1 to form a non-functional complex are provided, including amino acid sequences of the fusion polypeptides....
2019/0016772 GM-CSF and IL-4 Conjugates, Compositions, and Methods Related Thereto
In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are...
2019/0016771 TRIMERIC COSTIMULATORY TNF FAMILY LIGAND-CONTAINING ANTIGEN BINDING MOLECULES
The invention relates to novel trimeric costimulatory TNF family ligand-containing antigen binding molecules comprising three fusion polypeptides, each of the...
2019/0016770 COMPOUNDS FOR INDUCING TISSUE FORMATION AND USES THEREOF
The present disclosure provides a peptide, or a variant or analog thereof, or peptidomimetic comprising between 25 and 60 amino acids, having growth factor...
2019/0016769 TISSUE PROTECTIVE PEPTIDES AND USES THEREOF
The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor...
2019/0016768 EGF(A) ANALOGUES WITH FATTY ACID SUBSTITUENTS
The invention relates to compounds derived from the EGF(A) domain of LDL-R, in particular compounds comprising a peptide analogue of the wild-type EGF(A)...
2019/0016767 MULTIMODAL TRAIL MOLECULES AND USES IN CELLULAR THERAPIES
Described herein are novel compositions comprising multimodal TRAIL agents and cells engineered to express such multimodal TRAIL agents, including cells...
2019/0016766 Use of improved modulators of complement function as cancer therapeutics
The invention relates generally to derivatives of human C3 protein containing a number of single amino acid changes in the .alpha.- and .beta.-chains of C3,...
2019/0016765 ENDOPLASMIC RETICULUM LOCALIZATION SIGNALS
The invention relates to cellular localization signals. In particular, the invention relates to endoplasmic reticulum localization signals in monomeric or...
2019/0016764 FUSION POLYPEPTIDE IN WHICH ANTI-INFLAMMATORY POLYPEPTIDE AND FERRITIN MONOMER FRAGMENT ARE BOUND AND...
The present invention relates to: a fusion polypeptide in which an anti-inflammatory polypeptide and a ferritin monomer fragment are bound; and a...
2019/0016763 Fibroin-Like Protein Variant and Cell Culture Method
A technique for efficiently culturing cells such as stem cells is provided. Cells such as stem cells are cultured using a cell culture vessel coated with a...
2019/0016762 LACTOBACILLUS ACIDOPHILUS SURFACE LAYER PROTEIN A (SLPA) AS A THERAPEUTIC AGENT FOR THE TREATMENT OF...
The current invention provides a recombinant bacterium, the recombinant bacterium being genetically modified to decrease or eliminate the display of...
2019/0016761 Compositions and Vaccines Comprising Vesicles and Methods of Using the Same
The disclosure relates to compositions, pharmaceutical compositions, vaccines, and methods of making and using the same. The compositions of the disclosure are...
2019/0016760 Multimerization of Recombinant Protein by Fusion to a Sequence from Lamprey
The present invention relates to polymerized recombinant proteins, to recombinant nucleic acids coding for the polymerized recombinant proteins, to expression...
2019/0016759 CAPSID-MODIFIED RAAV VECTOR COMPOSITIONS AND METHODS THEREFOR
Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations containing them. Also...
2019/0016758 Potent Compstatin Analogs
Compounds comprising peptides and peptidomimetics capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display...
2019/0016757 ANTIMICROBIAL PEPTIDES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
Disclosed herein are novel antimicrobial peptides, pharmaceutical compositions containing the peptides, and methods of use of the peptides to inhibit the...
2019/0016756 NOVEL a4B7 THIOETHER PEPTIDE DIMER ANTAGONISTS
The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of .alpha.4.beta.7 to the mucosal addressing cell adhesion...
2019/0016755 PROCESS FOR PRODUCTION OF FIBRINOGEN AND FIBRINOGEN PRODUCED THEREBY
A process for purifying fibrinogen from a fibrinogen containing source by precipitation of fibrinogen by a precipitating agent from a fibrinogen containing...
2019/0016754 METHODS OF PRODUCING AND PURIFYING MATRIX-BINDING FUSION PROTEINS BY ION-EXCHANGE CHROMATOGRAPHY
The invention provides methods of producing and purifying fusion proteins containing a domain capable of binding one or more extracellular matrix components,...
2019/0016753 METHODS FOR SEPARATING ISOFORMS OF MONOCLONAL ANTIBODIES
Charge variants of a recombinantly expressed antibody population may be separated both from the main antibody molecule and from each other. Separation and...
2019/0016752 POLY(AMINO ACID), PROTEIN-POLY(AMINO ACID) CONJUGATE AND PREPARATION METHOD THEREOF
The disclosure provides a protein-poly(amino acid) conjugate and a protein-poly(amino acid) cyclic conjugate, as well as a poly(amino acid) for preparing such...
2019/0016751 COMPOSITIONS AND METHODS DIRECTED TO TREATING LIVER FIBROSIS
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the COL1A1, TGF-.beta., and SMAD2/3 genes, and methods of using such...
2019/0016750 CYCLIC DINUCLEOTIDES FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY SUCH AS CANCER
This disclosure features dinucleotide compounds that modulate Stimulator of Interferon Genes (STING) activity, for use for example in the treatment of cancer....
2019/0016749 2'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
Provided are compounds of Formula I, ##STR00001## as well as pharmaceutical compositions containing compounds of Formula I and methods for treating...
2019/0016748 COMPOSITIONS AND METHODS FOR MODULATING ANGIOPOIETIN-LIKE 3 EXPRESSION
Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods,...
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