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Patent # Description
2019/0055277 Immune Modulatory Compositions
A class of phosphorus containing polycyclic compounds of general formula I, of general formula I' or of general formula I'', wherein B.sup.1, B.sup.2, R.sup.1,...
2019/0055276 IONIC LIQUID SUPPORTED SYNTHESIS
The present invention relates to ionic liquids for use in chemical applications and capable of serving the dual function of solvent and liquid support. The...
2019/0055275 PROCESS FOR PREPARATION OF NICOTINAMIDE RIBOSIDE (NR) AND COSMETIC COMPOSITION COMPRISING (NR AND A...
Disclosed herein is a process for preparing nicotinamide riboside (NR) from an NR precursor and a phosphate-binding agent in a solvent. The reaction-derived...
2019/0055274 FERRIC ORGANIC COMPOUNDS, USES THEREOF AND METHODS OF MAKING SAME
The present invention discloses a novel form of ferric organic compounds, including a form of ferric citrate, which are soluble over a wider range of pH, and...
2019/0055273 ACYCLIC ANTIVIRALS
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HBV and/or HDV...
2019/0055272 PRODRUGS OF PHENOLIC TRPV1 AGONISTS
Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate...
2019/0055271 ORGANOMODIFIED MONOSILYL COMPOUND, ITS PREPARATION AND APPLICATIONS THEREOF
Organomodified monosilyl compounds as defined herein exhibit excellent resistance to hydrolysis over a wide range of pH and excellent wetting properties. The...
2019/0055270 Process for Preparing a Triazine-Based Precursor, the Precursor Prepared Thereby, a Method for Producing a...
A process for preparing a triazine-based precursor for producing a micro-particulate complex containing a far infrared-emissive silica particle comprises steps...
2019/0055269 HETEROARYL INHIBITORS OF PDE4
The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory...
2019/0055268 BORON COMPOUNDS AS INHIBITORS OF LIPOXYGENASE AND THE LIPOXYGENASE PATHWAY, AND PREPARATION AND USE THEREOF
The invention relates to chemical compound of the general structure [A-R.sub.3--X--R.sub.4] where A=[R.sub.1-R.sub.2] or [R.sub.1] R.sub.1=aryl, heteroaryl...
2019/0055267 ORGANOTRIFLUOROBORATE MIMICS OF AMINO ACIDS AND USES THEREOF
Disclosed are boron mimics of amino acids which are compounds, salts, solvates, or stereoisomers of the Formula (I): wherein A, R.sup.1, R.sup.2, and R.sup.3...
2019/0055266 HETEROCYCLIC COMPOUNDS, IN PARTICULAR 2-OXO-4,4,5,5,6,6,7,7-OCTAHYDROBENZOXAZOLE DERIVATIVES, AND THEIR USE AS ...
This invention relates to antibacterial drug compounds containing a bicyclic core, typically a bicycle in which one of the rings is an oxazolidinone. It also...
2019/0055265 HETEROCYCLE-SUBSTITUTED BICYCLIC AZOLE PESTICIDES
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein Q is ##STR00002## and A,...
2019/0055264 Macrocyclic MCL-1 inhibitors and methods of use
The present disclosure provides for compounds of Formula (I) ##STR00001## wherein A.sup.2, A.sup.3, A.sup.4, A.sup.6, A.sup.7, A.sup.8, A.sup.15, R.sup.A,...
2019/0055263 Polymorphic form of TG02
The present disclosure provides crystalline polymorphic forms of TG02 free base and TG02 acid addition salts, pharmaceutical compositions comprising...
2019/0055262 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS
The present invention is directed to compounds of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the substituents R.sup.1,...
2019/0055261 PRODUCTION METHOD OF THIENOPYRIMIDINE DERIVATIVE
The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH)...
2019/0055260 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF...
Optically active 2-hydroxytetrahydrothienopyridine derivatives represented by Formula I and pharmaceutically acceptable salts, preparation method and use in...
2019/0055259 METHOD FOR PRODUCING DIOL HAVING CYCLIC ACETAL SKELETON
The present invention provides a method for producing a diol having a cyclic acetal skeleton, in which the method include an acetalization reaction step of...
2019/0055258 BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT
This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those benzodiazepine derivatives and methods...
2019/0055257 SUBSTITUTED 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic...
2019/0055256 ANTI-VIRAL DRUG
An antiviral compound for use in the treatment of positive-sense, single-stranded RNA (herein after ssRNA] virus infections different from the West Nile Fever...
