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Patent # Description
2019/0055227 GAMMA-DIKETONES AS WNT/BETA -CATENIN SIGNALING PATHWAY ACTIVATORS
The present disclosure provides .gamma.-diketones or analogs thereof, that activate Wnt/.beta.-catenin signaling and thus treat or prevent diseases related to...
2019/0055226 5-FLUORO-C-(ARYL OR HETEROCYCLYL)-GLYCOSIDE DERIVATIVES USEFUL AS DUAL SGLT1 / SGLT2 MODULATORS
The present invention is directed to 5-fluoro-C-(aryl or hetercyclyl)-glycoside derivatives, pharmaceutical compositions containing them and their use in the...
2019/0055225 INDAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL...
Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4);...
2019/0055224 NOVEL FORMS OF LUMACAFTOR AND PROCESSES FOR THE PREPARATION THEREOF
The present disclosure provides amorphous lumacaftor, amorphous solid dispersions of lumacaftor, crystalline lumacaftor acetic acid solvate, crystalline...
2019/0055223 TOXIN AND METHOD FOR PREPARING INTERMEDIATE THEREOF
The present invention relates to a new toxin and a method for preparing an intermediate thereof. In particular, the present invention relates to a new toxin...
2019/0055222 COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME
The present application relates to a compound of Chemical Formula 1 and an organic light emitting device including the same.
2019/0055221 HISTONE DEMETHYLASE INHIBITORS
The present embodiments provide for substituted triazolylpyridine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject...
2019/0055220 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
The present disclosure features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R.sub.1, R.sub.2, W, X, Z, n, p, and Rings A and...
2019/0055219 INDOLE DERIVATIVES AND USES THEREOF
The present disclosure provides a compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a...
2019/0055218 AHR INHIBITORS AND USES THEREOF
The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
2019/0055217 PIPERIDINYLALKYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
The present invention relates to piperidinylalkylamide derivatives having dual pharmacological activity towards both the sigma (.sigma.) receptor and the...
2019/0055216 METHODS OF PREPARING HYDROXYLAMINE DERIVATIVES USEFUL IN THE PREPARATION OF ANTI-INFECTIVE AGENTS
The present invention relates to processes for the preparation of N-protected 4-((2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carb- ...
2019/0055215 ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY
The invention provides a compound of formula (I): ##STR00001## or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various...
2019/0055214 SIGNALING-BIASED MU OPIOID RECEPTOR AGONISTS
The invention provides--opioid receptor agonists that are analgesic agents and that promote diminished side effects relative to a comparably effective dose of...
2019/0055213 INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE
A compound of Formula I: ##STR00001## or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of...
2019/0055212 HISTONE DEMETHYLASE INHIBITORS
This disclosure relates to compounds that inhibit histone demethylase activity. In particular, the disclosure relates to compounds that inhibit histone lysine...
2019/0055211 INHIBITORS OF KRAS G12C MUTANT PROTEINS
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically...
2019/0055210 PHOTOCURING METHOD, COMPOUND AND COMPOSITION USED THEREIN
An object of the present invention is to provide a photocuring method, which makes it possible to rapidly and efficiently obtain a crosslinked product (resin),...
2019/0055209 BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATORS
This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
2019/0055208 MU OPIOID RECEPTOR MODULATORS
Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.
2019/0055207 Method for Producing Flutemetamol
Provided is a method for producing flutemetamol including the steps of: reacting a precursor compound represented by a predetermined general formula with a...
2019/0055206 POLYESTER RESIN COMPOSITION CONTAINING AMINO-TRIAZINE DERIVATIVE
A polyester resin composition containing 100 parts by mass of a polyester resin and 0.01 to 10 parts by mass of a 2-amino-1,3,5-triazine derivative of Formula...
2019/0055205 New Methods for 1,4-Diazo N-Heterocycle Synthesis
The present disclosure relates to novel synthetic method of making 1, 4-diazo N-heterocycles via intermolecular amphoteric diamination of allenes, and to the...
2019/0055204 COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF
Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of...
2019/0055203 POTENT DUAL BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS
Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are...
2019/0055202 PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR
The present disclosure provides pyrimidine compounds of Formula 1 and uses thereof for example, for the potential treatment of diseases associated with P2X...
2019/0055201 METHODS FOR PRODUCING OPTICALLY ACTIVE VALERIC ACID DERIVATIVES
A method for producing a compound (4), which comprises allowing a compound (1) to react with hydrogen gas in an inert solvent, in the presence of a specific...
2019/0055200 Catalytic Hydrogenation Process for Preparing Pyrazoles
The present invention relates to a catalytic process for preparing pyrazoles comprising the step of cyclizing hydrazone substituted .alpha.,.beta.-unsaturated...
2019/0055199 BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME
Provided is a compound showing excellent Antifungal activity against Trichophyton fungus, which is a major causative microorganism of superficial mycosis, and...
