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Patent # Description
2019/0134231 METHODS AND COMPOSITIONS FOR DETECTING ANEURYSMS
Provided herein are methods and compositions for the detection of vulnerable, rupture-prone aneurysms using multi-meric folate conjugated peptides (FCPs)....
2019/0134230 CHALLENGE TEST FOR DIAGNOSING SUBTYPES OF ASD
The present invention is directed to a method for differentiating between ASD phenotype 1, phenotype 2 and other ASD patients, wherein the method comprises,:...
2019/0134229 METHOD OF IDENTIFYING ASD PHENOTYPE 1 PATIENTS
The present invention is directed to a method of identifying autism spectrum disorder (ASD) phenotype 1 patients, wherein the method comprises: administering...
2019/0134228 System and Method for Managing All Cancers by Disabling the Cancer Cells Ability to Reproduce
This invention provides tools and methods that prevent a cancer cell from growing and reproducing more cancer cells. When growth ceases the body's immune...
2019/0134227 GENERATION OF GENETICALLY ENGINEERED ANIMALS BY CRISPR/CAS9 GENOME EDITING IN SPERMATOGONIAL STEM CELLS
The present disclosure provides methods and compositions for the production of genetically engineered animals, such as mice, by genomic editing of the...
2019/0134226 INTRATHECAL DELIVERY OF RECOMBINANT ADENO-ASSOCIATED VIRUS 9
The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and...
2019/0134225 INTRATHECAL DELIVERY OF RECOMBINANT ADENO-ASSOCIATED VIRUS 9
The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and...
2019/0134224 DIET CONTROLLED EXPRESSION OF A NUCLEIC ACID ENCODING A PRO-APOPTOTIC PROTEIN
A nucleic acid for the controlled expression of a nucleic acid encoding a pro-apoptotic protein in an individual, including: a regulatory polynucleotide...
2019/0134223 METHODS AND COMPOSITIONS FOR TREATING HEART FAILURE
This invention is generally related to novel compositions for treating or preventing heart failure. Specifically, the disclosure provides a composition...
2019/0134222 PHARMACEUTICAL COMPOSITION CONTAINING A STABILISED mRNA OPTIMISED FOR TRANSLATION IN ITS CODING REGIONS
The present invention relates to a pharmaceutical composition comprising a modified mRNA that is stabilised by sequence modifications and optimised for...
2019/0134221 CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY
Disclosed herein are vectors that targets a dystrophin gene, encoding at least one Cas9 molecule or a Cas9 fusion protein, and at least one gRNA molecule...
2019/0134220 Conjugates and Conjugating Reagents
A conjugate of a protein or peptide conjugated to a therapeutic, diagnostic or labelling agent via a linker, in which the linker includes a protein or peptide...
2019/0134219 INHIBITION OF SPONTANEOUS METASTASIS VIA PROTEIN INHIBITORS OF CYSTEINE PROTEASES
Two disparate biological mechanisms which predispose to the dissemination and metastases of solid tumors is described. The treatment of metastatic lesions via...
2019/0134218 COMPLEX OF ADENOVIRUS AND PAMAM-PEG-ERBITUX, AND USE THEREOF
The present invention relates to a complex of an antitumor adenovirus coated with ErbB-PEG-PAMAM and the use thereof. When using the complex of the present...
2019/0134217 COMPOSITIONS AND METHODS FOR THE DEPLETION OF CD117+ CELLS
The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic...
2019/0134216 ANTI-EGFR ANTIBODIES AND ANTIBODY DRUG CONJUGATES
The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said...
2019/0134215 COMBINATION OF CD33 ANTIBODY DRUG CONJUGATES WITH CHEMOTHERAPEUTIC AGENTS
This invention relates to treatment of cancer using a CD33 antibody drug conjugate in combination with chemotherapeutic agents.
2019/0134214 GLP-1 Receptor Ligand Moiety Conjugated Oligonucleotides and Uses Thereof
The present embodiments provide compounds and methods for targeting cells expressing GLP-1 receptor.
2019/0134213 BICYCLIC PEPTIDE-TOXIN CONJUGATES SPECIFIC FOR MT1-MMP
The present invention relates to drug conjugates comprising bicyclic peptides specific for MT1-MMP conjugated to one or more effector and/or functional groups...
2019/0134212 SUPRAMOLECULAR PROTEIN ASSEMBLIES WITH ADVANCED FUNCTIONS AND SYNTHESIS THEREOF
The present invention discloses stimuli-sensitive protein conjugate which can make supramolecular protein assemblies and methods for using the same. The...
2019/0134211 CAR PEPTIDE FOR HOMING, DIAGNOSIS & TARGETED THERAPY FOR PULMONARY AND FIBROTIC DISORDERS
Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and...
2019/0134210 MACROMOLECULAR CHEMOTHERAPEUTICS
Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block...
2019/0134209 MULTIFUNCTIONALIZED BIOACTIVE POLYCAPROLACTONE
A multifunctionalized polycaprolactone polymer, a process for forming a multifunctionalized polycaprolactone polymer, and an article of manufacture comprising...
2019/0134208 MULTIFUNCTIONAL FORMS OF POLYOXAZOLINE COPOLYMERS AND DRUG COMPOSITIONS COMPRISING THE SAME
The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically...
2019/0134207 Nicotine Delivery Product, Related Uses and Oral Dosage Forms, and Methods of Production
The present invention relates to a nicotine delivery product comprising, or even consisting essentially of, a population of nicotine-loaded cation exchange...
2019/0134206 CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION
This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA...
