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Patent # Description
2019/0127751 ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES AND METHODS OF USING SAME FOR INCREASING PLANT YIELD, BIOMASS, GROWTH...
Provided are isolated polynucleotides comprising a nucleic acid sequence encoding a polypeptide at least 80% identical to SEQ ID NO: 422, 362-421, 423-601,...
2019/0127750 INHIBITION OF BOLTING AND FLOWERING OF A BETA VULGARIS PLANT
The present invention provides means for inhibiting the bolting and flowering of a Beta vulgaris plant, including an isolated nucleic acid, which can be used...
2019/0127749 RESOURCE USE EFFICIENCY IMPROVEMENT IN PLANTS
Polynucleotides and polypeptides incorporated into expression vectors are introduced into plants and were ectopically expressed. These polypeptides may confer...
2019/0127748 SEED- AND FUNICULUS-PREFERENTIAL PROMOTERS AND USES THEREOF
The present invention relates to Brassica sequences comprising seed- and funiculus-preferential promoter activity. Provided are recombinant genes comprising...
2019/0127747 SEED-SPECIFIC AND ENDOSPERM-PREFERENTIAL PROMOTERS AND USES THEREOF
The present invention relates to Brassica sequences comprising early stage seed-specific and endosperm preferential promoter activity. Provided are recombinant...
2019/0127746 ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES, AND METHODS OF USING SAME FOR INCREASING YIELD OF PLANTS
Provided are isolated polynucleotides and nucleic acid constructs which comprise a nucleic acid sequence at least 80% identical to a nucleic acid sequence...
2019/0127745 FERMENTATIVE GLYCEROL-FREE ETHANOL PRODUCTION
The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent...
2019/0127744 BACTERIAL LEADER SEQUENCES FOR PERlPLASMIC PROTEIN EXPRESSION
Provided herein are bacterial leader sequences for periplasmic expression of heterologous proteins, fusion proteins comprising bacterial leader sequences, and...
2019/0127743 METHOD FOR PRODUCTION OF RECOMBINANT E. COLI ASPARAGINASE
Provided herein are methods of production of recombinant E. coli asparaginase. Methods herein allow production of asparaginase in Pseudomonadales host cells at...
2019/0127742 METHOD FOR PRODUCTION OF RECOMBINANT ERWINIA ASPARAGINASE
Provided herein are methods of production of recombinant Erwinia asparaginase. Methods herein produce asparaginase having high expression levels in the...
2019/0127741 COMPOSITIONS AND METHODS FOR REGULATING CELL OSMOLARITY
The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in...
2019/0127740 Targeting the Steroidogenic Pathway For Treating and/or Preventing Allergic Diseases
The present invention relates to methods and compositions for treating and/or preventing allergic diseases or conditions by inhibiting one or more components...
2019/0127739 SELF-ASSEMBLED 3D RNA CAGE NANOPARTICLES
Disclosed herein are three-dimensional cage molecules, wherein the cage molecule is composed of RNA. Also disclosed is a composition including the...
2019/0127737 SINGLE-STRANDED RNAI OLIGONUCLEOTIDES TARGETING APOC-III
The present disclosure pertains generally to chemically-modified oligonucleotides for use in research, diagnostics, and/or therapeutics. In certain...
2019/0127736 INHIBITION OF MIR-22 MIRNA BY APT-110
Increase of energy expenditure as an effective treatment of obesity and related disorders is a target for drug research and development. A 15% increase of...
2019/0127735 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA
Provided are LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.
2019/0127734 MIR-29 MIMICS AND USES THEREOF
The present invention relates to synthetic oligonucleotide mimetics of miRNAs. In particular, the present invention provides double-stranded, ...
2019/0127733 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided...
2019/0127732 ASSAY FOR EXO-SITE BINDING MOLECULES
Methods for the identification of agents the bind to exo-sites of proteins are provided. Agents identified by the methods described herein and pharmaceutical...
2019/0127731 METHODS FOR PREPARING NUCLEIC ACID MOLECULES
Provided herein are methods for preparing nucleic acid molecules for sequencing. The methods may include generation of individual partitions (e.g., droplets or...
2019/0127730 Engineered FHA Domains
A binding agent to a target molecule, or method or kit where the binding agent is selected from a library where each variant has a circular permutation of the...
2019/0127729 DEVICE AND METHOD FOR ISOLATING NUCLEIC ACIDS FROM WHOLE BLOOD
The invention relates to a composition for stabilizing the total nucleic acids from whole blood, in particular RNA, and to a process for stabilizing the total...
2019/0127728 METHODS FOR CELL-FREE DNA EXTRACTION FOR NON-INVASIVE PRENATAL SCREENING
Provided herein are methods and systems for cell-free DNA extraction from liquid biological samples. The methods can be employed for determination of fetal DNA...
2019/0127727 METHOD FOR EXTRACTING POLYHYDROXYALKANOATES (PHAS)
The present invention provides a method for extracting polyhydroxyalkanoates (PHAs), which comprises a pre-process step and an extraction step: removing water...
2019/0127726 DELIVERING ENZYME USING AN INJECTABLE HYDROGEL DEPOT
Compositions and methods for delivering enzymes in enzyme hydrogel formulations are disclosed. More particularly, the present disclosure relates to injectable...
2019/0127725 ACETYL-COA CARBOXYLASES
The present invention provides various combinations of genetic modifications to a transformed host cell that provide increase conversion of carbon to a...
2019/0127724 METHYLMALONYL COENZYME A MUTASE (MCM) FUSION CONSTRUCTS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH MCM...
