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Patent # Description
2019/0111090 BIFIDOBACTERIUM LONGUM FOR TREATING OBESITY AND ASSOCIATED METABOLIC DISORDERS
Bifidobacterium longum AH1362 (NCIMB 41715) produces a polysaccharide and increases energy excretion. The strain is used in the prevention or treatment of...
2019/0111089 Method and System for Repairing Damaged Tissue Using Nucleated Plasma Particles (Nuc-P2s) and Mesodermal Stem...
The current invention is a method and system for optimally isolating adult derived stem cells from whole blood and reintroducing the adult derived stem cells...
2019/0111088 Amniotic Membrane Hydrogel and Methods of Making
The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic...
2019/0111087 XENOGRAFT SOFT TISSUE IMPLANTS AND METHODS OF MAKING
The present application is directed to the field of implants comprising soft tissue for use in implantation in humans. The soft tissue implants of the present...
2019/0111086 METHODS AND COMPOSITIONS FOR GENERATING CHONDROCYTE LINEAGE CELLS AND/OR CARTILAGE LIKE TISSUE
A method for generating chondrocytes and/or cartilage, optionally articular like non-hypertrophic chondrocyte cells and/or cartilage like tissue and/or...
2019/0111085 ENHANCED STEM CELL COMPOSITION
The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and...
2019/0111084 METHOD FOR REMOLDING BONE MARROW MICROENVIRONMENT
The present invention discloses a method for remolding bone marrow microenvironment in a subject having an impaired bone marrow microenvironment, which...
2019/0111083 IMPROVEMENT IN MUSCLE FUNCTIONALITY OF ELDERLY MALES
A composition comprising a protein source and an antioxidant, optionally in combination with an omega-3 fatty acid, can treat or prevent sarcopenia in elderly...
2019/0111082 INTRACELLULAR DELIVERY OF BIOMOLECULES TO INDUCE TOLERANCE
The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an...
2019/0111081 NOVEL PEPTIDES AND SCAFFOLDS FOR USE IN IMMUNOTHERAPY AGAINST HEAD AND NECK SQUAMOUS CELL CARCINOMA AND OTHER...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0111080 POLYPEPTIDE COMPOSITIONS COMPRISING SPACERS
Disclosed herein are methods and compositions including antigen-binding polypeptides comprising a stalk region and a stalk extension region. In some cases, the...
2019/0111079 MULTI-SPECIFIC ANTIGEN-BINDING CONSTRUCTS TARGETING IMMUNOTHERAPEUTICS
Multi-specific antigen-binding constructs that target immunotherapeutics are described. The multi-specific antigen-binding constructs comprise a first...
2019/0111078 PRETREATMENT DRUG FOR T CELL INFUSION THERAPY FOR IMMUNE-CHECKPOINT INHIBITOR-RESISTANT TUMOR
An antigen-loaded nanogel is formed by loading or encapsulating one or more long peptide antigens or one or more protein antigens in a hydrophobized...
2019/0111077 LHRH-Platinum Conjugates for Treating Reproductive Cancers
The conjugation of luteinizing hormone-releasing hormone (LHRH) with activated cisplatin using a malonate linker gives rise to a new Platinum-LHRH conjugate...
2019/0111076 METHOD FOR SYNTHESIZING HIGH-PURITY MONTMORILLONITE
A method for synthesizing high purity montmorillonite is disclosed. According to this synthesis method, bentonite is dissolved in aqua regia to produce a...
2019/0111075 STORAGE-STABLE OPHTHALMIC COMPOSITION
The present invention relates to a drop-forming, storage stable, multiphase, ophthalmic composition comprising at least one liquid aqueous phase and at least...
2019/0111074 TREATMENT OF PRIMARY CILIARY DYSKINESIA WITH SYNTHETIC MESSENGER RNA
Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively...
2019/0111073 NUCLEIC ACID MOLECULE FOR REDUCTION OF PAPD5 AND PAPD7 mRNA FOR TREATING HEPATITIS B INFECTION
The present invention relates to nucleic acid molecules that are complementary to both PAP associated domain containing 5 (PAPD5) and PAP associated domain...
2019/0111072 TRANS-SPLICING RNA (tsRNA)
The invention concerns a trans-splicing RNA (tsRNA) molecule comprising one or multiple unstructured binding domains; a cell or vector comprising said tsRNA;...
2019/0111071 METHOD FOR PROMOTING MUSCLE REGENERATION
The invention solves the problem of providing new therapies that are effective in the treatment of muscular dystrophies through the use of compositions...
2019/0111070 METABOLICALLY STABILIZED DOUBLE STRANDED mRNA
Double stranded mRNA. e.g., produced in vitro, as well as method of making and using the ds mRNA, are provided.
2019/0111069 Adenosine Receptor Modulators for the Treatment of Circadian Rhythm Disorders
The present invention relates to the use of adenosine receptor modulators to affect the circadian rhythm, in particular, to the use of such modulators for the...
2019/0111068 COMBINATION FORMULATION OF TWO ANTIVIRAL COMPOUNDS
Disclosed are pharmaceutical compositions having an effective amount of substantially amorphous ledipasvir and an effective amount of substantially crystalline...
2019/0111067 ANTIMICROBIAL COMBINATIONS AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTION
The present invention relates to the use of one or more compounds selected from the following: carvacrol, thymol, curcumin and piperidine, in combination with...
2019/0111066 SALTS OF PRODRUGS OF PIPERAZINE AND SUBSTITUTED PIPERIDINE ANTIVIRAL AGENTS
This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. ##STR00001## wherein: X is C or N...
