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Patent # Description
2019/0076551 MATERIALS AND METHODS FOR TREATMENT OF HEREDITARY HAEMOCHROMATOSIS
Materials and methods for treating a patient with hereditary hemochromatosis (HHC), both ex vivo and in vivo, and materials and methods for modulating the...
2019/0076550 GENE THERAPY FOR TREATING HEMOPHILIA B
Compositions and regimens useful in treating hemophilia B are provided. The method involves administering to the human subject via a peripheral vein by...
2019/0076549 COMBINATIONS OF PBD-BASED ANTIBODY DRUG CONJUGATES WITH BCL-2 INHIBITORS
This invention relates to treatment of cancer using antibody drug conjugates that comprise PBD molecules in combination with Bcl-2 inhibitors.
2019/0076548 COMPOSITIONS AND METHODS FOR THE DEPLETION OF CD137+ CELLS
The invention provides methods of preventing and treating graft-versus-host-disease and autoimmune diseases, such as those arising from transplant therapy, by...
2019/0076547 ANTIBODY ADJUVANT CONJUGATES
The invention provides an immunoconjugate comprising an antibody construct which includes an antigen binding domain and an Fc domain, an adjuvant moiety, and a...
2019/0076546 ENHANCED ACTIVE AGENTS
The teachings provide active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents....
2019/0076545 COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER
Conventional cancer immunotherapy falls short at efficiently expanding T cells that specifically target cancerous cells in numbers sufficient to significantly...
2019/0076544 FORMULATIONS FOR IMPROVING THE EFFICACY OF HYDROPHOBIC DRUGS
Novel amphiphilic peptide, peptide amphiphile lipid micelles, processes for making peptide amphiphile lipid micelles comprising an amphiphilic peptide and...
2019/0076543 Method of treating cancer by using siRNA nanocomplexes
The present invention is related to a method for treating cancer by using siRNA nanocomplexes. The present nanocomplex consists of a nucleic acid molecule, a...
2019/0076542 C3-CARBON LINKED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a...
2019/0076541 HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) ("Degrons"), which can be used as is or linked to...
2019/0076540 SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting...
2019/0076539 AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
This invention provides amine-linked C.sup.3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use...
2019/0076538 CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY
Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a...
2019/0076537 COMPOSITIONS FOR TREATMENT OF CANCER, METHODS AND SYSTEMS FOR FORMING THE SAME
Solutions having a solvent and a cold atmospheric plasma dissolved in the solvent are described. Methods and systems of forming cold atmospheric plasma...
2019/0076536 PHARMACEUTICAL COMPOSITIONS FOR GASTROINTESTINAL DRUG DELIVERY
A novel pharmaceutical composition, which comprises a therapeutically effective amount of active principle(s) or a pharmaceutically acceptable salt or...
2019/0076535 CROSSLINKED PROTEIN-POLYSACCHARIDE COMPLEXED CONSUMABLE MACROCAPSULE
A consumable macromolecular article of manufacture formed by the complexation of protein and polysaccharide polymers stabilized by chemical or physical...
2019/0076534 PRESERVED COMPOSITIONS CONTAINING HYALURONIC ACID OR A PHARMACEUTICALLY-ACCEPTABLE SALT THEREOF AND RELATED METHODS
The invention provides a composition containing hyaluronic acid (HA) or a pharmaceutically-acceptable salt thereof preserved with a cationic preservative and...
2019/0076533 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
Bolaamphiphilic compounds are provided according to formula I: HG.sup.2-L.sup.1-HG.sup.1 I where HG.sup.1, HG.sup.2 and L.sup.1 are as defined herein. Provided ...
2019/0076532 FORMULATION FOR ANTI-ALPHA4BETA7 ANTIBODY
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-.alpha.4.beta.7 antibody and at least one amino acid. The disclosed...
2019/0076531 COMPOSITIONS AND METHODS FOR TREATING DISEASES OF THE NAIL
Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are...
2019/0076530 HIGH CAPACITY DIKETOPIPERAZINE MICROPARTICLES AND METHODS
Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine ...
2019/0076529 PROSTAGLANDIN COMPOSITIONS AND METHODS FOR THE TREATMENT OF VASOSPASM
Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the...
2019/0076528 METHOD FOR TREATING CANCER
The present invention relates to a method for the treatment of cancer in a subject which comprises the steps of: (i) administering electroporation to a tumour...
2019/0076527 GLUTAMINE-HIGH Z ELEMENT COMPOUNDS FOR TREATING CANCER
The present invention is a glutamine compound having a non-radioisotope high Z element attached via a linker, which enters the mitochondrion and is...
2019/0076526 UPCONVERSION NANOPARTICLE, HYALURONIC ACID-UPCONVERSION NANOPARTICLE CONJUGATE, AND A PRODUCTION METHOD THEREOF...
An upconversion nanoparticle includes at least one host selected from LiYF.sub.4, NaY, NaYF.sub.4, NaGdF.sub.4, and CaF.sub.3, at least one sensitizer selected...
2019/0076525 THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER
The present invention generally provides a therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, in particular...
2019/0076524 CONSTRAINED CONDITIONALLY ACTIVATED BINDING PROTEINS
The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure...
