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Patent # Description
2019/0136260 PROCESS FOR TRANSFECTING PLANTS
A process of transfecting a plant, comprising spraying parts of said plant with an aqueous suspension containing cells of an Agrobacterium strain and at least...
2019/0136259 METHODS OF USING CYT1A MUTANTS AGAINST COLEOPTERAN PESTS
The disclosure provides nucleic acids, and variants of Bacillus thuringiensis polypeptides having pesticidal activity against insect pests, including...
2019/0136258 INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal...
2019/0136257 GENE FOR IMPROVING PLANT DISEASE RESISTANCE AND USE THEREOF
The ReXEG1 gene for improving plant disease resistance has a nucleotide sequence as shown in SEQ ID NO. 1, and encodes a product having an amino acid sequence...
2019/0136256 METHODS OF CONTROLLING VEGETATIVE GROWTH AND FLOWERING TIMES BY MODULATING PHOSPHOENOLPYRUVATE SHUNT BETWEEN...
Disclosed herein are methods of producing plants with preferred levels of vegetative growth periods, flowering times, and resistance to stress and pathogens;...
2019/0136255 PLANTS SHOWING A REDUCED WOUND-INDUCED SURFACE DISCOLORATION
The present invention relates a plant which may comprise a modified F5H gene homolog, wherein said gene homolog may comprise a modification as compared to its...
2019/0136254 ALS Inhibitor Herbicide Tolerant Mutant Plants
The present invention relates to an ALS inhibitor herbicide tolerant polyploid plants, such as B. napus or B. juncea plants, progeny and parts thereof...
2019/0136253 Application of IPS1 Gene in Improving Photosynthesis of Rice
A method for improving photosynthesis of rice includes the step of knocking out IPS1 gene in rice. The IPS1 gene has a nucleotide sequence shown in SEQ ID NO: 1.
2019/0136252 USE OF THE SOYBEAN SUCROSE SYNTHASE PROMOTER TO INCREASE PLANT SEED LIPID CONTENT
Recombinant DNA constructs comprising the soybean sucrose synthase promoter operably linked to polynucleotides encoding transcription factors such as ODP1,...
2019/0136251 GENE IMPACTING CELLULOSE CONTENT AND BIOMASS FORMATION AND METHODS OF USE
The invention relates to expression of the PdHB3 gene and uses thereof. The invention provides genetically engineered plants expressing the PdHB3 gene and...
2019/0136250 SIMULTANEOUS GENE EDITING AND HAPLOID INDUCTION
The presently disclosed subject matter relates to using a haploid inducing line (whether existing or created) and transforming the haploid line so that it...
2019/0136249 ORGANELLE GENOME MODIFICATION USING POLYNUCLEOTIDE GUIDED ENDONUCLEASE
Provided herein are methods and systems for altering the genome of an organelle. In some embodiments, the method comprises introducing into an organelle a...
2019/0136248 NOVEL GUIDE RNA/CAS ENDONUCLEASE SYSTEMS
Compositions and methods are provided for novel guide RNA/Cas endonuclease systems. Type II Cas9 endonuclease systems originating from Brevibacillus...
2019/0136246 PLANT-PRODUCED CHIMAERIC ORBIVIRUS VLPS
This invention relates to a second generation, plant-produced synthetic Orbivirus candidate vaccine. The vaccine comprises a plant produced chimaeric Orbivirus...
2019/0136245 Restorer Plants
Hybrid cereals are described which are obtained by restoring the pollen fertility for the Pampa cytoplasmic male sterility (P-CMS) and which are characterized...
2019/0136244 PHAGE-MEDIATED MANIPULATION OF WOLBACHIA
The invention relates to systems, methods, and compositions for the genetic modification of Wolbachia.
2019/0136243 METHOD FOR PREVENTING OR TREATING OBESITY BY USING A COMPOSITION INCLUDING HOGA1-INHIBITING SUBSTANCE AND...
Provided are a method for preventing or treating obesity by using a composition including an inhibitor of expression of the Hoga1 gene or an inhibitor of...
2019/0136242 PAN-GENOTYPIC AGENTS AGAINST INFLUENZA VIRUS AND METHODS OF USING THE SAME
Methods of inhibiting influenza A virus in a sample are provided. Aspects of the methods include contacting a sample comprising viral RNA (vRNA) having a PSL2...
2019/0136241 APTAMER-BASED ANALYTE ASSAYS
The present invention relates to aptamer-based assays to capture and/or detect analytes comprising primary and secondary aptamers, as well as compositions...
2019/0136240 NUCLEIC ACID APTAMERS
Disclosed herein are compositions including an aptamer bound to a complex, wherein the complex comprises at least two polypeptides. Accordingly, methods of...
2019/0136239 GLYPICAN-3 SPECIFIC APTAMER AND USE THEREOF
The present invention relates to a DNA aptamer specifically binding to a hepatocellular carcinoma-related Glypican-3(GPC3) protein, treatment of cancers...
2019/0136238 TARGETING THE GLUTAMINE TO PYRUVATE PATHWAY FOR TREATMENT OF ONCOGENIC KRAS-ASSOCIATED CANCER
Methods and kits for GPP-targeting, e.g., for the treatment of oncogenic Kras-associated cancers, and methods for determining the efficacy of those methods are...
2019/0136237 METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION
Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of...
2019/0136236 The LNCRNA MEG3 for Therapy and Diagnosis of Cardiac Remodelling
The present invention relates to a compound inhibiting the expression and/or the activity of maternally expressed 3 (Meg3) for use in treating or preventing...
2019/0136235 MODIFIED U6 PROMOTER SYSTEM FOR TISSUE SPECIFIC EXPRESSION
The present invention relates to a tissue-specific promoter system for expressing microRNA (miRNA) for RNA interference-based methods of gene therapy. In these...
