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Patent # Description
2019/0040068 PYRROLOPYRIMIDINE FIVE-MEMBERED AZACYCLIC DERIVATIVE AND APPLICATION THEREOF
A pyrrolopyrimidine five-membered azacyclic derivative as a novel JAK kinase (Janus kinase) inhibitor, and use thereof in a preparation of a pharmaceutical...
2019/0040067 USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3K-DELTA RELATED DISORDERS
The present application provides methods of treating PI3K.delta. related disorders using compounds of Formula I: ##STR00001## or pharmaceutically acceptable...
2019/0040066 PROCESS FOR THE PREPARATION OF PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR
The present invention relates to processes for the preparation of Phosphatidylinositol 3-Kinase Inhibitor (PI3K) compound of formula-1 via novel intermediates...
2019/0040065 EGFR Inhibitors and Methods of Treating Disorders
The present invention relates to novel pyrimidine, pyrrolo-pyrimidine, pyrrolo-pyridine, pyridine, purine and triazine compounds which are able to modulate...
2019/0040064 MULTI-KINASE INHIBITOR COMPOUND, AND CRYSTAL FORM AND USE THEREOF
The present invention relates to a compound as represented by formula (I) or a pharmaceutically acceptable salt and stereoisomer thereof, wherein R1, R2, X, Y,...
2019/0040063 TRICYCLIC COMPOUND FOR BROMODOMAIN-CONTAINING PROTEIN INHIBITOR AND PREPARATION PHARMACEUTICAL COMPOSITION, AND...
The present application present application relates to a compound represented by Formula (III) or a pharmaceutically acceptable salt, solvent compound, active...
2019/0040062 BCL-2 INHIBITORS
The disclosure includes compounds of Formula (I) ##STR00001## wherein W, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, m, n, L, and Z.sub.1, are...
2019/0040061 Tetrahydro-Pyrido-Pyrimidine Derivatives
The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), ##STR00001## wherein Y, R.sup.1, R.sup.2 and m are as defined...
2019/0040060 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS
Compounds of formula I ##STR00001## wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers,...
2019/0040059 SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Provided is a compound having .alpha.4 integrin inhibitory action. The compound is a sulfonamide derivative represented by the following formula (I), or...
2019/0040058 IMIDAZOPYRIDINES AND IMIDAZOPYRAZINES AS LSD1 INHIBITORS
The present invention is directed to imidazo[1,5-a]pyridine and imidazo[1,5-a]pyrazine derivatives of Formula I, or a pharmaceutically acceptable salt thereof,...
2019/0040057 HETEROARYL CARBOXAMIDES
The invention relates to novel heteroaryl carboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or...
2019/0040056 NOVEL ORGANIC SEMICONDUCTOR COMPOUND, PRODUCTION METHOD THEREOF, AND ORGANIC ELECTRONIC DEVICE USING THE SAME
Provided are a novel organic semiconductor compound, a production method thereof, and an organic electronic device using the same, wherein the organic...
2019/0040055 Cycloalkyl-Linked Diheterocycle Derivatives
The present invention relates to compounds of formula (I) ##STR00001## or pharmaceutically acceptable salts thereof, wherein A, L, D, R.sup.1-R.sup.15, w, x,...
2019/0040054 SOLID STATE FORMS OF DASATINIB AND PROCESSES FOR THEIR PREPARATION
The present invention provides crystalline form of (R)-propylene glycol solvate of dasatinib and crystalline form of (S)-propylene glycol solvate of dasatinib.
2019/0040053 Iminothiadiazinane Dioxide Derivatives as Plasmepsin V Inhibitors
A series of 3-imino-5-methyl-1,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted in the 5-position by a phenyl moiety NH which in turn is...
2019/0040052 SUVOREXANT INTERMEDIATE AND PREPARATION METHOD THEREOF
The present invention relates to a synthesis process of suvorexant, novel compounds represented by formulas II, III, IV or V, or salts thereof for preparing...
2019/0040051 CHEMICAL COMPOUNDS
The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): ##STR00001## and salts thereof. The...
2019/0040050 AZOLINE COMPOUNDS SUBSTITUTED BY A CONDENSED RING SYSTEM
The present invention relates to compounds of formula I wherein the variables are as defined in the claims and the description. The invention further relates...
2019/0040048 PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZO[B]THIOPHENE COMPOUNDS
A process for preparing compounds of formula (I), or a salt or solvate thereof, including Brexpiprazole, which process comprises cyclization of a compound of...
2019/0040047 SUBSTITUTED DIHYDROISOQUINOLINONE COMPOUNDS
This invention relates to compounds of general formula (I) ##STR00001## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, L, X and Z are as defined herein, and the...
2019/0040046 ITRACONAZOLE ANALOGS AND USE THEREOF
Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2...
2019/0040045 BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM
The present invention provides compounds having a CB.sub.1 receptor-binding moiety and a directing moiety. In related aspects, the invention provides...
2019/0040044 MCL-1 ANTAGONISTS
Provided herein are Mcl-1 antagonist compositions and methods of treating cancer using the compositions described herein.
2019/0040043 PYRAZOLO AND TRIAZOLO BICYCLIC COMPOUNDS AS JAK KINASE INHIBITORS
The invention provides compounds of formula (I): ##STR00001## or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the...
