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Patent # Description
2019/0125881 STABLE LIQUID FORMULATIONS FOR PHARMACEUTICALS AND SUPPLEMETNTS
A liquid composition comprising: a primary component being an Active Pharmaceutical Ingredient (API), a nutritional supplement, or combinations thereof: a...
2019/0125880 TOPICAL COMPOSITIONS FOR IMPROVED DELIVERY OF ACTIVE AGENTS
A topical composition and methods of making the composition is disclosed. The composition may comprise an ointment base, C11-C40 alcohols or acids, and a...
2019/0125879 ITRACONAZOLE COMPOSITIONS AND DOSAGE FORMS, AND METHODS OF USING THE SAME
The disclosure relates to, among other things, pharmaceutical compositions, such as solid oral dosage forms, comprising itraconazole, methods of making the...
2019/0125878 POLYMER-BASED SUSTAINED RELEASE DEVICE
This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for...
2019/0125877 Ophthalmic Composition
The first aspect of the present invention relates to an ophthalmic composition comprising (A) one or more kinds selected from the group consisting of...
2019/0125876 METHOD FOR MANUFACTURING NUCLEIC ACID FILM AND APPARATUS FOR INJECTING MEDICINE USING NUCLEIC ACID FILM
A nucleic acid film fabrication method, includes: a mixing step in which a nucleic acid is added in powder form to distilled water or deionized water to...
2019/0125875 ATAZANAVIR SULFATE FORMULATIONS WITH IMPROVED Ph EFFECT
Disclosed are compressed tablets containing atazanavir sulfate and an acidifying agent, optionally with another active agent, e.g., anti-HIV agents, and...
2019/0125874 POLY (BETA-AMINO ESTERS) AND USES THEREOF
Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed...
2019/0125873 GLUCOSAMINE PEPTIDE COMPOUNDS FOR TREATING LIVER METABOLIC DISORDERS
A glucosamine peptide compound or a pharmaceutically acceptable salt thereof are useful for treating liver metabolic disorders, wherein the glucosamine peptide...
2019/0125872 PERIODONTAL REGENERATION COMPOSITION AND METHOD OF USING SAME
A periodontal structure regeneration composition for treatment of periodontal disease is a mixture of particles of a bone growth material and free collagen....
2019/0125871 DEVICES, SYSTEMS AND METHODS FOR OPTOGENETIC MODULATION OF ACTION POTENTIALS IN TARGET CELLS
Aspects of the disclosure include devices, systems and methods for optogenetic modulation of action potentials in target cells. The subject devices include...
2019/0125870 PHOTOCLEAVABLE DRUG CONJUGATES
Novel photocleavable drug conjugates for forming drug depots comprise drugs attached to photocleavable groups. The drug is crosslinked via photocleavable...
2019/0125869 PULSED ELECTROMAGNETIC THERAPY FOR DIRECTING AGENTS TO CANCER CELLS
Provided among other things is a method of treating a diseased tissue that is a cancer tissue, virally infected tissue, or a tissue infected with an obligate...
2019/0125868 HIGH CONCENTRATION IMMUNOGLOBULIN COMPOSITION FOR PHARMACEUTICAL APPLICATION
The present invention relates to a liquid composition comprising polyclonal immunoglobulins, at least one viscosity modulating amino acid, selected from...
2019/0125867 THERAPEUTIC AGENT FOR SOLID CANCER
Disclosed is a novel means effective for treatment, metastasis-inhibition, and recurrence-inhibition of human solid cancer. A therapeutic agent for solid...
2019/0125866 AGONIST ANTIBODIES THAT BIND HUMAN CD137 AND USES THEREOF
The present disclosure relates to compounds (e.g., antibodies, or antigen-binding fragments thereof) that bind to an epitope of CD137 and agonize CD137, and to...
2019/0125865 METHODS FOR TREATING OR PREVENTING ASTHMA BY ADMINISTERING AN IL-4R ANTAGONIST
The invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods featured in the invention comprise...
2019/0125864 COMBINATION THERAPY OF RAMUCIRUMAB AND ABEMACICLIB FOR USE IN TREATMENT OF MANTLE CELL LYMPHOMA
The disclosure relates to a combination of an anti-human VEGFR2 antibody ramucirumab (Ramucirumab or I MC-1121B is a fully human IgG1 specific for the VEGF...
2019/0125863 NANOEMULSION ADJUVANT FOR NASAL MUCOSA AND PREPARATION METHOD THEREOF
The invention provides a nanoemulsion adjuvant and a preparation method thereof, which are composed of the following components: a continuous aqueous phase...
2019/0125862 IMPROVED METHOD FOR PRODUCING VIRUS LIKE PARTICLES
The present invention relates to the production of structural proteins and virus-like particles (VLPs) of flaviviruses and hepatitis C. Production is through...
2019/0125861 RSV F Protein Mutants
The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein...
2019/0125860 Equine Influenza Virus Live Attenuated Vaccines
The present invention provides compositions and methods related to equine live-attenuated influenza vaccines.
2019/0125859 INFLUENZA VIRUS VACCINATION REGIMENS
Provided herein are immunization regimens for inducing an immune response (e.g., and antibody response) against influenza virus. In specific aspects, the...
2019/0125858 COLD ADAPTED AND VIRULENCE FACTOR DELETED LIVE ATTENUATED VACCINE SUITABLE FOR MUCOSAL DELIVERY
Compositions and methods are provided for a live, attenuated influenza vaccine suitable for nasal administration. The vaccine utilizes a cold adapted influenza...
