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Patent # Description
2019/0038653 COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY DISEASES
Described herein are compounds and pharmaceutical compositions useful for treating inflammatory diseases.
2019/0038652 EFFECTS OF LGM2605 ON A PRIMATE MODEL OF ASTHMA
The invention provides compositions and methods for treating asthma in a subject in need thereof comprising administering chemically synthesized ...
2019/0038651 USE OF FLORIDOSIDE OR ISETHIONIC ACID TO POTENTIATE ANTIMICROBIAL ACTIVITY OF ANTIBIOTICS
The present disclosure provides: floridoside or isethionic acid for use as an antibiotic potentiator; floridoside or isethionic acid in a combination therapy...
2019/0038650 COMPOSITIONS AND METHODS FOR THE TREATMENT OF ATHEROSCLEROSIS AND HEPATOSTEATOSIS AND OTHER DISEASES
The present disclosure provides compositions comprising trehalose, and optionally a trehalase inhibitor, for the treatment of atherosclerosis and liver steatosis.
2019/0038649 MEDICAMENT FOR USE IN TREATING DIABETES
A medicament for treating diabetes and complications thereof, the medicament being a glycoprotein, or a mixture of a polysaccharide and a protein, or a...
2019/0038648 MATERIALS AND METHODS FOR SUPPRESSING AND/OR TREATING BACTERIAL INFECTIONS AND RELATED SYMPTOMS
Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reducing resistence to the treatment, prevention, and diagnosis...
2019/0038647 METHOD OF TREATING HEART FAILURE
Disclosed herein is a method for treating heart failure in a subject in need thereof. The method includes administering a therapeutically effective amount of...
2019/0038646 METHODS, AGENTS, AND DEVICES FOR LOCAL NEUROMODULATION OF AUTONOMIC NERVES
Methods, agents, and devices to treat medical conditions through local chemical neuromodulation of the autonomic nervous system are described. Drug...
2019/0038645 AGENT FOR OVERCOMING IMMUNOSUPPRESSION AND USE THEREOF
To provide an agent for overcoming immunosuppression which can overcome immunosuppression by regulatory T cells. An agent for overcoming immunosuppression and...
2019/0038644 PREPARATION FOR NASAL-NASOPHARYNGEAL TREATMENT
Medicinal compositions or preparations or drugs for the treatment of disorders of the respiratory system such as the nasal-nasopharyngeal area. The preparation...
2019/0038643 Hydrogen Sulfide (H2S) Releasing Donor Compound For Dermal Wound Regeneration
A dressing for wound healing is provided, wherein the dressing includes a hydrogen sulfide (H.sub.2S) donor compound. The dressing facilitates the delivery of...
2019/0038642 TREATING AND PREVENTING DISEASE WITH TMA AND TMAO LOWERING AGENTS
Provided herein are compositions, systems, and methods for treating a disease, such as kidney and/or cardiovascular disease, with an agent that reduces the...
2019/0038641 COMBINATION THERAPY FOR CASTRATION-RESISTANT PROSTRATE CANCER
Certain embodiments of the current disclosure are directed to a combined vitamin D (calcitriol or analog thereof) and androgen therapy that reduces the growth...
2019/0038640 COMPOSITION, FORMULATIONS AND METHODS OF MAKING AND USING BOTANICALS AND NATURAL COMPOUNDS FOR THE PROMOTION OF...
The present disclosure provides compositions and formulations comprising botanicals and natural compounds for the promotion of healthy brain aging in adults,...
2019/0038639 METHODS OF TREATING EPILEPSY OR STATUS EPILEPTICUS
Described herein are methods of treating epilepsy or status epilepticus, e.g., convulsive status epilepticus, e.g., early status epilepticus, established...
2019/0038638 FORMULATIONS OF DEOXYCHOLIC ACID AND SALTS THEREOF
The present application is directed to an aqueous pharmaceutical formulation comprising less than about 5% w/v sodium deoxycholate maintained at a pH...
2019/0038637 Use of Hydroxyprogesterone Derivatives for Enhanced Health and Physical Performance II
A method for the use of derivatives of hydroxyprogesterone (17-alpha-hydroxypregn-4-ene-3,20-dione) to enhance health and physical performance in humans and...
2019/0038636 Use of Medications with Neuroprotective Properties to Prevent or Reduce the Risk of Ischemia-Reperfusion Injury...
Provided are methods for treatment and prevention of ischemia-reperfusion injury and chronic intermittent hypoxia related injury through administering a...
2019/0038635 SOLID DOSAGE FORMULATIONS OF AN OREXIN RECEPTOR ANTAGONIST
The present invention is directed to a pharmaceutical composition comprising the compound suvorexant, or a pharmaceutically acceptable salt thereof, a...
2019/0038634 PROCESS FOR PREPARATION OF OPTICALLY PURE AND OPTIONALLY SUBSTITUTED 2-(1-HYDROXY-ALKYL)-CHROMEN-4-ONE...
The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the...
2019/0038633 METHODS OF TREATING CANCER
The disclosure relates to a method for treating cancer comprising administering a therapeutically effective amount of an EZH2 inhibitor to a subject in need...
2019/0038632 COPANLISIB BIOMARKERS
This invention provides biomarkers based on the gene expression profiling which can discriminate between patients who response to and/or with longer...
2019/0038631 6-AMINO-PURIN-8-ONE COMPOUNDS
Compounds of formula (I): ##STR00001## wherein R.sup.1 is C.sub.1-6alkylamino, C.sub.1-6alkoxy, or C.sub.3-7cycloalkyloxy; m is an integer having a value of 3 to...
