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Patent # Description
2019/0112355 STABLE PROTEINS
The invention provides a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a Family B G-protein coupled receptor (GPCR) that...
2019/0112354 METHODS AND COMPOSITIONS TO ENHANCE THE ANTI-INFLAMMATORY EFFECTS OF INTERLEUKIN 10
This invention relates to methods and compositions for overcoming the dose-dependent down regulation of interleukin 10 (IL-10) by expressing, in addition to an...
2019/0112353 MATERIALS AND METHODS FOR TREATMENT OF SEVERE COMBINED IMMUNODEFICIENCY (SCID) OR OMENN SYNDROME
Materials and methods for treating a patient with severe combined immunodeficiency (SCID) or Omenn Syndrome, both ex vivo and in vivo, and materials and...
2019/0112352 TGF- RECEPTOR II ISOFORM, FUSION PEPTIDE, METHODS OF TREATMENT AND METHODS IN VITRO
An isoform of the TGF beta receptor II comprising a sequence of about of 80 amino acids and lacking a transmembrane domain. The isoform comprises the amino...
2019/0112351 EXOSOME-TARGETED DNA VACCINE
In order to further increase antigenicity to provide a DNA vaccine which is clinically usable in humans, the inventors of the present invention focused on...
2019/0112350 PEPTIDIC TGF-BETA ANTAGONISTS
The present invention provides peptidic TGF-.beta. antagonists capable of inhibiting TGF-.beta. signaling and disrupting the biochemical events that promote...
2019/0112349 MODIFIED CHIMERIC RECEPTORS AND USES THEREOF IN IMMUNE THERAPY
Disclosed herein are chimeric receptors that comprise an extracellular domain and a cytoplasmic signaling domain, wherein the extracellular domain has a...
2019/0112348 PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES
Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain...
2019/0112347 Novel peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0112346 COMPOSITION HAVING COVERED FIBROUS PROTEIN ANTIGENIC PROPERTIES AND PRODUCTION METHOD THEREFOR
The present invention is a novel composition including a fibrous protein having covered antigenicity, and the composition contains a complex prepared by...
2019/0112345 Polypeptides Capable of Forming Homo-Oligomers with Modular Hydrogen Bond Network-Mediated Specificity and...
Methods and apparatus for identifying and screening hydrogen bond networks are provided. A computing device can determine a search space for hydrogen bond...
2019/0112344 STREPTAVIDIN MUTEINS AND METHODS OF USING THEM
The invention concerns novel streptavidin muteins and their use for determination, isolation or purification of proteins under denaturing conditions. In one...
2019/0112342 COMPOSITIONS AND METHODS RELATED TO ANTIBODIES THAT NEUTRALIZE COAGULASE ACTIVITY DURING STAPHYLOCOCCUS AUREUS...
Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects...
2019/0112341 PICORNAVIRUS-LIKE PARTICLE PRODUCTION IN PLANTS
A method of producing a picornavirus-like particle (PVLP) in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic...
2019/0112340 SUBSTITUTIONS-MODIFIED PREFUSION RSV F PROTEINS AND THEIR USE
Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are...
2019/0112339 BK CHANNEL-MODULATING PEPTIDES AND THEIR USE
The present invention concerns peptides and nucleic acids encoding the peptides, and their use for modulating large conductance Ca.sup.2+ activated K.sup.+...
2019/0112338 Decoy Peptides Inhibiting Protein Phosphatase 1-Medicated Dephosphorylation of Phospholamban
The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: ...
2019/0112337 PEPTIDE FOR PREVENTING OR TREATING INFLAMMATORY DISEASES AND USE THEREOF
Provided is a novel peptide for preventing or treating inflammatory diseases and a use thereof. According to the novel dimeric or trimeric peptide, it is...
2019/0112336 PEPTIDE FOR SKIN REGENERATION OR WOUND TREATMENT AND USE THEREOF
Provided is a novel peptide for skin regeneration or wound healing and a use thereof. The novel peptide not only promotes the wound healing by increasing the...
2019/0112335 Antimicrobial Compositions
Antimicrobial molecules, their synthesis and use as antimicrobial treatments are described. The antimicrobial compounds are teixobactin analogues. Methods of...
2019/0112334 SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the...
2019/0112333 Opioid Receptor Modulators
The present invention provides compounds that can modulate opioid receptors. Some compounds of the invention are modulators of .mu.- and/or .delta.-opioid...
2019/0112332 Protein Electrodialiysis (PED) Device for Enrichment of the Extracellular Proteins Deposited by Microorganisms...
An efficient tool with low cost to rapidly isolate and concentrate the secreted proteins of microorganisms in high quality. By this device, the secreted...
2019/0112331 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): ##STR00001## and pharmaceutical compositions thereof. Such compounds...
2019/0112330 BILE SALT HYDROLASE PROBE AND METHOD OF MAKING AND USING THE SAME
Probe embodiments for targeting, identifying, and isolating enzymes exhibiting BSH activity as well as devices and kits that use the probes are described...
2019/0112329 METHODS OF FUNCTIONALIZATION AND REAGENTS USED IN SUCH METHODS USING AN AZA-ISATOIC ANHYDRIDE OR A DERIVATIVE...
A method of functionalizing RNA in a liquid sample includes reacting an anhydride function of a binding molecule with at least one RNA molecule at one or more...
