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Patent # Description
2019/0112608 METHODS OF USING SMAD7 ANTISENSE OLIGONUCLEOTIDES
Described herein are methods of treating inflammatory bowel disease (IBD) in a patient having IBD using SMAD7 antisense oligonucleotides.
2019/0112607 CANCER THERAPY
The invention relates to a genetically transformed or transfected bacterial cell chromosome wherein said cell is made to express interfering RNA (siRNA) active...
2019/0112606 COMPLEX CONTAINING OLIGONUCLEOTIDE HAVING IMMUNOPOTENTIATING ACTIVITY AND USE THEREOF
The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly...
2019/0112605 FUNCTIONAL LIGANDS TO IGG
The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for...
2019/0112604 METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
The. invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an...
2019/0112603 Methods and Compositions for Managing Vascular Conditions Using miR-483 Mimics and HIF1alpha Pathway Inhibitors
This disclosure relates to the use of miRNA-483 and its target genes, UBE2C, pVHL and HIF1alpha, in managing the treatment of cardiovascular and inflammatory...
2019/0112602 MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE
The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA...
2019/0112601 OLIGOMERS
Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be...
2019/0112600 CONDITIONAL PROTEIN TRANSLATION SWITCHES, CONDITIONAL GENE EXPRESSION SYSTEMS AND USES THEREOF
Disclosed herein are protein translation switches and conditional gene expression systems that are compatible with retroviral and lentiviral gene delivery. The...
2019/0112599 Methods and Compositions for the Single Tube Preparation of Sequencing Libraries Using Cas9
Methods and compositions of single tube preparation of sequencing libraries from a target DNA are provided. The methods include contacting the DNA with a...
2019/0112598 Methods and Systems of Cell-Free Enzyme Discovery and Optimization
Methods and systems of cell-fee enzyme discovery and optimization are provided.
2019/0112597 BIOSENSORS FOR CHLORIDE IONS
This invention provides biosensors, cell models, and methods of their use for monitoring chloride ion, where the biosensors can include targeting domains,...
2019/0112596 TAL-EFFECTOR ASSEMBLY PLATFORM, CUSTOMIZED SERVICES, KITS AND ASSAYS
The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized...
2019/0112595 Method, Systems and Apparatus for Single Cell Analysis
The disclosed embodiments relate to method, apparatus and system for high throughput single-cell DNA sequencing with droplet microfluidic. In an exemplary...
2019/0112594 COMPOSITIONS AND METHODS THAT ARE USEFUL FOR IDENTIFYING ALLELE VARIANTS THAT MODULATE GENE EXPRESSION
The invention features compositions and methods that are useful for identifying allele variants that modulate gene expression. Compositions and articles...
2019/0112593 METHOD FOR THE SELECTION OF APTAMERS FOR UNBOUND TARGETS
Disclosed is a method for the selection of aptamers that does not require immobilization of the target or the oligonucleotide library. The method includes: (i)...
2019/0112592 SITE-SPECIFIC NUCLEASE SINGLE-CELL ASSAY TARGETING GENE REGULATORY ELEMENTS TO SILENCE GENE EXPRESSION
This invention relates to a single cell assay for determining the effect of chromosomal contact on the transcriptional activity of genes of interest in a cell...
2019/0112591 ENZYME IMMOBILIZATION IN HIERARCHICAL METAL-ORGANIC FRAMEWORKS
Enzyme-immobilizing MOFs and methods for their use in enzymatically catalyzed reactions are provided. The MOFs are channel-type MOFs that present a...
2019/0112590 ARABINOSE ISOMERASES FOR YEAST
A group of arabinose isomerases are disclosed that provide effective amounts of activity for use of arabinose in production of ethanol, when expressed in yeast...
2019/0112589 HEXURONATE C4-EPIMERASE VARIANT HAVING IMPROVED D-TAGATOSE CONVERSION ACTIVITY, AND D-TAGATOSE PRODUCTION...
Provided are a hexuronate C4-epimerase variant with improved activity in converting D-fructose by D-tagatose of hexuronate C4-epimerase and a method for...
2019/0112588 COMPOSITIONS AND METHODS FOR INTERNALIZING ENZYMES
Compositions and methods for treating lysosomal storage diseases are disclosed. Biotherapeutic complexes containing an internalization effector binding domain...
2019/0112587 Engineered Nucleic-Acid Targeting Nucleic Acids
The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the...
2019/0112586 Engineered Nucleases and Their Uses for Nucleic Acid Assembly
Aspects of the invention provide engineered endonucleases that are characterized by both a long recognition sequence and specific cleavage outside of the...
2019/0112585 GLUCOSYLTRANSFERASE AMINO ACID MOTIFS FOR ENZYMATIC PRODUCTION OF LINEAR POLY ALPHA-1,3-GLUCAN
Reactions comprising water, sucrose, and one or more glucosyltransferase enzymes are disclosed herein. Glucosyltransferase enzymes used in these reactions...
2019/0112584 COMPOSITIONS AND METHODS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN
In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile...
2019/0112583 NOVEL MULTIPLY BACKBONE N-METHYL TRANSFERASES AND USES THEREOF
The present invention is directed to all aspects of novel methyl transferase enzymes that methylate backbone amides of (poly)peptides. The present invention...