2019/0125857 NUCLEIC ACID MOLECULES AND USES THEREOF
The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or prophylaxis of an infection with Norovirus...
2019/0125856 Improvement of L2 Peptide Immunogenicity
The present invention relates to an immunogenic polypeptide comprising a multitude of human papillomavirus (HPV) L2 N-terminal peptides corresponding to amino...
2019/0125855 RAPID METHOD OF GENERATING LIVE ATTENUATED VACCINES
The present invention relates to a method of generating a live attenuated vaccine. The present invention also relates to a live attenuated vaccine produced...
2019/0125854 VACCINE AGAINST RSV
Novel nucleic acid molecules encoding a pre-fusion RSV F protein or immunologically active part thereof are described, and the pre-fusion RSV F protein...
2019/0125853 NOROVIRUS VACCINE FORMULATIONS
The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and...
2019/0125852 COMPOSITIONS AND METHODS FOR TUMOR VACCINATION USING PROSTATE CANCER-ASSOCIATED ANTIGENS
Methods and compositions for constructing and producing recombinant adenovirus-based vector vaccines are provided. In particular aspects, there are be provided...
2019/0125850 IMMUNOTHERAPY FOR CANCER
Disclosed is a composition comprising an immunogenic composition for use in treatment of squamous cell carcinoma in combination with myeloid-derived suppressor...
2019/0125849 SCAFFOLDS FOR CELL TRANSPLANTATION
A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold...
2019/0125848 DENDRITIC CELL-EXTRACELLULAR VESICLE FUSIONS AND METHODS OF USING SAME
The present invention provides compositions and methods for treating cancer.
2019/0125847 Methods, Antibodies, and Vaccines Utilizing Epitopes of Alpha Synuclein for Treatment of Parkinson's Disease
The present invention pertains to a dendritic cell-based vaccine against rh-.alpha.-Syn, .alpha.-synuclein specific peptide antibodies and related vaccines,...
2019/0125846 NEW IMMUNOBIOLOGICAL PRODUCTS
The invention relates to a method comprising the step of incubating chitosan in an aqueous solution of an organic carboxylic acid or a salt thereof, a modified...
2019/0125845 COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of...
2019/0125844 NEUROTOXIN COMPOSITIONS FOR USE IN IMPROVING LUNG FUNCTION
Disclosed herein are compositions and methods for use in reducing lung function inhibition.
2019/0125843 Use of antiplatelet thrombolysin in the preparation of medicine for treating thrombotic thrombocytopenic purpura
A method and pharmceutical compositon for the treatment of thrombotic thrombocytopenic purpura. The method and pharmceutical compositon uses a therapuetically...
2019/0125842 LYSOSOMAL ACID LIPASE THERAPY FOR NAFLD AND RELATED DISEASES
The present invention comprises methods and compositions for the treatment or alleviation of NAFLD (non-alcoholic fatty liver disease) and those conditions...
2019/0125841 STABLE FORMULATIONS FOR CNS DELIVERY OF ARYLSULFATASE A
The present invention provides, among oilier things, compositions and methods for CNS delivery of lysosomal enzymes (e.g., recombinant human arylsulfatase A...
2019/0125840 COMBINATION THERAPY COMPRISING AN INFLAMMATORY IMMUNOCYTOKINE AND A CHIMERIC ANTIGEN RECEPTOR (CAR)-T CELL
The present invention relates to a combination comprising at least fusion protein comprising a binding protein specifically recognizing a cancer-related...
2019/0125839 POLYNUCLEOTIDES ENCODING INTERLEUKIN-12 (IL12) AND USES THEREOF
The present disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human interleukin-12 (IL12), functional...
2019/0125838 METHOD FOR THE TREATMENT OR PREVENTION OF OSTEOARTHRITIS
The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in...
2019/0125837 METHOD FOR THE TREATMENT OR PREVENTION OF OSTEOARTHRITIS
The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in...
2019/0125836 USE OF aFGF FOR PREVENTING OR TREATING DISEASES RELATED TO MUSCLE WASTING
Disclosed are methods and compositions useful in preventing or treating a disease related to muscle wasting by using acidic fibroblast growth factor (aFGF).
2019/0125835 COMPOSITION FOR REGULATING CUTANEOUS PIGMENTATION OR SKIN WHITENING COMPRISING SDF1
A method of preventing or treating cutaneous pigmentation disease in a subject in need thereof, includes: providing a pharmaceutical composition comprising...
2019/0125834 NOVEL RECOMBINANT FUSION PROTEINS, PREPARATION AND USE THEREOF
The present invention provides a recombinant fusion protein containing an anti-PD-L1 antibody, with at least one paratope of the anti-PD-L1 antibody linked via...
2019/0125833 NOPE FOR TREATMENT OF PATHOLOGICAL MUSCLE LOSS AND WEAKNESS
Methods of treating muscle wasting and other disorders with NOPE extracellular domain (ECD) polypeptides and NOPE ECD fusion molecules are provided.
2019/0125832 PHARMACEUTICAL COMPOSITION FOR REDUCING THE SYMPTOMS AND DISEASE OF THE RESPIRATORY INFECTION CAUSED BY HUMAN...
The present invention relates to a pharmaceutical composition for ameliorating the symptoms and disease of the respiratory infection caused by human...
2019/0125831 ANTI-INFECTIVE PROPERTIES OF ANTIFREEZE PROTEIN
As microbial drug-resistance increases, there is a critical need for new classes of compounds to combat infectious diseases. The Ixodes scapularis tick...
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