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Patent # Description
2019/0127396 SYNTHESIS OF BORONATE ESTER DERIVATIVES AND USES THEREOF
Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein...
2019/0127395 Arginase Inhibitors and Methods of Use
The present invention is directed to arginase inhibitor compounds of formula IA or formula IB: ##STR00001## or a pharmaceutically acceptable salt thereof,...
2019/0127394 BODIPY DYES FOR BIOLOGICAL IMAGING
This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for making the same. For examples, provided herein...
2019/0127393 Lanthanide Toolbox for Organelle Specific Molecular Imaging with Multi-color
Provided herein are lanthanide complexes that exhibit specific subcellular localization to primary cilium. The lanthanide complexes provided herein are useful...
2019/0127392 QUANTUM DEVICES COMPRISING LANTHANIDE COMPLEXES
A quantum device for interfacing Lanthanide ions with optical fields or microwave fields or both. The device includes waveguides or resonators or both for...
2019/0127391 NOVEL IMIDAZOPYRIDAZINE COMPOUNDS AND THEIR USE
This disclosure provides novel imidazopyridazine compounds of formula (I) and pharmaceutical acceptable salt thereof, pharmaceutical compositions containing...
2019/0127390 MACROCYCLIC RIP2 KINASE INHIBITORS
The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of...
2019/0127389 Processes And Oxazolidine-Containing Intermediates For The Preparation Of Morphine Analogs And Derivatives
The present invention relates to processes useful in the preparation of morphine analogs and derivatives, such as naltrexone, naloxone and nalbuphine and...
2019/0127388 PROCESSES FOR PRODUCING METHENAMINE MANDELATE
Processes are provided for the production of methenamine mandelate that do not require the isolation of produced methenamine prior to production of the...
2019/0127387 MDM2 PROTEIN DEGRADERS
The present disclosure provides compounds represented by Formula I-A: A.sup.1-L.sup.1-B.sup.1 I-A and the pharmaceutically acceptable salts, hydrates, and...
2019/0127386 NOVEL [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES
The invention relates to a compound of formula (I) ##STR00001## wherein R.sup.1 to R.sup.4 are defined as in the description and in the claims. The compound of...
2019/0127385 NOVEL [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES
The invention relates to a compound of formula (I) ##STR00001## wherein R.sup.1 to R.sup.4 are defined as in the description and in the claims. The compound of...
2019/0127384 [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES WITH AFFINITY FOR THE TYPE-2 CANNABINOID RECEPTOR
The invention relates to a compound of formula (I) ##STR00001## wherein R.sup.1 to R.sup.4 and n are defined as in the description and in the claims. The...
2019/0127383 NOVEL [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES
The invention relates to a compound of formula (I) ##STR00001## wherein R.sup.1 to R.sup.4 are defined as in the description and in the claims. The compound of...
2019/0127382 BICYCLIC SULFONES AND SULFOXIDES AND METHODS OF USE THEREOF
The invention provides novel compounds having the general formula I: ##STR00001## wherein R.sup.1, R.sup.B1, R.sup.B2, n, p, q, the A ring and the B ring are as...
2019/0127381 SUBSTITUTED FUSED PYRIMIDINONE COMPOUNDS
Provided herein are novel fused pyrimidinone derivatives of Formula I and synthetic intermediates that are useful in preparing the compounds of formula (I)....
2019/0127380 SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS
Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR.sub.4 or N; Y is CR.sub.4 or N, provided that Y is N only if X is N; R.sub.1 is...
2019/0127379 ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
The present invention relates to a compound suitable for use as a kinase inhibitor according to general formula (I) [compound (C), herein after], or the...
2019/0127378 NOVEL HETEROCYCLIC RING DERIVATIVES USEFUL AS SHP2 INHIBITORS
Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2...
2019/0127377 JANUS KINASE INHIBITORS AND USES THEREOF
The invention described herein pertains to selective Janus kinase (JAK) inhibitors and methods of use thereof. Also described are methods for treating diseases...