2019/0055255 NEW CRYSTALLINE FORMS OF (6-(1H-INDAZOL-6-YL)-N-[4-(4-MORPHOLINYL)PHENYL]IMIDAZO[1,2-A]PYRAZIN-8-A- MINE)...
The present disclosure relates to novel crystalline form I, form II and form III of 6-(1H-indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]imidazo ...
2019/0055254 PYRROLOBENZODIAZEPINES
A compound with the formula I, wherein R.sup.2 is of formula II, where A is a C.sub.5-7 aryl group, X is selected from the group consisting of: OH, SH,...
2019/0055253 PYRROLO[1,2-f][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS
Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating...
2019/0055252 COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA
Provided herein are compounds of the formula (I): ##STR00001## as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those...
2019/0055251 METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS
Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: ...
2019/0055250 HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS
The present invention is directed to compounds of Formula I which are LSD1 inhibitors useful in the treatment of diseases such as cancer. ##STR00001##
2019/0055249 SUPPRESSION AND REGENERATION PROMOTING EFFECT OF LOW MOLECULAR WEIGHT COMPOUND ON CANCER AND FIBROSIS
To obtain a novel therapeutic drug for a malignant tumor or fibrosis. Used is a compound represented by formula (1), a salt thereof, or a solvate thereof. Also...
2019/0055248 INHIBITORS OF CYCLINDEPENDENT KINASE 7 (CDK7)
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers,...
2019/0055247 TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING HETEROATOM-LINKED AROMATIC MOIETIES, CONJUGATES THEREOF, AND...
Compounds having a structure according to formula (I) or (II) ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, Ar and X.sup.1 are as defined herein, are...
2019/0055246 TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A HETEROBIARYL MOIETY, CONJUGATES THEREOF, AND METHODS AND USES...
Compounds having a structure according to formula (I) or (II) ##STR00001## where R.sup.1, R.sup.2, and Ar are as defined herein, are agonists for the Toll-like...
2019/0055245 TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A PYRIDINE OR PYRAZINE MOIETY, CONJUGATES THEREOF, AND METHODS AND...
Compounds having a structure according to formula (I) ##STR00001## where R.sup.1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7)...
2019/0055244 TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A TRICYCLIC MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR
Compounds having a structure according to formula (I), (II), or (III) ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.5X.sup.1, X.sup.2, and X.sup.3 are as...
2019/0055243 TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A BENZOTRIAZOLE MOIETY, CONJUGATES THEREOF, AND METHODS AND USES...
Compounds having a structure according to formula (I) ##STR00001## where R.sup.1, R.sup.2, and R.sup.3 are as defined herein, are agonists for the Toll-like...
2019/0055242 INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
2019/0055241 GUANIDINE SUBSTITUTED IMIDAZO[4,5-c] RING COMPOUNDS
Imidazo[4,5-c] ring compounds, (particularly imidzao[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and...
2019/0055240 HETEROCYCLIC INHIBITORS OF ATR KINASE
The present invention relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
2019/0055239 GLYCOSIDASE INHIBITORS
Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and...
2019/0055238 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-B]PYRIDINE AND THERAPEUTIC USES THEREOF
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole...
2019/0055237 CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR PREPARING THE SAME
The present disclosure relates to solid forms of N-{[2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[- ...
2019/0055236 NLRP3 MODULATORS
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination...
2019/0055235 SUBSTITUTED BICYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS
The present disclosure relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their...
2019/0055234 COMPOSITIONS AND METHODS FOR INHIBITING KINASES
The present invention provides compounds for the prevention or treatment of cancer or a bacterial or viral infection. Additionally, the present invention...
2019/0055233 ACID ADDITION SALTS OF PIPERAZINE DERIVATIVES
The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as...
2019/0055232 NOVEL COMPOUNDS
The present invention relates to novel compounds of formula (I) and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In...
2019/0055231 BACE1 INHIBITORS
The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
2019/0055230 NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK
The present invention is concerned with substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by...
2019/0055229 Heteroaryl Substituted Pyridines and Methods of Use
The invention discloses compounds of Formula I, ##STR00001## wherein X.sup.1, X.sup.2, R.sup.1, and R.sup.2 are as defined herein. The present invention relates...
2019/0055228 BENZISOXAZOLES
The present invention relates to novel fatty acid esters of the reversible Iloperidone metabolite P-88-8991, their preparation, their use as pharmaceuticals...
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