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Patent # Description
2019/0125780 METHOD FOR PREVENTING AND TREATING RENAL DISEASE
Assays, methods and kits for predicting a subjects (e.g., human) risk of primary glomerulopathy, secondary glomerulopathy or recurrence (e.g., post-transplant...
2019/0125779 PHARMACEUTICAL COMPOSITIONS
Novel treatment methods of controlling cell hyperexcitability occurring in a neurological disease or disorder associated with epileptogenesis or cardiac...
2019/0125778 HAPTEN-ENHANCED CHEMOIMMUNOTHERAPY BY ULTRA-MINIMUM INCISION PERSONALIZED INTRATUMORAL CHEMOIMMUNOTHERAPY
Embodiments disclosed herein provide methods for treating neoplasm in a mammal, comprising intratumorally administering to the neoplasm an effective amount of...
2019/0125777 METHODS AND MATERIALS FOR REDUCING THE RISK OF INFECTIONS
This document relates to methods and materials for reducing the risk of infection after a shoulder surgery or medical procedure. For example, this document...
2019/0125776 TOPICAL PHARMACEUTICAL FORMULATIONS CONTAINING A LOW CONCENTRATION OF BENZOYL PEROXIDE IN SUSPENSION IN WATER...
An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration...
2019/0125775 Methods and Compounds for Stimulating Read-Through of Premature Termination Codons
The present disclosure provides compositions and methods for treating and/preventing diseases and conditions associated with premature termination mutations....
2019/0125774 ANTIMICROBIAL ADHESIVE FORMULATION AND FILM DRESSINGS HAVING AN ANTIMICROBIAL ADHESIVE
An adhesive formulation is provided for use in a film wound dressing. The adhesive formulation includes a medical-grade adhesive and an antimicrobial...
2019/0125773 METHODS FOR CANCER THERAPY
The present disclosure relates to methods or dosing regimens comprising a proteasome inhibitor of formula (I), or a pharmaceutically acceptable salt thereof, ...
2019/0125772 IMPROVED DRUG COMBINATIONS FOR DRUG-RESISTANT AND DRUG-SENSITIVE MULTIPLE MYELOMA
Disclosed are pharmaceutical compositions and methods of treating multiple myeloma by providing a pharmaceutically effective amount of each drug in a...
2019/0125771 LIVER SPECIFIC DELIVERY-BASED ANTIVIRAL PRODRUG NUCLEOSIDE CYCLOPHOSPHATE COMPOUND AND USES THEREOF
Disclosed are a liver specific delivery (LSD)-based antiviral prodrug nucleoside cyclophosphate compound and uses thereof, and in particular, provided are a...
2019/0125770 (R)-3-((3S,4S)-3-FLUORO-4-(4-HYDROXYPHENYL)PIPERIDIN-1-YL)-1-(4-METHYLBENZ- YL)PYRROLIDIN-2-ONE AND ITS PRODRUGS...
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds...
2019/0125769 COMBINATIONAL THERAPIES FOR TREATMENT OF CANCER COMPRISING A BACTERIOCHLOROPHYLL DERIVATIVE
An anti-myeloid-derived suppressor cells agent ("anti-MDSCs agent") and a bacteriochlorophyll derivative (hereinafter "Bchl-D) for use in combination therapy...
2019/0125768 TREATMENT OF RHEUMATOID ARTHRITIS
A composition for treating chronic inflammation, including an antibiotic, a lipophilic potentiating agent, a guanosine analog antiviral agent, and Vitamin D in...
2019/0125767 9-AMINOMETHYL MINOCYCLINE COMPOUNDS AND USES THEREOF
Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides...
2019/0125766 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MEIBOMIAN GLAND DYSFUNCTION
Described herein are compositions and methods for the treatment of meibomian gland dysfunction. Said compositions and methods comprise keratolytic agents, such...
2019/0125765 COMBINATION THERAPIES AND METHODS OF USE THEREOF FOR TREATING CANCER
Pharmaceutical compositions including an effective amount of an antiandrogen or androgen antagonist in combination with a Plk inhibitor and methods of use...
2019/0125764 OXYSTEROLS AND METHODS OF USE THEREOF
Compounds are provided according to Formula (I): Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein...
2019/0125763 NON-HORMONAL STEROID MODULATORS OF NF-kB FOR TREATMENT OF DISEASE
Provided herein is a pharmaceutical composition comprising a compound having the structural formula ##STR00001## wherein the compound is present in an amount...
2019/0125762 INJECTABLE PHARMACEUTICAL COMPOSITIONS COMPRISING A CYCLODEXTRIN A HYDROPHOBIC DRUG, A CO-SOLVENT, AND A...
Injectable pharmaceutical compositions, methods of use and formulation are disclosed. The compositions comprise: one or more water soluble complexes, each...
2019/0125761 Reduction of Side Effects from Aromatase Inhibitors Used for Treating Breast Cancer
The present invention is directed generally to pharmaceutical compositions, methods, and kits for improving side effects associated with aromatase inhibitor...
2019/0125760 HIGH-STRENGTH TESTOSTERONE UNDECANOATE COMPOSITIONS
The present disclosure is drawn to pharmaceutical compositions and oral dosage capsules containing testosterone undecanoate, as well as related methods. The...
2019/0125758 COMPOSITIONS AND METHODS FOR OPHTHALMIC AND/OR OTHER APPLICATIONS
Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some...
2019/0125757 METHOD FOR TREATING CANCER USING A SELENOUREA-COORDINATED GOLD(I)-CARBENE COMPLEX
Gold(I)-carbene complexes having a selenium donor ligand with anti-cancer activity and a method of treating cancer. Methods of treating cancer comprising...
