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Patent # Description
2019/0054111 TALEN-BASED GENE CORRECTION
The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the...
2019/0054110 MODULATORS OF CCR9 FOR TREATING TUMOR RESISTANCE TO IMMUNE RESPONSES
The present invention pertains to novel modulators of tumor resistance against T-cell mediated cytotoxic immune responses. The invention provides antagonists...
2019/0054109 An antiviral composition and a method for application thereof
The present invention relates to an antiviral composition and a method for application thereof in the treatment of hepatitis C virus. Said antiviral composition...
2019/0054108 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a...
2019/0054107 COMPOSITIONS AND METHODS FOR TREATING AN INFECTION
A dry formulation may include one or more active agents including one or more anti-infective agents such as an anti-bacterial agent, anti-fungal agent, or...
2019/0054106 FOAMABLE COMPOSITIONS, BREAKABLE FOAMS AND THEIR USES
A substantially surface active agent-free foamable composition which includes short-chain alcohol, water, polymer, fatty alcohol or fatty acid or a combination...
2019/0054105 ANTITUMOR ARYLNAPHTHALENE LIGAND GLYCOSIDES
Described are arylnaphthalene lactone derivatives. Also disclosed herein are methods of use of the arylnaphthalene lactone derivatives as anticancer agents.
2019/0054104 PROTON-MOTIVE FORCE STIMULATION TO POTENTIATE AMINOGLYCOSIDE ANTIBIOTICS AGAINST PERSISTENT BACTERIA
Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific...
2019/0054103 METHOD OF TREATMENT OF TP53 WILD-TYPE TUMORS WITH 2',2'-DIFLUORO-5-AZA-2'-DEOXYCYTIDINE OR PRODRUGS THEREOF
This disclosure provides methods and strategies for inhibiting the growth of TP53 wild-type cancer cells, comprising contacting the cell with ...
2019/0054102 ANTHRACYCLINE DISULFIDE INTERMEDIATES, ANTIBODY-DRUG CONJUGATES AND METHODS
The invention provides antibody-drug conjugates comprising an antibody conjugated to an anthracycline drug moiety via a disulfide linker, anthracycline...
2019/0054101 ARGINASE INHIBITORS AS THERAPEUTICS
Compounds according to Formula I are potent inhibitors of Arginase I and II activity: ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, D, W, X, Y, and Z...
2019/0054100 MEDICAMENT FOR TREATMENT OF DIABETIC FOOT INFECTIONS
The present invention provides means and methods for treating diabetic foot infections. In particular, drug compounds are provided that combine a high...
2019/0054099 NERIDRONIC ACID FOR TREATING COMPLEX REGIONAL PAIN SYNDROME
Oral dosage forms of osteoclast inhibitors, such as neridronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions,...
2019/0054098 AGENTS AND METHODS USING THEREOF FOR THE PREVENTION AND TREATMENT OF STEM CELLS SENESCENCE
The present invention relates to agents that prevent or reverse process of stem cell senescence. Further, the invention relates to methods and compositions...
2019/0054097 COMPOSITIONS TARGETING SENESCENT CELLS AND THE USES THEREOF
The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises a compound of Formula (I)...
2019/0054096 METHODS FOR ATTENUATING PARASITE VIRULENCE
Pharmaceutical compositions and methods for the treatment of malaria are presented. Such compositions and methods may target energy-sensing pathways of the...
2019/0054095 Aqueous Nebulization Composition
Compositions and methods for making and using stable, homogeneous budesonide compositions are disclosed.
2019/0054094 PHARMACEUTICAL COMPOSITION INCLUDING DUTASTERIDE AND CAPSULE FORMULATION COMPRISING THE SAME
The present disclosure relates to a pharmaceutical composition comprising dutasteride and propylene glycol monolaurate, and a capsule formulation comprising...
2019/0054093 TREATMENT OF SARCOPENIA WITH ECDYSTEROIDS
The current disclosure relates to methods for treating loss of muscle mass, by administering compositions comprising a combination of: 20-hydroxy-ecdysone...
2019/0054092 COMPOUNDS, COMPOSITIONS AND METHODS FOR REDUCING OR AMELIORATING MORTALITY AND/OR MORBIDITY DUE TO CHLORINE...
The present invention includes compounds, compositions and methods for reducing or ameliorating mortality and/or morbidity due to chlorine inhalation.
2019/0054091 PROPHYLACTIC AGENT AND/OR THERAPEUTIC AGENT FOR DIFFUSE LARGE B-CELL LYMPHOMA
To provide a medicament which shows more remarkable effect in treatment of activated B-cell like diffuse large B-cell lymphoma (ABC-CLBCL) than the existing...
2019/0054090 COMBINATION OF A BTK INHIBITOR AND A CHECKPOINT INHIBITOR FOR TREATING CANCERS
Provided herein are methods relating to a therapeutic strategy for treatment of cancer, including hematological malignancies. In particular, the methods...
2019/0054089 METHODS USED TO TREAT CANCER
The technology encompasses methods of treating a patient with cancer, such as glioblastoma. The methods may include the administration of one or more...
2019/0054088 Pharmaceutical Formulations for Treating Endometriosis, Uterine Fibroids, Polycystic Ovary Syndrome or Adenomyosis
The present disclosure relates to pharmaceutical compositions comprising a gonadotropin-releasing hormone (GnRH) antagonist and methods of preparing and using...