2019/0040042 SUBSTITUTED 2-OXYIMIDAZOLYLCARBOXAMIDES AS PESTICIDES
The present invention relates to compounds of the general formula (I) ##STR00001## in which Q, V, T, W, X, Y and A have the meanings given in the ...
2019/0040041 THERAPEUTIC COMPOUNDS
The present invention relates to compounds that are antagonists of the orexin-1 receptor. The compounds have the structural formula (I) defined herein. The...
2019/0040040 PYRIDAZINE DERIVATIVES AS EAAT2 ACTIVATORS
Pyridazine derivatives that activate the excitatory amino acid transporter 2 (EAAT2), and methods of use thereof for treating or preventing diseases,...
2019/0040039 PIPERIDINE DERIVATIVE
The purpose of the present invention is to provide a compound having excellent antibacterial activity against mycobacterium tuberculosis, multidrug-resistant...
2019/0040038 HETEROCYCLIC COMPOUND
A compound represented by formula (I) ##STR00001## or an N-oxide compound thereof is provided with excellent control efficacies against harmful arthropods,...
2019/0040037 METHOD FOR THE PRODUCTION OF POMALIDOMIDE
The object of the invention relates to a novel group of compounds of general formula 20 that may be used as an intermediate for the production of the...
2019/0040036 HYPERVALENT IODINE CF2CF2X REAGENTS AND THEIR USE
Described herein are hypervalent iodine reagents.
2019/0040035 METHOD FOR PRODUCING 1,2,3,5,6-PENTATHIEPANE
The present invention can provide a method for producing 1,2,3,5,6-pentathiepane, comprising Steps A and B: Step A: a step of synthesizing a...
2019/0040034 MATERIALS FOR ELECTRONIC DEVICES
The present application relates to compounds of a formula (I), to the use thereof in electronic devices, and to processes for preparing the compounds.
2019/0040033 Novel antibiotic
The present invention relates to novel compounds, comprising an 8- or 9-membered cyclic structure, wherein an (E)-1,4-dioxo-but-2-ene moiety is embedded in...
2019/0040032 NOVEL MOLECULE WITH ANTI-CANCER ACTIVITY
The present invention provides a new compound of formula (I): extracted from a seaweed, and its use for inhibiting the growth of cancer cells, as well as...
2019/0040031 UROLITHINS-CONTAINING AQUEOUS SOLUTION, DRIED SOLID COMPOSITION THEREOF AND PRODUCTION METHOD THEREFOR, AND...
A urolithin-containing aqueous solution containing urolithin and collagen, a dried solid composition thereof, methods for producing these, and a stabilization...
2019/0040030 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING A SYMPTOM ASSOCIATED WITH GOUT OR HYPERURICEMIA
The inventive subject matter provides compounds, compositions and methods for lowering serum acid (sUA) for the treatment of gout, and having reduced liver...
2019/0040029 A type of aryl benzofuran amidated derivative and medical use thereof
The present invention relates to a type of aryl benzofuran amidated derivatives, the medical use thereof, and the preparation method; said derivatives have...
2019/0040028 ARYLATION OF ALIPHATIC AMINES
The invention relates to a method for arylation of amines, such as aliphatic amines by reaction of aryl-halogens, e.g. chloro- or fluorobenzene derivatives...
2019/0040027 Synthesis of 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine
The invention relates to a method for synthesis of 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine in the presence of a strong base.
2019/0040026 COMPOSITIONS AND METHODS OF TREATMENT WITH PRODRUGS OF TIZOXANIDE, AN ANALOGUE OR SALT THEREOF
Prodrugs of tizoxanide, an analogue or salt thereof are disclosed. The prodrugs have an ester moiety comprising an amino acid moiety, and increase the...
2019/0040025 INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION
The present invention relates to an indoleamine 2,3-dioxygenase inhibitor having the structure of formula (I), a preparation method therefor, and an...
2019/0040024 AMINE-CONTAINING ACYCLIC HYDROFLUOROETHERS AND METHODS OF USING THE SAME
An acyclic fluorinated compound of formula (I) is amine-containing acyclic hydrofluoroethers. The acyclic fluorinated compound is useful as heat transfer,...
2019/0040023 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE
Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their...
2019/0040022 PROPHYLACTIC OR THERAPEUTIC AGENT FOR AUTISM SPECTRUM DISORDER
The present invention provides a prophylactic or therapeutic agent for an autism spectrum disorder containing compound (I) having melatonin receptor affinity....
2019/0040021 FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS
The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse...
2019/0040020 TETRAZOLE DERIVATIVES AS CYTOCHROME P450 INHIBITORS
According to the invention there is provided a compound of formula I, wherein R.sup.1 and R.sup.2 have meanings given in the description, which compounds are...
2019/0040019 PROCESS FOR PRODUCING BIGUANIDINE SALTS AND S-TRIAZINES
A process for producing biguanidine salts of formula (III) and s-triazines of formula (V) is described. ##STR00001## Therein, R.sup.1 and R.sup.2 are in each...
2019/0040018 HOMOPIPERAZINE-BASED CATALYSTS FOR NEUTRALIZATION OF ORGANOPHOSPHORUS-BASED COMPOUNDS
Novel compositions of matter based on homopiperazine precursor materials and forming a homopiperazine-based ligand are disclosed, along with suitable...
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