2019/0076523 TREATMENT OF SEVERE COMMUNITY ACQUIRED PNEUMONIA
The present invention provides for a new therapeutic tools capable of treating infectious diseases, in particular, a new pharmaceutical composition comprising...
2019/0076522 METHODS FOR PROVIDING POLYMERIC SYNTHETIC NANOCARRIERS FOR GENERATING ANTIGEN-SPECIFIC TOLERANCE IMMUNE RESPONSES
Disclosed are synthetic nanocarrier compositions that provide controlled release of immunosuppressants as well as related methods. The synthetic nanocarrier...
2019/0076521 SOYBEAN ALLERGY ANTIGEN
The present invention provides novel antigens of an allergy to soybean, methods and kits for diagnosing an allergy to soybean, pharmaceutical compositions...
2019/0076520 VACCINES AND IMMUNOTHERAPEUTICS USING IL-28 AND COMPOSITIONS AND METHODS OF USING
Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination...
2019/0076519 IMMUNOGENIC RHINOVIRUS PEPTIDES
Fusion proteins comprising a carrier protein and a Human Rhinovirus (HRV) peptide, and immunogenic compositions containing such fusion proteins.
2019/0076518 Composition for Oral or Nasal Delivery of Tetanus, Diphtheria, and Pertussis Vaccine alone or in combination...
The present invention describes a neurotoxin associated protein from botulinum neurotoxin complex used as an oral or nasal delivery system for a vaccine. The...
2019/0076517 PRODUCTION OF RECOMBINANT VACCINE IN E.COLI BY ENZYMATIC CONJUGATION
Provided herein are prokaryotic cells proficient to produce glycoconjugates in vivo, as well as methods for generating these cell and methods of using these...
2019/0076516 IMMUNOGENIC COMPOSITION FOR USE IN VACCINATION AGAINST STAPHYLOCOCCI
The present application relates to immunogenic compositions comprising a mixture of staphylococcal antigens which combines antigen having different functions,...
2019/0076515 ANTI-ICOS AGONIST ANTIBODIES AND USES THEREOF
The present invention provides isolated monoclonal antibodies (e.g., humanized and human monoclonal antibodies) that bind to human Inducible T Cell...
2019/0076514 Novel peptides and combination of peptides for use in immunotherapy against NHL and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0076513 Novel peptides and combination of peptides for use in immunotherapy against NHL and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0076512 METHODS AND KITS FOR USE IN PREVENTING AND TREATING VULVOVAGINAL CANDIDIASIS
The invention features methods and kits use in for preventing and treating vulvovaginal candidiasis (VVC), in particular, recurrent VVC.
2019/0076511 TREATMENT OF IMMUNE DISEASE BY MUCOSAL DELIVERY OF ANTIGENS USING GENETICALLY MODIFIED LACTOCOCCUS
The present invention relates to the treatment of autoimmune and allergic diseases by mucosal delivery by micro-organism, in particular Lactococcus lactic, of...
2019/0076510 PROTEIN KINASE C INHIBITION TO EXTEND TISSUE PLASMINOGEN ACTIVATOR TREATMENT FOR ISCHEMIC DISEASE
The disclosure provides methods for extending the time post-ischemia during which a tissue plasminogen activator compound can be efficaciously and safely...
2019/0076509 PREVENTION AND/OR TREATMENT OF ISCHEMIA OR ISCHEMIA/REPERFUSION INJURY
The present invention relates to pharmaceutical compositions comprising a compound selected from the group consisting of: a) a polypeptide of SEQ ID NO:1, b) a...
2019/0076508 LYSOSOMAL ACID LIPASE AND PPAR GAMMA LIGANDS AS IMMUNE THERAPIES FOR CANCER TREATMENT
Methods of cancer treatment are disclosed. Particularly, disclosed herein are methods of administering LAL and PPAR.gamma. ligands for treating various cancer...
2019/0076507 Artificial Red Blood Cell Having Ability to Inhibit Conversion of Hemoglobin into Methemoglobin
Disclosed is an artificial red blood cell containing purified and enriched hemoglobin that substantially has no enzymatic activity to reduce methemoglobin,...
2019/0076506 ACYLATED GLUCAGON ANALOGUES
The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes and associated metabolic...
2019/0076505 IMMUNITY INDUCER
The present invention addresses the problem of finding a novel peptide useful as an active ingredient in an agent for treating or preventing cancer, and to...
2019/0076504 COMPOSITIONS, ASSAYS, AND METHODS FOR TARGETING HDM2 AND HDMX TO REVERSE THE INHIBITION OF p53 IN PEDIATRIC CANCERS
Methods for assessing the efficacy of internally cross-linked p53 transactivation domain-based inhibitor peptides in the treatment of pediatric cancer and...
2019/0076503 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING CANCER OR CANCER METASTASIS, CONTAINING FSTL1 PROTEIN AS...
The present invention relates to a pharmaceutical composition for preventing and treating cancer, cancer metastasis and bone metabolic diseases, which...
2019/0076502 MEDICAL USE OF CREG PROTEIN
The present invention relates to a medical use of Cellular Repressor of E1A-stimulated Genes (CREG), in particular to a use of CREG protein or active fragment...
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