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Patent # Description
2019/0054212 CORE-CENTERED GRANULE COMPOSED OF MICRO-STRUCTURE BODY
A granule form e d from a tubular body having an outer surface and an inner surface separated by a matrix, and at least one core defining an opening extending...
2019/0054211 INTERPENETRATING POLYMER NETWORK HYDROGEL
An interpenetrating polymer network (IPN) structured hydrogel includes a crosslinked first natural polymer macromer with a first elasticity and an ...
2019/0054210 PRODUCING BONE TISSUE ENGINEERED CONSTRUCTS
A process for producing a bone construct, including the steps of providing a perfusion bioreactor having an inlet and an outlet; providing the perfusion...
2019/0054209 ARTIFICAL CORNEA STROMA MATERIAL, AND ARTIFICAL CORNEA STROMA AND ARTIFICAL CORNEA SCAFFOLD OF SUCH MATERIAL
An artificial cornea stroma material comprises a methacrylated hyaluronic acid, a collagen, a photo-initiator, and a solvent. Ultraviolet radiation of the...
2019/0054208 COLLAGEN-BASED MENISCUS IMPLANTS
A method for producing a collagen meniscus implant by obtaining a freshly excised non-human meniscus, rinsing it in an aqueous solution, drying the rinsed...
2019/0054207 HYDROGELS WITH DYNAMICALLY ADJUSTABLE MECHANICAL PROPERTIES
A composition includes a dual crosslinkable hydrogel that includes a plurality of polymer macromers, which are crosslinked with a first agent and a second...
2019/0054206 BIOACTIVE AGENT SPATIAL PATTERNED BIODEGRADABLE HYDROGELS
A method for forming a bioactive agent spatially patterned includes providing a photocrosslinkable hydrogel that includes a photocrosslinkable base polymer,...
2019/0054205 BIOPOLYMER COMPOSITIONS, SCAFFOLDS AND DEVICES
Compositions and blends of biopolymers and copolymers are described, along with their use to prepare biocompatible scaffolds and surgically implantable devices...
2019/0054204 PHOTOCROSSLINKED POLYMERS FOR ENHANCED DURABILITY
A block copolymer including a plurality of polymeric chains and a plurality of cross-linking compound residues linking together the plurality of polymeric...
2019/0054203 HEMOSTATIC MIXTURE OF CELLULOSE-BASED SHORT AND LONG FIBERS
The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.
2019/0054202 ANTI-MICROBIAL ARTICLES AND METHODS OF USING SAME
An article having anti-microbial effect is provided. The article includes an occlusive layer; a substrate having two opposing major surfaces, wherein one...
2019/0054201 FLOWING FLUID DISINFECTION METHOD AND DISINFECTOR
A method for disinfecting a fluid includes emitting UV light into a flowing fluid pillar along its axial direction. The flowing fluid pillar is surrounded by...
2019/0054200 HOUSEHOLD PRODUCT DELIVERING WARMING AND/OR TINGLING SENSATIONS
A household product includes a fragrance composition. The fragrance composition includes a chemaesthethic agent selected from: vanillyl ethyl ether, vanillyl...
2019/0054199 GAS DELIVERY SYSTEM AND METHOD OF SANITIZING THE GAS FLOW PATH WITHIN A GAS DELIVERY SYSTEM
A gas delivery system (50) for delivering a flow of breathing gas to a patient (54) includes a blower assembly (100) structured to generate the flow of...
2019/0054198 CATALYTIC RADIOFLUORINATION
One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a...
2019/0054197 RADIOLABELED MACROCYCLIC EGFR INHIBITOR
The present invention relates to 18-Fluor radiolabeled macrocyclic quinazoline compounds, which are suitable as positron emission tomography (PET) tracers for...
2019/0054196 MRI AND CT CONTRAST-ENABLED COMPOSITE IMPLANTS FOR IMAGE-GUIDED TISSUE REGENERATION AND THERAPY
A composite implant for providing simultaneous magnetic resonance imaging (MRI) and computed tomographic (CT) imaging contrast is disclosed. The composite...
