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Patent # Description
2019/0112405 RESIN PRECURSOR COMPOSITION FOR OPTICAL MATERIALS, OPTICAL ELEMENT OBTAINED FROM THE COMPOSITION, AND...
Low refractive index and high dispersion material which can produce a bonded-multilayer DOE having an excellent optical performance is obtained, and the...
2019/0112404 POLAR FUNCTIONAL NON-AQUEOUS ACRYLIC DISPERSIONS
Described herein is a polar non-aqueous dispersion comprising polar polymeric microparticles in a polar non-aqueous medium, the polar polymeric microparticles...
2019/0112403 PROCESS FOR PRODUCING FLUORORESIN
A process for producing a fluororesin in which a low-boiling component is reduced, by subjecting a melt-formable fluororesin to melt-kneading treatment by a...
2019/0112402 SOFT POLYOLEFIN COMPOSITION
The present disclosure provides a polyolefin composition made from or containing: A) from about 60 to about 89% by weight based upon the total weight of the...
2019/0112401 INJECTION MOLDED ARTICLE BASED ON PROPYLENE HOMOPOLYMER
Injection molded article for healthcare applications based on propylene homopolymer.
2019/0112400 POLYMERS FROM BIS-ARYLCYCLOBUTENE GROUP CONTAINING MONOMERS THAT CURE THROUGH OTHER GROUPS AND METHODS FOR...
The present invention provides organic solvent soluble or aqueous alkali soluble polymer composition comprising, in copolymerized form, one or more...
2019/0112399 PROCESS FOR PRODUCING A POLYACRYLAMIDE SOLUTION WITH INCREASED VISCOSITY
The present invention relates to a method for producing a polyacrylamide solution having increased viscosity. In particular, the present invention is related...
2019/0112398 A MULTIPLE-COMPONENT COMPOSITION FOR PRODUCING A CORROSION INHIBITING HYDROGEL
A multiple-component composition that can be used for producing a corrosion inhibiting (meth)acrylic hydrogel. The multiple-component composition including at...
2019/0112397 POLYVINYL ACETAL WITH REDUCED FLOWABILITY
Polyvinyl acetals with a degree of acetalization of 70-84 mol %, and characterized by a molar ratio of the amount of continuous syndiotactic sequences of vinyl...
2019/0112396 Activated Pectin-Containing Biomass Compositions, Products, and Methods of Producing
Methods for producing an activated pectin-containing biomass composition are provided. The method includes (A) mixing a starting pectin-containing biomass...
2019/0112395 Method of producing hemicellulose extracts
This invention describes a method for the purification of a hemicellulose extract produced for example through hot water extraction. Such extracts often...
2019/0112394 USING SORTASES TO INSTALL CLICK CHEMISTRY HANDLES FOR PROTEIN LIGATION
Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry...
2019/0112393 ANTIGEN-BINDING MOLECULE FOR PROMOTING ELIMINATION OF ANTIGENS
The present inventors created antigen-binding molecules containing an antigen-binding domain and an Fc.gamma.-receptor-binding domain, wherein the molecules...
2019/0112392 T CELL RECRUITING POLYPEPTIDES BASED ON TCR ALPHA/BETA REACTIVITY
T cell recruiting polypeptides are provided that bind the constant domain of TCR on a T cell. The polypeptides can be used in methods for treatment of cancers.
2019/0112391 HEPARANASE-NEUTRALIZING MONOCLONAL ANTIBODIES
The present invention relates to heparanase-neutralizing monoclonal antibodies (m Abs), pharmaceutical composition comprising same, and use thereof for...
2019/0112390 ANTIBODY SUBSTITUTING FOR FUNCTION OF BLOOD COAGULATION FACTOR VIII
The present inventors produced a variety of bispecific antibodies that specifically bind to both F. IX/F. IXa and F. X, and functionally substitute for F....
2019/0112389 ANTI-CD3 ANTIBODIES AND METHODS OF USE
The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
2019/0112388 INTEGRAL MEMBRANE PROTEIN DISPLAY ON POXVIRUS EXTRACELLULAR ENVELOPED VIRIONS
This disclosure provides compositions and methods for expressing and displaying isolated integral membrane proteins (IMPs) or fragments thereof in a native...
2019/0112387 ERBB2-TARGETING ANTIBODY
The present invention relates to an antibody, particularly a monoclonal antibody, which binds a novel epitope of the ERBB2 tyrosine kinase receptor, wherein...
2019/0112386 COMPOSITIONS AND METHODS FOR TUMOR TRANSDUCTION
The invention relates to cancer therapeutics, in particular, the system of making cancer cells more susceptible to effector cells by introduction of cellular...
2019/0112385 ANTI-MESOTHELIN ANTIBODIES
The present invention relates to a human or humanized antibody, or an antibody-based binding protein, modified antibody format retaining target binding...
2019/0112384 COMPOSITIONS AND METHODS FOR THE DETECTION DIAGNOSIS AND THERAPY OF HEMATOLOGICAL MALIGNANCIES
Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias,...
2019/0112383 TREATMENT OF B-CELL LYMPHOMA
A method of treating B-cell lymphoma comprises administering to a patient a chemotherapeutic regimen, followed by treatment with a radiolabeled anti-CD20...
