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Patent # Description
2019/0127497 Toluene Free Silica Supported Single-Site Metallocene Catalysts from In-Situ Supported MAO Formation in...
The present disclosure provides a method for preparing a catalyst system comprising contacting in an aliphatic solvent at a temperature of from less than...
2019/0127496 CONTINUOUS TUNING OF Cl:Mg RATIO IN A SOLUTION POLYMERIZATION
The activity of an in situ prepared Ziegler Natta catalyst in a solution polymerization may be tuned on a continuous basis by monitoring the catalyst activity...
2019/0127495 PROCESS FOR PRODUCING EPOXIDIZED POLYMERS
A process for forming an epoxidized rubber including dissolving a rubber in a solvent and epoxidizing the rubber in the presence of an epoxidation reagent. The...
2019/0127494 Method for Obtaining at Least One or More Beta-Glucan Compounds or a Solids Suspension Containing Beta Glucan...
The invention relates to a method for obtaining beta glucan from yeast cells, at least comprising the following steps: A. enriching yeast cells (10); B....
2019/0127493 METHOD FOR EXTRACTING TREMELLA POLYSACCHARIDE WITH BUFFER SOLUTION
The present invention provides a method for extracting Tremella polysaccharides by using buffer solution, which comprises the following steps: leaching...
2019/0127492 BIOPOLYMERS HAVING COILED NANOSTRUCTURES AND PROCESSES INCORPORATING THE BIOPOLYMERS
The present disclosure is generally directed to biopolymers having coiled nanostructures, methods of making those biopolymers, and applications involving those...
2019/0127491 METAL-CONTAINING OXIDIZED CELLULOSE NANOFIBER DISPERSION AND METHOD OF PRODUCING THE SAME
Disclosed is a dispersion of metal-containing oxidized cellulose nanofibers with superior dispersibility, which is applicable to various uses. The disclosed...
2019/0127490 METHODS OF MAKING GELS AND FILMS USING CURLI NANOFIBERS
Provided are compositions and methods of making hydrogels, aerogels, films and composites directly from a microbial culture or complex mixture using curli...
2019/0127489 Dual Specificity Antibody Fusions
The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab' fragment with specificity for an antigen of...
2019/0127488 ANTIBODY WITH NON-NATURAL AMINO ACID INTRODUCED THEREIN
The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a...
2019/0127487 CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or...
2019/0127486 ANTIBODIES TO MATRIX METALLOPROTEINASE 9
The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind...
2019/0127485 CRYSTALLINE ANTIBODY FORMULATIONS
Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
2019/0127484 Compositions and Methods of Inhibiting MASP-1 and/or MASP-2 and/or MASP-3 for the Treatment of Various Diseases...
In one aspect, the invention provides methods and compositions for inhibiting MASP-3-dependent complement activation in a subject suffering from or at risk for...
2019/0127483 METHODS FOR TREATMENT AND DIAGNOSIS OF CANCER BY TARGETING GLYCOPROTEIN A REPETITIONS PREDOMINANT (GARP) AND...
Isolated or recombinant monoclonal antibodies that bind to GARP are provided. In some cases, antibodies of the embodiments can be used for the detection,...
2019/0127482 CONJUGATES OF SURROGATE LIGHT CHAIN CONSTRUCTS
The present invention concerns methods for identifying, producing, and engineering binding molecule conjugates, and to the conjugates produced. In particular,...
2019/0127481 Bispecific HER2 Ligands for Cancer Therapy
The invention relates to a bispecific HER2-targeting agent that includes (a) a first polypeptide ligand that binds to HER2 extracellular domain 1, (b) a second...
2019/0127480 Anti-PSMA Antibodies, Bispecific Antigen-Binding Molecules that Bind PSMA and CD3, and Uses Thereof
The present invention provides antibodies that bind to prostate-specific membrane antigen (PSMA), bispecific antibodies that bind to PSMA and CD3, and methods...
2019/0127479 Methods of Treating High Risk Multiple Myeloma
Disclosed are methods of treating a subject having high-risk multiple myeloma, methods of achieving negative minimal residual disease status in a subject...
2019/0127478 ANTI-PD-1 ANTIBODIES, METHOD FOR PRODUCING SAME AND METHOD FOR USING SAME
The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind...
2019/0127477 NEW ANTI-SIRPa ANTIBODIES AND THEIR THERAPEUTIC APPLICATIONS
The present invention provides new anti-SIRPa antibodies able to specifically antagonize the interaction between SIRPa and CD47, without affecting the...
2019/0127476 NOVEL ANTI-TNFRSF21 ANTIBODIES AND METHODS OF USE
Provided are novel anti-TNFRSF21 antibodies and antibody drug conjugates, and methods of using such anti-TNFRSF21 antibodies and antibody drug conjugates to...
2019/0127475 ANTI-SORTILIN ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments,...
2019/0127474 GALECTIN IMMUNOTHERAPY
A method of modulating immunity in a mammal is provided by modulating Galectin-9 activity in the mammal. Promoting or enhancing immunity may be effected by...
2019/0127473 ANTI-GALECTIN-1 (GAL1) MONOCLONAL ANTIBODIES AND FRAGMENTS THEREOF FOR NEUTRALIZING GAL1
The present invention is based, in part, on the discovery of galectin 1 (Gal1) epitopes against which anti-Gal1 agents can neutralize Gal1 function, as well as...
2019/0127472 ANTI-GALECTIN-9 ANTIBODIES AND USES THEREOF
Disclosed herein are anti-Galectin-9 antibodies and methods of using such for inhibiting a signaling pathway mediated by Galectin-9 or eliminating pathologic...
