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Patent # Description
2019/0127446 Polypeptides With Enhanced Anti-Inflammatory And Decreased Cytotoxic Properties And Relating Methods
The invention provides a polypeptide containing at least one IgG Fc region, wherein said at least one IgG Fc region is glycosylated with at least one galactose...
2019/0127445 SUCCINIMIDE-ACTIVATED NITROXYL COMPOUNDS AND METHODS FOR THE USE THEREOF FOR NITROXYLATION OF PROTEINS
The present invention relates to succinimide-activated nitroxyl compounds and methods for the synthesis of such compounds. The present invention also relates...
2019/0127444 COMPOSITIONS AND METHODS FOR ANTI-STAPHYLOCOCCAL BIOLOGIC AGENTS
The present disclosure is directed to staphylococcal leukotoxin and hemolysin binding molecules and fusion constructs. The present disclosure is further...
2019/0127443 MULTIVALENT HETEROMULTIMER SCAFFOLD DESIGN AND CONSTRUCTS
Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein...
2019/0127442 COMPOSITIONS AND METHODS FOR ANTI-THROMBOTIC AND HEMOSTATIC THERAPIES
In various embodiments, disclosed herein are assays for measuring thrombin generated (TG) in a blood sample, comprising: incubating the blood sample with TF,...
2019/0127441 METHODS AND COMPOSITIONS FOR REDUCING VIRUS INFECTIVITY
The invention relates, in part, to compounds, compositions, and methods to reduce infectivity of virus particles and to treat viral infections in subjects.
2019/0127440 NOVEL TSLP INHIBITORS
The present invention relates to monomeric fusion proteins comprising the extracellular part of the thymic stromal lymphopoietin receptor (TSLPR) and the...
2019/0127439 ENGINEERED PD-1 VARIANTS
Isolated polypeptides comprising engineered mutant PD-1 polypeptide are provided, as are fusion polypeptides comprising the mutant and methods of use thereof....
2019/0127438 ALPHA CHAIN OF THE HIGH-AFFINITY IGE RECEPTOR (FCERIA)
Disclosed is an alpha chain of the human high-affinity IgE receptor (FceRIa), wherein the amino acid lysine at position 43 (K43) is exchanged with an amino...
2019/0127437 NOVEL CTLA4-IG IMMUNOADHESINS
The present application relates to CTLA4-Ig immunoadhesins that target CD80 and CD86, and their use, particularly for therapeutic purposes.
2019/0127436 T CELL RECEPTORS
The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the MAGE-A4...
2019/0127435 IMMUNOMODULATORY IL2R FUSION PROTEINS AND USES THEREOF
The present disclosure relates to fusion proteins containing an extracellular cytokine binding domain and an intracellular signaling domain of one or more...
2019/0127434 METHOD FOR PRODUCING TLR5 AGONIST PROTEIN
The present disclosure relates to a method for producing a TLR5 agonist protein. According to the present disclosure, the TLR5 agonist protein can be easily...
2019/0127433 GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS
Provided herein are peptides and variant peptides that exhibit enhanced activity at the GLP-1 receptor, as compared to native glucagon.
2019/0127432 GLYCOPROTEIN HORMONE LONG-ACTING SUPERAGONISTS
This invention provides long-acting, superactive analogs of glycoprotein hormones demonstrating enhanced bioactivity both in vitro and in vivo as compared to...
2019/0127431 CELL-PENETRATING PEPTIDE
A cell-penetrating peptide has remarkably excellent cell penetration efficiency, and is capable of penetrating 100% into all cells within 1 hour even in an...
2019/0127430 RECOMBINANT FILAGGRIN POLYPEPTIDES FOR CELL IMPORTATION
Disclosed are recombinant polypeptides that include (a) a filaggrin amino acid sequence and (b) a cell importation signal sequence that includes a motif of two...
2019/0127429 CONJUGATES OF ISLET NEOGENESIS PEPTIDES AND ANALOGS, AND METHODS THEREOF
The invention provides novel compounds, in particular peptide and peptide analogs, which exhibit functionalities useful for treating a variety of diseases and...
2019/0127428 Fusion Protein and Nucleic Acid Molecule for Light-Dependent Stress Granule Assembly
A nucleic acid molecule encoding a fusion protein composed of a plant cryptochrome at the amino terminus, and a GTPase-Activating Protein SH3 Domain-Binding...
2019/0127427 CHIMERIC NEUROTOXINS
The present invention relates to chimeric neurotoxins with enhanced properties and their use in therapy.
2019/0127426 NEISSERIA MENINGITIDIS COMPOSITION AND METHODS THEREOF
In one aspect, the invention relates to a non-lipidated and non-pyruvylated Neisseria meningitidis serogroup B polypeptide and methods of use thereof. In...
2019/0127425 COMPOSITIONS AND METHODS FOR INSECT CONTROL
Described herein are expression vectors encoding the Wolbachia protein WalE1. Also described are insects transformed with an expression vector of the present...
2019/0127424 CAPSID-MODIFIED RAAV VECTOR COMPOSITIONS AND METHODS THEREFOR
Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations containing them. Also...
2019/0127423 Hexon protein hypervariable region gene sequence of adenovirus and its application
The invention provides a Gene sequence which can encode and express adenovirus hexon protein in vitro, and is represented as SEQ ID NO: 3. Also invented a...
