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Patent # Description
2019/0076400 OPIOID AGONIST PEPTIDES AND USES THEREOF
The invention is directed to opioid agonist peptides and their use.
2019/0076399 DETECTION AND TREATMENT OF ANTI-PD-1 THERAPY RESISTANT METASTATIC MELANOMAS
Methods of predicting or detecting sensitivity to therapeutic effects of anti-PD-1 therapy in a patient suffering from melanoma, as well as for selecting...
2019/0076398 MU OPIOID RECEPTOR MODULATORS
Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.
2019/0076397 Inhibited Expression of PD-L1 and Enhanced Expression of PD-1
Processes for decreasing expression of a CD274 gene and/or a PD-L1 protein and increasing expression of a PDCD1 gene and/or a PD-1 protein in a subject in need...
2019/0076396 FORMULATION OF RESINIFERATOXIN
Disclosed herein are safer formulations of resiniferatoxin (RTX) for intrathecal, intraganglionic intraarticular and pericardial administration. More...
2019/0076395 METHODS OF TREATING OR REDUCING THE RISK OF CARDIOVASCULAR EVENTS AND RELATED DISEASES USING SGLT-2 INHIBITORS
The present invention relates to the use of certain SGLT-2 inhibitors, such as ertugliflozin or a pharmaceutically acceptable salt or a co-crystal thereof, for...
2019/0076394 Therapeutics for Malaria
The present disclosure describes a composition and method for treating and preventing malaria. The disclosure describes a peroxybioflavonoid composition...
2019/0076393 Methods and Compositions for the Inhibition of the Expression of PD-L1 in Tumor Cells
Processes for decreasing expression of a CD274 gene and/or a PD-L1 protein in a subject in need of such expression changes are provided. The processes include...
2019/0076392 METHODS FOR TREATING CANCER
Methods of treating cancer using and kits comprising at least one gemcitabine, at least one nab-paclitaxel, and at least one compound of formula (I). ...
2019/0076391 Methods of Subtyping CRC and their association with Treatment of Colon Cancer Patients With Oxaliplatin
A gene expression signature identifies stage II colon and/or Stage III cancer patients who will receive benefit from oxaliplatin. Oxaliplatin has been shown to...
2019/0076390 Methods of Reducing Apolipoprotein C-III
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of...
2019/0076389 METHODS OF REDUCING THE RISK OF A CARDIOVASCULAR EVENT IN A SUBJECT ON STATIN THERAPY
In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in...
2019/0076388 METHODS OF REDUCING THE RISK OF A CARDIOVASCULAR EVENT IN A SUBJECT ON STATIN THERAPY
In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in...
2019/0076387 COMPOSITION AND METHOD FOR TREATMENT OF NEURODEGENERATIVE DISEASES
The present invention, in embodiments, is a composition and method of treatment using a composition that includes: a first component comprising: 75 to 97...
2019/0076386 TREATMENT OF UREA CYCLE DISORDERS IN NEONATES AND INFANTS
Nitrogen scavenging drugs such as glycerol phenylbutyrate can be administered safely to infants and toddlers with urea cycle disorders by adjusting the dosage...
2019/0076385 METHODS AND COMPOSITIONS FOR TREATING CANCER
Methods for treating cancer are disclosed which comprise administering to a subject T cells which have been pretreated ex vivo or in vitro with a fatty acid...
2019/0076384 METHODS FOR TREATING UREA CYCLE DISORDERS
Provided are methods of administering glycerol phenylbutyrate to a patient in need thereof, wherein said patient is also being treated with a CYP3A4 substrate...
2019/0076383 METHODS FOR TREATING UREA CYCLE DISORDERS
Provided are methods of administering glycerol phenylbutyrate to a patient in need thereof, wherein said patient is also being treated with a CYP3A4 substrate...
2019/0076382 Targeted Treatment Of Anerobic Cancer
The present invention relates to a pharmaceutical cocktail and methods of cancer treatment. In particular, one such cocktail comprises a combination of...
2019/0076381 Method of and Improved Composition for Treating Triterpene-Responsive Conditions, Diseases or Disorders
A method of treating a triterpene-responsive condition, disease or disorder in a subject by administration of an improved triterpene-based composition is...
2019/0076380 Biguanide Compositions and Methods of Treating Metabolic Disorders
Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by...
2019/0076379 METHODS OF TREATING BREAST CANCER
Methods of regulating disorders and diseases in cells expressing .beta.2-adrenergic receptor (AR), cannabinoid (CB) receptor and epidermal growth factor...
2019/0076378 METHODS OF USING DIPIVEFRIN
The disclosure provides a method for systemic delivery of a therapeutically effective amount of epinephrine to a subject comprising orally administering...
2019/0076377 ORGANOSULFUR COMPOUNDS FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES
Divalent salts of S-allylmercapto-N-acetylcysteine and related compositions are disclosed which can be administered in order to provide protection from the...
2019/0076376 METHODS FOR TREATING MUCOPOLYSACCHARIDOSIS
The present invention provides methods and compositions for the treatment of mucopolysaccharidoses (MPS).
2019/0076375 METHOD FOR TREATING BRAIN ATROPHY
The invention pertains to the use of therapeutically effective amounts of (i) one or more of uridine and cytidine, or salts, phosphates, acyl derivatives or...
2019/0076374 ABUSE AND MISUSE DETERRENT TRANSDERMAL SYSTEMS
An abuse deterrent and misuse deterrent transdermal patch comprising aversive agents incorporated in the backing layer of the patch. The aversive agents can...