2019/0134205 PYRROLOBENZODIAZEPINE CONJUGATES AND THEIR USE FOR THE TREATMENT OF CANCER
A conjugate of formula (I): L-(D.sup.L).sub.p, wherein L is a Ligand unit, D is a Drug Linker unit of formula (II), wherein p is an integer of from 1 to 20. ...
2019/0134204 SURFACTANT-FREE WATER-FREE FOAMABLE COMPOSITIONS, BREAKABLE FOAMS AND GELS AND THEIR USES
A substantially surface active agent free composition which includes a hydrophobic solvent, and/or a petrolatum, a paraffin wax and/or a fatty alcohol, a fatty...
2019/0134203 TOPICAL TETRACYCLINE COMPOSITIONS
A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b)...
2019/0134202 Liquid Injectable Copolymer
The invention provides liquid injectable copolymers of TMC and HTMC that are degradable in vivo. Degradation can be tailored by adjusting the amount of HTMC in...
2019/0134201 STATIN-CONTAINING NANOPARTICLE PREPARATION FOR ENHANCING FUNCTION OF STEM CELLS FOR TREATING INFLAMMATORY...
A statin-encapsulated nanoparticle contains a bioabsorbable polymer and statin encapsulated in the nanoparticle. Suitable bioabsorbable polymers include a...
2019/0134200 USE OF AN AMINO SUGAR AS PLASTICIZER
The present invention relates to the use of an amino sugar as plasticizer in formulations comprising a polymer as carrier for active ingredients, in particular...
2019/0134199 METHOD FOR THE PRODUCTION OF HYDROLYZED ALLERGENS
A pharmaceutical composition of hydrolyzed allergens and its use for treating, curing or preventing allergic reactions. The hydrolyzed allergens are prepared...
2019/0134198 NANOSTRUCTURED CARRIERS FOR GUIDED AND TARGETED ON-DEMAND SUBSTANCE DELIVERY
Methods, systems, and devices are disclosed for fabricating and implementing nanoscale and microscale structured carriers to provide guided, targeted, and...
2019/0134197 ARTHROGENIC ALPHAVIRUS VACCINE
The invention relates to a vaccine comprising live attenuated recombinant alphavirus comprising mutated capsid protein. The invention also relates to a method...
2019/0134196 ETAR ANTIBODY, AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
Provided herein are a stable solution formulation of an ET.sub.AR antibody, and use thereof in treating, preventing, or alleviating one or more symptoms of...
2019/0134195 COMPOSITIONS AND METHODS FOR THE TREATMENT OF HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED DISEASES
Methods and compositions for constructing and producing recombinant adenovirus-based vector vaccines are provided. In particular aspects, there are be provided...
2019/0134194 SELECTIVELY ALTERING MICROBIOTA FOR IMMUNE MODULATION
The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of...
2019/0134193 USE OF TAM RECEPTOR INHIBITORS AS IMMUNOENHANCERS AND TAM ACTIVATORS AS IMMUNOSUPPRESSORS
This disclosure concerns compositions and methods for immunoenhancement and/or immunosuppression. In certain embodiments, the disclosure concerns methods of...
2019/0134192 TM4SF19 AS MARKER FOR DIAGNOSING OBESITY AND METHOD USING SAME
The diagnosis of obesity can be effectively carried out by using a composition for diagnosing obesity comprising a substance, which specifically couples to...
2019/0134191 ALHYDROGEL-SODIUM CHLORIDE COMPOUND IMMUNOLOGIC ADJUVANT, PREPARATION METHOD AND USE THEREOF (As Amended)
The invention belongs to the field of biological medicine, in particular refers to an alhydrogel-sodium chloride compound immunologic adjuvant, preparation...
2019/0134190 COMBINATION THERAPY WITH CPG TLR9 LIGAND
The present invention generally relates to an immunostimulatory combination comprising a first composition comprising a therapeutic vaccine and a second...
2019/0134189 TREATMENT OF PEANUT ALLERGY
The present invention relates to compositions, immunogenic or vaccine compositions and pharmaceutical compositions for the prevention or treatment of peanut...
2019/0134188 Recombinant Newcastle Disease Virus Expressing an Immunomodulatory Protein as a Molecular Adiuvant
The present invention refers to recombinant Newcastle disease viruses (rNDV) having inserted a transcriptional unit foreign to its genome, which codifies for...
2019/0134187 MODIFIED RSV F PROTEINS AND METHODS OF THEIR USE
The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them,...
2019/0134186 INFLUENZA VACCINES WITH REDUCED AMOUNT OF EMULSION ADJUVANT
Influenza vaccines with oil-in-water emulsion adjuvants are known. The amount of emulsion adjuvant required for an influenza vaccine can be reduced, thereby...
2019/0134185 UNIVERSAL INFLUENZA VACCINE BASED ON HETEROLOGOUS MULTIPLE M2E PROTEINS
Disclosed are universal influenza A vaccines capable of providing broader cross-protection. The vaccine contains a fusion protein comprising tandem repeats of...
2019/0134184 ZIKA VIRAL ANTIGEN CONSTRUCTS
Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against viral infection, methods for their...
2019/0134183 RECOMBINANT ADENOVIRUS VECTORED FMDV VACCINES AND USES THEREOF
The present invention encompasses FMDV vaccines or compositions. The invention encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes...
2019/0134182 COMPOSITIONS AND METHODS FOR LIVE, ATTENUATED ALPHAVIRUS FORMULATIONS
Embodiments herein relate to compositions of and methods for live attenuated alphaviruses. In certain embodiments, a live, attenuated virus composition...
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