2019/0127422 HUMAN CYTOMEGALOVIRUS GB POLYPEPTIDE
The present invention relates to a polypeptide that includes at least one mutation in the fusion loop 1 region and/or in the fusion loop 2 region and/or in the...
2019/0127421 INSECT, TICK, AND MITE REPELLENT DERIVED FROM XENORHABDUS BUDAPESTENSIS
Insect-repellent compositions containing compounds of Formula I: ##STR00001## wherein R is a 5-membered or 6-membered carbon-containing ring, having zero, one,...
2019/0127420 DIPEPTIDE ANALOGS AS TGF-BETA INHIBITORS
The present disclosure is concerned with dipeptide analogs that are capable of inhibiting TGF-.beta. and methods of treating cancers such as, for example,...
2019/0127419 NEUROPEPTIDE S RECEPTOR (NPSR) AGONISTS
Neuropeptide S receptor agonists are provided. The NPS agonists include trimeric, tetrameric, pentameric or hexameric peptidomimetic analogs exhibiting...
2019/0127418 METHODS OF PURIFYING FC-CONTAINING PROTEINS
The present invention relates to methods of purifying proteins containing Fc regions, such as antibodies and Fc fusion proteins. In particular, the present...
2019/0127417 CRYSTALLINE POLYMORPH OF 15B-HYDROXY-OSATERONE ACETATE
Provided is a crystalline polymorphic form A of 15.beta.-hydroxy-osaterone acetate having an improved stability (storage stability, pulverization stability,...
2019/0127416 NEW SQUALAMINE SOLID FORMS AND METHODS OF MAKING THE SAME
Provided herein are crystalline solid forms of squalamine phosphate designated as Form 1 and Form 2, compositions containing one or both forms, and methods of...
2019/0127415 SYNTHETIC BILE ACID COMPOSITIONS AND METHODS
Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being...
2019/0127414 NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF
Compounds are provided according to Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein...
2019/0127413 Compositions and Methods for Non-Toxic Delivery of Antiprogestins
The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. New compounds and methods for treating...
2019/0127412 SCALABLE SYNTHESIS OF REDUCED TOXICITY DERIVATIVE OF AMPHOTERICIN B
Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2'epiAmB, an efficacious...
2019/0127411 GLYCOLIPOPEPTIDE BIOSURFACTANTS
Surfactants based on a newly discovered class of compounds include a hydrophobic lipid oligomer covalently linked to a peptide or peptide-like chain and a...
2019/0127410 MANGIFERIN-6-O-CALCIUM SALT AND PREPARATION METHOD AND USE THEREOF
The present invention provides a mangiferin-6-O-calcium salt and a preparation process thereof. In addition, use of the mangiferin-6-O-calcium salt as defined...
2019/0127409 SIALIC ACID ANALOGS
The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
2019/0127408 PROCESS FOR PREPARING TRANSITION METAL CARBONATES
A process for preparing transition metal carbonates with a mean particle diameter in the range from 6 to 19 .mu.m (D50), which comprises combining, in a...
2019/0127407 TETRADENTATE LIGAND, AND PRODUCTION METHOD THEREFOR, SYNTHETIC INTERMEDIATE THEREOF, AND TRANSITION METAL...
The present invention relates to: a compound as a ligand in a variety of catalytic organic synthetic reactions; a method for producing the compound; a...
2019/0127406 FLUORENYL THIENOPYRIMIDINE LUMINESCENT MATERIALS
Fluorenyl thienopyrimidine luminescent materials are disclosed. These novel compounds have a pyrimidine heterocycles structure, which can be used as emitters...
2019/0127405 QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION
Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a...
2019/0127404 TH-302 SOLID FORMS AND METHODS RELATED THERETO
The present invention provides a new method for making TH-302 and solid forms thereof. The compound in its solid form is an effective anti-cancer agent and may...
2019/0127403 SILICON-CONTAINING SULFURIC ACID ESTER SALT
Provided is a silicon-containing sulfuric acid ester salt comprising a silicon-containing sulfuric acid ester anion represented by formula (1) and a cation...
2019/0127402 UNIVERSAL ENZYME RESPONSIVE LINKER FOR ASSEMBLING LIGANDS ON DNA FUNCTIONALIZED NANOMATERIALS
Described herein is an enzyme-mediated approach to bioconjugation at nanoparticle (NP) surfaces. This process is enabled by a new synthetic linker compatible...
2019/0127401 CHARGED LINKERS AND THEIR USES FOR CONJUGATION
Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.
2019/0127400 CHARGED LINKERS AND THEIR USES FOR CONJUGATION
Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.
2019/0127399 CHARGED LINKERS AND THEIR USES FOR CONJUGATION
Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.
2019/0127398 PROCESS FOR ORGANOCHLOROSILANE PRODUCTION IN THE FLUIDIZED BED PROCESS
A process for producing organochlorosilanes in a fluidized bed reaction comprises reacting haloorganic reaction gas with a catalytic composition comprising...
2019/0127397 Complexes for Nucleophilic, Radical, and Electrophilic Polyfluoroalkylation
Disclosed herein are borazine complexes and use of the same in perfluoroalkylation reactions.
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