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Patent # Description
2019/0040118 SURFACE, ANCHORED FC-BAIT ANTIBODY DISPLAY SYSTEM
The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent...
2019/0040117 METHODS OF PURIFYING ANTIBODIES
The invention provides methods of purifying antibodies using various antibody-specific purification media to rapidly and efficiently separate mixtures of...
2019/0040116 COMPOSITIONS AND METHODS FOR TREATMENT OF NETHERTON SYNDROME WITH LEKTI EXPRESSING RECOMBINANT MICROBES
The present disclosure provides, inter alia, engineered microbes expressing recombinant LEKTI domains that are effective to treat or ameliorate the symptoms of...
2019/0040115 Immunotherapy against melanoma and other cancers
A method of treating a patient who has melanoma includes administering to said patient a composition containing a population of activated T cells that...
2019/0040114 Immunotherapy against melanoma and other cancers
A method of treating a patient who has melanoma includes administering to said patient a composition containing a population of activated T cells that...
2019/0040113 Immunotherapy against melanoma and other cancers
A method of treating a patient who has melanoma includes administering to said patient a composition containing a population of activated T cells that...
2019/0040112 IMMUNOTHERAPY AGAINST MELANOMA AND OTHER CANCERS
A method of treating a patient who has melanoma includes administering to said patient a composition containing a population of activated T cells that...
2019/0040111 T CELL RECEPTORS RECOGNIZING HLA-CW8 RESTRICTED MUTATED KRAS
Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented...
2019/0040110 COMPOSITE MATERIALS COMPRISING SYNTHETIC DRAGLINE SPIDER SILK
Composites based on a polymer and a mixture of proteins derived from a MaSp (major ampullate spidroin) protein are provides. Further, methods for preparation...
2019/0040109 Molded Article and Method for Producing Molded Article
Provided is a molded article of a composition comprising a polypeptide, wherein the polypeptide is at least one kind selected from the group consisting of...
2019/0040108 VACCINE AND METHODS FOR DETECTING AND PREVENTING FILARIASIS
The present invention is a multivalent vaccine for immunizing an animal against filariasis. In some embodiments, the antigens of the multivalent vaccine are...
2019/0040107 ASTEXIN PEPTIDES
Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticcacaulis excentricus, and methods of making and...
2019/0040106 USE OF HUMAN DERIVED IMMUNOSUPPRESSIVE PROTEINS AND PEPTIDES AS MEDICAMENTS
The present invention concerns uses of immune modulating and immune suppressing peptides from human endogenous retroviruses. In particular, the present...
2019/0040105 Method for Preventing and Treating Hyperpermeability
A peptide is described, which consists of 7-17 adjacent amino acids and comprises the hexamer TXEXXE, wherein X, X and X can be any natural or non-natural...
2019/0040104 STABILIZED PEPTOID-PEPTIDE HYBRIDS AND USES THEREOF
The current invention pertains to stabilized peptoids or peptoid-peptide hybrids. The peptoids or peptoid-peptide hybrids are stabilized by side chain-side to...
2019/0040103 PROTEINACEOUS COMPOUNDS AND USES THEREFOR
Disclosed are proteinaceous molecules and their use in conditions associated with PKC-.theta. overexpression, such as cancer. More particularly, the present...
2019/0040102 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME
The present invention is directed to somatostatin receptor antagonist compounds having the structure of Formula I, compositions comprising the same, and...
2019/0040101 COMPOUND FOR TREATING SEQUELAE OF ISCHEMIC CEREBRAL STROKE
The present invention provides a compound (I) for treating sequelae of ischemic cerebral stroke: ...
2019/0040100 PEPTIDE HAVING ACTIVITY TO IMPROVE SKIN CONDITION AND USE THEREOF
The present invention provides a peptide having activity to improve skin condition. The peptide of the present invention exhibits a very excellent effect in...
2019/0040099 CHROMATOGRAPHY MEMBRANES, DEVICES CONTAINING THEM, AND METHODS OF USE THEREOF
Described herein are fluid treatment devices for use in tangential flow filtration, comprising a housing unit and a composite material, wherein the composite...
2019/0040098 STEROIDAL COMPOUND, COMPOSITION CONTAINING THE SAME AND USE THEREOF
Disclosed are a steroidal compound as shown in formula (I) and a drug composition containing the same, or a crystal form, a pharmaceutically acceptable salt, a...
2019/0040097 METHOD FOR SEPARATING AND PURIFYING MOGROSIDE V BY SUBCRITICAL WATER DESORPTION TECHNOLOGY
The invention relates to a method for separating and purifying mogroside V by subcritical water desorption technology. The macroporous adsorption resin...
2019/0040096 CRYSTALLINE FORMS OF A MACROLIDE, AND USES THEREFOR
New crystalline forms of macrolide compounds, and pharmaceutical compositions thereof, are described herein. In addition, processes for preparing the...
2019/0040095 Rhamnolipid Amides For Hair Scent Retention
The invention provides derivatives of rhamnolipids, formulations comprising these, and the use thereof.
2019/0040094 PROCESS FOR THE PREPARATION OF D-GLUCITOL, 1,5-ANHYDRO-1-C-[4-CHLORO-3-[[4-[[(3S)-TETRAHYDRO-3-FURANYL]...
The present invention relates to process for the preparation of D-glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl] ...
