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Patent # Description
2019/0111040 IN VIVO AMELIORATION OF ENDOGENOUS ANTI-TUMOR AUTOANTIBODIES TARGETING SURFACE TUMOR ANTIGENS VIA LOW-DOSE P4N
In accordance with the present invention, the immunoregulatory activity of low doses of P.sub.4N was investigated. Unlike previously described antitumor drugs,...
2019/0111039 TREATMENT OF ANDROGEN DEPRIVATION THERAPY ASSOCIATED SYMPTOMS
The present invention provides a method of treating symptoms associated with Androgen Deprivation Therapy comprising administering to a patient in need of such...
2019/0111038 COMPOSITIONS AND METHODS FOR TREATING NASAL AND PARANASAL MUCOSA DISEASES WITH NICOTINIC ACETYLCHOLINE RECEPTOR...
Methods of treating and preventing conditions of a nasal or paranasal mucous membrane are described. The methods include administering a pharmaceutical...
2019/0111037 METHODS OF TREATMENT
This disclosure relates to use of certain aldehyde compounds for treating pulmonary fibrosis, hypoxia, and connective tissue and autoimmune disease such as...
2019/0111036 ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER
Described herein are methods of treating non-metastatic castrate-resistant prostate cancer using an approved drug product comprising apalutamide, enzalutamide...
2019/0111035 PHARMACEUTICAL COMPOSITIONS
This invention relates to the use of low doses of (+)-.alpha.-dihydrotetrabenazine for the treatment of movement disorders, such as Tourette's syndrome.
2019/0111034 COMPOUNDS FOR TREATMENT OF HYPOPROLIFERATIVE DISORDERS
The present invention relates to the use of CDK8 and/or CDK19 inhibitors in the treatment of ribosomopathies as well as conditions characterized by reduced...
2019/0111033 USE OF GABOXADOL IN THE TREATMENT OF TINNITUS
Methods of treating tinnitus with gaboxadol or a pharmaceutically acceptable salt thereof are provided. Also provided are therapeutic compositions that may be...
2019/0111032 CALCIUM SENSING RECEPTORS, LIGANDS, COMPOSITIONS, AND METHODS OF USE
Described herein are compounds that can bind CaSR and/or a CaSR extracellular domain and formulations thereof. Also described herein are methods of inhibiting...
2019/0111031 ANALGESIC COMPOUNDS
Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an analgesic.
2019/0111030 SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and...
2019/0111029 TREATMENT OF IMPULSIVITY-RELATED DISORDERS
The invention relates to the treatment of impulsivity-related disorders, such as a substance-related addiction, a behavioural addiction, relapse to a...
2019/0111028 Polymorphic Forms of 2-(5-Bromo-4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-ylthio)Ace- tic Acid...
Crystalline polymorph forms of 2-(5-bromo-4-(4-cyclopropyl naphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid are described. Pharmaceutical compositions...
2019/0111027 COMPOSITION FOR CONTROLLING MICROSPORIDIA IN FISHES AND METHOD FOR CONTROLLING MICROSPORIDIA IN FISHES USING SAME
A composition for controlling or preventing microsporidia in a fish or a seafood is prepared by using, as an active ingredient, at least one compound selected...
2019/0111025 MOFEZOLAC DERIVATIVES AS MULTI-FUNCTIONS SELECTIVE COX-1 INHIBITORS
Multi-functions Selective COX inhibitors The invention relates to a new class of compounds targeting COX-1. The invention also relates to the use of some of...
2019/0111024 Method of Treatment of Post-Traumatic Stress Disorder
A method of treating post-traumatic stress disorder is provided. The method includes administering a composition of amino acids, melatonin, and vitamins, and...
2019/0111023 USE OF ACYL-HOMOSERINE LACTONE DERIVATIVES AS ANTI-THROMBOTIC AGENTS
Uses of acyl-homoserine lactone compounds are described. In particular, uses of acyl-homoserine lactone compounds as anti-thrombotic agents, to inhibit...
2019/0111022 Method for Inhibiting Tumor Growth
The present invention provides a method for inhibiting growth of at least one tumor selected from the group consisting of uterine cancer, esophageal cancer,...
2019/0111021 FORMULATION FOR EFFECTIVE TOCOTRIENOL DELIVERY
The present invention disclosed a formulation in the form of self-emulsifying drug delivery formulation for improved delivery of tocotrienols comprising a...
2019/0111020 NANOSIZED CAROTENOID CYCLODEXTRIN COMPLEXES
Methods for the preparation of nanosized nutrient formulations for enhanced absorption of nutritional agents. The methods include the complexation of...
2019/0111019 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES
Since a compound represented by the general formula (I) (wherein definition of each group is as described in the specification), a salt thereof, a solvate...
2019/0111018 ISOTHIOCYANATE FUNCTIONAL COMPOUNDS AUGMENTED WITH SECONDARY ANTINEOPLASTIC MEDICAMENTS AND ASSOCIATED METHODS...
A formulation, including: (a) a first medicament, wherein the first medicament includes an isothiocyanate functional compound/surfactant; and (b) a second...
2019/0111017 Compositions and Methods for Treating Non-Alcoholic Steatohepatitis
The disclosure provides for a method for treating a fatty liver disorder in a subject in need thereof, comprising selecting a subject having or suspected of...
2019/0111016 METHODS OF TREATING MUSCLE AND LIVER DISORDERS
Provided are methods of treating muscle and liver disorders, and for increasing mitochondrial mass and/or functionality in a mammalian myocyte and/or hepatocyte.
