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Patent # Description
2019/0038804 PARTICULATE TISSUE GRAFT WITH COMPONENTS OF DIFFERING DENSITY AND METHODS OF MAKING AND USING THE SAME
Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these...
2019/0038803 Extracellular Matrix-Derived Gels and Related Methods
Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions...
2019/0038802 IMPROVED TREATMENT OF IMPLANTS WITH PHOSPHONIC ACID COMPOUNDS
The present invention relates to a process of treating an implant, comprising a step of treating the surface of the implant with at least one phosphonic acid...
2019/0038801 POROUS COMPOSITE AND BONE REGENERATION MATERIAL
[Problem to be Solved] To provide a porous composite that has excellent uniform dispersability of OCP and that comprises OCP and collagen in a sufficiently...
2019/0038800 COMPOSITIONS AND METHODS FOR MACROPHAGE CONVERSION
One aspect of the invention provides a method of sequentially inducing macrophage conversion in a wound. The method includes: (a) administering IL-4 to induce...
2019/0038799 CURABLE POLYMERIC MATERIALS AND METHODS OF USING SAME
Polymeric materials are disclosed herein that include a Polymer A, a Polymer B, and an oxalate ester or reaction product thereof. Polymer A contains...
2019/0038798 NATURAL POLYMER BASED TISSUE ADHESIVE WITH HEALING PROMOTING PROPERTIES
A tissue adhesive with healing promotion properties formed from a mixture of natural polymers and an activating agent that enhances the adhesive properties of...
2019/0038797 Sanitary Napkin
A sanitary napkin, towel, or pad having one or more of Manuka honey, Tourmaline powder, Jade powder, Amethyst powder, or silver applied to or sewn into a layer...
2019/0038796 POLYMER NANOFIBER SCAFFOLDS AND USES THEREOF
A polymer nanofiber scaffold includes a plurality of melt extruded nanofibers that are chemically modified to append surface functionality to the nanofibers.
2019/0038795 Peroxide Contact Lens Care Solution
The invention is directed to a method of cleaning and disinfecting a contact lens. The method includes instructing a consumer to disinfect their contact lens...
2019/0038794 LONG-ACTING DEODORIZATION OF NOXIOUS ODORS USING A WATER-BASED DEODORIZING SOLUTION IN AN ULTRASONIC DISPENSER
A long-acting ultrasonic dispenser that effuses a water-based deodorizer solution into ambient air as a dry fog in a closed environment, and a method for...
2019/0038793 VAPOR GENERATION AND DISTRIBUTION DEVICES, SYSTEMS, AND METHODS
Vapor generation and distribution devices, systems, and methods. An exemplary system of the present disclosure comprises a vapor generation system configured...
2019/0038792 STERILIZING FLOOR ARRAY
Various devices for sterilizing a surface and an object in contact with the surface are disclosed. For example, a first device includes an ultraviolet light...
2019/0038791 Medical Device Inspection and Sterilization
A method of ensuring the structural integrity and decontamination of a medical device includes inserting a distal end of a borescope into a lumen of the...
2019/0038790 SYSTEM AND METHOD FOR ASEPTIC PACKAGING OF A DRUG DELIVERY DEVICE COMPONENTS
A method for sterilizing a drug delivery device may comprise disposing a liquid drug container, a needle conduit and a cap in a sterilization enclosure so that...
2019/0038789 APPARATUS AND METHOD FOR STERILIZING INTERNAL CHANNEL SURFACE OF ENDOSCOPE
Provided are an apparatus and method for sterilizing an internal channel surface of an endoscope, and more particularly, to an apparatus and method for...
2019/0038788 FILTER SYSTEM WITH OUTLET FUNCTION
A gas-permeable filter system for a sterile container includes a filter element and a seal portion that sealingly surrounds a gas exchange opening provided in...
2019/0038787 ANTIBACTERIAL FIBER, SHEET, AND SHEET COVER
An antibacterial fiber that includes a plurality of charge generation fibers. The plurality of charge generation fibers generate electric charges with...
2019/0038786 SYSTEM AND METHOD FOR DAMAGING PARASITES
A method of damaging a parasite while being a resident in or on a surface of a body of a mammal. The method comprises irradiating the parasite with ultrasound...
2019/0038785 COMPOUNDS, COMPOSITIONS AND ASSOCIATED METHODS USING ZIRCONIUM-89 IN IMMUNO-POSITRON EMISSION TOMOGRAPHY
Disclosed are novel compounds, complexes, compositions and methods using Zirconium-89 combined with azamacrocyclic chelators in connection with PET. The...
2019/0038784 TAU PET IMAGING LIGANDS
The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using...
2019/0038783 COMPOSITIONS AND METHODS TO DETECT GLUA1 IN BRAIN AND TO IDENTIFY THE PRESENCE OF GLUA1-MEDIATED PTSD
The present invention provides compositions and methods for detecting GluA1, as a subunit protein and/or as a GluA1-containing, GluA2-lacking AMPAR complex....
2019/0038782 BRUSH-ARM STAR POLYMER IMAGING AGENTS AND USES THEREOF
Disclosed are methods, compositions, reagents, systems, and kits to prepare nitroxide-functionalized brush-arm star polymer organic radical contrast agent...
2019/0038781 ASSESSMENT OF CORONARY HEART DISEASE WITH CARBON DIOXIDE
There are provided methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO.sub.2 to a...
2019/0038780 VECTORS AND SYSTEM FOR MODULATING GENE EXPRESSION
A polynucleotide that modulates transcription from a plurality of genomic targets can include, generally, a polynucleotide encoding a gRNA array and a...