2019/0054195 MIRNA PROFILING COMPOSITIONS AND METHODS OF USE
Disclosed herein is a nanosensor of miRNA activity in a target cell, and methods of use, for detection and diagnostic applications. The nanosensor comprises a...
2019/0054194 System and Method For Evaluation of Subjects Using Magnetic Resonance Imaging and Oxygen-17
A system and method for evaluating subjects using MRI and a contrast agent that overcomes the low sensitivity nature of previous detection methods is provided...
2019/0054193 ACTIVITY BASED PROBE AND USES THEREOF FOR IMAGING
Provided is a compound including at least one carrier moiety associated with a plurality of CT imaging moieties, and with at least one enzyme interacting...
2019/0054192 ISOLATION OF EXTRACELLULAR VESICLES (EVs) FROM RED BLOOD CELLS FOR GENE THERAPY
A method of RNA delivery using extracellular vesicles (EVs) derived from red blood cells (RBCs). The method comprises the purification and electroporation of...
2019/0054191 SYNP161, A PROMOTER FOR THE SPECIFIC EXPRESSION OF GENES IN ROD PHOTORECEPTORS
The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid...
2019/0054190 METHODS FOR THE TREATMENT OF DANON DISEASE AND OTHER DISORDERS OF AUTOPHAGY
This disclosure provides gene therapy vectors comprising a polynucleotide encoding one or more isoforms of lysosome-associated membrane protein 2 (LAMP-2), and...
2019/0054189 RNA CONTAINING COMPOSITION FOR TREATMENT OF TUMOR DISEASES
The present invention relates to RNA containing compositions for use in the treatment or prophylaxis of tumor and/or cancer diseases, to a pharmaceutical...
2019/0054188 ADENO-ASSOCIATED VIRUS (AAV) CLADES, SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR
Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such...
2019/0054187 DRUG DELIVERY POLYMERS AND USES THEREOF
Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as...
2019/0054186 Magnetic Nanoparticle-Polymer Complexes and uses Thereof
The present invention relates to magnetic nanoparticles coated with block copolymers. The invention further relates to methods of increasing cellular uptake of...
2019/0054185 USE OF NANO-SIZED CLAY CRYSTALLITES TO RESTORE ADHESION AMONG TUMOR AND AGING STEM CELLS
A method for enhancing or restoring adhesion to cells that have partially or completely loss the ability to adhere to a substrate or other cells using...
2019/0054184 Targeting Macrophages to Modulate Electrical Conduction in the Heart
Compositions comprising a macrophage-targeted carrier and one or more therapeutic agents that modulate cardiac conductance, and methods of using the same for...
2019/0054183 Compositions and Methods for Targeted Delivery of Therapeutic and/or Diagnostic Agents
In one aspect, methods of targeted nanoparticle and cell delivery are described herein. In some embodiments, methods described herein comprise coupling...
2019/0054182 TRISPECIFIC AND/OR TRIVALENT BINDING PROTEINS FOR PREVENTION OR TREATMENT OF HIV INFECTION
Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding...
2019/0054181 FAP-ACTIVATED PROTEASOME INHIBITORS FOR TREATING SOLID TUMORS
Disclosed are proteasome inhibitors, fibroblast activation protein (FAP)-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of...
2019/0054180 GENE/CARRIER COMPLEX FOR PREVENTING OR TREATING INFLAMMATORY DISEASES
Disclosed is a gene/carrier complex for preventing or treating inflammatory diseases, including tumor necrosis factor-.alpha. converting enzyme (TNF-.alpha....
2019/0054179 NOVEL PHARMACEUTICAL COMPOSITION CONTAINING HYDROXAMIC ACID DERIVATIVE OR SALT THEREOF
This pharmaceutical composition contains a hvdroxamic acid derivative, or a salt thereof, and a solubilizer, said hydroxamic acid derivative being selected...