2019/0111015 CHLOROGENIC ACID COMPOSITION FOR THE TREATMENT OF METABOLIC DISORDERS
A composition of chlorogenic acids and method of its use and manufacture in the treatment of metabolic disorders. The composition can be obtained from...
2019/0111014 DUAL ACE C-DOMAIN/NEP INHIBITORS
A superior dual ACE/NEP inhibitor is a combination that selectively targets the ACE C-domain in addition to inhibiting NEP. Such a dual ACE C-domain/NEP...
2019/0111013 Controlled Release Dosage Form
The present invention provides a simple and improved dosage form that is capable of providing a controlled release of GABA.sub.B receptor agonist contained in...
2019/0111012 METHODS OF TREATMENT OF CHOLESTATIC DISEASES
The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethyl-methyloxyphenyl]- prop-2-en-1-one (Elafibranor or...
2019/0111011 DELAYED RELEASE PHARMACEUTICAL FORMULATIONS COMPRISING VALPROIC ACID, AND USES THEREOF
There is provided herein a pharmaceutical formulation having one or more component comprising valproic acid (VPA) and/or a pharmaceutically acceptable salt...
2019/0111010 METHOD OF TREATING ER MUTANT EXPRESSING BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS)
This invention relates to the treatment of breast cancer in a subject, for example a female subject. Including methods of: treating metastatic breast cancer;...
2019/0111009 N-ACETYLCYSTEINE AMIDE (NAC AMIDE) IN THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS
Methods and compositions comprising N-acetylcysteine amide (NAC amide) and derivatives thereof are used in treatments and therapies for human and non-human...
2019/0111008 METHODS FOR STORING CYSTEAMINE FORMULATIONS AND RELATED METHODS OF TREATMENT
Methods of storing and methods of stabilizing pharmaceutical compositions comprising cysteamine, or a pharmaceutically acceptable salt thereof, are provided....
2019/0111007 SPHINGOSINE KINASE TYPE 1 INHIBITORS AND USES THEREOF
Provided are inhibitors of sphingosine kinase Type I and their use in the treatment of asthma, among other indications and diseases.
2019/0111006 METHOD OF LONG-TERM PRESERVATION OF CHEMICAL AND BIOLOGICAL SPECIES USING SUGAR GLASSES
A method of preserving the one or more chemical and/or biological species in a polymer matrix comprising pullulan and trehalose is described. The method...
2019/0111005 HYDROCOLLOID-BASED SKIN TREATMENT
The present technology relates generally to devices for treatment of skin and skin conditions, as well as methods for preparing the devices and methods of...
2019/0111004 THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME
The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable...
2019/0111003 COMBINATIONS OF MRNAS ENCODING IMMUNE MODULATING POLYPEPTIDES AND USES THEREOF
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides...
2019/0111002 NOVEL VEHICLES FOR THE TRANSFECTION OF miRNAS
The invention relates to a nanoparticle comprising: (i) between 60 wt.-% and 99 wt.-% sorbitan ester, relative to the total weight of the nanoparticle; (ii) a...
2019/0111001 MICROPARTICULATE SYSTEM FOR COLONIC DRUG DELIVERY
A delivery system that allows for targeted released of therapeutics in selected regions of the GI tract is provided. The delivery system is adapted to deliver...
2019/0111000 MULTISTAGE DELIVERY OF ACTIVE AGENTS
Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or...
2019/0110999 PREVENTION OF LIPID ABSORPTION USING ARTIFICIAL LIPID SEQUESTRATION DEVICES
An artificial device, method and system are provided for the manufacture and use of artificial nanospheres, enclosed resins, and similar technologies for...
2019/0110998 PARTICLE COMPOSITION FOR EASY-TO-USE SOLID PREPARATION AND EASY-TO-USE SOLID PREPARATION INCLUDING SAID...
An object of the present invention is to provide a particulate composition for an easy-to-take solid preparation, which has excellent moldability (hardness)...
2019/0110997 ORAL ADMINISTRATION FORM COMPRISING PROBIOTIC BACTERIA
The invention relates to an oral administration form which comprises at least one species of probiotic microorganisms, where it itself and/or the probiotic...
2019/0110996 Pharmaceutical Formulation Containing Gelling Agent
Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together...
2019/0110995 MODIFIED RELEASE TABLET COMPOSITION COMPRISING MIRABEGRON
The present invention relates to a pharmaceutical composition, particularly a modified release tablet composition comprising mirabegron or a pharmaceutically...
2019/0110994 PHARMACEUTICAL COMPOSITION OF DAPAGLIFLOZIN
Present invention discloses the stable pharmaceutical composition comprising premix of dapagliflozin with at least one pharmaceutically acceptable excipient(s)...
2019/0110993 Solid Nanoparticle Formulation of Water Insoluble Pharmaceutical Substances with Reduced Ostwald Ripening
The present invention provides pharmaceutical compositions composed of solid nanoparticles dispersed in aqueous medium of substantially water insoluble...
2019/0110992 MODIFIED RELEASE ABUSE DETERRENT DOSAGE FORMS
The invention relates to a pharmaceutical dosage form for oral administration comprising a pharmacologically active compound; wherein a portion of said...
2019/0110991 REMOTE LOADING OF SPARINGLY WATER-SOLUBLE DRUGS INTO LIPOSOMES
The present invention provides liposome compositions containing sparingly soluble drugs that are used to treat life-threatening diseases. A preferred method of...
2019/0110990 LIPOPROTEINS CONTAINING PLATINUM COMPLEXES FOR THE TREATMENT OF CANCER
The present invention relates to lipoproteins containing platinum complex. The invention also relates to a kit comprising said lipoproteins. In particular, the...
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