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Patent # Description
2019/0135804 COMPOSITIONS AND METHODS FOR THE INHIBITION OF PRURITUS
Pharmaceutical compositions comprising a molecular inhibitor of Npr1 are disclosed. Also disclosed are methods of treating, reducing, or preventing acute...
2019/0135803 NOVEL PROCESS FOR PREPARATION OF TETRABENAZINE AND DEUTETRABENAZINE
The present invention provides process for preparation of dihydroxy benzoquinoline compound (III) comprising reacting dihydroxy isoquinoline compound (IV) or a...
2019/0135802 MODULATION OF N-ACYLETHANOLAMINE-HYDROLYSING ACID AMIDASE (NAAA) FOR DISEASE TREATMENT
Pharmaceutical compositions make up a compound acting as inhibitor of N-acylethanolamine-hydrolysing acid amidase (NAAA), may be used for the therapeutical...
2019/0135801 COMPOUNDS THAT INDUCE DEGRADATION OF ANTI-APOPTOTIC BCL-2 FAMILY PROTEINS AND THE USES THEREOF
The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises a compound of Formula (I)...
2019/0135800 HALO-SUBSTITUTED PIPERIDINES AS OREXIN RECEPTOR MODULATORS
The present application relates to certain halo-substituted piperidine compounds, pharmaceutical compositions containing them, and methods of using them,...
2019/0135798 Substituted Oxadiazoles for Combating Phytopathogenic Fungi
The present invention relates to novel oxadiazoles of the formula I, or the N-oxides and/or their agriculturally useful salts and to their use for controlling...
2019/0135797 COMPOUND AND ORGANIC LIGHT-EMITTING DISPLAY DEVICE
The present disclosure provides a compound having property of thermally activated delayed fluorescence (TADF) and a display device. The compound has a...
2019/0135796 EZH2 INHIBITORS AND USES THEREOF
The present disclosure provides compounds of any one of Formulae (I), (II), and (III). The compounds described herein are inhibitors of histone ...
2019/0135795 MONOGLYCIDYL ISOCYANURATE COMPOUND AND PRODUCTION METHOD THEREFOR
There are provided a novel isocyanurate compound having a glycidyl group as a substituent to be bonded to a nitrogen atom. A monoglycidyl isocyanurate compound...
2019/0135794 BENZIMIDAZOLE-LINKED INDOLE COMPOUND ACTING AS NOVEL DIVALENT IAP ANTAGONIST
The present invention discloses a benzimidazole-linked indole compound acting as novel divalent IAP antagonist, specifically disclosing the compound shown in...
2019/0135793 HETEROCYCLIC INHIBITORS OF KDM5 FOR THE TREATMENT OF DISEASE
The present invention relates to compounds and methods useful as inhibitors of KDM5 for the treatment or prevention of cancer.
2019/0135792 CRYSTALLINE FORM OF COMPOUND SUPPRESSING PROTEIN KINASE ACTIVITY, AND APPLICATION THEREOF
Provided are a compound as represented by structural formula (I) ({5 -[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-aminopyridazin-3-yl}-N-{4- ...
2019/0135791 SUBSTITUTED 1,2,3-TRIAZOLES AS NR2B-SELECTIVE NMDA MODULATORS
Substituted 1,2,3-triazoles as NR2B receptor ligands. Such compounds may be used in NR2B receptor modulation and in pharmaceutical compositions and methods for...
2019/0135790 DIAMINOPYRIMIDINE BENZENESULFONE DERIVATIVES AND USES THEREOF
The present invention provides compounds of Formula (II) (e.g., compounds of Formula (I)), and pharmaceutically compositions thereof. Compounds of Formula (II)...
2019/0135789 INHIBITING ATAXIA TELANGIECTASIA AND RAD3-RELATED PROTEIN (ATR)
Novel compounds inhibiting ATR protein kinase include compounds of formula (I) disclosed herein, as well as liposome formulations comprising ATR protein kinase...
2019/0135788 DIHYDROPYRIMIDINYL BENZAZEPINE CARBOXAMIDE COMPOUNDS
This invention relates to new benzazepine carboxamide compounds of the formula ##STR00001## wherein X and R.sup.1 to R.sup.6 are as defined in the description...
2019/0135787 PYRIMIDINE COMPOSITIONS, ULTRA-PURE COMPOSITIONS AND SALTS THEREOF, METHODS OF MAKING THE SAME, AND METHODS OF...
The present application relates to ultra-pure compositions containing N.sup.4-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimi- ...
2019/0135786 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
The present invention relates to a novel heterocyclic compound inhibiting a cyclin-dependent kinase (CDK) and a pharmaceutical composition comprising the same...
2019/0135785 QUINOLINE DERIVATIVE
A compound represented by general formula (I) has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon...
2019/0135784 ANTIPROLIFERATIVE PYRIMIDINE-BASED COMPOUNDS
This invention is in the area of pyrimidine-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited...
2019/0135783 SMALL MOLECULE INHIBITORS OF SHARED EPITOPE-CALRETICULIN INTERACTIONS AND METHODS OF USE
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a ...
2019/0135782 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS
The present invention provides, inter alia, a compound having the structure: ##STR00001## Also provided are compositions containing a pharmaceutically...
2019/0135781 PYRIDINYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
The invention relates to methods of reducing the level of 2-hydroxyglutarate in cells by administration of an inhibitor of mutant isocitrate dehydrogenase-1.
2019/0135780 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
Provided are 4'-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of...