2019/0136234 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE
Oligonucleotides, chemically-modified oligonucleotides, and oligonucleotide-conjugate complexes for use in research, diagnostics, and/or therapeutics are...
2019/0136233 MODULATING APOLIPOPROTEIN (A) EXPRESSION
Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments, the apo(a) targeting oligomeric...
2019/0136232 Compositions And Methods For Manipulation Of Adipocyte Energy Consumption Regulatory Pathway
Provided herein is a pathway for adipocyte energy consumption regulation involving ARID5B, genetic variant rs1421085, IRX3, and IRX5. Compositions and methods...
2019/0136231 LIPID NANOPARTICLE FORMULATIONS FOR CRISPR/CAS COMPONENTS
The invention provides lipid nanoparticle-based compositions and methods useful for delivery of CRISPR/Cas gene editing components.
2019/0136230 GENETICALLY ENGINEERED CELLS AND METHODS OF MAKING THE SAME
Provided are CRIS PR/CAS-related methods, compositions and components for editing a target nucleic acid sequence, or modulating expression of a target nucleic...
2019/0136229 COMPOSITIONS AND METHODS OF IMPROVING SPECIFICITY IN GENOMIC ENGINEERING USING RNA-GUIDED ENDONUCLEASES
Disclosed herein are optimized guide RNAs (gRNAs) and methods of designing and using said optimized gRNAs that have increased target binding specificity and...
2019/0136228 REAGENTS, KITS AND METHODS FOR MOLECULAR BARCODING
Multimeric barcoding reagents for labelling a target nucleic acid comprise: first and second barcode molecules linked together, wherein each of the barcode...
2019/0136227 METHOD FOR THE SYNTHESIS OF A BIFUNCTIONAL COMPLEX
Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex...
2019/0136226 DEVICES AND METHODS FOR NUCLEIC ACID EXTRACTION
Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform...
2019/0136225 BLOOD CELL LYSIS REAGENT
Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for...
2019/0136224 Hydrodynamically Controlled Electric Fields for High Throughput Transformation & High Throughput Parallel...
Methods and apparatuses for cell electroporation are provided. An apparatus includes a fluid transport structure, such as a pipette, that includes an...
2019/0136223 HEXURONATE C4-EPIMERASE MUTANT WITH IMPROVED CONVERSION ACTIVITY, AND METHOD FOR PRODUCING D-TAGATOSE BY USING SAME
A hexuronate C4-epimerase with improved conversion activity and a method for producing D-tagatose using the hexuronate C4-epimerase. The hexuronate...
2019/0136222 HIGHLY ACTIVE MUTANT ENZYME FOR PRODUCING 4-HYDROXYBENZOIC ACID OR SALT THEREOF
The mutant chorismate-pyruvate lyase (A) or (B) as described below is capable of producing 4-hydroxybenzoic acid or a salt thereof with sufficient practical...
2019/0136221 VALENCENE SYNTHASE
The present invention relates to a novel valencene synthase, to a nucleic acid encoding such valencene synthase, to a host cell comprising said encoding...
2019/0136220 VARIANTS OF THERMOVIBRIO AMMONIFICANS CARBONIC ANHYDRASE AND CO2 CAPTURE METHODS USING THERMOVIBRIO...
The present description relates to recombinant or engineered carbonic anhydrase polypeptides, variants, and functional derivatives thereof, having improved...
2019/0136219 Genetically Engineered Arginine Deiminase Modified by Site-Directed Mutagenesis
A genetically engineered arginine deiminase reconstructed by site-directed mutagenesis belongs to the technical field of genetic engineering technology. Its...
2019/0136218 PROTEASE VARIANTS AND USES THEREOF
Disclosed herein is one or more subtilisin variant useful for cleaning applications and in methods of cleaning, as well as in a variety of industrial...
2019/0136217 COMPOSITIONS AND METHODS COMPRISING SERINE PROTEASE VARIANTS
The present invention provides serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one...
2019/0136216 A NOVEL BOTULINUM NEUROTOXIN AND ITS DERIVATIVES
Provided herein are Clostridial Botulinum neurotoxin (BoNT) polypeptides of a novel serotype (BoNT/X) and methods of making and using the BoNT polypeptides,...
2019/0136215 Replication Conditional Virus that Specifically Kills Senescent Cells
Polypeptides, viruses, methods and compositions provided herein are useful for the selective elimination of senescent cells. Method aspects include methods for...
2019/0136214 GENERATION OF STABLE PROTEIN FILMS USING FLUOROUS SOLVENT
Methods of preparing protein films in the presence of organofluorine compounds are provided that can produce protein films that retain the solution phase...
2019/0136213 CARBOHYDRATE DEGRADING POLYPEPTIDE AND USES THEREOF
The invention relates to a polypeptide having hemicellulase activity which comprises the amino acid sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32,...
2019/0136212 COMBINATION CHEMOTHERAPY FOR THE TREATMENT OF CANCER
The present disclosure provides compositions, methods and kits for the treatment of cancer. Particularly, the present disclosure provides synergistic...
2019/0136211 Method For In Vivo High-Throughput Evaluating Of RNA-Guided Nuclease Activity
The present invention relates to a method for evaluating the activity of an RNA-guided nuclease in a cell in a high-throughput manner, and specifically to a...
2019/0136210 CAS9 FUSION MOLECULES, GENE EDITING SYSTEMS, AND METHODS OF USE THEREOF
Disclosed herein are enzymatically active Cas9 (eaCas9) fusion molecules, comprising an eaCas9 molecule linked, e.g., covalently or non-covalently, to a...
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