2019/0055198 PROLYL HYDROXYLASE INHIBITORS
Disclosed herein are prolyl hydroxylase inhibitors that can stabilize hypoxia inducible factor-1 alpha (HIF-1.alpha.), as well as hypoxia inducible factor-2...
2019/0055197 CRYSTALLINE MODIFICATIONS OF METHYL (3Z)-3-{[(4-{METHYL[(4-METHYLPIPERAZIN-1-YL)ACETYL]AMINO}PHENYL)AMINO](PH- ...
The present solution relates to crystalline modifications of methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](ph- ...
2019/0055196 NUCLEAR RECEPTOR MODULATORS
The invention provides compounds of Formula (I) ##STR00001## pharmaceutically acceptable salts, thereof wherein the variable are defined herein. The compounds of...
2019/0055195 Phenyl, bromo-maleimide as a coupling group for conjugation to sulfhydryl group
The invention pertains to the creation of two new classes of compounds, referred to as "phenyl, bromo-maleimide acids" and "Phenyl, bromo-maleimide amines",...
2019/0055194 Azetidinimines as Carbapenemases Inhibitors
The present application relates to novel azetidinimine of formula (I). Wherein R.sub.1-R.sub.6 are as defined in claim 1. The azetidinimine of the invention...
2019/0055192 SELECTIVE ANDROGEN RECEPTOR MODULATOR AND METHODS OF USE THEREOF
This invention provides substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject including, inter alia,...
2019/0055191 ADAMANTANE DERIVATIVE AND USE THEREOF
The present invention provides a pharmaceutical composition for treating or preventing a cognitive disease or disorder, containing a compound represented by...
2019/0055190 PEPTIDE NUCLEIC ACID (PNA) MONOMERS WITH AN ORTHOGONALLY PROTECTED ESTER MOIETY AND NOVEL INTERMEDIATES AND...
The present disclosure pertains to peptide nucleic acid (PNA) monomers and oligomers, as well as methods and compositions useful for the preparation of PNA...
2019/0055189 A PROCESS FOR PREPARING BETA AGONIST
Disclosed is a process for preparing .beta.-agonist, 1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino) ethanol, of Formula I. The process comprises refluxing...
2019/0055188 BACTERIAL EFFLUX PUMP INHIBITORS
Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds...
2019/0055187 AMINE-BASED COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
An amine-based compound represented by Formula 1, in which one of R.sub.1 to R.sub.10 is a group represented by Formula 2, and an organic light-emitting device...
2019/0055186 METHOD FOR EXTRACTING 1,5-PENTANEDIAMINE FROM SOLUTION SYSTEM CONTAINING 1,5-PENTANEDIAMINE SALT
Provided is a method for extracting a 1,5-pentanediamine from a solution system containing a 1,5-pentanediamine salt. The method comprises adding to the...
2019/0055185 TREATMENT METHOD OF COMPOSITION CONTAINING FLUORINE-CONTAINING ORGANIC ACID HAVING CARBON NUMBER OF 2 TO 7 AND...
A treatment method of at least partially removing impurities from a composition containing a fluorine-containing organic acid having the carbon number of 2 to...
2019/0055184 PROCESSES FOR PURIFYING ACETIC ACID AND HYDRATING ANHYDRIDE
Processes for purifying acetic acid by distilling a process stream in a column in which acetic anhydride is formed in the lower portion of the column. The...
2019/0055183 PROCESS TO PRODUCE ACETIC ACID WITH RECYCLE OF WATER
A process for producing acetic acid is disclosed in which the recycle ratio of the mass flow of the light liquid phase recycled to the reactor to the mass flow...
2019/0055182 ASYMMETRIC CATALYTIC DECARBOXYLATIVE ALKYL ALKYLATION USING LOW CATALYST CONCENTRATIONS AND A ROBUST PRECATALYST
This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers....
2019/0055181 Process For Preparing Spirogalbanone
A method of making spirogalbanone includes the steps of: (a) subjecting ethynylspirodecanol to a Rupe rearrangement to give a compound of the formula I ...
2019/0055180 BISPHENOL HAVING FLUORENE SKELETON, METHOD FOR PRODUCING SAME, POLYARYLATE RESIN, (METH)ACRYLATE COMPOUND AND...
Provided are a bisphenol represented by the general formula (1), a method for producing the bisphenol, and a polyarylate resin, a (meth)acrylate compound and...
2019/0055179 CYCLOPROPANE COMPOUND
Provided are a compound and a fragrance composition that are excellent in harmony with various other fragrance materials and can be blended to impart a natural...
2019/0055178 PROCESS FOR GENERATION OF OLEFINS
This disclosure relates to processes, compositions, and systems useful for the oxydehydrogenation of alkanes to form olefins (e.g., for the conversion of...
2019/0055177 ALKANE OXIDATIVE DEHYDROGENATION (ODH)
Processes and associated reaction systems for the oxidative dehydrogenation of an alkane containing 2 to 6 carbon atoms, preferably ethane or propane, more...
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