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Patent # Description
2019/0055328 OLEFIN POLYMERIZATION PROCESS
A process for the preparation of an ethylene polymer including the step of polymerizing ethylene or copolymerizing ethylene and one or more other olefins in...
2019/0055327 METHOD FOR MANUFACTURING FILTER MEMBRANE FOR INHIBITING MICROORGANISMS
A method for manufacturing a filter membrane for inhibiting microorganisms includes the following steps: obtaining a nano-zinc precursor and dissolving it into...
2019/0055326 PARTICULATE POLYVINYL ALCOHOL COPOLYMERS, PROCESS FOR MAKING AND USES OF THE SAME
The present invention relates generally to a highly-hydrolyzed polyvinyl alcohol composition having increased cold-water solubility, a process for making such...
2019/0055325 METHOD OF MAKING A FUNCTIONALIZED ELASTOMER
The present invention is directed to a method of making a functionalized elastomer, comprising the step of polymerizing monomers comprising a conjugated diene...
2019/0055324 METHOD FOR PREPARING MODIFIED NANOCRYSTALLINE CELLULOSE
The present disclosure provides methods for functionalizing the surfaces of cellulose nanoparticles. In embodiments, nanoparticles are aerosolized, and then...
2019/0055323 METHOD FOR PRODUCING CARBOXYMETHYL CELLULOSE OR SALT THEREOF, AND BINDING AGENT FOR ELECTRODE
Provided is a carboxymethyl cellulose or a salt thereof, in which when the carboxymethyl cellulose or the salt thereof is used as a binding agent for an...
2019/0055322 PSEUDOMONAS AERUGINOSA PCRV BINDING SINGLE VARIABLE DOMAIN ANTIBODIES
Polypeptides are provided that are capable of significantly inhibiting and/or neutralizing P. aeruginosa. The polypeptides comprise two or more immunoglobulin...
2019/0055321 PRODRUGGABLE ANTIBODIES, PRODRUGS THEREOF, AND METHODS OF USE AND MAKING
A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits...
2019/0055320 ANTIBODIES AGAINST CD73 AND USES THEREOF
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high...
2019/0055319 Methods for Determining the Likelihood of Survival and for Predicting Likelihood of Metastasis in Cancer Patients
The present invention relates generally to methods of accurately quantifying HER2 and/or p95 expression in subjects with a HER2 positive cancer and indicating...
2019/0055318 ELIMINATING MHC RESTRICTION FROM THE T CELL RECEPTOR AS A STRATEGY FOR IMMUNOTHERAPY
The present disclosure generally relates to chimeric antigen receptors, more specifically to chimeric antigen receptor compositions and methods for use of the...
2019/0055317 TREATMENT WITH ANTI-ErbB2 ANTIBODIES
The present invention concerns dosages for treatment of human cancer patients with an anti-Epidermal Growth Factor Receptor (EGFR) antibody.
2019/0055316 ANTI-MESOTHELIN BINDING PROTEINS
The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which...
2019/0055315 MULTISPECIFIC NK ENGAGER PROTEIN
Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells...
2019/0055314 ANTI-CD137 MOLECULES AND USE THEREOF
The present disclosure provides antibodies that bind to human CD137 or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic...
2019/0055313 ANTIBODIES AGAINST G-CSFR AND USES THEREOF
The present disclosure provides proteins comprising antigen binding domains of antibodies that bind to human granulocyte-colony stimulating factor receptor.
2019/0055312 BINDING MEMBERS TO PD-L1
The present invention relates to anti-PD-L1 binding members and in particular to monovalent, high potency PD-L1-binding antibody fragments being highly stable...
2019/0055311 Agents for Treatment of Claudin Expressing Cancer Diseases
The present invention provides binding agents that contain n binding domain that is specific for CD3 allowing binding to T cells and a binding domain that is...
2019/0055310 Fusion proteins and their related methods
The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated...
2019/0055309 Compositions and Methods for Treating Cancer with Anti-ROR1 Immunotherapy
Chimeric antigen receptors containing ROR1 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding...
2019/0055308 MULTIPLE-VARIABLE DOSE REGIMEN FOR TREATING TNFalpha-RELATED DISORDERS
Multiple-variable dose methods for treating TNFa-related disorders, including Crohn's disease and psoriasis, comprising administering TNFa inhibitors,...
2019/0055307 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS BY INTRANASAL ADMINISTRATION OF IMMUNOGLOBULIN G
The present invention provides, among other aspects, methods and compositions for treating a central nervous system (CNS) disorder by delivering a...
2019/0055306 ANTI-TENASCIN C ANTIBODIES AND USES THEREOF
There is provided antibodies or antigen-binding fragments, derivatives or variants thereof which are capable of binding to the FBG domain of tenascin-C. There...
2019/0055305 ANTIBODY TARGETING CELL SURFACE DEPOSITED COMPLEMENT PROTEIN C3d AND USE THEREOF
An anti-C3d antibody or antibody fragment; method for use thereof to kill cancer cells; and related methods and compositions.
