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Patent # Description
2019/0112304 TREATMENT OF OSTEOARTHRITIS
Provided are compositions and methods for treating osteoarthritis including intra-articular administration of a compound of Formula (I) including amorphous and...
2019/0112303 PESTICIDALLY ACTIVE AMIDE HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS
Compounds of formula I ##STR00001## wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers,...
2019/0112302 HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS
The present invention encompasses compounds of the formula (I) ##STR00001## wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the...
2019/0112301 ACTIVATION OF TRPV4 ION CHANNEL BY PHYSICAL STIMULI AND CRITICAL ROLE FOR TRPV4 IN ORGAN-SPECIFIC INFLAMMATION...
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing...
2019/0112300 Compositions And Methods For Treating Attention Deficit Disorders
The present invention relates to ampakines, including low impact ampakines, and pharmaceutical compositions and methods employing ampakines for treating...
2019/0112299 Crystalline Form of Lumacaftor
The present invention provides a novel crystalline form of Lumacaftor, specifically Lumacaftor Form APO-1, a co-crystal of Lumacaftor and nicotinamide,...
2019/0112298 PROCESS FOR THE PREPARATION OF 1-(ARYLMETHYL)QUINAZOLINE-2,4(1H,3H)-DIONES
This disclosure provides a process for preparing 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones, specially provides a method for preparing the compound of Formula...
2019/0112297 Novel N-[(Pyrimidinylamino)Propanyl]-and N-[(Pyridinylamino)Propanyl]Arylcarboxamides
The present invention relates to novel N-[(Pyrimidinylamino)propanyl]- and N-[(Pyridinylamino)propanyl]arylcarboxamide derivatives, processes for their...
2019/0112296 NOVEL N-[(PYRAZINYLOXY)PROPANYL]BENZAMIDES
This invention relates to compounds of formula (I) a process for their preparation, pharmaceutical compositions containing them and their use in the treatment...
2019/0112295 NOVEL N-[(PYRIMIDINYLOXY)PROPANYL]BENZAMIDES
This invention relates to compounds of formula (I), a process for their preparation, pharmaceutical compositions containing them and their use in the treatment...
2019/0112294 BICYCLIC AZA COMPOUNDS AS MUSCARNIC M1 RECEPTOR AND/OR M4 RECEPTOR ANTAGONISTS
This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic...
2019/0112293 PYRROLIDINE GPR40 MODULATORS
The present invention provides compounds of Formula (I): ##STR00001## or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a...
2019/0112292 NOVEL N-[(HETEROARYLOXY)PROPANYL]HETEROARYL CARBOXAMIDES
This invention relates to compounds of formula (I), a process for their preparation, pharmaceutical compositions containing them and their use in the treatment...
2019/0112291 NOVEL N-[(PYRIDYLOXY)PROPANYL]BENZAMIDES
This invention relates to compounds of formula (I), a process for their preparation, pharmaceutical compositions containing them and their use in the treatment...
2019/0112290 INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING
The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the...
2019/0112289 D-AMINO ACID OXIDASE INHIBITORS AND THERAPEUTIC USES THEREOF
The present invention relates to compounds of Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein: each of A, B, C, D, and E,...
2019/0112288 HERBICIDAL COMPOUNDS
The invention relates to pyrrolone compounds of the formula (I) ##STR00001## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.a, R.sup.b, R.sup.c and R.sup.d are as...
2019/0112287 COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods...
2019/0112286 SALT AND PHOTORESIST COMPOSITION CONTAINING THE SAME
A salt comprising a group represented by the formula (aa): ##STR00001##
2019/0112285 Aminothiazole Derivatives Useful As Antiviral Agents
The invention relates to novel compounds of the Formula (I), to a process for their preparation and to their use as medicaments, in particular as antiviral...
2019/0112284 3-ARYL-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with...
2019/0112283 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an...
2019/0112282 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an...
2019/0112281 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an...
2019/0112280 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an...
2019/0112279 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an...
2019/0112278 PROCESS FOR THE PREPARATION OF A DUAL-ACTING ANGIOTENSIN RECEPTOR-NEPRILYSIN INHIBITOR COMPOUND
The present invention relates to a process for preparing amorphous form of Sacubitril/Valsartan sodium salt of Formula-II and pharmaceutical composition...
2019/0112277 PROCESS FOR THE PREPARATION OF DIPHENYLPYRAZINE DERIVATIVES
The present invention relates to a process for the preparation of amorphous Selexipag from Selexipag crystalline salts using a solvent.
2019/0112276 PU.1 INHIBITORS
Disclosed herein are inhibitors of PU.1. The inhibitors are useful for treating disorders associated with abnormal PU.1 levels and function.