2019/0054087 TREATMENT OF SMALL CELL LUNG CANCER WITH A PARP INHIBITOR
Described are methods of treatment of a small cell lung cancer subject expressing Schlafen-11 (SLFN 11) with a Poly (ADP-ribose) polymerases (PARP) inhibitor...
2019/0054086 PHARMACEUTICAL FORMULATIONS
This invention relates to solid oral pharmaceutical formulations of (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-- ...
2019/0054085 COMPOSITION AND METHOD FOR TREATMENT OF DEPRESSION AND PSYCHOSIS IN HUMANS
This application relates to combination compositions for use in treatment of depression, comprising an effective amount of an N-methyl-D-aspartate receptor...
2019/0054084 COMBINATION PRODUCTS FOR THE TREATMENT OF RSV
The present invention is directed to the combination of the RSV inhibiting Compound A, i.e. ...
2019/0054083 METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE
A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of a ribonucleotide reductase...
2019/0054082 METHODS OF TREATING CANCER USING COMPOSITIONS COMPRISING PERILLYL ALCOHOL DERIVATIVE
A method for treating brain metastases of a cancer in a mammal includes administering to the mammal a therapeutically effective amount of a perillyl alcohol...
2019/0054081 TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION
A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and...
2019/0054080 ABUSE-RESISTANT PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF OPIOID DEPENDENCE
There is provided pharmaceutical compositions for the treatment of e.g. opioid dependency comprising microparticles of a pharmacologically-effective amount of...
2019/0054078 COMPOSITIONS AND METHODS FOR TREATMENT OF SYMPTOMS IN PARKINSON'S DISEASE PATIENTS
The invention provides dosage forms and methods utilizing nicotine to treat symptoms of a neurologic disorder. In some embodiments, the invention provides...
2019/0054077 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING AND/OR TREATING CHLORINE INHALATION TOXICITY AND/OR INJURY
The present invention includes compounds, compositions and methods for treating and/or preventing chlorine inhalation toxicity and/or injury in a subject...
2019/0054076 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF
Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of...
2019/0054075 HYPERBARIC INJECTION SOLUTION OF ROPIVACAINE HYDROCHLORIDE AND PROCESS FOR PREPARATION THEREOF
Disclosed herein is hyperbaric solution for injection of Ropivacaine Hydrochloride which comprises Ropivacaine Hydrochloride; a base/acid to adjust the pH and...
2019/0054074 ANTI-MALARIAL AGENT
The present invention aims to prevent and/or treat malaria using an antimalarial drug comprising, as an active ingredient, a metal chelator represented by the...
2019/0054073 PHARMACEUTICAL COMPOSITION COMPRISING PYRROLO-FUSED SIX-MEMBERED HETEROCYCLIC COMPOUND
The present invention provides a pharmaceutical composition containing a pyrrolo-fused six-membered heterocyclic compound or a pharmaceutically acceptable salt...
2019/0054072 HSP90 TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
Conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to an HSP90 targeting moiety via a linker have been designed....
2019/0054071 SMALL MOLECULE INHIBITORS OF PENDRIN ION EXCHANGE AND PHARMACEUTICAL COMPOSITIONS
Provided herein are small molecule inhibitors of pendrin. More specifically, the small molecules disclosed herein may be used to inhibit pendrin-mediated anion...
2019/0054070 Methods and Compositions for Regenerative Synaptogenesis
Provided herein are uses of pharmaceutically effective amounts of an inhibitor of an arginine methyltransferase alone or in combination with one or more...
2019/0054069 NEW USE OF A COMBINATION OF SACUBITRIL AND VALSARTAN
The present invention relates to methods and pharmaceutical compositions for treating heart failure in a pediatric human patient comprising administration to...
2019/0054068 Indole Amide Derivatives and Related Compounds for Use in the Treatment of Neurodegenerative Diseases
This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative...
2019/0054067 COMPOSITIONS AND METHODS FOR TREATING COMPULSIVE-LIKE BEHAVIOR IN A SUBJECT
The present invention includes methods of treating obsessive-compulsive disorder and/or an obsessive-compulsive related disorder or disease. The present...
2019/0054066 THERAPEUTIC AGENT FOR AMYOTROPHIC DISORDERS
It is an object of the present invention to provide a novel therapeutic agent and method for treating amyotrophic diseases, and more specifically a therapeutic...
2019/0054065 SIP MODULATOR IMMEDIATE RELEASE DOSAGE REGIMEN
The present invention relates to siponimod (BAF312) for use in the treatment of an autoimmune disease, wherein an immediate release dosage form is administered...
2019/0054064 VITAMIN C AND VITAMIN K COMPOUND FOR TREATING PANCREATIC CANCER
Provided herein is a method of treating, preventing, or alleviating one or more symptoms of pancreatic cancer in a subject, comprising administering to the...
2019/0054063 NOVEL TREATMENT FOR NON-ALCOHOLIC FATTY LIVER DISEASES
The present invention relates to the use of mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) as agents for the prevention, control and/or...
2019/0054062 Topical Compositions for Treatment of Psoriasis
The present invention provides safe and effective topical compositions for the treatment of psoriasis and alleviation and prevention of frequent recurrence of...
2019/0054061 COMPOSITIONS AND METHODS FOR TREATING AN INFECTION
The present application relates to compounded compositions, methods of making compounded compositions, and methods of using compounded compositions. For...
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