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Patent # Description
2019/0119349 PAR3 MIMETIC PEPTIDES AND USES THEREOF
This invention is in the field of medicinal pharmacology. In particular, the invention relates to protease activated receptor type 3 (PAR3) modulating...
2019/0119348 PARATHYROID HORMONE RECEPTOR 1 ANTAGONIST AND INVERSE AGONIST POLYPEPTIDES AND METHODS OF THEIR USE
Parathyroid hormone receptor 1 (PTHR1) antagonist and inverse agonist polypeptides and pharmaceutically acceptable salts thereof are disclosed. The...
2019/0119347 GLUCAGON DERIVATIVE, CONJUGATE THEREOF, COMPOSITION COMPRISING SAME, AND THERAPEUTIC USE THEREOF
The present invention relates to a glucagon derivative, a conjugate thereof, and a composition comprising the same, and a therapeutic use thereof, and in...
2019/0119346 SUPERAGONISTS, PARTIAL AGONISTS AND ANTAGONISTS OF INTERLEUKIN-2
Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for...
2019/0119345 COMPOSITIONS AND METHODS FOR TARGETED CYTOKINE DELIVERY
The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to an...
2019/0119344 CONTROL SYSTEM AND METHOD FOR TAPERED STRUCTURE CONSTRUCTION
A control system for forming a tapered structure includes a sensor providing feedback for a machine for forming a tapered structure including at least three...
2019/0119343 ARTIFICIAL SYNAPSE INDUCER AND METHOD OF MAKING THE SAME
Disclosed is a polypeptide containing an extracellular domain of a synaptogenic protein, and a method for manufacturing a nerve cell, a complex containing a...
2019/0119342 Novel peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0119341 Compositions of phosphorylated tau peptides and uses thereof
Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides,...
2019/0119340 PEPTIDES AND NANOPARTICLE FORMULATIONS THEREOF
The present invention relates to peptides, methods for production of the same, nanoparticle formulations of the same and the use of these new peptides and...
2019/0119339 NOVEL HUMAN ULIP/CRMP PROTEIN AND USE THEREOF IN DIAGNOSIS AND TREATMENT OF CANCERS AND PARANEOPLASTIC...
A purified polypeptide, designated ULIP6, comprising the amino acid sequence SED ID No. 2 or an epitopic fragment of said polypeptide, comprising the sequence...
2019/0119338 COMPOSITIONS AND METHODS FOR OLIGODENDROCYTE DEVELOPMENT
The present invention provides compositions and methods for increasing myelination in the nervous system or a subject, including for the treatment of a disease...
2019/0119337 METHODS OF TREATING MITOCHONDRIAL DISORDERS
Provided herein are methods for treating a disease or disorder associated with mitochondrial dysfunction through ex vivo introduction of a nucleic acid...
2019/0119336 PESTICIDAL FUSION PROTEIN IMPROVEMENTS
Methods of increasing the biological activity of toxins. Methods of increasing the biological activity of pesticide toxins through the incorporation of...
2019/0119335 MODIFIED BIOTIN-BINDING PROTEIN, FUSION PROTEINS THEREOF AND APPLICATIONS
The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins...
2019/0119334 INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal...
2019/0119333 MODIFIED IMMUNOGLOBULIN K CHAIN VARIABLE REGION-BINDING PEPTIDE
A first immunoglobulin .kappa. chain variable region-binding peptide includes an amino acid sequence of SEQ ID NO: 20 with at least one substitution at one or...
2019/0119332 METHODS TO PURIFY AVIDIN-LIKE PROTEINS AND FUSION PROTEINS THEREOF
The present invention generally relates to separation matrix comprising a lipoic acid (LA) compound or derivative thereof for use in a method for purifying and...
2019/0119331 SYSTEM AND METHOD OF OPTOGENETICALLY CONTROLLING METABOLIC PATHWAYS FOR THE PRODUCTION OF CHEMICALS
A system and method for controlling metabolic enzymes or pathways in cells to produce a chemical above the levels of a wild-type strain is disclosed. The...
2019/0119330 STABILIZED SOLUBLE PRE-FUSION RSV F PROTEINS
Stable pre-fusion respiratory syncitial virus (RSV) F proteins (or fragment thereof) are described. Compositions containing the proteins and uses of the...
2019/0119329 COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE AND INFLAMMATORY DISORDERS
Ligand-specific HVEM variants, compositions comprising such variants, and methods of treating inflammatory diseases comprising administering such variants, are...
2019/0119328 MODULATION OF COMPLEMENT ACTIVITY
The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
2019/0119327 SELECTIVE DELIVERY MOLECULES AND METHODS OF USE
Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells...
2019/0119325 CNP CYCLIC PEPTIDE, AND MEDICINE, EXTERNAL PREPARATION AND COSMETIC EACH CONTAINING SAID CYCLIC PEPTIDE
The present invention is aimed at providing a novel peptide with quick expression of drug efficacy/effect and long duration of maintaining amelioration, a...
2019/0119324 PEPTIDE FOR PREVENTING OR TREATING INFLAMMATORY DISEASES AND USE THEREOF
Provided is a peptide for preventing or treating inflammatory diseases and a use thereof. According to a novel dimeric peptide according to the present...
2019/0119323 BONE DELIVERY CONJUGATES AND METHOD OF USING SAME TO TARGET PROTEINS TO BONE
A bone delivery conjugate having a structure selected from the group consisting of: A) X-D.sub.n-Y-protein-Z; and B) Z-protein-Y-D.sub.n-X, wherein X is absent...