2019/0127375 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
Provided herein are compounds of the General Formula I: ##STR00001## and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B,...
2019/0127374 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
Provided herein are compounds of the General Formula I: ##STR00001## and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B,...
2019/0127373 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
Provided herein are compounds of the General Formula I: ##STR00001## and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B,...
2019/0127372 S1PR2 ANTAGONISTS AND USES THEREFOR
Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) through the administration of a therapeutically...
2019/0127371 FUSED IMIDAZO-PIPERIDINE JAK INHIBITORS
The invention provides compounds of formula (I): ##STR00001## where the variables are defined in the specification, or a pharmaceutically-acceptable salt...
2019/0127370 DIAZANAPHTHALEN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
Diazanaphthalene compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2019/0127369 Process for preparing (4S)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthy- ...
The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihy- ...
2019/0127368 NLRP3 MODULATORS
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination...
2019/0127367 NLRP3 MODULATORS
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination...
2019/0127366 THERAPEUTIC INHIBITORY COMPOUNDS
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds which are complement factor D inhibitors. Such...
2019/0127365 INHIBITORS OF HEPATITIS C VIRUS REPLICATION
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the...
2019/0127364 PYRIMIDINE COMPOUND AS JAK KINASE INHIBITOR
The invention provides a compound of formula (I): ##STR00001## or a pharmaceutically-acceptable salt thereof, that is an inhibitor of JAK kinases. The invention...
2019/0127363 NOVEL GPR119 AGONIST COMPOUNDS
The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds. ##STR00001##
2019/0127362 SPIROCYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof,...
2019/0127361 Therapeutic Compounds
Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions...
2019/0127360 COMPOUNDS FOR MODULATING AQUAPORINS
The invention relates to compounds of formula (I) pharmaceutical compositions thereof and methods for modulating aquaporin 9. ##STR00001##
2019/0127359 Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin...
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of...
2019/0127358 BRIDGED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof,...
2019/0127357 ARYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
The present invention relates to arylamide derivatives having dual pharmacological activity towards both the .alpha.2.delta. subunit, in particular the...
2019/0127356 Substituted Chromanes and Method of Use
The invention provides for compounds of formula (I) ##STR00001## wherein R.sup.1, X, Y, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11,...
2019/0127355 HEPATITIS C VIRUS INHIBITORS
A compound of Formula (I) or (II), for treating or preventing an HCV infection in a subject. ##STR00001##
2019/0127354 2,4,6,7-TETRASUBSTITUTED QUINOLINE COMPOUNDS AS INHIBITORS OF DNA METHYLTRANSFERASES
It relates to the compounds of formula (I), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures of stereoisomers,...
2019/0127353 PYRIMIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF
Provided are a pyrimidine compound represented by Formula 1, a method of preparing the same, and a pharmaceutical use of the pyrimidine compound for the...
2019/0127352 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME
The present specification provides a heterocyclic compound and an organic light emitting device comprising the same.
2019/0127351 PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the...
2019/0127350 METHOD FOR PREPARING TYROSINE KINASE INHIBITOR AND DERIVATIVE THEREOF
The present invention relates to a method for preparing a tyrosine kinase inhibitor and a derivative thereof. The present method has a short synthesis route,...
2019/0127349 PYRIDAZINONE-BASED BROAD SPECTRUM ANTI-INFLUENZA INHIBITORS
The present invention relates to compounds of formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, as well as processes for their...
2019/0127348 CRYSTALLINE FORMS OF C21H22Cl2N4O2
The present invention provides crystalline forms of a compound of formula (I): ##STR00001## Also provided are pharmaceutical compositions that include the...
2019/0127347 TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases,...
2019/0127346 BETA- AND GAMMA-AMINO-ISOQUINOLINE AMIDE COMPOUNDS AND SUBSTITUTED BENZAMIDE COMPOUNDS
Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that...
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