2019/0038630 USE OF ADENOSINE RECEPTOR SIGNALING TO REGULATE P-GP FUNCTION
The present invention relates to a method of inhibiting p-glycoprotein (P-gp) expression in a cell. The method involves contacting a cell expressing P-gp with...
2019/0038629 CONCENTRATED METHOTREXATE SOLUTIONS
Concentrated methotrexate solutions are described which are suitable for the use of an active substance in the production of a parenterally administered...
2019/0038628 USE OF INHIBITORS OF THE ACTIVITY OR FUNCTION OF PI3K FOR THE TREATMENT OF PRIMARY SJOGREN'S SYNDROME
The invention relates to the use of 1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro- ...
2019/0038627 METHANOCARBA DERIVATIVES OF PSEUDORIBOSE THAT INHIBIT ADENOSINE KINASE
Adenosine kinase inhibitors, including pharmaceutical compositions containing the adenosine kinase inhibitors, and their use for preventing epilepsy and its...
2019/0038626 HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME
The present subject matter relates to a compound represented by the general formula (I) or (I') or a pharmacologically acceptable salt thereof; pharmaceutical...
2019/0038625 INHIBITORS AND THEIR USES
The invention relates to inhibitors of CDK12 (cyclin-dependent kinase 12), and there use in the treatment or prevention of a disorder in a subject caused by...
2019/0038624 USE OF ABELSON TYROSINE KINASE INHIBITOR IN TREATMENT OF MULTIPLE SYSTEM ATROPHY
The present disclosure relates to a method for treating or alleviating a symptom of MSA, comprising administering a therapeutically effective amount of an...
2019/0038623 THERAPEUTIC REGIMENS FOR TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
Provided herein are methods for treating a subject with PNH comprising administering to a subject a therapeutically effective amount of complement component C5...
2019/0038622 NEUROPROTECTIVE AGENTS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
A compound having formula IA is useful for treating a neurodegenerative disease: ##STR00001## or a pharmaceutically acceptable salt or ester thereof, where...
2019/0038621 POSACONAZOLE DERIVATIVE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
The present disclosure provides a posaconazole derivative, a pharmaceutical composition and use thereof, which specifically include a compound represented by...
2019/0038620 DELTA OPIOID AGONIST MU OPIOID ANTAGONIST COMPOSITIONS AND METHODS FOR TREATING PARKINSONS DISEASE
The present invention provides for compositions and methods for the treatment of Parkinson's disease comprising a compound of formula (i): ##STR00001## or a...
2019/0038619 PRODUCT AND METHOD FOR TREATING DIARRHEA
A method of treating diarrhea in a patient includes administering an H1 receptor antagonist and an H2 receptor antagonist to the patient.
2019/0038618 MORPHINAN COMPOUNDS
This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a...
2019/0038617 METHODS OF TREATING CANCER WITH FARNESYLTRANSFERASE INHIBITORS
The present invention relates to the field of cancer therapy. Specifically, provided are methods of treating cancer in a subject having clinical signs of bone...
2019/0038616 ANTI-NEUTROPHIL ACTIVITY ON INNATE IMMUNE RESPONSE
Disclosed are compositions, medical devices and methods for ameliorating sterile injury due object use in a subject in need thereof. More particularly, the...
2019/0038615 PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF
The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II...
2019/0038614 PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD THEREFOR
The present invention provides an oral pharmaceutical composition and a usage thereof, comprising a pharmaceutically acceptable acidic medicinal auxiliary...
2019/0038613 COMBINATION THERAPY
The present invention provides a method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment...
2019/0038612 N3,N6-BIS(2-(5-METHOXY-1H-INDOLE-3-YL)ETHYL)-2,6-DIMETHYL-4-(2-NITROPHENYL- )PYRIDINE-3,5-DICARBOXAMIDE AND USE...
The invention relates to a molecule enabling removal of neurotoxicity observed in neuron cells due to various reasons.
2019/0038611 Novel CYP34A-Specific Inhibitors and Methods of Using Same
The present invention includes novel compositions inhibiting CYP3A4. The present invention further includes a novel method of inhibiting CYP3A4 in a subject in...
2019/0038610 CANCER THERAPY
A method of treating haematological cancer with a therapy comprising a DHODH inhibitor. Also provided is a combination therapy comprising a pan-HER inhibitor...
2019/0038609 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PRESBYOPIA
The invention provides compositions and methods for the treatment of presbyopia. The compositions preferably comprise aceclidine and a cryoprotectant. The...
2019/0038607 CHEMICAL COMPOUNDS
The invention concerns compounds of Formula (I) ##STR00001## or pharmaceutically-acceptable salts thereof, wherein R.sup.1 to R.sup.5 have any of the meanings...
2019/0038606 USE OF GABOXADOL IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS
Methods and compositions for treating a metabolic disease include administering gaboxadol or a pharmaceutically acceptable salt thereof to a patient diagnosed...
2019/0038605 PHARMACEUTICAL COMPOSITION COMPRISING RAPAMYCIN OR DERIVATIVE THEREOF
It is an object of the present invention to provide a pharmaceutical composition, which can suppress a reduction in the content of an active ingredient caused...
2019/0038604 BICYCLIC COMPOUND, PRODUCTION AND USE THEREOF
The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound...
2019/0038603 METHODS OF TREATING DISEASES CHARACTERISED BY VASOCONSTRICTION
There is herein provided a compound that is an mPGES-1 inhibitor, or a prodrug thereof, for use in the treatment or prophylaxis of a disease or disorder...
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