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Patent # Description
2019/0040169 Aqueous polymer dispersion, its use and method for preparing aqueous polymer dispersion
The invention relates to an aqueous polymer dispersion having a viscosity of .ltoreq.150 m Pas at 40% solids content and comprising polymer particles having a...
2019/0040168 Mixed Catalysts with 2,6-Bis(imino)pyridyl Iron Complexes and Bridged Hafnocenes
The present invention provides a supported catalyst system comprising: a bridged group 4 metallocene compound, an iron compound, specifically a ...
2019/0040167 Mixed Catalysts with Unbridged Hafnocenes with -CH2-SiMe3 Moieties
The present disclosure provides a supported catalyst system and process for use thereof. In particular, the catalyst system includes an unbridged metallocene...
2019/0040166 LIQUID QUALITY DETECTING DEVICE WITH INBUILT LIQUID BLOCKING FUNCTION
A liquid quality detecting device includes a spherical frame and a hydrogel ball received in the spherical frame. The hydrogel ball can be in an original state...
2019/0040165 Bridged Biphenyl Phenol Transition Metal Complexes, Production and Use Thereof
The present disclosure provides catalysts having a homoallylic bridge (and/or naphthyl moieties) located at a certain position on the catalysts which provides...
2019/0040164 Method for Producing (Meth)Acrylic Polymer Having Substituent at One End
An object of the present invention is to achieve a high polymerization ratio and high functional group introduction ratio during production of a (meth)acrylic...
2019/0040163 MOLDING MATERIAL, SHEET MOLDING COMPOUND AND FIBER-REINFORCED COMPOSITE MATERIAL
The present invention provides a SMC of which excessive thickening with time is suppressed while of which sufficient initial thickening by an isocyanate-based...
2019/0040162 TRI-N-OCTYL ALUMINUM CO-CATALYST FOR HIGHER DENSITY HOMOPOLYMERS FOR THE SOLUTION PROCESS
Catalyst systems and solution olefin polymerization processes using a combination of titanium compounds (e.g. halides) with vanadium compounds (e.g. halides or...
2019/0040161 Bisphenolate Transition Metal Complexes, Production and Use Thereof
Bis phenolate transition metal complexes are disclosed for use in alkene polymerization, with optional chain transfer agent, to produce polyolefins.
2019/0040160 Process for Making Polyethylene Copolymers with a Reversed Comonomer Distribution
The present invention relates to a process for the (co)polymerization of olefins to make polyethylene (co)polymers having sporadic long chain branches in high...
2019/0040159 CATIONIC POLYMERS AND POROUS MATERIALS
According to one or more embodiments, a mesoporous zeolite may included a microporous framework that includes a plurality of micropores having diameters of...
2019/0040158 PRODUCTION OF CRYSTALLINE CELLULOSE
A method of producing crystalline cellulose from a cellulosic material includes the step of reacting the cellulosic material in an aqueous slurry comprising a...
2019/0040157 NOVEL POLYPEPTIDE SELECTIVELY BINDING TO IMMUNOGLOBULIN G OF MOUSE OR RABBIT AND USE THEREOF
The present invention relates to a novel polypeptide that binds selectively to mouse or rabbit immunoglobulin G. More specifically, the present invention...
2019/0040156 ANTI-TNF- / ANTI-IL-23 IgG BISPECIFIC ANTIBODIES
IgG bispecific antibodies are provided that bind tumor necrosis factor alpha (TNF.alpha.) and the p19 subunit of interleukin-23 (IL-23p19) and are...
2019/0040155 MULTIVALENT FV ANTIBODIES
The application pertains to a trispecific antibody molecule which may comprise a diabody-unit integrated into a polypeptide chain having at least six variable...
2019/0040154 METHODS AND COMPOSITIONS FOR TREATMENT OF IMMUNE-RELATED DISEASES OR DISORDERS AND/OR THERAPY MONITORING
Described herein are methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring based on the level of TIGIT, Flg2...
2019/0040153 FGF21 MIMETIC ANTIBODIES AND USES THEREOF
The present disclosure relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human .beta.-klotho, and pharmaceutical compositions...
2019/0040152 BCMA Monoclonal Antibody-Drug Conjugate
The disclosure is directed to an antibody-drug conjugate (ADC) comprising a monoclonal antibody, or an antigen-binding fragment thereof, directed against...
2019/0040151 IMMUNOCONJUGATE AND USES THEREOF
Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to...
2019/0040150 Motile Sperm Domain Containing Protein 2 and Cancer
Disclosed herein are methods of treating, reducing the incidence of, or preventing one or more activities in or of a cancer cell, methods of treating, reducing...
2019/0040149 PD-1 ANTIBODIES
The present invention relates to antibodies that bind human programmed cell death 1 (PD-1), and may be useful for treating cancer alone and in combination with...
2019/0040148 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS & ANTAGONISTS
The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as...
2019/0040147 METHODS FOR TREATING CHRONIC SINUSITIS WITH NASAL POLYPS BY ADMINISTERING AN IL-4R ANTAGONIST
The present invention provides methods for decreasing a nasal polyp score in a subject. The methods include administering to a subject in need thereof a...
2019/0040146 METHODS FOR TREATING NASAL POLYPOSIS BY ADMINISTERING AN IL-4R ANTAGONIST
The present invention provides methods for treating nasal polyposis. The methods include administering to a subject in need thereof a therapeutic composition...
2019/0040145 ANTIBODY MOLECULE FOR HUMAN GM-CSF RECEPTOR ALPHA
Binding members for alpha chain of receptor for granulocyte macrophage colony stimulating factor (GM-CSFR.alpha.), especially antibody molecules. Use of the...