2019/0112382 HUMANIZED ANTIBODIES AGAINST CD269 (BCMA)
A method of treating a medical disorder associated with the presence of pathogenic B cells expressing B cell maturation antigen (BCMA), the method comprising...
2019/0112381 TRISPECIFIC PROTEINS AND METHODS OF USE
Provided herein are B cell maturation agent (BCMA) targeting trispecific proteins comprising a domain binding to CD3, a half-life extension domain, and a...
2019/0112380 CHIMERIC ANTIGEN RECEPTORS TARGETING CANCER
Provided herein is a composition comprising, a cell, comprising nucleic acids encoding a chimeric antigen receptor (CAR) and one or more of signaling proteins...
2019/0112379 EARLY INTERVENTION METHODS TO PREVENT OR AMELIORATE TOXICITY
Provided are methods for preventing or ameliorating toxicity caused by or due to a therapy, such as an immunotherapy or a cell therapy, by pre-emptive or early...
2019/0112378 NOVEL CANCER TREATMENT INVOLVING MODULATION OF IL-3 ACTIVITY
A method of treating or preventing breast cancer (eg invasive ductal carcinoma) and/or cancer associated with elevated levels of either one or both of the IL-3...
2019/0112377 CANCER IMMUNOTHERAPY BY DISRUPTING PD-1/PD-L1 SIGNALING
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a...
2019/0112376 CANCER IMMUNOTHERAPY BY DISRUPTING PD-1/PD-L1 SIGNALING
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a...
2019/0112375 ANTIBODIES TO TIGIT
The present invention provides antibodies, or antigen binding fragments thereof, that bind to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), as...
2019/0112374 HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODIES TO CD47
Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic...
2019/0112373 THERAPEUTIC CD47 ANTIBODIES
Provided are anti-CD47 monoclonal antibodies (anti-CD47 mAbs) with distinct functional profiles as described herein, methods to generate anti-CD47 mAbs, and to...
2019/0112372 MULTIPARTITE SIGNALING PROTEINS AND USES THEREOF
The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally...
2019/0112371 Reducing Systemic Regulatory T Cell Levels or Activity for Treatment of Disease and Injury of the CNS
A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a...
2019/0112370 PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF CANCERS
The present invention relates to a pharmaceutical composition for treatment and/or prevention of a cancer, which comprises, as an active ingredient, an...
2019/0112369 USE OF IL-31RA MONOCLONAL ANTIBODIES FOR ANTAGONIZING SIGNAL TRANSDUCTION IN DORSAL ROOT GANGLION CELLS
Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing...
2019/0112368 METHODS OF PRODUCING TWO CHAIN PROTEINS IN BACTERIA
Provided herein are methods of producing a polypeptide containing two chains, such as an antibody including a light chain and a heavy chain. In particular,...
2019/0112367 HUMAN ANTI-IL-32 ANTIBODIES
Provided are novel IL-32 binding molecules of human origin, particularly human anti-IL-32 antibodies as well as IL-32 binding fragments, derivatives and...
2019/0112366 Treatment of Cancer Using Inhibitors of TGF-Beta and PD-1
The present disclosure relates, in general, to combination therapy using an inhibitor of transforming growth factor beta (TGF.beta.) and an inhibitor of...
2019/0112365 ANTI-TAU ANTIBODIES AND USES THEREOF
Provided herein are antibodies that specifically bind Tau and methods of using the same.
2019/0112364 ANTI-TAU ANTIBODIES AND USES THEREOF
Provided herein are antibodies that specifically bind Tau and methods of using the same.
2019/0112363 POLYPEPTIDES AND POLYPEPTIDE CONSTRUCTS COMPRISING SINGLE DOMAIN ANTIBODIES DIRECTED AGAINST VON WILLEBRAND FACTOR
The present invention relates to polypeptides comprising at least one single domain antibody directed against vWF, vWF A1 domain, A1 domain of activated vWF,...
2019/0112362 ANTI-TAU ANTIBODIES AND METHODS OF USE
The invention provides anti-Tau antibodies and methods of using the same.
2019/0112361 ANTI-TAU ANTIBODIES AND METHODS OF USE
The invention provides anti-Tau antibodies and methods of using the same.
2019/0112360 ANTIBODY THAT BINDS TO ENVELOPE GLYCOPROTEIN OF SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS AND USE FOR SAME
The present invention relates to an antibody which specifically binds to the envelope glycoprotein of severe fever with thrombocytopenia syndrome virus...
2019/0112359 Separation of Triple-Light Chain Antibodies Using Cation Exchange Chromatography
Methods of separating triple-light chain (H2L3) antibodies (e.g., anti-CD123 H2L3 antibodies) or antigen-binding fragments thereof from an antibody composition...
2019/0112358 DNA-BINDING DOMAIN OF CRISPR SYSTEM, NON-FUCOSYLATED AND PARTIALLY FUCOSYLATED PROTEINS, AND METHODS THEREOF
The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and...
2019/0112357 PREVENTION OF PROTEIN DISULFIDE BOND REDUCTION
Disclosed are methods for testing the presence and/or activity of glutathione system components and thioredoxin system components during the manufacturing...
2019/0112356 HIGH-AFFINITY IMMUNOPOLYMERS
The present disclosure is directed to high-affinity immunopolymers for use in a variety of immunoassays and other techniques. The immunopolymers comprise a...
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