2019/0076373 INJECTABLE PREFORMED MACROSCOPIC 3-DIMENSIONAL SCAFFOLDS FOR MINIMALLY INVASIVE ADMINISTRATION
The invention provides polymer compositions for cell and drug delivery.
2019/0076372 DEVICE AND METHOD FOR FORMULATING PARTICLES AT SMALL VOLUMES
Methods and devices for making particles at small volumes.
2019/0076371 MAGNETIC FIELD-CONTROLLED MICROROBOT FOR CARRYING AND DELIVERING TARGETED CELLS
Magnetically driven biocompatible microrobots comprising a porous body having a magnetic layer and a biocompatible layer configured to carry and deliver cells...
2019/0076369 TIMED, PULSATILE RELEASE SYSTEMS
A unit multiparticulate dosage form for delivering one or more basic, active pharmaceutical ingredients into the body in need of such medications to achieve...
2019/0076368 PROLONGED RELEASE PHARMACEUTICAL COMPOSITION COMPRISING CYSTEAMINE OR SALT THEREOF
A prolonged release multiple unit dosage form, preferably pellets, of cysteamine, cystamine or a pharmaceutically acceptable salt thereof, preferably...
2019/0076367 ABUSE DETERRENT FORMULATIONS OF AMPHETAMINE
The present invention relates generally to abuse-deterrent formulations containing dextroamphetamine sulfate.
2019/0076366 PHARMACEUTICAL COMPOSITION OF ENTECAVIR AND PROCESS OF MANUFACTURING
The present invention relates to an adhesive-free pharmaceutical composition for the treatment of hepatitis B virus infections, comprising at least one...
2019/0076365 TABLET
Provided is a tablet which can be easily pinched even for an elderly person or a patient who has a limited range of joint motion, and which is hard to roll...
2019/0076364 METFORMIN HYDROCHLORIDE OSMOTIC PUMP TABLET AND PREPARATION METHOD THEREFOR
Provided are a metformin hydrochloride osmotic pump tablet and a preparation method therefor. According to the preparation method, a hetero-type...
2019/0076363 CONTROLLED RELEASE DELIVERY DEVICE COMPRISING AN ORGANOSOL COAT
A controlled release delivery device for controlled release of an active ingredient comprising: (i) a core particle comprising the active ingredient...
2019/0076362 Treatments and Formulations Comprising Torsemide
Disclosed herein are treatments for diseases such as hypertension, diabetes, and congestive heart failure using controlled-release (CR, e.g., extended-release...
2019/0076361 METHOD FOR PRODUCING PARTICLES
A method for producing particles, the method including: applying vibration to a liquid including a physiologically active substance and included in a...
2019/0076360 Method of Production of Inhalable Composite Particles using a Three-Fluid Nozzle
A method of preparing a pharmaceutical formulation which is suitable for inhalation, the method comprising: providing a solution comprising a first solvent or...
2019/0076359 FUMARATE POLYMERSOMES
The present invention relates to fumarate polymersomes. The polymersomes are capable of targeting immune cells and then hydrolysing to release the ...
2019/0076358 BIODEGRADABLE COMPOUND, LIPID PARTICLE, COMPOSITION CONTAINING LIPID PARTICLE, AND KIT
The compound according to the present embodiment is represented by the following formula (1): Q-L--CHR.sub.2 (1) (wherein, Q is a non-cationic aliphatic group...
2019/0076357 LIPOSOMAL PACLITAXEL PALMITATE FORMULATION AND PREPARATION METHOD THEREOF
A liposomal paclitaxel palmitate formulation, including: 0.1-1% (w/v) of a paclitaxel palmitate; 1-10% (w/v) of a lecithin; 0.05-1.0% (w/v) of distearoyl...
2019/0076356 Dicarboxylic Acid Foamable Vehicle and Pharmaceutical Compositions Thereof
The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a...
2019/0076355 METHODS AND SYSTEMS FOR FORMING STABLE DROPLETS
The present disclosure provides methods and systems for forming stable droplets as part of an emulsion. The emulsion may be, for example, formed by bringing an...
2019/0076354 OPHTHALMIC PREPARATIONS
The present invention provides ophthalmic formulations containing cyclosporine, methods for preparing the formulation, and methods for using the formulation.
2019/0076353 PROCESS FOR MAKING CONTROLLED RELEASE MEDICAL IMPLANT AND NON-IMPLANT PRODUCTS
A multi-step method of making a mammalian subcutaneous medical implant or non-implant for releasing self-contained drugs on a controlled basis over at least a...
2019/0076352 MEDROXYPROGESTERONE ACETATE INJECTABLE COMPOSITIONS AND METHODS OF USE
The disclosure is directed to medroxyprogesterone compositions suitable for subcutaneous injection comprising about 360 mg/ml to 440 mg/ml medroxyprogesterone...
2019/0076351 Prebiotic Oral Care Compositions Containing Amino Acids
The present invention provides an oral care composition comprising: (a) a dipeptide of the formula Xaa1-Xaa2 or Xaa2-Xaa1; wherein Xaa1 is an amino acid with a...
2019/0076350 COCONUT SHELL EXTRACTS, COMPOSITIONS CONTAINING SAME AND USES
A coconut shell extract characterized by a particular level of trans-piceatanol and cosmetic and/or dermatological compositions comprising the coconut shell...
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