2019/0135779 CRYSTALS OF QUINAZOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR
The invention relates to Crystal form I and Crystal form II of dihydrochloride of N-(4-((3-chloro-4-fluorophenyl)amino)-7-((7-methyl-7-azaspiro[3.5]nonan-2- ...
2019/0135778 THERAPEUTICALLY ACTIVE BICYCLIC-SULPHONAMIDES AND PHARMACEUTICAL COMPOSITIONS
Pharmaceutical compounds have a bicyclic-sulphonamide structure and pharmaceutical compositions including the compounds may be used in therapy as...
2019/0135777 QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO THE MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR
The present invention relates to quinoline compounds of formula I ##STR00001## wherein the variables are defined as in the claims and the description. The...
2019/0135776 THERAPEUTICS TARGETING TRUNCATED ADENOMATOUS POLYPOSIS COLI (APC) PROTEINS
The described invention provides small molecule anti-cancer compounds that selectively target and inhibit measurable biological activity of truncated APC...
2019/0135775 PROCESSES FOR THE PREPARATION OF A DIARYLTHIOHYDANTOIN COMPOUND
Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer. ...
2019/0135774 BIOMOLECULE PROCESSING FROM FIXED BIOLOGICAL SAMPLES
Molecular characterization of disease has become the dominant trend in modern medicine, and it has recently become increasingly important to obtain qPCR,...
2019/0135773 NOVEL COMPOSITIONS AND METHODS FOR CANCER TREATMENT
The present invention relates to the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer.
2019/0135772 MODULATORS OF THE INTEGRATED STRESS PATHWAY
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases;...
2019/0135771 FLUOROCHEMICAL PIPERAZINE CARBOXAMIDES
The present invention provides a novel partially fluorinated piperazine carboxamide compound, and polymer composition comprising the fluorinated compound and a...
2019/0135770 HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF RSV
Disclosed herein are compounds and compositions for treating or inhibiting RSV and related members of the pneumovirus and paramyxovirus families such as human...
2019/0135769 COMPOUNDS AS DNA PROBES, METHODS AND APPLICATIONS THEREOF
The present disclosure relates to the field of pharmaceutical chemistry and biotechnology. The present disclosure also relates to a compound of Formula I and a...
2019/0135768 ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE...
The invention provides aryl dihydro-2H-benzo[b] [1,4]oxazine sulfonamide and related compounds, pharmaceutical compositions, methods of promoting RORy...
2019/0135767 Heterocyclic Compounds Useful In The Treatment Of Disease
A method for treating a lysophosphatidic acid-dependent disease or condition in a subject in need thereof is provided. The method includes administering to the...
2019/0135766 METHOD OF SYNTHESIZING PROTHIOCONAZOLE AND OPTICALLY ACTIVE ISOMERS THEREOF AND INTERMEDIATES
Disclosed are a method of synthesizing prothioconazole and optically active isomers thereof and intermediates. The method includes reacting hydrazine with...
2019/0135765 NOVEL PYRIMIDINE-4-CARBOXYLIC ACID DERIVATIVE HAVING ANTICANCER ACTIVITY
The present invention relates to a novel pyrimidine-4-carboxylic acid derivative having an anticancer activity, and the compound of the present invention is...
2019/0135764 UREA COMPOUNDS AND THEIR USE AS ENZYME INHIBITORS
A compound having the following structure: ##STR00001## or a pharmaceutically acceptable salt or derivative thereof. The compound may be used in the treatment or...
2019/0135763 PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE
Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided.
2019/0135762 COMPOUNDS USEFUL AS KINASE INHIBITORS
This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are...
2019/0135761 COMPOSITION COMPRISING 3-(HALOALKYL OR FORMYL)-1H-PYRAZOLE-4-CARBOXYLIC ACIDS OR ESTERS, ITS MANUFACTURE AND...
The present invention concerns compositions comprising (i) a 3-(haloalkyl or formyl)-1H-pyrazole wherein R.sup.1 is a halogenated C.sub.1-4 alkyl group, or the...
2019/0135760 PHARMACEUTICAL FORMULATIONS CONTAINING IPIDACRINE AND THEIR USE FOR THE TREATMENT OF DISORDERS OF POTENCY AND...
The invention is based on the use of ipidacrine to treat potency disorders and can be used in clinics for treating potency disorders related to the reduced...
2019/0135759 METHOD OF TREATING PAIN
The instant application discloses methods of treating, reducing, or preventing pain in a mammal, which may include administering a compound capable of...
2019/0135758 INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said...
2019/0135757 ACETYL-COA CARBOXYLASE MODULATORS
Provided herein are compounds that exhibit activity as acetyl-CoA carboxylase modulators (e.g., inhibitors) and are useful, for example, in methods for the...
2019/0135756 3,4-DI-SUBSTITUTED PYRIDINE COMPOUND, METHODS OF USING AND COMPOSITIONS COMPRISING THE SAME
2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid is useful in the modulation of blood or serum uric acid levels. In some embodiments, ...
2019/0135755 CRYSTAL POLYMORPHISM OF KCNQ2-5 CHANNEL ACTIVATOR
Crystal polymorphism may exist in a crystalline compound. In the case where crystal polymorphism exists, depending on the crystal form, solubility, dissolution...
2019/0135754 METHODS FOR ENANTIOSELECTIVE ALLYLIC ALKYLATION OF ESTERS, LACTONES, AND LACTAMS WITH UNACTIVATED ALLYLIC ALCOHOLS
The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic .alpha.-quaternary carboxylic acid derivatives via ...
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