2019/0127471 NOVEL B7-H3 BINDING MOLECULES, ANTIBODY DRUG CONJUGATES THEREOF AND METHODS OF USE THEREOF
The present invention is directed to novel B7-H3-binding molecules capable of binding to human and non-human B7-H3, and in particular to such molecules that...
2019/0127470 HIGH AFFINITY B7-H6 ANTIBODIES AND ANTIBODY FRAGMENTS
Provided herein, in some embodiments, are antibodies, antigen-binding antibody fragments, chimeric antigen receptors (CARs) and bispecific T cell engagers...
2019/0127469 ANTIBODY THERAPEUTICS THAT BIND CTLA4
There is disclosed compositions and methods relating to or derived from anti-CTLA4 antibodies. More specifically, there is disclosed fully human antibodies...
2019/0127468 Chimeric and Humanized Anti-Human CTLA4 Monoclonal Antibodies and Uses Thereof
This invention relates to compositions of chimeric and humanized antibodies that bind to the human CTLA4 molecule and their use in cancer immunotherapy and for...
2019/0127467 PD-1-Binding Molecules and Methods of Use Thereof
The present invention is directed to selected anti-PD-1 antibodies capable of binding to both cynomolgus monkey PD-1 and to human PD-1: PD-1 mAb 1, PD-1 mAb 2,...
2019/0127466 HIV-1 VACCINE
A method for inducing an immune response against HIV in a subject includes the step of preparing an HIV-1 gp120 envelope protein coding sequence particle...
2019/0127465 ADMINISTRATION OF A BISPECIFIC CONSTRUCT BINDING TO CD33 AND CD3 FOR USE IN A METHOD FOR THE TREATMENT OF...
The present invention provides a bispecific construct comprising a first binding domain specifically binding to CD33 and a second binding domain specifically...
2019/0127463 COMPOUND THAT SPECIFICALLY BINDS TO KIR3DL2 FOR USE IN THE TREATMENT OF PERIPHERAL T CELL LYMPHOMA
The present invention relates to methods for the treatment, prevention and diagnosis of peripheral T cell lymphoma using compounds that specifically bind...
2019/0127462 Regulatory T Cell Activator and Use Thereof
A regulatory T cell activator including a substance that inhibits the binding between DNAX accessory molecule-1 (DNAM-1) and CD155.
2019/0127461 CANCER TREATMENT PHARMACEUTICAL COMPOSITION USING ANTI-MCT5 ANTIBODY
The present invention aims to provide a cancer-specific new pharmaceutical composition with fewer side effects. The present invention provides a pharmaceutical...
2019/0127460 Treatment for neoplastic diseases
Administration of a mAb that specifically binds IL-1.alpha. is useful for treating tumor-associated diseases in human subjects.
2019/0127459 ANTI-IL-22R ANTIBODIES
The present invention relates to antibodies and antigen binding fragments thereof which bind to the cytokine receptor IL-22R, particularly human IL-22R. The...
2019/0127458 IL8 BLOCKING EMT PATHWAY AND OVERCOMING CANCER STEM CELLS
Compositions, methods, and uses of recombinant recombinant IL-8 antibody, fragment thereof or single chain variable fragment (scFv) having high affinity to...
2019/0127457 FC-REGION VARIANTS WITH IMPROVED PROTEIN A-BINDING
Herein is reported a polypeptide comprising a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a...
2019/0127456 METHODS OF TREATING IDIOPATHIC PULMONARY FIBROSIS
The present invention relates to methods and medicaments useful for treating idiopathic pulmonary fibrosis (IPF) by administering an anti-CTGF antibody. In...
2019/0127455 Treatment of Ocular Diseases with Fully- Human Post-Translationally Modified Anti-VEGF Fab
Compositions and methods are described for the delivery of a fully human post-translationally modified (HuPTM) monoclonal antibody ("mAb") or the ...
2019/0127454 INHIBITION OF SCUBE2, A NOVEL VEGFR2 CO-RECEPTOR, SUPPRESSES TUMOR ANGIOGENESIS
An isolated anti-SCUBE2 (Signal peptide-complement protein Clr/CIs, Uegf: and Bmp 1 (CUB)-epidermal growth factor (EGF) domain-containing protein 2) antibody...
2019/0127453 AN ANTI-C5 ANTIBODY DOSING REGIMEN
The present invention relates to the use of an anti-C5 antibody or binding fragment thereof for the treatment of transplant rejection and in particular...
2019/0127452 DIRECT SELECTION OF CELLS EXPRESSING HIGH LEVELS OF HETEROMERIC PROTEINS USING GLUTAMINE SYNTHETASE INTRAGENIC...
This invention relates to the general field of recombinant expression of polypeptides in animal cell culture. More specifically, the invention concerns...
2019/0127451 Non-Glycosylated Anti-Tenascin Antibody
The present invention relates to variants of the anti-tenascin antibody F16 which are modified to abolish N-glycosylation at positions 88 to 90 in the VL...
2019/0127450 Therapy of multiple organ system failure by anti-toxin antibodies and prophylaxis by anaerobic toxoids
Multiple organ system failure constitutes the most common cause of mortality in intensive care units all over the world. About more than 70 thousand deaths...
2019/0127449 Compositions and methods for treating and preventing staphylococcus aureus infections
Antibodies having Fab regions that specifically bind to Staphylococcus aureus protein A are capable of mediating opsinization of Staphylococcus aureus bacteria...
2019/0127448 POLY-N-ACETYL GLUCOSAMINE (PNAG/DPNAG)-BINDING PEPTIDES AND METHODS OF USE THEREOF
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as...
2019/0127447 TREATMENT OF RSV INFECTION
Methods are provided for the treatment of RSV infections in young children. More specifically, methods are provided wherein polypeptides that bind F protein of...
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