2019/0055304 BINDING MOIETIES FOR BIOFILM REMEDIATION
Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected...
2019/0055303 METHOD FOR PREPARING LOW ENDOTOXIN COLLAGEN
A method for preparing low endotoxin collagen is disclosed. The method includes the following steps: providing an animal skin, removing residual adipose...
2019/0055302 UTERINE CANCER TREATMENTS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0055301 UTERINE CANCER TREATMENTS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0055300 AZlDE GROUP-CONTAINING Fc PROTEIN
The present invention provides a means capable of efficiently manufacturing a fused substance of an Fc protein and a substance of interest (for example, a...
2019/0055299 CHIMERIC ANTIGEN RECEPTOR MOLECULES AND USES THEREOF
Chimeric antigen receptor (CAR) polypeptides are provided comprising an antigen binding domain; a hinge domain; a transmembrane domain and an intracellular...
2019/0055298 ENGINEERED HIGH-AFFINITY HUMAN T CELL RECEPTORS
T cell receptors (TCRs) that have higher affinity for the Survivin antigen are provided. The high affinity TCRs were engineered through the generation of...
2019/0055297 USE OF GENE EDITING TO GENERATE UNIVERSAL TCR RE-DIRECTED T CELLS FOR ADOPTIVE IMMUNOTHERAPY
The present invention includes compositions and methods for a modified immune cell or precursor cell thereof comprising an inducible expression system. Also...
2019/0055296 GLUCAGON ANALOGUES
The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular,...
2019/0055295 TROPHIC HORMONE FUSION PROTEIN, PREPARATION METHOD AND APPLICATION THEREOF
Disclosed herein is a gonadotropin fusion protein or a thyroid stimulating hormone fusion protein, a method for preparing the same and use thereof....
2019/0055293 METHODS TO PRODUCE ROD-DERIVED CONE VIABILITY FACTOR (RDCVF)
The invention is related to methods of producing rod-derived cone viability factor (RdCVF). This invention also relates to the treatment of an ocular disease...
2019/0055292 Adhesin as Immunogen Against Enterotoxigenic Escherichia Coli
The inventive subject matter relates to the methods for the induction of immunity and prevention of diarrhea resulting from Escherichia coli. The inventive...
2019/0055291 FUSION RESPIRATORY SYNCYTIAL VIRUS INHIBITORS AND USE THEREOF
The present invention relates novel peptides useful for the prevention and/or treatment of respiratory syncytial virus (RSV) infections.
2019/0055290 STABILIZED HUMAN IMMUNODEFICIENCY VIRUS (HIV) ENVELOPE (ENV) TRIMER VACCINES AND METHODS OF USING SAME
The invention features stabilized human immunodeficiency virus (HIV) envelope (Env) trimers. The invention also features vaccines, nucleic acids, and vectors...
2019/0055289 IMMUNOGENS FOR HIV VACCINATION
The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment...
2019/0055288 METHODS AND PRODUCTS FOR GENETIC ENGINEERING
The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a...
2019/0055287 POLYPEPTIDE, DNA MOLECULE ENCODING THE POLYPEPTIDE, VECTOR, PREPARATION METHOD AND USE
A polypeptide, a DNA molecule encoding the polypeptide, a vector, a preparation method and a use therefor are disclosed. The polypeptide comprises an amino...
2019/0055286 NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS OF THE BLOOD, IN PARTICULAR CHRONIC LYMPHOID LEUKEMIA (CLL)
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
2019/0055285 SKIN-PENETRATING PEPTIDE AND METHOD FOR USING SAME
The present disclosure is directed to providing a new skin-penetrating peptide, a fusion product with a biologically active substance bound using the same, a...
2019/0055284 WATER-SOLUBLE RAPAMYCIN DERIVATIVES
The present invention relates to technical fields of organic chemistry and pharmaceutical chemistry, specifically to water-soluble rapamycin derivatives...
2019/0055283 AZA-PEPTIDE ALDEHYDES AND KETONES
The present disclosure relates to compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease...
2019/0055282 Methods for Extracting Proteins from a Blood-Based Material
Methods of producing multiple protein products from blood-based materials including alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins...
2019/0055281 REFOLDING PROTEINS USING A CHEMICALLY CONTROLLED REDOX STATE
A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying...
2019/0055280 TRANSITION METAL-BASED SELECTIVE FUNCTIONALIZATION OF CHALCOGENS IN BIOMOLECULES
Disclosed are methods of selective cysteine and selenocysteine modification on peptide/protein molecules under physiologically relevant conditions. The methods...
2019/0055279 NOVEL POLYPEPTIDES WITH IMPROVED PROTEOLYTIC STABILITY, AND METHODS OF PREPARING AND USING SAME
The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group...
2019/0055278 PROCESS FOR THE PREPARATION OF GUANYLATE CYCLASE 2C AGONIST
The present invention relates to an improved process for the preparation of Linaclotide of Formula I. The process disclosed in the present invention is simple,...
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