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Patent # Description
2019/0016747 PURIFIED REBAUDIOSIDE A
The invention provides a high throughput, high purity, high yield system and method of isolating and purifying rebaudioside A ("Reb A"), with acceptable water...
2019/0016746 AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS
Novel aminoglycosides, represented by Formulae I, Ia, III and IIIa, as defined in the instant specification, designed to exhibit stop codon mutation...
2019/0016745 AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING MICROBIAL INFECTIONS
Novel aminoglycosides, represented by Formulae Ia and Ib, as defined in the instant specification, are disclosed. Also disclosed are pharmaceutical...
2019/0016744 PHENYLPROPANOID COMPOUND AND PREPARATION METHOD AND USE THEREOF
The present invention provides a phenylpropanoid compound and a preparation method and use thereof. The phenylpropanoid compound has a structural formula shown...
2019/0016743 COMPOUNDS FOR INHIBITING CANCER AND VIRUS
The invention relates to compounds for inhibiting a cancer cell or a virus. Particularly, the invention provides compounds for inhibiting, treating and/or...
2019/0016742 Complexes
The present invention provides a complex of formula (1), ##STR00001## wherein, M is palladium or nickel, R.sub.1 and R.sub.2 are independently organic groups...
2019/0016741 SYMMETRICAL CCC-NHC PINCER METAL COMPLEXES AND SYMMETRICAL BIMETALLIC COMPLEXES: BIO-ACTIVITY, AND APPLICATIONS...
Provided herein are a symmetrical pincer metal and bimetallic complexes. The symmetrical pincer metal complex includes a structure according to Formula I: ...
2019/0016740 Metal Complexes, Comprising Carbene Ligands Having an O-Substituted Non-Cyclometalated Aryl Group and Their Use...
Cyclometallated Ir complex comprising three N,N diaryl substituted carbene ligands, bearing substituents in the 2 position of the non-cyclometallated aryl...
2019/0016739 LIGHT-EMITTING COMPOUND
A phosphorescent compound of formula (I): ##STR00001## wherein: M is a transition metal; C.sup.1 is a carbon atom forming a metal-carbene bond with M; A is a...
2019/0016738 SUPRAMOLECULAR ASSEMBLY OF RIGID MACROCYCLES THROUGH COOPERATIVE HYDROGEN BOND INTERACTIONS
Provided herein are supramolecular assemblies, the supramolecular assemblies comprising a racemic mixture of rigid macrocycles capable of interacting through...
2019/0016737 MECHANICALLY INTERLOCKED AIR-STABLE RADICALS
Provided herein are mechanically interlocked air-stable persistent organic radicals. The radical compositions may access a multiplicity of radical, cationic...
2019/0016736 COMPOUNDS THAT INHIBIT MCL-1 PROTEIN
Provided herein are compounds that are useful intermediates that may used to synthesize myeloid cell leukemia 1 protein (Mcl-1) inhibitors. Also provided are...
2019/0016735 SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables...
2019/0016734 C5-C6-Oxacyclic Fused Iminothiazine Dioxide Compounds Bearing an Ether Linker as BACE Inhibitors, Compositions,...
In its many embodiments, the present invention provides certain C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker, including...
2019/0016733 CRYSTALLINE FORMS OF THIENOPYRIMIDINE COMPOUND
The present invention relates to crystalline forms of N-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-y- loxy)phenyl)acrylamide, and...
2019/0016732 ACC INHIBITORS AND USES THEREOF
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
2019/0016731 FUSED TETRA OR PENTA-CYCLIC DIHYDRODIAZEPINOCARBAZOLONES AS PARP INHIBITORS
Provided are certain fused term or penta-cyclic compounds and salts thereof, compositions thereof, and methods of use thereof.
2019/0016730 TREATMENT OF H. PYLORI INFECTIONS USING MTAN INHIBITORS
Methods of treating infections due to Helicobacter pylori (H. pylori), in particular in subjects having a peptic ulcer, are disclosed where the methods...
2019/0016729 PROCESS FOR MAKING BETA 3 AGONISTS AND INTERMEDIATES
The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are...
2019/0016727 BICYCLIC HETEROARYL DERIVATIVES AS CFTR POTENTIATORS
The present invention relates to 1,3-disubstituted-1H-pyrazolo[3,4-d]pyrimidin-4-amine derivatives, 5,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazin-4-amine...
2019/0016726 TDO2 Inhibitors
Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3...
2019/0016725 FORMS OF A PI3K DELTA SELECTIVE INHIBITOR FOR USE IN PHARMACEUTICAL FORMULATIONS
The present invention relates to solid state forms of a p-toluenesulfonic acid salt (PTSA) of the selective PI3K delta inhibitor ...
2019/0016724 DISUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND THEIR USE AS FGFR KINASE INHIBITORS
This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R.sup.1 is...