2019/0119322 PREPARATION OF FUNCTIONAL HOMOCYSTEINE RESIDUES IN POLYPEPTIDES AND PEPTIDES
Methodology was developed for transformation of methionine residues into homocysteine derivatives. Methionine residues can undergo alkylation reactions at low...
2019/0119321 PEPTIDE SHOWING MELANIN GENERATION -PROMOTING ACTIVITY AND USE THEREOF
The present invention provides a peptide which shows a melanin generation-promoting activity. The peptide of the present invention increases the activity and...
2019/0119320 INHIBITORS OF METASTASIS
The present invention relates to methods and compounds for treating or preventing cancer. Methods and compositions provided include including inhibiting or...
2019/0119319 SUGAR-DIPEPTIDE CONJUGATES AS FLAVOR MOLECULES
The present invention relates to compounds and compositions for use in enhancing flavor and umami taste of food products. Particularly, the present invention...
2019/0119318 Separation Matrix
The invention relates to a separation matrix comprising at least 11 mg/ml Fc-binding ligands covalently coupled to a porous support, wherein: a) the ligands...
2019/0119317 CATION EXCHANGE CHROMATOGRAPHY METHODS
The present invention provides improved methods of protein purification using CEX chromatography. Such methods generally comprise the steps of: contacting a...
2019/0119316 NEW NUCLEOPHILE-REACTIVE SULFONATED COMPOUNDS FOR THE (RADIO)LABELLING OF (BIO)MOLECULES; PRECURSORS AND...
Nucleophile-reactive sulfonated compounds used as precursors to (radio)labelled (bio) molecules are produced by pre-introduction of a nucleophilic compound R*...
2019/0119315 Methods And Compositions For Incorporating Nucleotides
The invention provides methods and compositions, including, without limitation, algorithms, computer readable Media, computer programs, apparatus, and systems...
2019/0119314 SEPARATION OF OLIGOSACCHARIDES FROM FERMENTATION BROTH
The invention relates to a method for obtaining an N-acetylglucosamine containing neutral oligosaccharide from a fermentation broth, wherein said...
2019/0119313 IMPROVED PREPARATION OF VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE TYPE 3
The present invention relates to the preparation of a synthetic tetrasaccharide, hexasaccharide and octasaccharide representing part of the repeating unit of...
2019/0119312 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
A compound having the following formula ##STR00001## is disclosed. The compound is useful as an emitter in OLED applications.
2019/0119311 COMPOUNDS AND THE USE THEREOF IN METATHESIS REACTIONS
The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the...
2019/0119310 PREPARATION OF PSILOCYBIN, DIFFERENT POLYMORPHIC FORMS, INTERMEDIATES, FORMULATIONS AND THEIR USE
This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity...
2019/0119309 PHARMACEUTICAL COMPOUNDS
Therapeutically-effective amounts of novel analogs or derivatives of alkyl fatty acids, such as but not limited to lipoic acid, and pharmaceutical formulations...
2019/0119308 POLYCYCLIC AMINOSILANE COMPOUNDS AND MAKING METHOD
Polycyclic aminosilane compounds of specific structure are fully effective for use as silane coupling agents, surface treating agents, resin additives, paint...
2019/0119307 PROCESS TO PREPARE ALUMINOXANES
Process to prepare alkylaminoxane by reacting, in the absence of solvent, 1 molar equivalent of alkylaluminium with 0.1 to 0.8 molar equivalent of a...
2019/0119306 Novel Process for the Preparation of Tavaborole, Its Novel Polymorphic Forms and the Polymorphs Thereof
The invention relates to novel process for preparation of Tavaborole. The invention also relates to novel polymorphic forms of Tavaborole and process for...
2019/0119305 HIGHLY FLUORESCENT PYRROLE-BF2 CHROMOPHORES
Fluorescent chromophores nicknamed BOPHY are provided. The chromophores may be readily synthesized in two steps from readily available reagents via the...
2019/0119304 ENAMINES AND DIASTEREO-SELECTIVE REDUCTION OF ENAMINES
Described herein is a compound having a chemical structure of Formula A: ##STR00001## wherein m, p, q, W, Z, Y, X.sup.1, X.sup.2, R.sup.1, R.sup.2, R.sup.3 and ...
2019/0119303 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINE AND THERAPEUTIC USES THEREOF
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
2019/0119302 Fused Pentacyclic Imidazole Derivatives as Modulators of TNF Activity
A series of substituted fused pentacyclic benzimidazole derivatives, and analogues thereof, being potent modulators of human TNF.alpha. activity, are...
2019/0119301 THIAZOLYL-CONTAINING COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES
The present disclosure provides thiazolyl-containing compounds of Formula (I), (II), or (III). The compounds described herein may be able to inhibit protein...
2019/0119300 SUBSTITUTED AND FUSED 6-MEMBERED PROTEASE ACTIVATED RECEPTOR 4 (PAR-4) ANTAGONISTS
Embodiments of the invention include compounds and compositions thereof to inhibit protease activated receptor-4. Also described are methods of preparation of...
2019/0119299 CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS
Fused aromatic bicyclic substituted 5-(2-amino-4-pyrimidinyl)-cyanoindoline derivatives (I) useful for therapy and/or prophylaxis in a mammal, and in...
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