2019/0112328 DIARYLSULFIDE BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS
The present disclosure relates to photoactivable protecting groups containing a diarylsulfide chromophore, a method for the synthesis thereof and their use as...
2019/0112327 CRYSTAL FORM OF FLUDARABINE PHOSPHATE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Provided are a new crystal form of fludarabine phosphate, a preparation method therefor, a pharmaceutical composition containing same, and an application...
2019/0112326 Composition, Crocins Active Site, and Uses Thereof
A composition, and a crocins active site extracted from Gardenia jasminoides Ellis, mainly comprising the following ingredients: crocetin ...
2019/0112325 UNSYMMETRICAL METALLOCENE CATALYSTS AND USES THEREOF
Unsymmetrical metallocene compounds based on cyclopentadienyl ligands are disclosed, as well as catalytic compositions comprising the compounds supported on...
2019/0112324 ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
An organometallic compound represented by Formula 1: M(L.sub.1).sub.n1(L.sub.2).sub.n2(L.sub.3).sub.n3 Formula 1 wherein in Formula 1, M, L.sub.1, L.sub.2,...
2019/0112323 Process for preparing a colourless solution of 3-(N-benzyl-2-aminoethyl)aminopropyltrimethoxy-silane...
A process can prepare a colourless, methanolic solution of 3-(N-benzyl-2-aminoethyl)aminopropyltrimethoxysilane hydrochloride. The process includes, in step 1...
2019/0112322 CARBINOL FUNCTIONAL TRISILOXANE AND METHOD OF FORMING THE SAME
A trisiloxane having at least one carbinol functional group comprises the reaction product of (A) an initial trisiloxane and (B) an organic compound. Component...
2019/0112321 SILICON INCORPORATED QUINOLINES WITH ANTI-MALARIAL AND ANTI-TOXOPLASMOSIS ACTIVITY
The present invention discloses a silicon incorporated quinoline of formula (I) wherein, X, Y, A, R.sup.1 and R.sup.2 are as described. The present invention...
2019/0112320 METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
2019/0112319 FUSED POLYCYCLIC HETEROAROMATIC COMPOUND AND ORGANIC THIN FILM AND ELECTRONIC DEVICE
A fused polycyclic heteroaromatic compound represented by Chemical Formula 1, and an organic thin film, an organic thin film transistor, and an electronic...
2019/0112318 COMPOUNDS, COMPOSITIONS AND METHODS
The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.
2019/0112317 ACTIVATORS OF AUTOPHAGIC FLUX AND PHOSPHOLIPASE D AND CLEARANCE OF PROTEIN AGGREGATES INCLUDING TAU AND...
The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further...
2019/0112316 THIAZOLO[3,2-A] PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY
The invention provides heterobicyclic pyrimidinone compounds such as thiazolo[3,2-a]pyrimidinone compounds, compositions containing such compounds, medical...
2019/0112315 SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF
The present invention provides the following compounds having anti-viral activity. ##STR00001## A.sup.1 is CR.sup.1AR.sup.1B, S or O; A.sup.2 is ...
2019/0112314 Fused Pentacyclic Imidazole Derivatives as Modulators of TNF Activity
A series of fused pentacyclic imidazole derivatives, being potent modulators of f benefit in the treatment and/or prevention of various human ailments,...
2019/0112313 SALTS OF TAM INHIBITORS
The present application provides salt forms of N-(4-(4-Amino-7-(1-isobutyrylpiperidin-4-yl)pyrrolo[1,2-f][1,2,4]triazin-- ...
2019/0112312 INHIBITORS OF BRUTON'S TYROSINE KINASE
Disclosed herein are amido compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Also...
2019/0112311 THERAPEUTIC COMPOUND FOR PAIN AND SYNTHESIS THEREOF
The invention provides compounds of Formula XXIII: ##STR00001## wherein R.sub.1 is hydrogen, alkyl, acyl, or silyl, R.sub.2 is hydrogen, alkyl, benzyl, acyl, or...
2019/0112310 NOVEL CO-CRYSTALS
The disclosure provides new, stable, pharmaceutically acceptable co-crystal forms of 1-(4-fluoro-phenyl)-4-((6bR, 10aS)-3-methyl-2,3,6b,9, 10,...
2019/0112309 NOVEL SALTS AND CRYSTALS
The disclosure provides new, stable, pharmaceutically acceptable salt forms of 1-(4-fluoro-phenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexah- ...
2019/0112308 Use of Aza-Tryptanthrin Derivatives as Inhibitors of IDO1 and/or TDO
This invention discloses the use of aza-tryptanthrin derivatives as an IDO1 and/or TDO inhibitors, and the derivatives are represented by the general Formula...
2019/0112307 DEGRADATION OF CYCLIN-DEPENDENT KINASE 8 (CDK8) BY CONJUGATION OF CDK8 INHIBITORS WITH E3 LIGASE LIGAND AND...
The present application provides bifunctional compounds of Formula (Ia) or (Ib): ##STR00001## or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, ...
2019/0112306 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS
The invention relates to compounds of Formula (I): ##STR00001## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined in the description and claims, or...
2019/0112305 BONE MARROW ON X CHROMOSOME KINASE (BMX) INHIBITORS AND USES THEREOF
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers,...
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