The present invention provides compositions and methods relating to protein replacement therapy for the treatment of disorders associated with Methylmalonyl...
2019/0127723 Thermophilic and Thermoacidophilic Metabolism Genes and Enzymes from Alicyclobacillus Acidocaldarius and...
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are...
2019/0127722 ALGINATE LYASES AND A METHOD FOR PRODUCING UNSATURATED URONIC ACID MONOSACCHARIDE USING THE ENZYMES
Alginate lyase activity is exhibited by the amino acid sequences (polypeptides) shown in SEQ ID No:1 and SEQ ID No:2. These polypeptides and their homology...
2019/0127721 MODIFIED CASPASE-9 POLYPEPTIDES AND METHODS OF USE THEREOF
Provided herein are modified caspase-9 polypeptides, and chimeric caspase-9 proteins containing the modified caspase-9 polypeptides. The disclosure further...
2019/0127720 PROCESS FOR MAKING RECOMBINANT ANTIDOTE TO FACTOR XA INHIBITOR
Disclosed are methods and isolated cells useful for the improved production of function fXa derivative protein that acts as a fXa inhibitor antidote. One...
2019/0127719 NOVEL PROTEASE WITH IMPROVED WASHING PERFORMANCE
The present disclosure relates to proteases comprising an amino acid sequence which has at least about 70% sequence identity to the amino acid sequence...
2019/0127718 SUPPRESSION OF CANCER
Polypeptides for use in suppressing cancer and cancer disorders and methods of treatment using such polypeptides.
2019/0127717 Compositions Comprising Polypeptides having Galactanase Activity and Polypeptides having Beta-Galactosidase...
The present invention relates to compositions comprising polypeptides having galactanase activity and polypeptides having beta-galactosidase activity for use...
2019/0127716 LYSOZYME HAVING IMPROVED ENZYMATIC ACTIVITY
A lysozyme having improved enzymatic activity is disclosed. The amino acid sequence of the lysozyme is a modified amino acid sequence of SEQ ID NO: 2 or a...
2019/0127715 RECOMBINANT EXTRACELLULAR CHITINASE FROM BREVIBACILLUS LATEROSPORUS FOR BIOLOGICAL CONTROL AND OTHER INDUSTRIAL...
The present invention discloses a recombinant, modified extracellular chitinase having an amino acid sequence set forth in SEQ ID NO.4 or SEQ ID NO.5. The...
2019/0127714 HETEROLOGOUS EXPRESSION OF TERMITE CELLULASES IN YEAST
The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be...
2019/0127713 CRISPR/CAS9-BASED REPRESSORS FOR SILENCING GENE TARGETS IN VIVO AND METHODS OF USE
The present disclosure provides Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
2019/0127712 Phytases, Nucleic Acids Encoding Them and Methods for Making and Using Them
This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and...
2019/0127711 IDENTIFYING LIGANDS FOR BACTERIAL SENSORS
Methods to create two component signal transduction systems by replace the DNA binding domains and output promoters in bacteria are described.
2019/0127710 TIME RELEASE ENZYMATIC HYDROGEN SULFIDE SCAVENGERS
A method of reducing an amount of a sulfur-containing compound in a base fluid comprises contacting the base fluid comprising the sulfur-containing compound...
2019/0127709 MYRMECRIDIUM FLEXUOSUM NUK-21, NOVEL LACTOSE OXIDASE ISOLATED FROM MYRMECRIDIUM FLEXUOSUM NUK-21, AND METHOD...
A Myrmecridium flexuosum NUK-21, a novel lactose oxidase isolated from the Myrmecridium flexuosum NUK-21 and a method for conversion of lactose into...
2019/0127708 MESSENGER RNA BASED VIRAL PRODUCTION
The present invention provides methods for producing recombinant viral particles based on the use of exogenous mRNAs to supply various helper factors for...
2019/0127707 MEDIUM FOR CULTURING NAIVE PLURIPOTENT STEM CELLS AND METHOD FOR CULTURING PLURIPOTENT STEM CELLS
An object of the present invention is to provide a medium for culturing naive pluripotent stem cells which is for efficiently proliferating naive pluripotent...
2019/0127706 METHOD FOR HARVESTING STEM AND PROGENITOR CELLS AND METHOD OF TREATMENT OF KIDNEY DISEASE AND NEUROLOGICAL DISEASE
A method of generating one of podocyte progenitor cells and neural stem/progenitor cells comprising the steps of collecting a urine specimen from a patient;...
2019/0127705 METHOD FOR CULTURING MULTIPLE OVARIAN FOLLICLES BY USING ANGIOTENSIN II RECEPTOR AGONIST
A method for culturing multiple ovarian follicles by using an angiotensin II receptor agonist, including a first culturing step of culturing a cluster of...
2019/0127704 PANCREATIC ENDOCRINE CELLS, METHOD FOR PRODUCING SAME, AND TRANSDIFFERENTIATION AGENT
A method for producing pancreatic endocrine cells, the method including introducing one or more genes of a GLIS family or one or more gene products thereof and...
2019/0127703 Generation Of Glucose-Responsive Beta Cells
The present invention relates to a method for generating glucose-responsive beta cells.
2019/0127702 STEM CELL COMPOSITIONS AND METHODS OF PRODUCING STEM CELLS FOR THERAPEUTIC APPLICATIONS
The present method relates to methods of expanding or increasing stem cell production obtained from donor samples. The methods preferably including the steps...
2019/0127701 MSC GROWTH PREDICTOR ASSAYS
Methods for selecting lots of bone marrow stromal cells (MSCs) having a high proliferative capacity are provided. Such methods are useful in the manufacture of...
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