2019/0112582 IN VITRO METHOD FOR IDENTIFYING THORACIC AORTIC ANEURYSMS (TAA) IN A SUBJECT
The present invention refers to an In vitro method for screening for subjects at risk of developing thoracic aortic aneurysm (TAA) or a disease causing TAA...
2019/0112581 Host Cell Modification with Artificial Endosymbionts
The present invention is directed generally to host cells with artificial endosymbionts, wherein the artificial endosymbiont and the host cell communicate with...
2019/0112580 METHODS FOR TREATING CONTRACTURED MUSCLE AND RELATED CULTURED CELLS
This disclosure relates to the use of DNA methyltransferase inhibitors, alone or in combination with Aurora kinase inhibitors, to treat muscle cells isolated...
2019/0112579 METHODS OF PROMOTING ESOPHAGEAL DIFFERENTIATION OF PLURIPOTENT STEM CELLS
The current invention provides for methods of promoting differentiation of human pluripotent stem cells into esophageal progenitor cells as well as the cells...
2019/0112578 Derivation and Self-Renewal of Multipotent Cells and Uses Thereof
The present invention pertains inter alia to novel efficient methods for culturing mesenchymal stem (stromal) cells (MSCs), wherein the MSCs have maintained...
2019/0112577 EX VIVO EXPANSION METHOD FOR CORD BLOOD NK CELL, AND KIT AND APPLICATION THEREOF
Provides an ex vivo expansion method for a cord blood NK cell, and a kit and application thereof. The ex vivo expansion method for the cord blood NK cell...
2019/0112576 METHODS FOR CULTURING CELLS AND KITS AND APPARATUS FOR SAME
Provided herein are methods for culturing cells, including stimulating or expanding (proliferating), a plurality of cells in a composition of cells such as a...
2019/0112575 METHOD FOR PRODUCING DOPAMINERGIC NEURON PROGENITOR CELL
A cell population comprising Corin- and/or Lrtm1-positive cells was produced by the following steps (1) and (2), from which Corin positive and/or Lrtm1...
2019/0112574 Culture method for enhancing the activity of stem cells, method of preparing formulation for treating central...
A culture method for enhancing the activity of stem cells, and a method of preparing a formulation for treating central nervous diseases, and a method of...
2019/0112573 METHOD OF DIFFERENTIATING PLURIPOTENT STEM CELLS INTO MESENCHYMAL STEM CELLS UNDER 3D SPHEROIDAL CULTURE CONDITIONS
A method of differentiating pluripotent stem cells into mesenchymal stem cells, a culture medium used in the method of differentiating pluripotent stem cells...
2019/0112572 CELL CULTURE PROCESS
A cell culture medium comprising tyrosine at a concentration of at least 3 mM and polyvinylalcohol (PVA).
2019/0112571 PROCESSING OF BIOMASS MATERIALS
The use of cell matter in fermentation mixtures for producing a product is disclosed. In embodiments, the product comprises carbohydrates, alcohols, or organic...
2019/0112570 CELL SEPARATION APPARATUS AND METHODS OF USE
Cell separation systems and methods of separating cells are disclosed. In an embodiment, a cell separation system is described that comprises a non-transitory...
2019/0112569 In Situ Raman Spectroscopy Systems and Methods for Controlling Process Variables in Cell Cultures
The present invention provides in situ Raman spectroscopy methods and systems for monitoring and controlling one or more process variables in a bioreactor cell...
2019/0112568 METHODS OF PITCHING YEAST FOR FERMENTATION, AND RELATED METHODS OF FERMENTATION AND SYSTEMS
The present invention relates to methods and systems of pitching yeast to fermentation reactors. More particularly, the present invention involves pitching...
2019/0112567 VESSELS AND SPINNER FLASKS WITH REDUCED IMPELLER WOBBLE FOR CULTURING CELLS
A vessel for culturing cells is provided that includes a vessel body having a top portion, a bottom portion comprising a bottom interior surface, and a...
2019/0112566 PRESSURE MANIFOLD AND CULTURE MODULE
A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells...
2019/0112565 MEMBRANE SEPARATION METHOD OF CELL SUSPENSION, AND CELL CULTURE DEVICE
The present disclosure provides a membrane separation method of a cell suspension which can appropriately separate cells from debris, and a cell culture...
2019/0112564 INFUSED ALCOHOLIC BEVERAGE
The present invention relates to a ready-to-drink alcoholic beverage comprising a distilled spirit and at least one Aloaceae source.
2019/0112563 DETERGENT COMPOSITIONS HAVING AN IMPROVED PROFILE AGAINST EFFLORESCENCE
Provided herein are detergent formulations which can effectively suppress efflorescence in unit dose detergent packs. In accordance with one embodiment, the...
2019/0112562 ENZYMATIC CLEANING AND SANITIZING COMPOSITIONS AND METHODS OF USING THE SAME
The present disclosure relates to a composition for cleaning or sanitizing a surface, methods of using the same for cleaning and sanitizing a surface, and kits...
2019/0112561 LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS
A laundry care composition including at least one laundry care ingredient, a leuco composition, from 0.05 wt % to 15 wt % of a primary amine compound and from...
2019/0112560 LEUCO COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME
A laundry care composition including (a) at least one laundry care ingredient and (b) a leuco compound including an antioxidant moiety covalently bonded to a...
2019/0112558 LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITION
A laundry care composition including (a) at least one laundry care ingredient and (b) a leuco composition including at least one leuco compound. The leuco...
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