2019/0038779 Indirect Chromoendoscopy with an Oral Indigo Carmine Base Preparation
Indirect chromoendoscopy is performed by providing a subject with an orally administered composition which includes indigo carmine dye mixed with polyethylene...
2019/0038778 Hybrid System for Efficient Gene Delivery to Cells of the Inner Ear
Methods for introducing a gene into a cell of the inner ear, e.g., a cochlear or vestibular cell, e.g., a hair cell, e.g., for therapy, that include the use of...
2019/0038777 INJECTION OF SINGLE-STRANDED OR SELF-COMPLEMENTARY ADENO-ASSOCIATED VIRUS 9 INTO THE CEREBROSPINAL FLUID
It is disclosed herein that ssAAV and scAAV vectors of the same serotype administered by injection into the cerebrospinal fluid (CSF) via the ...
2019/0038776 Methods and Compositions for Modifying a Mutant Dystrophin Gene in a Cell's Genome
The present disclosure provides a method of modifying a mutant dystrophin gene in the genome of a cell. The present disclosure further provides compositions...
2019/0038775 THERAPEUTIC RETROVIRAL VECTORS FOR GENE THERAPY
Retroviral gene therapy vectors that are optimized for erythroid specific expression and treatment of hemoglobinopathic conditions are disclosed.
2019/0038774 COMPOUNDS, COMPOSITIONS, AND METHODS FOR USING HLA-F
The invention relates to compositions, compounds, methods, and uses for the treatment of amyotrophic lateral sclerosis. In particular, the invention relates to...
2019/0038773 METHOD TO ENHANCE THE EFFICIENCY OF SYSTEMIC AAV GENE DELIVERY TO THE CENTRAL NERVOUS SYSTEM
The disclosure relates, in some aspects, to compositions and methods for enhanced delivery of a transgene to the central nervous system (CNS) of a subject. In...
2019/0038772 GENE THERAPY FOR TREATING MUCOPOLYSACCHARIDOSIS TYPE I
A suspension useful for AAV9-mediated intrathecal/intracisternal and/or systemic delivery of an expression cassette containing a hIDUA gene is provided herein....
2019/0038771 MATERIALS AND METHODS FOR TREATMENT OF SEVERE COMBINED IMMUNODEFICIENCY (SCID) OR OMENN SYNDROME
The present application provides materials and methods for treating a patient with severe combined immunodeficiency (SCID) or Omenn Syndrome, both ex vive and...
2019/0038770 RNA GUIDED ERADICATION OF HUMAN JC VIRUS AND OTHER POLYOMAVIRUSES
The present invention includes methods and compositions for elimination of polyoma viruses, such as John Cunningham Virus (JVC), from host cells, and the...
2019/0038769 MICRO-RNA PROFILING, COMPOSITIONS, AND METHODS OF TREATING DISEASES
Compositions and methods for treating a disease are described herein. Compositions having plant preparations, microRNAs, and one or more rate limiters are...
2019/0038768 MODIFIED RNAi AGENTS
One aspect of the present invention relates to double-stranded RNAi (dsRNA) duplex agent capable of inhibiting the expression of a target gene. The dsRNA...
2019/0038767 ST-246 LIQUID FORMULATIONS AND METHODS
The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the...
2019/0038766 Nano-Enhanced Optical Delivery of Exogenous Molecules to Cells and Tissues
Principles of the present disclosure are directed to novel methods and devices for efficient and targeted delivery of impermeable exogenous materials such as...
2019/0038765 IMPROVED SULFAMIDE LINKERS FOR USE IN BIOCONJUGATES
The invention relates to a novel linker for use in bioconjugates such as antibody-drug-conjugates. The linker according to the invention is represented by...
2019/0038764 DISULFIDE BRIDGING CONJUGATES
Provided are bispecific conjugates having the general formula: ##STR00001## pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and...
2019/0038763 METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER
The present invention relates to methods and pharmaceutical composition for the treatment of cancer. In particular, the present invention relates to a method...
2019/0038762 GCC-TARGETED ANTIBODY-DRUG CONJUGATES
This invention relates to antibody-drug conjugates capable of delivering cytotoxic compounds to cancers expressing the guanylyl cyclase C (GCC) transmembrane...
2019/0038761 METHODS FOR IMPROVING THE THERAPEUTIC INDEX FOR A CHEMOTHERAPEUTIC DRUG
This disclosure relates to methods for improving the therapeutic index of a chemotherapeutic drug in the treatment of patients afflicted with cancer,...
2019/0038760 CO-ADMINISTRATION OF AN AGENT LINKED TO AN INTERNALIZATION PEPTIDE WITH AN ANTI-INFLAMMATORY
The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the...
2019/0038759 Cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide
The present disclosure relates to novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide, and methods to make and use the...
2019/0038758 PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS OF DELIVERY
The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a...
2019/0038757 PEPTIDE DERIVATIVE AND USE THEREOF
A peptide derivative represented by Formula (I) or a pharmaceutically acceptable salt thereof: ##STR00001## wherein X represents an oxygen atom or NR, Y...
2019/0038756 COMPOSITIONS INCLUDING BENZENESULFONAMIDE-CONTAINING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, SILK FIBROIN, AND A...
Provided herein are compositions that include a benzenesulfonamide-containing NSAID, silk fibroin, and a gelling agent. Also provided are kits that include any...
2019/0038755 PHARMACEUTICAL COMPOSITION CONTAINING IMIDAZOLINE DERIVATIVE
Provided in the present invention is a pharmaceutical composition containing an imidazoline derivative. In particular, the pharmaceutical composition provided...
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