2019/0054178 PHARMACEUTICAL COMPOSITION AND METHODS OF USES
The present invention provides compositions or formulations comprising the combination of a compound of ...
2019/0054177 PEPTIDE SLOW-RELEASE FORMULATIONS
A composition for the delayed delivery of a peptide active agent comprising: i) a salt of said peptide active agent comprising at least one positively charged...
2019/0054176 COMPOSITIONS OF THERAPEUTIC SUBSTANCES, METHODS AND USES THEREOF
Provided is a composition for oral administration which includes a lipophilic active substance and a phospholipid, providing a prolonged therapeutic effect.
2019/0054175 EXCIPIENT COMPOUNDS FOR PROTEIN PROCESSING
Disclosed herein are methods for improving a parameter of a protein-related process comprising providing a viscosity-reducing excipient compound selected from...
2019/0054174 NANOPARTICLES OF INDIRUBIN, DERIVATIVES THEREOF AND METHODS OF MAKING AND USING SAME
The disclosure provides nanoparticles of indirubin and methods of making and using these particles for the treatment of cancer, neurodegenerative disorders and...
2019/0054173 COMPOSITIONS FOR PHOTODYNAMIC THERAPY AND FLUORESCENCE DIAGNOSIS OF CANCERS AND OTHER DISEASES
The invention relates to pharmaceutical compositions comprising a conjugate of a porphyrin (e.g., PpIX) and a recombinant protein. The pharmaceutical...
2019/0054172 SYSTEM FOR THERMOTHERAPY TREATMENT OR PREVENTION OF ANTIMICROBIAL RESISTANT OR BIOFILM INFECTIONS
The system comprises a support to receive a nanoparticle assembly (NPA) and to be conveyed towards a localized area of an organism infected or at risk to be...
2019/0054171 FORMULATION OF HUMAN ANTIBODIES FOR TREATING TNF-ALPHA ASSOCIATED DISORDERS
A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability.
2019/0054170 MULTISPECIFIC ANTIBODIES FOR USE IN THE TREATMENT OF A NEOPLASM OF THE URINARY TRACT
The present invention provides a multispecific antibody, or an antigen binding fragment thereof, for use in the treatment of a neoplasm of the urinary tract,...
2019/0054169 STABLE ANTI-OSMR ANTIBODY FORMULATION
The present invention provides, among other things, stable formulations comprising an anti-oncostatin M receptor (OSMR) antibody and having a pH ranging from...
2019/0054168 IMMUNOGENIC PEPTIDE COMPOSITION AND METHOD
Immunogenic influenza hemagglutinin-derived peptide compositions described herein induce a specific therapeutic antibody response against influenza virus. The...
2019/0054167 METHOD FOR TREATING RHEUMATOID ARTHRITIS WITH A HUMAN IL-6 RECEPTOR ANTIBODY AND METHOTREXATE
A pharmaceutical composition for the treatment of interleukin-6 (IL-6) related diseases, comprising an interleukin-6 antagonist (IL-6 antagonist) and...
2019/0054166 NANOPARTICLES, CONTROLLED-RELEASE DOSAGE FORMS, AND METHODS FOR DELIVERING AN IMMUNOTHERAPEUTIC AGENT
The present disclosure relates to nanoparticles, controlled-release dosage forms, and methods for the administration of an immunotherapeutic agent.
2019/0054165 COMPOSITIONS COMPRISING HUMAN MILK OLIGOSACCHARIDES FOR USE IN INFANTS OR YOUNG CHILDREN TO PREVENT OR TREAT...
The present invention relates to a nutritional composition comprising at least one fucosylated oligosaccharide and at least one N-acetylated oligosaccharide,...
2019/0054164 VACCINATION IN NEWBORNS AND INFANTS
The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in newborns and/or...
2019/0054163 NOVEL INFLUENZA ANTIGENS
The present invention relates to novel influenza antigens, novel immunogenic or vaccine compositions, as well as to uses of and to methods for producing said...
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