2019/0016723 SUBSTRATE SELECTIVE INHIBITORS OF INSULIN-DEGRADING ENZYME (IDE) AND USES THEREOF
Provided herein are compounds of Formulae (RL), (I), (II), (III), (IV), and (V), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs,...
2019/0016722 NOVEL SUBSTITUTED XANTHINE DERIVATIVES
The present invention relates to substituted xanthine derivatives, pharmaceutical compositions containing them and their use in therapy, particularly in the...
2019/0016721 FUSED PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND USE THEREOF IN TREATMENT OF CANCERS, INFLAMMATION...
The present invention relates to pyrazole fused-ring derivatives, their preparation methods, and use thereof in medicine. In particular, the present invention...
2019/0016720 7-OXO-6-(SULFOOXY)-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE CONTAINING COMPOUNDS AND THEIR USE IN TREATING...
Compounds of Formula (I), their preparation, and use in preventing or treating a bacterial infection are disclosed. (I) ##STR00001##
2019/0016719 INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-c]PYRIDIN-2-ONE DERIVATIVES
The present invention is concerned with indolin-2-one and 1,3-dihydro-pyrrolo[3,2-c]pyridin-2-one derivatives of general formula I wherein Ar.sup.1, A.sup.2,...
2019/0016718 SALTS OF MORPHOLINE DERIVATIVE, CRYSTAL FORMS THEREOF, PROCESSES FOR PRODUCING THE SAME, PHARMACEUTICAL...
The present invention provides novel pharmaceutically acceptable salts of a morpholine derivative, including a malate, a tartrate, a hydrochloride, an acetate,...
2019/0016717 TANK-BINDING KINASE INHIBITOR COMPOUNDS
Compounds having the following formula (I) and methods of their use and preparation are disclosed: ##STR00001##
2019/0016716 Emetine Derivatives, Prodrugs Containing Same, And Methods Of Treating Conditions Using Same
Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific...
2019/0016715 METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF
Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the...
2019/0016714 DEOXYCYTIDINE KINASE BINDING COMPOUNDS
There are provided, inter alia, compounds useful for binding to deoxycytidine kinase, and compounds and methods useful to modulate deoxycytidine kinase.
2019/0016713 HETEROCYCLIC INHIBITORS OF ATR KINASE
The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
2019/0016712 PYRIDAZINONE HERBICIDES
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein X is O, S or NR.sup.5; or X is...
2019/0016711 BIHETEROCYCLIC COMPOUND
The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter ...
2019/0016710 MULTICYCLIC COMPOUNDS AND USES THEREOF
The present invention relates to multicyclic compounds containing a urea or a guanidine moiety, or pharmaceutically acceptable salts or compositions thereof...
2019/0016709 2-OXINDOLE COMPOUNDS
Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
2019/0016708 ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY
The invention provides a compound of formula (I): ##STR00001## or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various...
2019/0016707 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS
Compounds of the formulas ##STR00001## which are useful as colony stimulating factor-1 receptor inhibitors ("CSF-1R inhibitors").
2019/0016706 SMALL MOLECULE IRE1-ALPHA INHIBITORS
Described herein are IRE1.alpha. inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds....
2019/0016705 COT MODULATORS AND METHODS OF USE THEREOF
The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
2019/0016704 COMPOUND, LIGHT-EMITTING MATERIAL, AND ORGANIC LIGHT-EMITTING DEVICE
A compound having a structure represented by the following general formula emits delayed fluorescent light, and is useful as a light-emitting material. One or...
2019/0016703 BIFUNCTIONAL COMPOUNDS FOR HER3 DEGRADATION AND METHODS OF USE
The present invention provides bifunctional compounds which act as protein degradation inducing moieties for a HER family protein, such as Her3. The present...
2019/0016702 HINDERED AMINES
Disclosed are triazine compounds characterised by ester pendants and polyalkylpiperidine pendants. The compounds according to the invention, either alone or...
2019/0016701 TRPA1 MODULATORS
This disclosure relates to polycyclic heteroaromatic compounds useful as TRPA1 modulators, as well as compositions and methods of treating pain that include...
2019/0016700 METALLOENZYME INHIBITOR COMPOUNDS
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by...
2019/0016699 A PROCESS FOR THE PREPARATION OF NICOTINE
The present invention relates to a process for the preparation of racemic nicotine from 3-pyridylaldehyde using a one-pot or step-wise method. The process...
2019/0016698 NOVEL MANUFACTURING PROCESS FOR TRIAZINE, PYRIMIDINE AND PYRIDINE DERIVATIVES
The invention relates to a method of manufacturing triazine, pyrimidine and pyridine derivatives of formula (I) ##STR00001## wherein U, V, W and Z are nitrogen...
2019/0016697 CONFIGURATIONAL STEREOISOMER OF DIFETHIALONE, COMPOSITION AND RODENTICIDE BAIT COMPRISING SAME, AND METHOD FOR...
Disclosed is a laevorotatory enantiomer of the configurational stereoisomer of difethialone, named homo-stereoisomer, the formula of which is...
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