2019/0125756 METHOD OF TREATING HYPERTENSION
Disclosed herein are compositions and methods for the treatment of pulmonary hypertension, including pulmonary arterial hypertension. The methods include...
2019/0125755 A COMPOSITION COMPOSED OF CEFTRIAXONE SODIUM AND SULBACTUM SODIUM
The present invention provides a composition composed of ceftriaxone sodium and sulbactam sodium, a pharmaceutical composition comprising the same and the...
2019/0125754 BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE
The application relates to biaryl compounds, pharmaceutical compositions comprising the compounds, and methods of use the compounds for treating cell...
2019/0125753 COMPOUNDS AND METHODS FOR INCREASING HEMATOPOIESIS
Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is hydrogen or C.sub.1-C.sub.6 alkyl; ring A is...
2019/0125752 Highly Active Anti-Neoplastic and Anti-Proliferative Agents
This invention is in the area of improved compounds and methods for treating selected cancers and hyperproliferative disorders.
2019/0125751 ANTICANCER COMBINATION THERAPY
The invention describes anti-cancer therapies comprising using a 3G-EGFR inhibitor and an irreversible (2.sup.nd generation) EGFR TKI, each as described herein.
2019/0125750 HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS
The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity...
2019/0125749 POLYMORPHS OF ARRY-380, A SELECTIVE HER[[B]]2 INHIBITOR AND PHARMACEUTICAL COMPOSITIONS CONT[[l]]AINING THEM
Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dim- ethyl-4, 5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided...
2019/0125748 TREATMENT OF HIPPO PATHWAY MUTANT TUMORS AND METHODS OF IDENTIFYING SUBJECTS AS CANDIDATES FOR TREATMENT
The present invention relates to a method of treating a tumor in a subject. This method involves administering to a subject having a Hippo pathway mutant tumor...
2019/0125747 FORMULATIONS OF A COMPOUND MODULATING KINASES
Provided are solid dispersions of Compound I having the formula: ##STR00001## wherein Compound I is substantially amorphous, methods of manufacturing said solid...
2019/0125746 NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTI-CANCER AND ANTI-MIGRATORY AGENTS
A series of novel of EHop-016 derivatives is presented herein via designing and synthesizing compounds that mimics its more favorable "U-shaped" conformation...
2019/0125745 TREATMENT AND DIAGNOSIS OF CANCER
This invention features compounds that modulate the activity of liver X receptors, pharmaceutical compositions including the compounds of the invention, and...
2019/0125744 LANTHIONINE SYNTHETASE C-LIKE 2-BASED THERAPEUTICS
Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including...
2019/0125743 COMBINATION OF PURE 5-HT6 RECEPTOR ANTAGONISTS WITH ACETYLCHOLINESTERASE INHIBITORS
The present invention relates to pure 5-HT6 receptor antagonists, or the pharmaceutically acceptable salt(s) thereof in combination with or as adjunct to...
2019/0125742 TREATMENT OF GLIOMAS USING ORGANONITRO COMPOUND COMBINATION THERAPY
The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation...
2019/0125741 6-(5-MEMBERED HETEROARYL)ISOQUINOLIN-3-YL-(5-MEMBERED HETEROARYL) CARBOXAMIDES AND PREPARATION AND USE THEREOF
Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an...
2019/0125740 6-(6-MEMBERED HETEROARYL & ARYL)ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an...
2019/0125739 QUINOLINE DERIVATIVE FOR TREATING GASTRIC CANCER
Provided in the present invention is a quinoline derivative for treating gastric cancer. ...
2019/0125738 NEUROKININ ANTAGONISTS AND USES THEREOF
In some embodiments, methods of inhibiting, ameliorating, reducing the severity of, treating, reducing the likelihood of, or preventing social isolation stress...
2019/0125737 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
2019/0125736 USE OF 2-SUBSTITUTED INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF AUTOIMMUNE DISEASES
The present application relates to substituted indazoles, to the use thereof alone or in combinations for treatment and/or prophylaxis of autoimmune disorders,...
2019/0125735 INHIBITION OF P38 MAPK FOR THE TREATMENT OF CANCER
Methods are provided for treating cancer patients who have elevated expression of FOXC2. In certain aspects, patients having elevated FOXC2 are treated with an...
2019/0125734 COMPOSITION FOR TREATING OR PREVENTING ATOPIC DERMATITIS
The present invention provides a composition and a method both for treating or preventing atopic dermatitis effectively. Provided is a composition which...
2019/0125733 COMPOSITIONS COMPRISING SUBSTITUTED BENZOFUROQUINOLIZINE AND PSYCHOACTIVE DRUG
The present invention relates to compositions for use in sedation and/or anesthesia, where the composition comprises MK-467 and a psychoactive drug selected...
2019/0125732 PHARMACEUTICAL COMPOSITION FOR TREATING CANCER AND A METHOD THEREOF
A pharmaceutical composition containing an anticancer compound, named isopicrinine, isolated from the plant Rhazya Stricta. The pharmaceutical composition may...
2019/0125731 ANTIFIBROTIC COMPOUNDS AND USES THEREOF
The present invention provides compounds having the general structural formula (I) ##STR00001## and pharmaceutically acceptable derivatives thereof, as...
2019/0125730 OXADIAZOLES AND THIADIAZOLES AS TGF-BETA INHIBITORS
The present disclosure is concerned with oxadiazole and thiadiazole analogs that are capable of inhibiting TGF-.beta. and methods of treating cancers such as,...
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