2019/0040144 FRIZZLED PROTEIN-BINDING AGENTS AND METHODS OF USE THEREOF
The present disclosure is directed to novel FZD5-binding agents and methods and uses thereof for treating a disease or disorder associated with aberrant...
2019/0040143 BINDING MOLECULES SPECIFIC FOR HER3 AND USES THEREOF
The present invention relates to antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various...
2019/0040142 METHODS OF SCREENING FOR MULTISPECIFIC ANTIBODIES
The presently disclosed subject matter relates to multispecific antibodies, e.g., bispecific antibodies and biepitopic antibodies, and methods for screening...
2019/0040141 METHODS AND COMPOSITIONS FOR TREATING TUMOR DISEASES
The present invention provides, in part, methods for treating a tumor in a human subject comprising inhibiting IGF-1 receptor signaling, methods of determining...
2019/0040140 METHODS OF TREATING GASTROINTESTINAL IMMUNE-RELATED ADVERSE EVENTS IN IMMUNE ONCOLOGY TREATMENTS
The invention provides, inter alia, methods of reducing gastrointestinal immunerelated adverse events, such as colitis and diarrhea, in subjects undergoing an...
2019/0040139 METHODS OF ASSESSING AND TREATING CANCER IN SUBJECTS HAVING DYSREGULATED LYMPHATIC SYSTEMS
Provided herein is a method for determining cancer treatment using an immune modulating therapy in a subject in need thereof. The method comprises assessing...
2019/0040138 Anti-PD-1 monoclonal antibody
Proposed is an anti-PD-1 monoclonal antibody or an antigen binding fragment thereof, comprising a heavy chain variable region having at least one of the amino...
2019/0040136 ANTI-LAG-3 ANTIBODIES
Anti-LAG-3 antibodies are disclosed. Also disclosed are compositions comprising such antibodies, and uses and methods using the same.
2019/0040135 CD3-Binding Molecules Capable of Binding to Human and Non-Human CD3
The present invention relates to CD3-binding molecules capable of binding to human and non-human CD3, and in particular to such molecules that are ...
2019/0040134 GENETIC MODIFIED PLURI- OR MULTIPOTENT STEM CELLS AND USES THEREOF
The invention concerns pluri- or multipotent stem cells (SCs), e.g. human pluri- or multipotent stem cells (hSCs) engineered to express a multispecific...
2019/0040133 BISPECIFIC SINGLE CHAIN ANTIBODIES WITH SPECIFICITY FOR HIGH MOLECULAR WEIGHT TARGET ANTIGENS
The present invention provides a method for the selection of bispecific single chain antibodies comprising a first binding domain capable of binding to an...
2019/0040132 ANTI-ROR1 ANTIBODIES AND USES THEREOF
The present disclosure relates to anti-ROR1 binding proteins, including those that bind to a ROR1 or portion thereof such as an intracellular C terminal...
2019/0040131 ANTI-CD33 ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments,...
2019/0040130 ANTI-TREM2 ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically...
2019/0040129 ANTI P2X7 RECEPTOR ANTIBODIES AND FRAGMENTS THEREOF
The invention relates to an antigen binding site for binding to a P2X.sub.7 receptor, the antigen binding site being defined by general formula 1:...
2019/0040128 LECTIN-LIKE OXIDIZED LDL RECEPTOR 1 ANTIBODIES AND METHODS OF USE
The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes...
2019/0040127 NOVEL ANTIBODIES FOR THE TREATMENT OF CANCERS
Provided herein are novel anti-EMP2 antibodies useful for the treatment and diagnosis of cancers that express or overexpress EMP2. In one aspect, provided...
2019/0040126 METHODS FOR TREATING ACTIVE EOSINOPHILIC ESOPHAGITIS
The present invention provides methods for treating, preventing or reducing the severity of active eosinophilic esophagitis. In certain embodiments, the...
2019/0040125 METHODS OF TREATING DISEASES WHICH ARE MEDIATED BY CUTANEOUS LYMPHOCYTE ANTIGEN POSITIVE CELLS
The present invention relates to methods of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cell. In...
2019/0040124 USES AND COMPOSITIONS FOR TREATMENT OF ANKLOSING SPONDYLITIS
The invention provides methods, uses and compositions for the treatment of ankylosing spondylitis (AS). The invention describes methods and uses for treating...
2019/0040123 COMMON LIGHT CHAIN MOUSE
A genetically modified mouse is provided, wherein the mouse is incapable of rearranging and expressing an endogenous mouse immunoglobulin light chain variable...
2019/0040122 BIOLOGICAL MATERIALS AND USES THEREOF
There is provided agents for modulation of a chronic inflammatory response wherein the agent modulates the biological activity of tenascin-C. There is also...
2019/0040121 INHIBITION OF AUTISM SPECTRUM DISORDER USING DECOY ANTIGENS TO MATERNAL BRAIN-REACTIVE ANTIBODIES
Methods of diagnosis and methods of treatment and prevention for autism spectrum disorder are provided using decoy antigens to maternal brain-reactive antibodies.
2019/0040120 RSV-SPECIFIC BINDING MOLECULE
The invention provides antibodies and functional equivalents thereof which are capable of specifically binding RSV. Nucleic acid sequences encoding said...
2019/0040119 METHOD FOR PRODUCING ANTIBODY
Disclosed is an antibody in which the 80th amino acid residue in a variable region based on the Kabat method and the 171th amino acid residue in a constant...
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