2019/0111065 NERIDRONIC ACID FOR TREATING COMPLEX REGIONAL PAIN SYNDROME
Oral dosage forms of osteoclast inhibitors, such as neridronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions,...
2019/0111064 STATIN + VITAMIN D COMBINATION DRUG AND METHOD OF USE
A pharmaceutical composition and method reduces statin-related side effects, including myalgia, myositis, myopathy, and myonecrosis. The composition comprises...
2019/0111063 FORMULATIONS AND METHODS FOR PROVIDING PROGESTIN-ONLY CONTRACEPTION WHILE MINIMIZING ADVERSE SIDE EFFECTS...
Formulations and methods for providing progestin-only contraception to a woman while minimizing various side effects, such as breakthrough bleeding, that are...
2019/0111062 DOSING REGIMEN FOR SEDATION WITH CNS 7056 (REMIMAZOLAM)
The invention relates to a dosing regimen for sedation with the fast-acting benzodiazepine CNS 7056 in combination with an opioid, in particular fentanyl,...
2019/0111061 COMPOSITIONS AND METHODS TARGETING HCN CHANNELS FOR BREATHING THERAPEUTICS
An object of the present invention to provide therapeutic compositions and methods for the prevention and/or treatment of airway obstructive disorders that...
2019/0111060 SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS
Compounds of the general formula): ##STR00001## processes for the preparation of these compounds, compositions containing these compounds, and the uses of these...
2019/0111059 COMPOSITIONS AND METHODS FOR TREATING AUTISM SPECTRUM DISORDER
A method of treating suffering from a CNS disorder, comprising administering a reduced folate, or a derivative, prodrug, active metabolite, stereoisomer,...
2019/0111058 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES
This invention relates to JAK1 selective inhibitors, particularly pyrrolo[2,3-d]pyrimidine and pyrrolo[2,3-b]pyridine derivatives, and their use in treating...
2019/0111057 PHARMACEUTICAL COMPOSITIONS COMPRISING AZD9291
The present invention relates to pharmaceutical compositions suitable for oral administration, and more particularly to pharmaceutical compositions, including...
2019/0111056 COMPOUND HAVING MUTANT IDH INHIBITORY ACTIVITY, PREPARATION METHOD AND USE THEREOF
Provided in the present invention are a compound having the effects of preventing and treating diseases related to IDH mutation, and a preparation method and...
2019/0111055 USE OF PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SKIN ERYTHEMA IN POIKILODERMAS
The present invention pertains to the technological sector of the pharmaceutical industry and, more specifically, refers to a second use composition intended...
2019/0111054 NOVEL COMBINATORIAL THERAPIES OF NEUROLOGICAL DISORDERS
The present invention relates to combinations and methods for the treatment of neurological disorders related Amyloid beta toxicity and/or neuronal death. More...
2019/0111053 CLINICAL REGIMEN FOR TREATING MYELODYSPLASTIC SYNDROME WITH PHOSPHATASE INHIBITOR
This invention provides a method of treating myelodysplastic syndrome in a human subject afflicted therewith comprising administering to the subject an amount...
2019/0111052 METHODS OF TREATING A NEURODEGENERATIVE DISEASE
The present application relates to new uses of 5-HT.sub.6 receptor antagonists, specifically high doses of 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline, and to...
2019/0111051 ABUSE-RESISTANT CONTROLLED-RELEASE OPIOID DOSAGE FORM
Abuse-resistant, controlled release opioid tablets are a combination containing an opioid antagonist such as naloxone at a level above that needed to suppress...
2019/0111050 TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION
A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and...
2019/0111049 Pain Medicine Combination and Uses Thereof
Embodiments disclosed herein describe, amongst other things, dosage forms, compounds, compositions, pharmaceutical compositions that can be used in the...
2019/0111048 TRANSMUCOSAL DELIVERY DEVICES WITH ENHANCED UPTAKE
The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices....
2019/0111047 PHARMACEUTICAL COMPOSITIONS COMPRISING A DEXTROMETHORPHAN COMPOUND AND QUINIDINE FOR THE TREATMENT OF AGITATION...
The present disclosure is related to methods of treating agitation and/or aggression and/or associated symptoms in subjects with dementia, including, dementia...
2019/0111046 COMBINATION THERAPY COMPRISING OXAZOLIDINONE-QUINOLONES FOR USE IN TREATING BACTERIAL INFECTIONS
The present invention provides a combination of at least one oxazolidinone-quinolone hybrid with at least one further antibacterial compound and the use...
2019/0111045 PHARMACEUTICAL OPHTHALMIC COMPOSITIONS AND METHODS FOR FABRICATING THEREOF
Pharmaceutical ophthalmic compositions are described, the compositions consisting essentially of a therapeutically effective quantity of an anti-bacterial...
2019/0111044 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS
This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such...
2019/0111043 THERAPEUTIC AGENT FOR BILE DUCT CANCER
The present invention provides a therapeutic agent for bile duct cancer comprising 5-((2-(4-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-- ...
2019/0111042 Methods and Compositions for Treating Pruritus, Xerosis, and Associated Disease Using CCR-Inhibitors
Methods of treating symptoms of skin disorders with CCR3 modulating agents are provided. The methods include administering a therapeutically effective amount...
2019/0111041 ARIMOCLOMOL FOR TREATING GLUCOCEREBROSIDASE ASSOCIATED DISORDERS
The present invention relates to an active pharmaceutical ingredient selected from N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximioyl ...
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