2019/0040093 BIOPARTICLE ISOLATION AND THERAPEUTIC APPLICATION THEREOF
Compositions and methods for the isolation of protein-nucleic acid complexes, extracellular vesicle (EV) (e.g., microvesicles) and free nucleic acids...
2019/0040092 CRYSTALLINE FORMS OF ETHYL ((S)-((((2R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-FLUORO-2,5-DIHYDROFURAN-2-YL)- ...
The present invention relates to novel forms of ethyl ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)- ...
2019/0040091 COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME
Lanthionine ketimine derivatives, and methods of making and using the same, are described. Included are lanthionine ketimine phosphonate (LK-P), lanthionine...
2019/0040090 N,N-BIS(2-DIALKYLPHOSPHINOETHYL)AMINE-BORANE COMPLEX AND PRODUCTION METHOD THEREFOR, AND METHOD FOR PRODUCING...
The purpose of the present invention is to provide an N,N-bis(2-dialkylphosphinoethyl)amine-borane complex which is a ruthenium complex that exhibits excellent...
2019/0040089 GOLD COMPLEX-CONTAINING CANCER ACTIVITY COMPOSITION
Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g....
2019/0040088 PROCESS FOR THE PREPARATION OF A TRIARYL PHOSPHATE ESTER COMPOSITION
The invention relates to a process for the preparation of a triaryl phosphate ester composition comprising a. reacting a phosphorous oxyhalide with a...
2019/0040087 MICROBIOCIDALLY ACTIVE BENZOXABOROLES
Compounds of formula (I) are as defined in the claims, and their use in compositions and methods for the control and/or prevention of microbial infection,...
2019/0040086 Preparation Of Ammonium or Phosphonium Borate Salts
A process for preparing an ammonium or phosphonium borate salt KA containing a cation K and an anion A. The process includes providing a melt of a borate salt...
2019/0040085 PHOTOCHEMICAL METHODS OF MAKING CYCLOBUTANE BORONATES AND RELATED COMPOUNDS
The present technology relates generally cyclobutane boronates, including methods of preparation by exposing a mixture of a compound of Formula I in a solvent ...
2019/0040084 HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## which inhibit...
2019/0040083 ANTIBACTERIAL COMPOUNDS
This invention relates to antibacterial drug compounds containing a bicyclic core, typically a bicycle in which one of the rings is an oxazolidinone. It also...
2019/0040082 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The...
2019/0040081 C5-C6-Oxacyclic Fused Iminothiadiazine Dioxide Compounds Bearing an Ether Linker as BACE Inhibitors,...
In its many embodiments, the present invention provides certain C5-C6-oxacyclic fused iminothiadiazine dioxide compounds bearing an ether linker, including...
2019/0040080 BIARYL KINASE INHIBITORS
The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such...
2019/0040079 TRICYCLIC HETEROCYCLIC COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS
Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N--H, N--(C.sub.1-C.sub.10 alkyl) or S; each X is independently CH or...
2019/0040078 PESTICIDAL COMPOSITIONS AND USES THEREOF
Provided herein are compounds that exhibit activity as fungicides and are useful, for example, in methods for the control of fungal pathogens in plants and can...
2019/0040077 TRIAZOLE DERIVATIVES OF MELAMPOMAGNOLIDE B AND METHODS OF USE THEREOF
The present disclosure relates to triazole derivatives of melampomagnolide B, their synthesis, and their use as anti-cancer compounds.
2019/0040076 Spirocyclic Quinolizine Derivatives Useful as HIV Integrase Inhibitors
The present invention relates to spirocyclic quinolizine derivatives and pharmaceutically acceptable salts or prodrug thereof, compositions comprising at least...
2019/0040075 Substituted Pyrrolo, -Furano, and Cyclopentylpyrimidines Having Antimitotic and/or Antitumor Activity and...
The present invention provides substituted pyrrolo-, furano-, and cyclopentylpyrimidine bicyclic compounds of Formula III, ##STR00001## and Formula IV, ...
2019/0040074 PYRAZOLOPYRIMIDINE COMPOUNDS
The present teachings provide a compound represented by structural formula (I-0), or a pharmaceutically acceptable salt thereof. Also described are...
2019/0040073 NONANOIC AND DECANOIC ACID DERIVATIVES AND USES THEREOF
The present disclosure relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present disclosure also relates to...
2019/0040072 METHOD FOR PREPARING PYRROLO[3,2-D]PYRIMIDINE COMPOUND, AND INTERMEDIATES THEREOF
The present invention relates to a method for preparing a pyrrolo[3,2-d]pyrimidine compound (the compound represented by formula I), and corresponding...
2019/0040071 TLR7 AGONIST CRYSTALLINE FORM A, PREPARATION METHOD AND USE THEREOF
The present invention relates to crystalline form A of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)-benzyl)-5H-pyrrolo[3,2-d]pyrimidin-- 4-amine...
2019/0040070 PROCESS FOR THE SYNTHESIS OF STABLE AMORPHOUS IBRUTINIB
Disclosed herein is a new route of synthesis and a new stable amorphous form of ibrutinib. Also disclosed are pharmaceutical compositions, oral dosage forms...
2019/0040069 PROCESS FOR THE PREPARATION OF IBRUTINIB
The present invention relates to a process for the preparation of 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-- ...
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