2019/0112275 HETEROCYCLIC INHIBITORS OF MCT4
Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the...
2019/0112274 MCT4 INHIBITORS FOR TREATING DISEASE
Provided herein is a method for treating a monocarboxylate transporter MCT4-mediated disorder in a subject in need thereof. The method comprises the step of...
2019/0112273 AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE
The present invention relates to an improved process for the preparation of Butorphanol tartrate of formula (I), ##STR00001##
2019/0112272 SYNTHETIC RETINOIDS FOR USE IN RAR MEDIATED CONDITIONS
There are described novel compounds of formula I: in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X.sup.1 and X.sup.2 are each as herein defined, for use...
2019/0112270 POLYMORPHIC FORM OF N-{6-(2-HYDROXYPROPAN-2-YL)-2-[2-(METHYLSULPHONYL)ETHYL]-2H-INDAZOL-5-YL}- ...
The present invention relates to crystalline forms of N-{6-(2-Hydroxypropan-2-yl)-2-[2-(methylsulphonyl)ethyl]-2H-indazol-5-yl}- ...
2019/0112269 HYDROBROMIDE SALT OF N-(4-CHLORO-2-HYDROXY-3-((3S)-3-PIPERIDINYLSULFONYL)PHENYL-N'-(3-FLUORO-2- ...
A compound which is the hydrobromide salt of N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-- 2-methylphenyl)urea, compositions,...
2019/0112268 mTORC1 MODULATORS
Provided herein, inter alia, are methods and compounds for inhibiting mTORC1 and for treating diseases associated with mTORC1 activity.
2019/0112267 SMALL MOLECULE N-(ALPHA-PEROXY) INDOLE COMPOUNDS AND METHODS OF USE
The invention relates to novel N-(.alpha.-peroxy)indole compounds of Formula I and methods for use. (I) The N-(.alpha.-peroxy)indole compounds described herein...
2019/0112266 Substituted indoline derivatives as dengue viral replication inhibitors
The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates...
2019/0112265 SALT AND PHOTORESIST COMPOSITION CONTAINING THE SAME
A salt comprising a group represented by the formula (aa): ##STR00001## wherein X.sup.a and X.sup.b independently each represent an oxygen atom or a sulfur atom,...
2019/0112264 SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF
The invention provides compounds having the general formula I: (i) and pharmaceutically acceptable salts thereof, wherein the variables R.sup.A, R.sup.AA,...
2019/0112263 USE OF ISOTHIOCYANATE FUNCTIONAL SURFACTANTS AS NRF2 INDUCERS TO TREAT EPIDERMOLYSIS BULLOSA SIMPLEX AND...
The present invention relates to methods and compositions for the prevention and treatment of keratin-based skin diseases. In particular, the application...
2019/0112262 CYCLIC PROCESS FOR PRODUCING ALKALI TAURINATE
There is disclosed a cyclic process for producing alkali taurinate from a solution comprising alkali ditaurinate and alkali tritaurinate by the ammonolysis in...
2019/0112261 CYCLIC PROCESS FOR PRODUCING ALKALI TAURINATE
There is disclosed a cyclic process for producing alkali taurinate from a solution comprising alkali tritaurinate and isethionate by the ammonolysis in the...
2019/0112260 CYCLIC PROCESS FOR PRODUCING ALKALI TAURINATE
There is disclosed a cyclic process for producing alkali taurinate from a solution comprising alkali tritaurinate by the ammonolysis in the presence of one or...
2019/0112259 METHOD FOR PRODUCING 1,5-PENTANEDIISOCYANATE IN THE GAS PHASE
The invention relates to a method for producing 1,5-pentanediisocyanate (PDI) by reacting 1,5-pentanediamine (PDA) with phosgene in the gas phase.
2019/0112258 COMPOSITIONS AND METHODS FOR TREATING LIVER CANCER
Provided herein are compositions and methods of treating liver cancer by novel anticancer agents.
2019/0112257 Etheramine Compounds
Embodiments described herein provide a compound that may be used in a variety of applications such as corrosion inhibition, additives for metalworking, mining...
2019/0112256 POLYETHERAMINES BASED ON 1,3-DIALCOHOLS
Described herein is an etheramine mixture including at least 90% by weight, based on the total weight of the etheramine mixture, of an amine of Formula (I)...
2019/0112255 METHOD FOR PRODUCING METHYLMETHACRYLATE
The present invention relates to a process for producing methyl methacrylate, comprising the following steps: A) producing methacrolein and B) reacting the...
2019/0112254 METHOD OF PRODUCING HYDROXYCINNAMIC ACIDS
A method efficiently produces hydroxycinnamic acids having a high quality, from a cellulose-containing biomass. More specifically, the method includes the...
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